cell and tissue biophysics from bionumbers and physical ... · 9th european conf on math &...

Present and Future ofCell and Tissue Biophysics!(Final notes of participant)

Peter I Belobrov

MOLPIT, Siberian Federal University & Institute of Biophysics SB RAS. Krasnoyarsk, 660041, Russia

http://molpit.com/

http://molpit.com/

9th European Conf on Math & Theor Biology, Göteborg, 15-19 June 2014

Cell and Tissue Biophysics

1: Aggregation

2: Signalling

3: Cytoskeleton and mobility

4: Tissue-level modelling

5: Organ-level modelling

6: Modelling of cell components

Mechanism of the Nanodiamond – Protein Collective Aggregation

Аndrey A Zimin & Peter I Belobrov



Scheme for separation and purification of the recombinant protein from Escherichia coli cells using adsorption of proteins onto detonation ND (using the procedure described by Bondar et al. 2004).

Holt K B Phil. Trans. R. Soc. A 365, 2845 (2007); Bondar V S et al. Phys. Sol. State 46, 758 (2004).

Cell and Tissue Biophysics from BioNumbers and

Physical Biology of the CellPeter I Belobrov


http://molpit.com/

http://molpit.com/


Key Numbers for Cell Biologists• http://www.bionumbers.org/

• Cell size (1-3)

• Length Scales Inside Cells (4-8)

• Division, Replication, Transcription, Translation & Degradation Rates (9-12)

• Concentration (13-17)

• Energetics (18-20)

• Diffusion and Catalysis Rate (21, 22)

• Genome sizes & Error Rates (23-26)

• We can apply all above to cell and tissue biophysics

http://www.bionumbers.org/


Measure of biological interaction• Numbers are misleading and BioNumbers too!

• Mark Twain said about: "There are three kinds of lies: lies, damned lies, and statistics.“

• But what we should use instead biostatistics?

•To study biological interaction• individuality of every cell and every tissue

• cell and tissue integrity

• emergence of new tissues from interacting cells

• strong effect of lower levels of organization, e.g., protein, ncRNA, organelles, subcellular

• collective self-organization and multi-leveleffects of cells and tissues


Current (2013) SI System:

kg is recent artifact at SI sys

In 1960 m as artifact was redefinedin terms of fundamental physical constants c (the speed of light)


Proposed «Quantum SI» System (2014) 25th CGPM (18 Nov 2014) will define kg in terms of the Planck constant h

What about«Biological

SI» System?


Biological measures & gaugesConclusions

• From Key Numbers for Cell Biologists in the field of Cell and Tissue Biophysics

• Towards BioMeasures & BioGauges

• To make «Biological SI» System

• With Fundamental Biological Constant

• Based on «Quantum SI» System

• Let's think & act together



1: Aggregation

2: Signalling by self-organization





Bioparticles interaction model for Cell and Tissue Biophysics

Ivan A Denisov & Peter I Belobrov



Bioparticles, Forces & Levels


Master equation of self-organisation


Multiscale self-assembly modelhttp://molpit.com/?page=33

http://molpit.com/?page=33



1: Aggregation







Microtubuleshttp://molpit.com/?page=54

http://molpit.com/?page=54



1: Aggregation







• The introduction into• biological measures & nature of the biological signals

• Biological signals and droplet microfluidic principles of cell-cell interaction modeling and biological measurements.

• Theory of• absolute and relative biological measures has been analyzed in

case of cell-cell and cell-tissue measurement• organization with similar properties of structures and functions of

biological particles• collective multilevel hierarchical organization that can form the

basis of the description of the internal structures and relativebiological measures

• We analyze some applications of the theory to understandthe measurement problems in modern biology and in thescience of health

Cell-to-cell microfluidic interaction models in Cell and Tissue Biophysics


See you later at the next session:

Cell and Tissue BiophysicsTHE END TODAY

1: Aggregation







There are old & new Problems

• Self consistentmodeling

• Multilevelsubcellulardynamics?

• Analog for subcellular hierarchical

organization?

• Why all it work together and

even thinking?


Cell and Tissue BiophysicsToward new releases of the

1: Aggregation

2: Signalling





etc. Let’s go to 10th ECMTB 2016

cell and tissue biophysics from bionumbers and physical ... · 9th european conf on math &...

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