determination of bioavailability parameters
DESCRIPTION
DETERMINATION OF BIOAVAILABILITY PARAMETERS. GROUP ASSIGNMENT WORK UP. DESIRED PARAMETERS. [AUC] Total. ELIMINATION HALF-LIFE (T ½ ). Method of Residual. Where A =. RELATIVE BIOAVAILABILITY. - PowerPoint PPT PresentationTRANSCRIPT
DETERMINATION DETERMINATION OF OF
BIOAVAILABILITY BIOAVAILABILITY PARAMETERSPARAMETERS
GROUP ASSIGNMENT GROUP ASSIGNMENT WORK UPWORK UP
DESIRED PARAMETERSDESIRED PARAMETERSParameters PRODUCT A PRODUCT B
Bioequivalence Factor, F†
Relative Bioavailability‡
[AUC]Total (ng.Hr.ml-1)*
Cmax (ng/ml)
Tmax (Hours)
Ka (Hr-1)**
Kel (Hr-1)
T1/2 (Hr.)***
[AUC][AUC]TotalTotal
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ELIMINATION HALF-LIFE (TELIMINATION HALF-LIFE (T½½))
Method of ResidualMethod of Residual
• Where A =
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kelkaV
kaDoseFC
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dP e
kelkaV
kaDoseFe
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kaDoseFLnLnC
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RELATIVE BIOAVAILABILITYRELATIVE BIOAVAILABILITY
BT
ATR AUC
AUCBA
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