cytopathology conference 9/08/05 - case 1

Cytopathology

09/08/05

• Peritoneal fluid from a 77 year old female.

Diagnosis?

Diagnosis?

Metastatic Lobular Carcinoma of the Breast

Lobular Carcinoma of the Breast

• Arises from terminal ductules of the TDLUs

• Types: classic, alveolar, solid, pleomorphic

• Incidence: 1-20% of invasive breast cancers

• Pure ILC does not involve nipple

• Tendency to be multicentric and bilateral

Lobular Carcinoma of the Breast

• Cytology:– May see separate dyshesive cells or

groups of cells

– Well defined borders

– May see Indian filing

– May see intracytoplasmic vacuoles

Diff-Quick Stain Papanicolaou Stain

Stains

(diff-quick)

Wright Stain

• “Romanovsky-type” stain– – A.K.A. Wright-Giemsa; utilized in peripheral blood smears.

– Contains mixtures of methylene blue, azure, and eosin.

– Metachromasia: property of methylene blue and toluidine blue dyes.

• Cell components stain a different color than the dye itself.

– Mast cell granules, cartilage, and mucin will stain purple.

James Homer WrightDetermination of the cellular lineage of multiple myeloma.

Demonstration of spirochetes in syphilitic aneurysms of the aorta.

Identification of the megakaryocyte as the cell of origin of blood platelets.

Co-authored a book with Frank Mallory: “Patholgical Technique”, which was the staple laboratory manual for over 40 years.(1869-1928)

Pap Smear from a 71-year-old Female

Diagnosis?

Atrophic Vaginitis

Atrophy

Atrophy

• 64-year-old female with history of left breast mass

Mucocele with an associated Intraductal Papilloma

Comparison: Colloid Carcinoma

Comparison: Colloid Carcinoma