cell and tissue biophysics from bionumbers and physical ... · 9th european conf on math &...
Post on 10-Jun-2020
1 Views
Preview:
TRANSCRIPT
Present and Future ofCell and Tissue Biophysics!(Final notes of participant)
Peter I Belobrov
MOLPIT, Siberian Federal University & Institute of Biophysics SB RAS. Krasnoyarsk, 660041, Russia
http://molpit.com/
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Cell and Tissue Biophysics
1: Aggregation
2: Signalling
3: Cytoskeleton and mobility
4: Tissue-level modelling
5: Organ-level modelling
6: Modelling of cell components
Mechanism of the Nanodiamond – Protein Collective Aggregation
Аndrey A Zimin & Peter I Belobrov
MOLPIT, Siberian Federal University & Institute of Biophysics SB RAS. Krasnoyarsk, 660041, Russia
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Scheme for separation and purification of the recombinant protein from Escherichia coli cells using adsorption of proteins onto detonation ND (using the procedure described by Bondar et al. 2004).
Holt K B Phil. Trans. R. Soc. A 365, 2845 (2007); Bondar V S et al. Phys. Sol. State 46, 758 (2004).
Cell and Tissue Biophysics from BioNumbers and
Physical Biology of the CellPeter I Belobrov
MOLPIT, Siberian Federal University & Institute of Biophysics SB RAS. Krasnoyarsk, 660041, Russia
http://molpit.com/
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Key Numbers for Cell Biologists• http://www.bionumbers.org/
• Cell size (1-3)
• Length Scales Inside Cells (4-8)
• Division, Replication, Transcription, Translation & Degradation Rates (9-12)
• Concentration (13-17)
• Energetics (18-20)
• Diffusion and Catalysis Rate (21, 22)
• Genome sizes & Error Rates (23-26)
• We can apply all above to cell and tissue biophysics
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Measure of biological interaction• Numbers are misleading and BioNumbers too!
• Mark Twain said about: "There are three kinds of lies: lies, damned lies, and statistics.“
• But what we should use instead biostatistics?
•To study biological interaction• individuality of every cell and every tissue
• cell and tissue integrity
• emergence of new tissues from interacting cells
• strong effect of lower levels of organization, e.g., protein, ncRNA, organelles, subcellular
• collective self-organization and multi-leveleffects of cells and tissues
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Current (2013) SI System:
kg is recent artifact at SI sys
In 1960 m as artifact was redefinedin terms of fundamental physical constants c (the speed of light)
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Proposed «Quantum SI» System (2014) 25th CGPM (18 Nov 2014) will define kg in terms of the Planck constant h
What about«Biological
SI» System?
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Biological measures & gaugesConclusions
• From Key Numbers for Cell Biologists in the field of Cell and Tissue Biophysics
• Towards BioMeasures & BioGauges
• To make «Biological SI» System
• With Fundamental Biological Constant
• Based on «Quantum SI» System
• Let's think & act together
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Cell and Tissue Biophysics
1: Aggregation
2: Signalling by self-organization
3: Cytoskeleton and mobility
4: Tissue-level modelling
5: Organ-level modelling
6: Modelling of cell components
Bioparticles interaction model for Cell and Tissue Biophysics
Ivan A Denisov & Peter I Belobrov
MOLPIT, Siberian Federal University & Institute of Biophysics SB RAS. Krasnoyarsk, 660041, Russia
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Bioparticles, Forces & Levels
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Master equation of self-organisation
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Multiscale self-assembly modelhttp://molpit.com/?page=33
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Cell and Tissue Biophysics
1: Aggregation
2: Signalling by self-organization
3: Cytoskeleton and mobility
4: Tissue-level modelling
5: Organ-level modelling
6: Modelling of cell components
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Microtubuleshttp://molpit.com/?page=54
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Cell and Tissue Biophysics
1: Aggregation
2: Signalling by self-organization
3: Cytoskeleton and mobility
4: Tissue-level modelling
5: Organ-level modelling
6: Modelling of cell components
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
• The introduction into• biological measures & nature of the biological signals
• Biological signals and droplet microfluidic principles of cell-cell interaction modeling and biological measurements.
• Theory of• absolute and relative biological measures has been analyzed in
case of cell-cell and cell-tissue measurement• organization with similar properties of structures and functions of
biological particles• collective multilevel hierarchical organization that can form the
basis of the description of the internal structures and relativebiological measures
• We analyze some applications of the theory to understandthe measurement problems in modern biology and in thescience of health
Cell-to-cell microfluidic interaction models in Cell and Tissue Biophysics
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
See you later at the next session:
Cell and Tissue BiophysicsTHE END TODAY
1: Aggregation
2: Signalling by self-organization
3: Cytoskeleton and mobility
4: Tissue-level modelling
5: Organ-level modelling
6: Modelling of cell components
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
There are old & new Problems
• Self consistentmodeling
• Multilevelsubcellulardynamics?
• Analog for subcellular hierarchical
organization?
• Why all it work together and
even thinking?
9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014
Cell and Tissue BiophysicsToward new releases of the
1: Aggregation
2: Signalling
3: Cytoskeleton and mobility
4: Tissue-level modelling
5: Organ-level modelling
6: Modelling of cell components
etc. Let’s go to 10th ECMTB 2016
top related