determination of bioavailability parameters
Post on 31-Dec-2015
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DETERMINATION OF BIOAVAILABILITY PARAMETERS. GROUP ASSIGNMENT WORK UP. DESIRED PARAMETERS. [AUC] Total. ELIMINATION HALF-LIFE (T ½ ). Method of Residual. Where A =. RELATIVE BIOAVAILABILITY. - PowerPoint PPT Presentation
TRANSCRIPT
DETERMINATION DETERMINATION OF OF
BIOAVAILABILITY BIOAVAILABILITY PARAMETERSPARAMETERS
GROUP ASSIGNMENT GROUP ASSIGNMENT WORK UPWORK UP
DESIRED PARAMETERSDESIRED PARAMETERSParameters PRODUCT A PRODUCT B
Bioequivalence Factor, F†
Relative Bioavailability‡
[AUC]Total (ng.Hr.ml-1)*
Cmax (ng/ml)
Tmax (Hours)
Ka (Hr-1)**
Kel (Hr-1)
T1/2 (Hr.)***
[AUC][AUC]TotalTotal
lats
last
tt AUCAUCAUC 00
el
lastnn
nn
K
Ctt
CCAUC .....
2 11
0
elKT
693.0
2
1
ELIMINATION HALF-LIFE (TELIMINATION HALF-LIFE (T½½))
Method of ResidualMethod of Residual
• Where A =
tkatkel
dP ee
kelkaV
kaDoseFC
tka
d
tkel
dP e
kelkaV
kaDoseFe
kelkaV
kaDoseFLnLnC
kelkaV
kaDoseF
d
RELATIVE BIOAVAILABILITYRELATIVE BIOAVAILABILITY
BT
ATR AUC
AUCBA
,
,
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