cytopathology conference 11/17/05 - case 1
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Cytopathology Cytopathology Conference: A Few Conference: A Few Interesting CasesInteresting Cases
November 17, 2005November 17, 2005
Case #4Case #4
Cervicovaginal thinprep from a Cervicovaginal thinprep from a 55-year-old female.55-year-old female.
Diagnosis?Diagnosis?
Endocervical Endocervical AdenocarcinomaAdenocarcinoma
in Situ (AIS)in Situ (AIS)
Adenocarcinoma in SituAdenocarcinoma in Situ GroupsGroups
Very crowdedVery crowded
Stratified stripsStratified strips
RosettesRosettes
Conventional slides: “feathering”Conventional slides: “feathering”
Liquid-based slides: “knucklesLiquid-based slides: “knuckles””
Adenocarcinoma in SituAdenocarcinoma in Situ NucleiNuclei
High N/C ratioHigh N/C ratio
Oval to elongated or regularOval to elongated or regular
Marked hyperchromasiaMarked hyperchromasia
Coarse chromatinCoarse chromatin
Nucleoli typically inconspicuousNucleoli typically inconspicuous
Adenocarcinoma in SituAdenocarcinoma in Situ
No diathesisNo diathesis
Frequently associated with Frequently associated with squamous lesionssquamous lesions
Case #4Case #4
64-year-old female with 64-year-old female with a history of a left breast a history of a left breast mass.mass.
Diagnosis?Diagnosis?
Mucinous Neoplasm or Mucinous Neoplasm or LesionLesion
Suspicious for mucinous carcinomaSuspicious for mucinous carcinoma Differential includes mucocele-like lesionDifferential includes mucocele-like lesion
Mucocele with an associated Intraductal Papilloma
Papilloma: Benign Features
• Well developed fibrovascular core – Arborizing fronds
– Club-like fronds can have adenomatous component
• Two Cell types– Myoepithelial cell variably distinctive but
always present
Differential
• Colloid Carcinoma– Irregular groups of cells
– More single intact cells
– Abnormal nuclei
– Older patients
Comparison: Colloid Carcinoma
Comparison: Colloid Carcinoma
Colloid Carcinoma
Case #5Case #5
55-year-old male with an FNA 55-year-old male with an FNA from a right inguinal lymph from a right inguinal lymph node.node.
Diagnosis?Diagnosis?
High-grade mostly necrotic High-grade mostly necrotic malignant neoplasmmalignant neoplasm
ImmunohistochemistryImmunohistochemistry
Vimentin: Vimentin: PositivePositive
Pan-Keratin, CK7, CK20, LCA, Pan-Keratin, CK7, CK20, LCA, CD20, CD3 and c-kit: negative CD20, CD3 and c-kit: negative
Final DiagnosisFinal Diagnosis
High-grade mostly necrotic High-grade mostly necrotic malignant neoplasmmalignant neoplasm
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