chromatograms for summed and individual 15 transitions of 6 patient samples
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Chromatograms for summed and individual 15 transitions of 6
patient samples
CSF 845 (all transitions)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 0.00 - 12.01 SM: 3G
0 1 2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
7.69
7.826.506.145.55 7.997.00 8.70 10.545.24 9.553.83 11.87
NL: 3.97E5m/z= 914.94-915.44+942.96-943.46+975.73-976.23+1000.49-1000.99+1029.26-1029.76+1053.78-1054.28+1078.54-1079.04+1106.81-1107.31+1162.98-1163.48+1200.00-1200.50+1257.04-1257.54+1300.71-1301.21+1333.41-1333.91+1371.75-1372.25+1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (915.19@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
8.90
NL: 1.49E4m/z= 914.94-915.44 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (943.21@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.37
6.34
6.20 7.945.71 11.32
NL: 2.64E4m/z= 942.96-943.46 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (975.98@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
6.41
8.407.88
NL: 2.48E4m/z= 975.73-976.23 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1000.74@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.35
6.25 7.944.06 8.20
NL: 3.32E4m/z= 1000.49-1000.99 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1029.51@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
7.69
6.38
5.93 7.765.12 9.616.96 9.225.82
NL: 5.91E4m/z= 1029.26-1029.76 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1054.03@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
7.12 7.877.828.00 9.007.787.094.68 5.82
NL: 7.89E4m/z= 1053.78-1054.28 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1078.79@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
7.817.848.11
7.78 9.205.55 6.535.49 7.345.873.83 9.758.87
NL: 7.04E4m/z= 1078.54-1079.04 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1107.06@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.35
7.886.47
6.64
6.14 7.00 7.945.55 7.537.23
10.545.24 9.389.558.125.764.65
NL: 2.24E4m/z= 1106.81-1107.31 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1163.23@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.41
7.907.827.24
7.947.76
8.947.00 7.526.32
NL: 1.01E4m/z= 1162.98-1163.48 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1200.25@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.41
8.707.76
6.31 11.87
NL: 2.47E4m/z= 1200.00-1200.50 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1257.29@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.31
7.75
NL: 1.89E4m/z= 1257.04-1257.54 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1300.96@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37 6.40
6.29 6.76
NL: 1.49E4m/z= 1300.71-1301.21 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1333.66@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.37
NL: 1.20E4m/z= 1333.41-1333.91 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1372.00@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
7.59
NL: 8.77E3m/z= 1371.75-1372.25 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 845 (1405.02@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx31 CSF 845 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:17:02 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
8.22
NL: 1.52E4m/z= 1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx31
CSF 1332 (all transitions)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 0.00 - 12.01 SM: 3G
0 1 2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
7.84
7.787.886.686.21 7.69 8.50 8.675.943.83 5.00 9.64 11.5510.603.58
NL: 1.54E5m/z= 914.94-915.44+942.96-943.46+975.73-976.23+1000.49-1000.99+1029.26-1029.76+1053.78-1054.28+1078.54-1079.04+1106.81-1107.31+1162.98-1163.48+1200.00-1200.50+1257.04-1257.54+1300.71-1301.21+1333.41-1333.91+1371.75-1372.25+1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (915.19@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.37
7.23
NL: 6.53E3m/z= 914.94-915.44 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (943.21@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.37
6.44
11.55
NL: 1.32E4m/z= 942.96-943.46 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (975.98@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.41
6.34
6.21 11.993.58 5.08
NL: 1.17E4m/z= 975.73-976.23 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1000.74@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.44 7.84
7.996.58 7.46
NL: 1.46E4m/z= 1000.49-1000.99 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1029.51@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.41
6.38
6.35
7.69
8.50
7.847.11 7.997.47
NL: 2.15E4m/z= 1029.26-1029.76 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1054.03@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
7.85
7.55 8.197.09
4.67
NL: 3.30E4m/z= 1053.78-1054.28 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1078.79@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
7.87
7.847.96
7.816.61 7.55 8.096.976.265.17 9.649.47 10.56
NL: 2.87E4m/z= 1078.54-1079.04 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1107.06@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
7.84
6.68
6.317.066.21
7.88
7.75
5.94 7.967.295.495.00
8.415.67
NL: 8.11E3m/z= 1106.81-1107.31 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1163.23@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
7.76
6.40
6.37
6.12
7.79
7.71
8.128.93
NL: 6.12E3m/z= 1162.98-1163.48 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1200.25@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
7.84
8.67
3.83
NL: 1.04E4m/z= 1200.00-1200.50 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1257.29@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
7.64
5.83
NL: 7.63E3m/z= 1257.04-1257.54 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1300.96@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.41
6.35
7.78
7.88
10.60
NL: 5.64E3m/z= 1300.71-1301.21 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1333.66@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.43
NL: 5.78E3m/z= 1333.41-1333.91 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1372.00@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.43
NL: 3.99E3m/z= 1371.75-1372.25 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1332 (1405.02@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx44 CSF 1332 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:50:36 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38 NL: 6.74E3m/z= 1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx44
CSF 1502 (all transitions)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 0.00 - 12.01 SM: 3G
0 1 2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
7.827.79 7.966.506.26 7.125.93 8.67 9.283.70 4.62 9.85 10.78
NL: 2.22E5m/z= 914.94-915.44+942.96-943.46+975.73-976.23+1000.49-1000.99+1029.26-1029.76+1053.78-1054.28+1078.54-1079.04+1106.81-1107.31+1162.98-1163.48+1200.00-1200.50+1257.04-1257.54+1300.71-1301.21+1333.41-1333.91+1371.75-1372.25+1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (915.19@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.31
NL: 5.66E3m/z= 914.94-915.44 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (943.21@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38 NL: 1.72E4m/z= 942.96-943.46 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (975.98@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.35
6.85
NL: 1.22E4m/z= 975.73-976.23 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1000.74@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38 NL: 2.00E4m/z= 1000.49-1000.99 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1029.51@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
7.97
9.14
NL: 2.60E4m/z= 1029.26-1029.76 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1054.03@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
7.82
8.677.857.146.76 9.85
NL: 4.10E4m/z= 1053.78-1054.28 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1078.79@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.37
7.84
7.96
8.08
9.288.236.53 8.465.83 7.767.12
NL: 4.12E4m/z= 1078.54-1079.04 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1107.06@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.50
7.81
6.26
6.647.85
6.687.37
5.93
7.125.71 7.70
7.944.62 8.28 9.99
NL: 1.61E4m/z= 1106.81-1107.31 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1163.23@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.37
7.797.82
8.06
NL: 5.48E3m/z= 1162.98-1163.48 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1200.25@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.406.37
6.44
6.31
NL: 8.96E3m/z= 1200.00-1200.50 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1257.29@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
3.70
NL: 1.14E4m/z= 1257.04-1257.54 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1300.96@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.35
9.318.06
NL: 9.88E3m/z= 1300.71-1301.21 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1333.66@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.31
NL: 7.64E3m/z= 1333.41-1333.91 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1372.00@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40
6.34
10.78
NL: 5.60E3m/z= 1371.75-1372.25 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1502 (1405.02@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx42 CSF 1502 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:17:43 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.40 NL: 9.60E3m/z= 1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx42
CSF 1541 (all transitions)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 0.00 - 12.01 SM: 3G
0 1 2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
7.827.78 7.906.18 7.756.785.94 8.724.90 11.139.172.55 9.903.97
NL: 2.01E5m/z= 914.94-915.44+942.96-943.46+975.73-976.23+1000.49-1000.99+1029.26-1029.76+1053.78-1054.28+1078.54-1079.04+1106.81-1107.31+1162.98-1163.48+1200.00-1200.50+1257.04-1257.54+1300.71-1301.21+1333.41-1333.91+1371.75-1372.25+1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (915.19@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
RT: 6.35 NL: 7.57E3m/z= 914.94-915.44 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS ICIS hu_23aug2013_qx29
CSF 1541 (943.21@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.412.55
NL: 1.28E4m/z= 942.96-943.46 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (975.98@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
6.34
7.99
6.41
7.203.97 4.09 6.64
NL: 1.02E4m/z= 975.73-976.23 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1000.74@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
6.34
7.907.846.29 6.46
NL: 1.73E4m/z= 1000.49-1000.99 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1029.51@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
6.31
7.937.11 9.17
NL: 3.01E4m/z= 1029.26-1029.76 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1054.03@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
6.29
7.82
7.85
7.886.55 7.78 9.908.46
NL: 3.75E4m/z= 1053.78-1054.28 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1078.79@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.376.34
7.78
7.90
7.94 8.507.756.585.52 5.73
NL: 3.57E4m/z= 1078.54-1079.04 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1107.06@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.35
6.316.49
6.52
6.64
6.18
6.78 7.826.99
5.947.55
7.905.62 8.72
7.265.59
8.145.46
2.68
NL: 9.82E3m/z= 1106.81-1107.31 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1163.23@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
6.32
4.90
NL: 5.92E3m/z= 1162.98-1163.48 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1200.25@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
7.84
6.43 7.94
NL: 8.63E3m/z= 1200.00-1200.50 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1257.29@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
6.70
7.88
NL: 9.36E3m/z= 1257.04-1257.54 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1300.96@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.32
6.41
11.13
NL: 9.33E3m/z= 1300.71-1301.21 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1333.66@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35 NL: 8.08E3m/z= 1333.41-1333.91 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1372.00@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35 NL: 4.98E3m/z= 1371.75-1372.25 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1541 (1405.02@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.31
NL: 7.74E3m/z= 1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx29
CSF 1578 (all transitions)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 0.00 - 12.01 SM: 3G
0 1 2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.32
7.82
7.786.49 7.935.525.494.68 9.478.54 9.763.52
NL: 3.23E5m/z= 914.94-915.44+942.96-943.46+975.73-976.23+1000.49-1000.99+1029.26-1029.76+1053.78-1054.28+1078.54-1079.04+1106.81-1107.31+1162.98-1163.48+1200.00-1200.50+1257.04-1257.54+1300.71-1301.21+1333.41-1333.91+1371.75-1372.25+1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 915.19)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.32
6.29
7.49
NL: 1.32E4m/z= 914.94-915.44 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 943.21)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.32
6.25
7.717.784.21 6.213.52 6.74
NL: 3.18E4m/z= 942.96-943.46 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 975.98)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.31
6.34
6.38
8.263.94
NL: 1.51E4m/z= 975.73-976.23 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1000.74)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.31
7.797.754.68 7.876.184.44
NL: 2.76E4m/z= 1000.49-1000.99 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1029.51)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.27
6.34
7.877.976.40 7.84
7.06 7.71
NL: 2.88E4m/z= 1029.26-1029.76 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1054.03)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.32
6.25
7.81
7.11 7.767.907.14 9.767.08 8.785.49
NL: 7.11E4m/z= 1053.78-1054.28 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1078.79)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.31
7.82
7.78 7.857.695.59 7.205.52 7.937.08 8.14 9.47
NL: 6.06E4m/z= 1078.54-1079.04 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1107.06)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.31
6.266.49
6.567.82
6.79
6.93
7.78
6.17 7.09 7.565.52 7.945.565.44 8.94
NL: 1.77E4m/z= 1106.81-1107.31 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1163.23)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.32
7.816.67
NL: 1.04E4m/z= 1162.98-1163.48 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1200.25)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.32
7.585.855.06
NL: 1.67E4m/z= 1200.00-1200.50 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1257.29)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.31
7.46
8.54
NL: 1.71E4m/z= 1257.04-1257.54 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1300.96)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.32 NL: 1.35E4m/z= 1300.71-1301.21 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1333.66)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.31 NL: 9.31E3m/z= 1333.41-1333.91 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1372.00)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.31
6.37
7.46
NL: 6.06E3m/z= 1371.75-1372.25 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1578 (m/z = 1405.02)d:\xcalibur\...\hu_23aug2013_qx43 CSF 1578 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/24/2013 12:34:11 AMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.31 NL: 1.13E4m/z= 1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx43
CSF 1617 (all transitions)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 0.00 - 12.01 SM: 3G
0 1 2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
7.857.79 7.96
6.726.23 6.915.90 9.088.11 9.635.32 11.294.03 10.08
NL: 2.77E5m/z= 914.94-915.44+942.96-943.46+975.73-976.23+1000.49-1000.99+1029.26-1029.76+1053.78-1054.28+1078.54-1079.04+1106.81-1107.31+1162.98-1163.48+1200.00-1200.50+1257.04-1257.54+1300.71-1301.21+1333.41-1333.91+1371.75-1372.25+1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (915.19@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.728.75
NL: 6.53E3m/z= 914.94-915.44 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (943.21@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
6.34
6.41
7.09
NL: 1.74E4m/z= 942.96-943.46 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (975.98@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.31
8.036.78
NL: 2.03E4m/z= 975.73-976.23 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1000.74@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.32
9.087.79 8.347.64 8.88
NL: 1.95E4m/z= 1000.49-1000.99 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1029.51@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.38
7.90
6.27 8.03
NL: 4.37E4m/z= 1029.26-1029.76 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1054.03@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
7.85
7.797.117.886.49 8.117.145.855.50 10.969.14
NL: 5.64E4m/z= 1053.78-1054.28 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1078.79@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
7.85
7.76
7.94 8.055.765.465.03
NL: 4.83E4m/z= 1078.54-1079.04 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1107.06@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.38
6.32
6.43 7.796.59 6.64
7.76
6.236.91
5.907.84
7.647.975.75
5.67 6.99 7.345.32 8.124.03 7.29
NL: 1.61E4m/z= 1106.81-1107.31 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1163.23@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.38
7.96
7.829.63
NL: 9.23E3m/z= 1162.98-1163.48 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1200.25@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.31
7.65 8.406.27
NL: 1.18E4m/z= 1200.00-1200.50 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1257.29@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.346.38
7.96 8.05
5.738.31
NL: 1.05E4m/z= 1257.04-1257.54 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1300.96@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.31
11.2910.08
NL: 1.42E4m/z= 1300.71-1301.21 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1333.66@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.35
6.40
7.55
NL: 7.27E3m/z= 1333.41-1333.91 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1372.00@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.38
6.34
7.96
NL: 6.12E3m/z= 1371.75-1372.25 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
CSF 1617 (1405.02@hcd17.00)d:\xcalibur\...\hu_23aug2013_qx30 CSF 1617 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 9:00:38 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
RT: 2.00 - 12.01 SM: 3G
2 3 4 5 6 7 8 9 10 11 12Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e Ab
unda
nce
6.37
6.40
NL: 1.22E4m/z= 1404.77-1405.27 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00] MS hu_23aug2013_qx30
Spectra for summed and individual 15 transitions of 6 patient samples (bottom) compared to standard in artificial CSF (top) and theoretical
spectra (inset) computed using IsoPro V3.0
CSF 845 (all transitions)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
900 950 1000 1050 1100 1150 1200 1250 1300 1350 1400 1450m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.031078.79
1029.26
1107.33
1200.591000.75 1334.001257.29
1405.03975.98 1300.97942.971162.56
1112.68 1438.051372.34
1219.26914.95 1124.87
1353.01953.78
1130.68 1380.141328.32
1273.38
1054.03 1079.04
1107.331029.26
1200.591257.29
1130.89 1333.991000.751300.97 1405.03
975.98943.22 1162.561438.05
1372.01914.95 1219.60
1353.33953.45
1167.29
920.10 1237.92 1268.48
NL: 2.66E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.17E4hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Standard
CSF 845
CSF 845 (915.19@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
912.0 912.5 913.0 913.5 914.0 914.5 915.0 915.5 916.0 916.5 917.0 917.5 918.0 918.5 919.0 919.5m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
914.95914.70
915.20
914.44
915.46
916.51915.94
914.95
914.70915.20
914.45
915.44
915.70 916.54
NL: 3.73E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.62E3hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
917916915914
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (943.21@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
940.0 940.5 941.0 941.5 942.0 942.5 943.0 943.5 944.0 944.5 945.0 945.5 946.0 946.5 947.0 947.5m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
942.97
943.22
943.47
942.72943.72
943.98
943.22
943.47
942.97
943.72
942.72
943.97
941.58
NL: 7.95E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 7.11E3hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
946945944943
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (975.98@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
973.5 974.0 974.5 975.0 975.5 976.0 976.5 977.0 977.5 978.0 978.5 979.0 979.5 980.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
975.98
976.23
975.73
976.47
976.73975.49
976.98
975.98
975.74
976.23
976.48
975.48
976.73
976.99973.80
NL: 8.08E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 7.21E3hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
978977976975
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1000.74@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
997 998 999 1000 1001 1002 1003 1004m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1000.75
1000.501001.00
1001.25
1001.491000.25
1001.76
1000.75
1001.001000.50
1001.24
1001.491000.25
1001.75
NL: 1.13E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 8.58E3hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0031.0021.0011.000
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1029.51@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1026 1027 1028 1029 1030 1031 1032 1033m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1029.26
1029.51
1029.01
1029.76
1030.011028.76
1030.26
1029.26
1029.51
1029.01
1029.76
1030.01
1028.761030.26
1030.74
NL: 1.64E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.41E4hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0321.0311.0301.029
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1054.03@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1051.0 1051.5 1052.0 1052.5 1053.0 1053.5 1054.0 1054.5 1055.0 1055.5 1056.0 1056.5 1057.0 1057.5m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.031054.28
1053.781054.53
1054.78
1053.53
1055.02
1055.271051.02 1056.22
1054.03
1054.27
1053.78
1054.52
1054.78
1053.52
1055.02
1055.25
NL: 2.66E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.14E4hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0561.0551.0541.053
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1078.79@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1075 1076 1077 1078 1079 1080 1081 1082 1083 1084m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1078.79
1078.54
1079.29
1079.54
1078.29
1079.79
1082.511080.03 1082.19 1082.861075.03 1075.521079.04
1078.79
1078.541079.29
1079.54
1078.29
1079.79
1080.05 1082.511082.19 1082.841076.021075.03
NL: 2.51E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.17E4hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0821.0811.0801.0791.078
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1107.06@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1105.0 1105.5 1106.0 1106.5 1107.0 1107.5 1108.0 1108.5 1109.0 1109.5 1110.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1107.33
1107.06
1107.581106.811108.03
1109.18 1109.431106.57
1108.93 1109.671108.371105.66 1109.93
1107.33
1107.05
1107.671108.031106.81
1109.421109.191106.58 1108.921108.671108.391106.351105.991105.65 1109.66
NL: 1.41E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.46E4hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1101.1091.1081.1071.106
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1163.23@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1160 1161 1162 1163 1164 1165 1166 1167m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1162.561162.89
1163.23
1162.24
1163.56
1163.90
1162.56
1162.89
1163.22
1162.23
1163.56
1163.89
1167.021164.24
NL: 7.21E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.73E3hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1661.1651.1641.1631.162
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1200.25@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1197 1198 1199 1200 1201 1202 1203 1204m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1200.59
1200.921200.26
1199.931201.25
1201.59
1201.93 1202.28
1200.59
1200.26
1200.92
1201.261199.93
1201.59
1201.911199.70
NL: 1.20E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.05E4hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2041.2031.2021.2011.200
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1257.29@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1255.0 1255.5 1256.0 1256.5 1257.0 1257.5 1258.0 1258.5 1259.0 1259.5 1260.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1257.29
1256.961257.62
1257.951256.63
1258.29
1258.63
1257.29
1256.95
1257.62
1257.96
1256.63
1258.29
1258.65
NL: 1.09E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 9.67E3hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2611.2601.2591.2581.2571.256
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1300.96@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1296 1297 1298 1299 1300 1301 1302 1303 1304 1305 1306m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1300.97
1301.301300.64
1301.64
1300.31
1301.97
1300.97
1301.31
1300.64
1301.64
1300.31
1301.97
NL: 8.04E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 8.02E3hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3041.3031.3021.3011.300
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1333.66@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1329 1330 1331 1332 1333 1334 1335 1336 1337 1338 1339m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1334.00
1334.33
1333.66
1334.66
1335.00
1333.33
1335.34
1333.99
1333.661334.32
1334.66
1335.001333.33
1335.301337.81
NL: 1.12E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 8.85E3hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3371.3361.3351.3341.333
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1372.00@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1367 1368 1369 1370 1371 1372 1373 1374 1375 1376m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1372.34
1372.01
1371.68
1372.68
1373.011371.34
1372.01
1371.67
1372.35
1372.66
1371.35
1373.00
1373.34
NL: 5.44E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 4.24E3hu_23aug2013_qx31#865-894 RT: 6.31-6.44 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3751.3741.3731.3721.371
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 845 (1405.02@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1400 1401 1402 1403 1404 1405 1406 1407 1408 1409 1410m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1405.03
1405.37
1404.701405.71
1406.041404.36
1406.37
1405.03
1405.37
1404.69
1405.70
1406.031404.36
1406.36
NL: 8.18E3hu_23aug2013_qx15#837-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 8.66E3hu_23aug2013_qx31#868-892 RT: 6.32-6.44 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.4081.4071.4061.4051.404
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 845theoretical
CSF 1332 (all transitions)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
900 950 1000 1050 1100 1150 1200 1250 1300 1350 1400 1450m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.031078.79
1029.26
1107.33
1200.591000.75 1334.001257.29
1405.03975.98 1300.97942.971162.56
1112.68 1438.051372.34
1219.26914.95 1124.87
1353.01953.78
1130.681380.141328.32
1273.381107.34
1112.681054.02
1078.79
1130.901029.26
1200.59
1257.29 1333.991000.75 1300.97975.98942.97 1162.89 1405.02
1438.05914.95
1372.001219.60
1353.33953.44 1233.481184.97
930.19
NL: 2.66E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.23E4hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Standard
CSF 1332
CSF 1332 (915.19@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
913.0 913.5 914.0 914.5 915.0 915.5 916.0 916.5 917.0 917.5 918.0 918.5 919.0 919.5 920.0 920.5m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
914.95914.70
915.20
914.44
915.46
916.51915.94
914.95
914.70915.20
914.44913.88
NL: 3.73E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.81E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
917916915914
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (943.21@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
939.5 940.0 940.5 941.0 941.5 942.0 942.5 943.0 943.5 944.0 944.5 945.0 945.5 946.0 946.5m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
942.97
943.22
943.47
942.72943.72
943.98
942.97 943.22
943.47
942.72
943.72943.97
NL: 7.95E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.31E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
946945944943
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (975.98@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
973 974 975 976 977 978 979 980m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
975.98
976.23
975.73
976.47
976.73975.49
972.47976.98972.78
975.98
975.73
976.23
976.74975.46
972.46
NL: 8.08E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.44E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
978977976975
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1000.74@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
998 999 1000 1001 1002 1003 1004 1005m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1000.75
1000.50 1001.00
1001.25
1001.491000.25
1001.76
1000.75
1001.00
1000.491001.25
1000.25
1001.47
NL: 1.13E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.75E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0031.0021.0011.000
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1029.51@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1026 1027 1028 1029 1030 1031 1032 1033m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1029.26
1029.51
1029.01
1029.76
1030.011028.76
1030.26
1029.26
1029.51
1029.01
1029.76
1030.00
1028.781030.25
NL: 1.64E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.61E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0321.0311.0301.029
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1054.03@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1052.5 1053.0 1053.5 1054.0 1054.5 1055.0 1055.5 1056.0 1056.5 1057.0 1057.5 1058.0 1058.5 1059.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.031054.28
1053.781054.53
1054.78
1053.53
1055.02
1055.271056.22
1054.02
1054.27
1053.771054.52
1054.77
1053.53
1055.01
NL: 2.66E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 9.92E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0561.0551.0541.053
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1078.79@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1075 1076 1077 1078 1079 1080 1081 1082 1083m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1078.79
1078.54
1079.29
1079.54
1078.29
1079.79
1082.511080.03 1082.861074.78 1081.871075.52
1078.79
1078.54
1079.29
1079.54
1078.30
1079.78
1077.54 1083.661075.05 1076.62 1082.49
NL: 2.51E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 8.43E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0821.0811.0801.0791.078
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1107.06@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1106 1107 1108 1109 1110 1111 1112m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1107.33
1107.06
1107.581106.811108.03 1112.38
1109.18 1111.671106.57
1108.93 1112.001109.671108.371105.66 1109.93 1111.16
1107.34
1107.68
1112.37
1111.671108.02
1107.041109.17 1112.00
1108.931108.381106.63 1109.421111.411105.65 1110.991106.31
NL: 1.41E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.23E4hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1101.1091.1081.1071.106
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1163.23@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1158 1159 1160 1161 1162 1163 1164 1165 1166 1167 1168m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1162.56
1163.23
1162.24
1163.56
1163.90
1162.89
1162.57
1162.23 1163.23
1163.56
1163.90
NL: 7.21E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.07E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1661.1651.1641.1631.162
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1200.25@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1198.0 1198.5 1199.0 1199.5 1200.0 1200.5 1201.0 1201.5 1202.0 1202.5 1203.0 1203.5 1204.0 1204.5 1205.0m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1200.59
1200.921200.26
1199.931201.25
1201.59
1201.93 1202.28
1200.59
1200.92
1200.27
1201.25
1199.93
1201.591199.461201.92
NL: 1.20E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 5.13E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2041.2031.2021.2011.200
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1257.29@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1254 1255 1256 1257 1258 1259 1260 1261 1262m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1257.29
1256.961257.62
1257.951256.63
1258.29
1258.63
1257.29
1256.95
1257.62
1256.62 1257.95
1258.29
1258.62
NL: 1.09E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 4.32E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2611.2601.2591.2581.2571.256
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1300.96@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1299 1300 1301 1302 1303 1304 1305 1306m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1300.97
1301.301300.64
1301.64
1300.31
1301.97
1300.97
1300.64
1301.30
1301.63
1301.971300.33
NL: 8.04E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.70E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3041.3031.3021.3011.300
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1333.66@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1331 1332 1333 1334 1335 1336 1337m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1334.00
1334.33
1333.66
1334.66
1335.00
1333.33
1335.34 1335.67
1333.99
1334.33
1333.66
1334.66
1334.971333.33 1335.32
NL: 1.12E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 4.08E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3371.3361.3351.3341.333
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1372.00@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1369 1370 1371 1372 1373 1374 1375m/z
0
10
20
30
40
50
60
70
80
90
100
110
120
0
10
20
30
40
50
60
70
80
90
100
110
120
Rel
ativ
e Ab
unda
nce
1372.34
1372.01
1371.68
1372.68
1373.011371.34
1372.00
1372.34
1372.67
1371.66
NL: 5.44E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.41E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3751.3741.3731.3721.371
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1332 (1405.02@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1401 1402 1403 1404 1405 1406 1407 1408 1409 1410m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1405.03
1405.37
1404.701405.71
1406.041404.36
1406.37
1405.021405.36
1404.69
1405.70
1406.03
1404.37
NL: 8.18E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.04E3hu_23aug2013_qx44#869-892 RT: 6.34-6.44 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.4081.4071.4061.4051.404
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1332theoretical
CSF 1502 (all transitions)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
900 950 1000 1050 1100 1150 1200 1250 1300 1350 1400m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.031078.79
1029.26
1107.33
1200.591000.75 1334.001257.29
1405.03975.98 1300.97942.971162.56
1112.68 1438.051372.34
1219.26914.95 1124.87
1353.011129.58953.78
1328.32
1273.381054.02 1078.79
1131.23
1107.34
1029.26
1257.29
1000.75 1200.60 1300.971405.031333.99
1162.89975.98943.221438.06
1219.601372.01914.95
1353.00953.44
1281.701242.541193.00938.96
1418.50
NL: 2.66E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.44E4hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Standard
CSF 1502
CSF 1502 (915.19@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
911.0 911.5 912.0 912.5 913.0 913.5 914.0 914.5 915.0 915.5 916.0 916.5 917.0 917.5 918.0 918.5m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
914.95914.70
915.20
914.44
915.46
916.51915.94
914.95
914.70
914.45 915.45915.21
913.82 917.38
NL: 3.73E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.94E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
917916915914
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (943.21@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
940.5 941.0 941.5 942.0 942.5 943.0 943.5 944.0 944.5 945.0 945.5 946.0 946.5 947.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
942.97
943.22
943.47
942.72943.72
943.98
943.22942.97
943.47
943.72
942.72
943.97940.72 944.23 945.17
NL: 7.95E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.67E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
946945944943
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (975.98@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
973.0 973.5 974.0 974.5 975.0 975.5 976.0 976.5 977.0 977.5 978.0 978.5 979.0 979.5 980.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
975.98
976.23
975.73
976.47
976.73975.49
976.98972.78
975.98
976.23
975.73
976.48
976.73
976.98975.49
NL: 8.08E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.84E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
978977976975
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1000.74@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
997 998 999 1000 1001 1002 1003 1004m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1000.75
1000.50 1001.00
1001.25
1001.491000.25
1001.76
1000.75
1000.99
1000.51
1001.25
1000.251001.74
996.75
NL: 1.13E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 5.32E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0031.0021.0011.000
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1029.51@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1026.5 1027.0 1027.5 1028.0 1028.5 1029.0 1029.5 1030.0 1030.5 1031.0 1031.5 1032.0 1032.5 1033.0 1033.5m/z
0
10
20
30
40
50
60
70
80
90
100
1100
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1029.26
1029.51
1029.01
1029.76
1030.011028.76
1030.26
1029.26
1029.51
1029.01
1029.76
1030.011028.76
1030.26
NL: 1.64E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 9.55E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0321.0311.0301.029
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1054.03@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1051 1052 1053 1054 1055 1056 1057 1058m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.03
1053.781054.53
1054.78
1053.53
1055.02
1055.271050.51 1051.02 1056.22
1054.02
1054.27
1053.77 1054.52
1054.77
1053.531055.02
1055.27
NL: 2.66E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.44E4hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0561.0551.0541.053
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1078.79@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1076 1077 1078 1079 1080 1081 1082 1083m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1078.79
1078.54
1079.29
1079.54
1078.29
1079.79
1082.511080.03 1082.19 1082.861075.52
1078.79
1079.04
1078.54
1079.29
1079.54
1078.29
1079.78
1082.181081.851075.50 1082.51 1083.16
NL: 2.51E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.41E4hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0821.0811.0801.0791.078
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1107.06@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1104 1105 1106 1107 1108 1109 1110 1111m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1107.33
1107.06
1107.581106.811108.03
1109.18 1109.431106.57
1108.93 1109.671108.371105.661104.15 1104.91 1109.93 1111.16
1107.34
1107.68
1107.05
1108.02
1109.431106.82 1108.911109.671108.36
1104.17 1105.98 1106.671104.66 1111.381105.42 1110.911109.93
NL: 1.41E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.23E4hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1101.1091.1081.1071.106
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1163.23@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1160.5 1161.0 1161.5 1162.0 1162.5 1163.0 1163.5 1164.0 1164.5 1165.0 1165.5 1166.0 1166.5 1167.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1162.561162.89
1163.23
1162.24
1163.56
1163.90
1162.891162.56
1163.23
1162.23
1163.55
1165.191163.88
NL: 7.21E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.98E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1661.1651.1641.1631.162
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1200.25@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1197 1198 1199 1200 1201 1202 1203 1204m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1200.59
1200.921200.26
1199.931201.25
1201.59
1201.93 1202.28
1200.601200.251200.92
1199.931201.25
1201.59
NL: 1.20E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 5.35E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2041.2031.2021.2011.200
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1257.29@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1253 1254 1255 1256 1257 1258 1259 1260 1261 1262m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1257.29
1256.961257.62
1257.951256.63
1258.29
1258.63
1257.29
1257.621256.96
1257.95
1256.62
1258.28
NL: 1.09E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.68E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2611.2601.2591.2581.2571.256
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1300.96@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1298.5 1299.0 1299.5 1300.0 1300.5 1301.0 1301.5 1302.0 1302.5 1303.0 1303.5 1304.0 1304.5 1305.0 1305.5m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1300.97
1301.301300.64
1301.64
1300.31
1301.97
1300.97
1300.64 1301.30
1301.61
1301.971300.33
1302.30
NL: 8.04E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 5.34E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3041.3031.3021.3011.300
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1333.66@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1330 1331 1332 1333 1334 1335 1336 1337 1338 1339m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1334.00
1334.33
1333.66
1334.66
1335.00
1333.33
1335.34
1333.99
1334.331333.66
1334.66
1333.33
1335.00
1335.31
NL: 1.12E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 4.75E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3371.3361.3351.3341.333
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1372.00@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1367 1368 1369 1370 1371 1372 1373 1374 1375 1376m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1372.34
1372.01
1371.68
1372.68
1373.011371.34
1372.01
1372.34
1371.67
1372.671371.36 1373.37
NL: 5.44E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.27E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3751.3741.3731.3721.371
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1502 (1405.02@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1403 1404 1405 1406 1407 1408 1409 1410m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1405.03
1405.37
1404.701405.71
1406.041404.36
1406.37
1405.03
1404.69
1405.37
1405.70
1406.021404.37
1406.37
NL: 8.18E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 4.73E3hu_23aug2013_qx42#866-891 RT: 6.32-6.43 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.4081.4071.4061.4051.404
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1502theoretical
CSF 1541 (all transitions)d:\xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
900 950 1000 1050 1100 1150 1200 1250 1300 1350 1400 1450m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054
.03
z=4
1078
.79
z=4
1029
.26
z=4
1107
.33
z=4
1200
.59
z=3
1000
.75
z=4
1333
.99
z=3
1257
.29
z=3
1405
.03
z=3
975.
98z=
4
1300
.97
z=3
942.
97z=
4
1113
.67
z=?
1162
.56
z=3
1438
.05
z=3
1372
.34
z=3
1079
.79
z=4
1219
.60
z=3
1047
.03
z=4
1055
.02
z=4
914.
95z=
4
1124
.87
z=?
1353
.00
z=3
1301
.97
z=3
976.
73z=
4
953.
79z=
3
1258
.62
z=3
1055
.27
z=4
1439
.39
z=3
1380
.14
z=?
1273
.38
z=?
1107
.34
z=?
1078
.79
z=4
1112
.68
z=4
1054
.03
z=4
1113
.68
z=4
1029
.26
z=4
1130
.89
z=?
1200
.59
z=3
1000
.75
z=4
1257
.29
z=3
943.
22z=
4
1162
.88
z=?
1405
.04
z=3
1334
.00
z=3
1300
.97
z=3
1079
.55
z=4
975.
98z=
4
1438
.36
z=?
1372
.01
z=3
1201
.26
z=310
55.0
3z=
4
1047
.28
z=4
1219
.26
z=3
915.
20z=
4
1089
.29
z=?
1352
.67
z=?
1101
.67
z=3
1301
.97
z=3
1055
.26
z=?
953.
45z=
?
1178
.84
z=?
1158
.79
z=?
938.
68z=
?
1218
.95
z=?
1138
.49
z=?
NL: 2.40E4hu_23aug2013_qx15#835-862 RT: 6.15-6.29 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.06E4hu_23aug2013_qx29#860-888 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Standard
CSF 1541
CSF 1541 (915.19@hcd17.00)
Standard
CSF 1541
d:\xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
911.0 911.5 912.0 912.5 913.0 913.5 914.0 914.5 915.0 915.5 916.0 916.5 917.0 917.5 918.0 918.5 919.0m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
914.
95z=
4
914.
70z=
4
915.
20z=
4
914.
44z=
4
915.
46z=
4
916.
51z=
?
915.
94z=
4
915.
20z=
4
914.
70z=
491
4.96
z=4
915.
46z=
4
NL: 3.32E3hu_23aug2013_qx15#835-862 RT: 6.15-6.29 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.08E3hu_23aug2013_qx29#860-888 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
917916915914
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (943.21@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx29 CSF 1541 (AL13-039)ProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 8:44:11 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
941.0 941.5 942.0 942.5 943.0 943.5 944.0 944.5 945.0 945.5m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
942.
97z=
4
943.
22z=
4
943.
47z=
4
942.
72z=
4
943.
72z=
4
943.
98z=
4
943.
22z=
4
943.
47z=
4
942.
97z=
4
942.
71z=
4
943.
73z=
?
943.
97z=
4
NL: 6.78E3hu_23aug2013_qx15#835-862 RT: 6.15-6.29 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.57E3hu_23aug2013_qx29#860-888 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
946945944943
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (975.98@hcd17.00)
Standard
CSF 1541
d:\xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
974.0 974.5 975.0 975.5 976.0 976.5 977.0 977.5 978.0 978.5 979.0m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
975.
98z=
4
976.
23z=
4
975.
73z=
?
976.
47z=
4
976.
73z=
4
975.
49z=
?
976.
98z=
4
975.
98z=
4
976.
24z=
4
975.
73z=
4
976.
48z=
4
976.
73z=
4
976.
99z=
?
975.
49z=
?
NL: 6.92E3hu_23aug2013_qx15#835-862 RT: 6.15-6.29 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.21E3hu_23aug2013_qx29#860-888 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
978977976975
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1000.74@hcd17.00)
Standard
CSF 1541
d:\xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
996 997 998 999 1000 1001 1002 1003 1004 1005 1006 1007m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1000
.75
z=4
1001
.00
z=4
1000
.50
z=4
1001
.25
z=4
1001
.49
z=4
1000
.25
z=4
1001
.76
z=?
996.
27z=
?
1002
.57
z=?
1000
.75
z=4
1001
.00
z=4
1000
.50
z=4
1001
.25
z=4
1000
.24
z=4
1001
.50
z=4
1001
.75
z=4
NL: 9.73E3hu_23aug2013_qx15#835-862 RT: 6.15-6.29 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.78E3hu_23aug2013_qx29#860-888 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0031.0021.0011.000
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1029.51@hcd17.00)
Standard
CSF 1541
d:\xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1024 1025 1026 1027 1028 1029 1030 1031 1032 1033 1034 1035m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1029
.26
z=4
1029
.51
z=4
1029
.01
z=4
1029
.76
z=4
1030
.01
z=4
1028
.76
z=4
1030
.25
z=4
1025
.24
z=?
1029
.26
z=4
1029
.51
z=4
1029
.01
z=4
1029
.76
z=4
1030
.01
z=4
1028
.77
z=?
1030
.25
z=?
NL: 1.39E4hu_23aug2013_qx15#835-862 RT: 6.15-6.29 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.51E3hu_23aug2013_qx29#860-888 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0321.0311.0301.029
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1054.03@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1050 1051 1052 1053 1054 1055 1056 1057 1058 1059m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054
.03
z=4
1054
.28
z=4
1053
.78
z=4
1054
.53
z=4
1054
.78
z=4
1053
.53
z=4
1055
.02
z=4
1055
.27
z=4
1049
.77
z=4
1049
.52
z=4
1050
.27
z=4
1050
.51
z=4
1051
.02
z=4
1055
.53
z=4
1056
.22
z=?
1054
.03
z=4
1054
.28
z=4
1053
.78
z=4
1054
.53
z=4
1054
.78
z=4
1053
.53
z=4
1055
.03
z=4
1055
.26
z=?
1049
.77
z=1
1059
.45
z=?
NL: 2.66E4hu_23aug2013_qx15#837-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.19E4hu_23aug2013_qx29#865-885 RT: 6.31-6.40 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0561.0551.0541.053
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1078.79@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1076.0 1076.5 1077.0 1077.5 1078.0 1078.5 1079.0 1079.5 1080.0 1080.5 1081.0 1081.5 1082.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1078.791079.04
1078.54
1079.29
1079.54
1078.29
1079.79
1080.03 1082.191081.87
1078.79
1079.041078.55
1079.30
1079.55
1078.30
1079.791077.88
NL: 2.51E4hu_23aug2013_qx15#836-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.12E4hu_23aug2013_qx29#860-885 RT: 6.29-6.40 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0821.0811.0801.0791.078
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1107.06@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1104.5 1105.0 1105.5 1106.0 1106.5 1107.0 1107.5 1108.0 1108.5 1109.0 1109.5 1110.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1107.33
1107.06
1107.581106.811108.03
1109.18 1109.431106.57
1108.93 1109.671108.371105.661104.15 1104.91 1109.931104.40
1107.34
1107.691108.02
1107.05
1109.431109.17
1106.651108.93
1108.65 1109.671104.16
1108.37
1105.661104.65 1105.961104.90 1106.36
NL: 1.41E4hu_23aug2013_qx15#836-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.06E4hu_23aug2013_qx29#860-885 RT: 6.29-6.40 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1101.1091.1081.1071.106
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1163.23@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1159 1160 1161 1162 1163 1164 1165 1166 1167m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1162.561162.89
1163.23
1162.24
1163.56
1163.90
1162.88
1162.57
1163.21
1162.231163.57
1158.79 1164.76
NL: 7.21E3hu_23aug2013_qx15#836-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.61E3hu_23aug2013_qx29#860-885 RT: 6.29-6.40 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1661.1651.1641.1631.162
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1200.25@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1195 1196 1197 1198 1199 1200 1201 1202 1203 1204m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1200.59
1200.921200.26
1199.931201.25
1201.59
1201.93
1200.59
1200.261200.93
1201.261199.93
1201.60
NL: 1.20E4hu_23aug2013_qx15#836-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 5.08E3hu_23aug2013_qx29#860-885 RT: 6.29-6.40 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2041.2031.2021.2011.200
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1257.29@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1252 1253 1254 1255 1256 1257 1258 1259 1260 1261 1262 1263 1264m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1257.29
1256.961257.62
1257.951256.63
1258.29
1258.63
1257.29
1256.96
1257.62
1257.96
1256.64
1258.29
NL: 1.09E4hu_23aug2013_qx15#836-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 4.20E3hu_23aug2013_qx29#860-885 RT: 6.29-6.40 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2611.2601.2591.2581.2571.256
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1300.96@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1296 1297 1298 1299 1300 1301 1302 1303 1304 1305 1306m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1300.97
1301.301300.64
1301.64
1300.31
1301.97
1300.641301.31
1301.64
1300.311301.97
NL: 8.04E3hu_23aug2013_qx15#836-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.31E3hu_23aug2013_qx29#860-885 RT: 6.29-6.40 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3041.3031.3021.3011.300
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1333.66@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1328 1329 1330 1331 1332 1333 1334 1335 1336 1337 1338 1339 1340 1341m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1334.00
1334.33
1333.66
1334.66
1335.00
1333.33
1335.34
1328.32
1334.00
1333.67 1334.33
1334.66
1333.351334.99
NL: 1.12E4hu_23aug2013_qx15#836-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.45E3hu_23aug2013_qx29#860-885 RT: 6.29-6.40 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3371.3361.3351.3341.333
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1372.00@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1368 1369 1370 1371 1372 1373 1374 1375 1376 1377m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1372.34
1372.01
1371.68
1372.68
1373.011371.34
1372.011372.35
1371.68
1373.01
NL: 5.44E3hu_23aug2013_qx15#836-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.08E3hu_23aug2013_qx29#860-885 RT: 6.29-6.40 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3751.3741.3731.3721.371
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1541 (1405.02@hcd17.00)
Standard
CSF 1541
D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1399 1400 1401 1402 1403 1404 1405 1406 1407 1408 1409 1410 1411 1412m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1405.03
1405.37
1404.701405.71
1406.041404.36
1406.37
1405.04
1405.36
1404.69
1405.701406.04
1404.38
1406.37
NL: 8.18E3hu_23aug2013_qx15#836-864 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.59E3hu_23aug2013_qx29#860-885 RT: 6.29-6.40 AV: 8 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.4081.4071.4061.4051.404
100
90
80
70
60
50
40
30
20
10
0
theoretical
CSF 1578 (all transitions)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
900 950 1000 1050 1100 1150 1200 1250 1300 1350 1400 1450m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.031078.79
1029.26
1107.33
1200.591000.75 1334.001257.29
1405.03975.98 1300.97942.971162.56
1112.68 1438.051372.34
1219.26914.95 1124.87
1353.01953.78
1130.68
1328.321273.381054.03 1078.79
1029.261107.33
1200.591000.74 1257.291333.991131.23
1162.89 1405.031300.97943.22
976.23 1438.05
1372.341219.27914.95
1353.01953.451457.31
939.23
1239.951169.19 1270.611380.63
NL: 2.66E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.29E4hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Standard
CSF 1578
CSF 1578 (m/z = 915.19)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
912.5 913.0 913.5 914.0 914.5 915.0 915.5 916.0 916.5 917.0 917.5 918.0 918.5 919.0 919.5m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
914.95914.70
915.20
914.44
915.46
916.51915.94
914.95914.70
915.20
914.44
915.47
915.70 915.95914.17
NL: 3.73E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.52E3hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
917916915914
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 943.21)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
940.5 941.0 941.5 942.0 942.5 943.0 943.5 944.0 944.5 945.0 945.5 946.0 946.5 947.0 947.5m/z
0
10
20
30
40
50
60
70
80
90
100
110
120
0
10
20
30
40
50
60
70
80
90
100
110
120
Rel
ativ
e Ab
unda
nce
942.97
943.22
943.47
942.72943.72
943.98
943.22
942.97943.46
943.72942.72
943.96940.71
NL: 7.95E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.98E3hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
946945944943
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 975.98)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
972 973 974 975 976 977 978 979m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
975.98
976.23
975.73
976.47
976.73975.49
972.47971.22 976.98972.78
976.23975.98
975.73
976.47975.49
976.72
976.98973.45973.15972.23
NL: 8.08E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.20E3hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
978977976975
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1000.74)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
998.5 999.0 999.5 1000.0 1000.5 1001.0 1001.5 1002.0 1002.5 1003.0 1003.5 1004.0 1004.5 1005.0m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1000.75
1000.50 1001.00
1001.25
1001.491000.25
1001.76
1000.74
1001.001000.50
1001.25
1001.49
1000.251001.76
NL: 1.13E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.07E4hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0031.0021.0011.000
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1029.51)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1027 1028 1029 1030 1031 1032 1033 1034m/z
0
10
20
30
40
50
60
70
80
90
100
1100
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1029.26
1029.51
1029.01
1029.76
1030.011028.76
1030.26
1029.26
1029.51
1029.01
1029.76
1030.01
1028.76
1030.25
NL: 1.64E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.51E4hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0321.0311.0301.029
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1054.03)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1051.5 1052.0 1052.5 1053.0 1053.5 1054.0 1054.5 1055.0 1055.5 1056.0 1056.5 1057.0 1057.5 1058.0 1058.5m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.031054.28
1053.781054.53
1054.78
1053.53
1055.02
1055.271056.22
1054.03
1054.27
1053.78
1054.53
1054.781053.53
1055.02
1055.26
NL: 2.66E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.29E4hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0561.0551.0541.053
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1078.79)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1077.0 1077.5 1078.0 1078.5 1079.0 1079.5 1080.0 1080.5 1081.0 1081.5 1082.0 1082.5 1083.0 1083.5m/z
0
10
20
30
40
50
60
70
80
90
100
0
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1078.791079.04
1078.54
1079.29
1079.54
1078.29
1079.79
1082.511080.03 1082.19 1082.861081.87 1083.19
1078.791079.04
1078.541079.29
1079.54
1078.29
1079.79
1082.521082.18 1082.851080.02 1083.171081.85
NL: 2.51E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.25E4hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0821.0811.0801.0791.078
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1107.06)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1105 1106 1107 1108 1109 1110 1111 1112m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1107.33
1107.06
1107.581106.811108.03 1112.38
1109.18 1111.671106.57
1108.93 1112.001109.671108.371105.66 1109.93 1111.16
1107.33
1107.05
1107.68 1108.03 1109.431112.37
1111.671106.821109.18
1106.581112.001109.661108.66
1108.39
1105.67 1111.361105.13 1110.68
NL: 1.41E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.39E4hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1101.1091.1081.1071.106
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1163.23)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1158 1159 1160 1161 1162 1163 1164 1165 1166 1167m/z
0
10
20
30
40
50
60
70
80
90
100
1100
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1162.56
1163.23
1162.24
1163.56
1163.90
1162.89
1162.57
1163.23
1162.23 1163.56
1163.90
1164.24
NL: 7.21E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 7.93E3hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1661.1651.1641.1631.162
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1200.25)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1198 1199 1200 1201 1202 1203 1204 1205m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1200.59
1200.921200.26
1199.931201.25
1201.59
1201.93 1202.28
1200.591200.26
1200.92
1199.931201.25
1201.59
1205.36
NL: 1.20E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.07E4hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2041.2031.2021.2011.200
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1257.29)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1254 1255 1256 1257 1258 1259 1260 1261m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1257.29
1256.961257.62
1257.951256.63
1258.29
1258.63
1257.29
1257.621256.96
1256.63
1257.95
1258.29
1261.481258.61
NL: 1.09E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.02E4hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2611.2601.2591.2581.2571.256
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1300.96)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1298.5 1299.0 1299.5 1300.0 1300.5 1301.0 1301.5 1302.0 1302.5 1303.0 1303.5 1304.0 1304.5 1305.0m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1300.97
1301.301300.64
1301.64
1300.31
1301.97
1300.97
1301.311300.64
1301.64
1300.31
1301.96
1302.29
NL: 8.04E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 7.70E3hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3041.3031.3021.3011.300
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1333.66)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1330 1331 1332 1333 1334 1335 1336 1337 1338 1339m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1334.00
1334.33
1333.66
1334.66
1335.00
1333.33
1335.34
1333.99
1334.33
1333.66
1334.66
1333.341334.99
NL: 1.12E4hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 9.13E3hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3371.3361.3351.3341.333
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1372.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1369 1370 1371 1372 1373 1374 1375m/z
0
10
20
30
40
50
60
70
80
90
100
110
120
0
10
20
30
40
50
60
70
80
90
100
110
120
Rel
ativ
e Ab
unda
nce
1372.34
1372.01
1371.68
1372.68
1373.011371.34
1372.34
1372.00
1371.67
1372.68
1371.341373.34
1373.01
NL: 5.44E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 4.54E3hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3751.3741.3731.3721.371
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1578 (m/z = 1405.02)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1403 1404 1405 1406 1407 1408 1409 1410m/z
0
10
20
30
40
50
60
70
80
90
100
110
0
10
20
30
40
50
60
70
80
90
100
110
Rel
ativ
e Ab
unda
nce
1405.03
1405.37
1404.701405.71
1406.041404.36
1406.37
1405.031405.37
1404.69
1405.70
1406.041404.36
NL: 8.18E3hu_23aug2013_qx15#838-863 RT: 6.17-6.29 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 7.80E3hu_23aug2013_qx43#854-876 RT: 6.26-6.35 AV: 7 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.4081.4071.4061.4051.404
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1578theoretical
CSF 1617 (all transitions)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
900 950 1000 1050 1100 1150 1200 1250 1300 1350 1400 1450m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.03
1078.79
1029.261107.33
1200.591000.75 1334.001257.29
1405.031300.97975.98942.97 1112.68 1162.561438.06
1372.341219.26
914.95 1124.871353.01
953.78
1328.32
1273.381167.91
1054.03
1078.79
1107.341029.26
1112.68
1200.59 1256.96 1300.97 1333.991000.75
1405.03 1438.391162.89943.22 975.99
1219.60 1372.01914.95
1353.00953.45 1380.65
925.591430.15
1240.23 1294.94
NL: 2.46E4hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.68E4hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Standard
CSF 1617
CSF 1617 (915.19@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
911 912 913 914 915 916 917 918 919m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
914.95914.70
915.20
914.44
915.46
916.51915.94
914.95
914.70
915.21
914.45915.49
NL: 3.35E3hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.10E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
917916915914
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (943.21@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
940.5 941.0 941.5 942.0 942.5 943.0 943.5 944.0 944.5 945.0 945.5 946.0 946.5 947.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
942.97
943.22
943.47
942.72943.72
943.98
943.22
943.47942.97
943.73
942.71
943.98
944.49
NL: 7.14E3hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.98E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
946945944943
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (975.98@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
972.0 972.5 973.0 973.5 974.0 974.5 975.0 975.5 976.0 976.5 977.0 977.5 978.0 978.5 979.0 979.5m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
975.98
976.23
975.73
976.47
976.73975.49
972.47976.98972.78
975.99976.23
975.73
976.48
975.49
976.74
976.99
NL: 7.26E3hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 3.90E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
978977976975
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1000.74@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
999 1000 1001 1002 1003 1004 1005 1006m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1000.75
1000.50 1001.00
1001.25
1001.491000.25
1001.76
1000.75
1001.00
1000.50
1001.25
1000.251001.49
NL: 1.01E4hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.15E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0031.0021.0011.000
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1029.51@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1027.0 1027.5 1028.0 1028.5 1029.0 1029.5 1030.0 1030.5 1031.0 1031.5 1032.0 1032.5 1033.0 1033.5 1034.0m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1029.26
1029.51
1029.01
1029.76
1030.01
1028.76
1030.26
1029.26
1029.01
1029.51
1029.75
1030.01
1028.771030.25
NL: 1.51E4hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.08E4hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0321.0311.0301.029
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1054.03@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1050 1051 1052 1053 1054 1055 1056 1057m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1054.03
1053.781054.53
1054.78
1053.53
1055.02
1055.271050.27 1051.02 1056.221054.03
1054.28
1053.78
1054.52
1054.78
1053.53
1055.02
NL: 2.46E4hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.68E4hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0561.0551.0541.053
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1078.79@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1076.0 1076.5 1077.0 1077.5 1078.0 1078.5 1079.0 1079.5 1080.0 1080.5 1081.0 1081.5m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1078.791079.04
1078.54
1079.29
1079.54
1078.29
1079.79
1080.03
1078.79
1079.04
1079.291078.54
1079.54
1078.29
1079.80
1080.02
NL: 2.29E4hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.34E4hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.0821.0811.0801.0791.078
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1107.06@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1103 1104 1105 1106 1107 1108 1109 1110 1111 1112m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1107.33
1107.06
1107.591106.81 1112.381108.03
1109.18 1111.68
1112.001106.57 1109.671108.931108.37
1105.661104.651103.66 1111.431109.93
1107.34
1107.05
1108.031112.37
1107.67
1111.681106.82
1109.42 1112.01
1108.671108.37
1111.381104.66 1109.661106.621103.67 1111.171105.94 1110.66
NL: 1.41E4hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 1.10E4hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1101.1091.1081.1071.106
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1163.23@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1159 1160 1161 1162 1163 1164 1165m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1162.561162.89
1163.23
1162.24
1163.56
1163.90
1162.89
1162.56
1163.23
1163.56
1162.24
1163.90
NL: 6.50E3hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 4.05E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.1661.1651.1641.1631.162
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1200.25@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1197 1198 1199 1200 1201 1202 1203 1204m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1200.59
1200.921200.26
1199.931201.25
1201.59
1201.93 1202.28
1200.591200.26
1200.92
1199.92 1201.26
1201.58
1203.88
NL: 1.12E4hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.58E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2041.2031.2021.2011.200
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1257.29@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1252 1253 1254 1255 1256 1257 1258 1259 1260 1261 1262m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1257.29
1256.961257.62
1257.951256.63
1258.29
1258.63
1256.96
1257.29
1257.63
1257.96
1256.63
1258.29
1258.62
NL: 9.79E3hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.40E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.2611.2601.2591.2581.2571.256
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1300.96@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1296 1297 1298 1299 1300 1301 1302 1303 1304 1305 1306m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1300.97
1301.301300.64
1301.64
1300.31
1301.97
1300.97
1300.64 1301.31
1301.64
1300.31
1301.96
NL: 7.39E3hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.18E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3041.3031.3021.3011.300
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1333.66@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1330 1331 1332 1333 1334 1335 1336 1337 1338m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1334.00
1334.33
1333.66
1334.66
1335.00
1333.33
1335.671335.34
1335.99
1333.99
1334.33
1333.66
1334.66
1333.33 1334.99
NL: 1.01E4hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 6.00E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3371.3361.3351.3341.333
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1372.00@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1369 1370 1371 1372 1373 1374 1375 1376 1377 1378m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1372.34
1372.01
1371.68
1372.68
1373.011371.34
1372.01
1372.34
1372.671371.67
1373.001371.34
NL: 4.90E3hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 2.64E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.3751.3741.3731.3721.371
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
CSF 1617 (1405.02@hcd17.00)D:\Xcalibur\...\hu_23aug2013_qx15 Cal X1 (HFIP) 2000pg/mlProSwift RP-4H No.066640 SN: 001145 Lot: 017-13-003 8/23/2013 4:53:58 PMD:\Xcalibur\methods\d_apr2013\d_02apr2013_betaamyloid_MRM_TV2008 V0_2.meth
1400 1401 1402 1403 1404 1405 1406 1407 1408 1409 1410m/z
0
10
20
30
40
50
60
70
80
90
1000
10
20
30
40
50
60
70
80
90
100
Rel
ativ
e Ab
unda
nce
1405.03
1405.37
1404.701405.71
1406.041404.36
1406.37
1405.03
1404.70
1405.36
1405.69
1404.371406.03
1406.36
NL: 7.54E3hu_23aug2013_qx15#837-865 RT: 6.17-6.31 AV: 10 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
NL: 4.57E3hu_23aug2013_qx30#860-887 RT: 6.29-6.41 AV: 9 F: FTMS + p ESI Full ms2 1129.58@hcd17.00 [266.00-4000.00]
Unregistered
1.4081.4071.4061.4051.404
100
90
80
70
60
50
40
30
20
10
0
Standard
CSF 1617theoretical
top related