Advil Vs. NanoVil

Advil Vs. NanoVilSolubility/BioavailabilityA new Nanomedicine Technology PlatformFor Ibuprofen

AdvilNanoAdvilHybrid-Nanoengineering1Nano Advil LLc. has the capability to use our own proprietary nano-technology platform to make an inventory of nano-technology based consumer products that will provide any Pharmaceutical company with a major advantage in the market place. In addition, we are looking to partner with an established Pharmaceutical company to propose solutions and create a suite of patented OTC and Rx products in line with our nano-technology competency and expertise.

NanoAdvil 2Dr. Mewa Singh

Dr. Mewa Singh has 18 years of experience in product development in the field of biotechnology. He is currently working on a process for discovery of new nano-medicines in various therapeutic areas. Dr. Mewa is specialized in various fields including new labs setup, manufacture of biopharmaceuticals and project management / leadership associated with product development. He has already delivered 23 products in the biopharmaceutical market including a nano-medicine for arthritis, Neisseria meningitides vaccine, and a compound formulated to treat acid reflux. Principals3WHO ReportBased on the Biopharmaceutics Classification System (BCS), about 30% of the drugs that are currently on the World Health Organization (WHO) Essential Drug List are reported to be poorly water-soluble and need to be improved. Over 40% of newly developed pharmaceutically active substances have solubility issues and are looking for a technology to improve their clinical development. The poor dissolution and/or permeability of these drugs often result in low and highly variable bioavailability. The major obstacle to successful commercialization or improvement of these compounds is the difficulty of enhancing their dissolution rate and extent of dissolution.

Advil (Ibuprofen) is one of those compounds that attracted our attention towards improvement of the dissolution rate.4What is new It will provide more than a nano-medicineNew concept and new approachTwo active molecules have never been used before to develop a nano-medicine. A hybrid nano-medicine has never been developed until now.An active molecule to developed a water soluble drug formulation has never been used until nowTwo water insoluble drugs have never been used before to developed a water soluble formulation, at least without changing the chemistryChemistry of individual drugs remains unchangedBut IT IS NOT JUST SOLUBILITY; IT IS A BETTER TREATMENT

5Problems, Challenges and OpportunitiesIbuprofen (advil etc.) is one of the most commonly used pain relievers due to its effectiveness and high tolerability in doses of 200 mg and 400 mg. Based on the amounts of ibuprofen produced globally, a consumption of around 30 billion tablets per year can be assumed. The available dosage forms mostly contain ibuprofen in the acid form in view of the lower costs . Ibuprofen, however, has a poor and highly pH-dependent solubility. As the solubility increases above a pH of 6.5, the active ingredient is dissolved and absorbed only in the intestinal tract but not in the stomach. Depending on the pH conditions in the intestinal tract, absorption may be further delayed due to physiological reasons. This is confirmed by numerous blood level tests which show a maximum blood level 1.5 to 2 hours after ingestion. This delay is a great disadvantage because patients expect a fast onset of the analgesic effect when taking a pain reliever and tend to unnecessarily raise the dosage when the effect is delayed.A clear improvement was, however, achieved through the use of ibuprofen salts with good water solubility such as ibuprofen lysinate, ibuprofen arginate and ibuprofen sodium salt. The distinct acceleration of absorption is astounding, since the ibuprofen salts are usually released under acidic conditions in the stomach which leads to precipitation of ibuprofen.

Our NanoAdil has all the requirements to have an optimal IBUPROFEN. Results are shown in the following sections.MOST IMPORTANT IS THAT WE KEEP THE ORIGINAL MOLECULE INTACT6

Nano IbuprofenTons of Raw MaterialReady to Formulate7

Multiple Batches of Nano Ibuprofen8Advil and NanoVil

AdvilAdvilNanoAdilNanoVil

9Dry Crystal Structure

AdvilNanovil

10Advil Solubility in water

After 1 minute

After 5 minute After 30 minute After 15 minute After 10 minute

11Comparative Solubility in water

NanoVil solubility after One minute

Advil solubility after One minute12Solubility

AdvilNanoVil13Solubility After 3 hours

AdvilNanoVil

NanoAdvil14Resolved acidic environment(pH2.3) precipitation of IbuprofenOur NanoVil beat the problem of all ibuprofen formulations and added value in fast relief of pain and fever, independent of pH in all parts of the system.

IbuprofenIn pH2.3

NanoVil15Solubility in waterNano 5mg/mlAdvil 20mg/mlIbuprofen salt 20mg/ml0.32mg/ml0.64mg/ml1.25mg/ml2.5mg/ml5mg/mlIbuprofen curve in ethanol 5 10 20 30 Time So What ?!Size and solubility dictates Bioavailability, Efficacy and Safety17Next Generation Only with us

Old equation of NanomedicineHybrid Nanoengineering Double edge swordIncrease effectLess side effectEnhanced compatibilityNew equation of NanomedicineKey Players:American Pharmaceutical PartnersCritiTech Novax Inc RTP Pharma Sheffield PharmaceuticalsNanosphereEiffel TechnologiesBiosante PharmaceuticalsAdvectus Life SciencesCopernicus Therapeutics One Player : Us18Conclusion Preliminary in vitro data show that NanoVil is a superior fast release, improved NSAID formulation of Ibuprofen compared with some brands.We suggest joint collaboration with GAP, LLC to proceed with in-vitro and in-vivo trials with NanoVil.Furthermore, we suggest joint collaboration to allow us to introduce the platform of our technology to explore further opportunities for use of fast release improved bioavailability technology with other OTC/Rx drugs in your portfolio.19Established For NanoAdvilThree pilot scale batches of 5 kg each have been processed to establish batch-to batch consistency. Stability established.Drug release at different pH established.Formulation established.Raw material vendors establishedManufacturing SOPs established.20Double edge action Of our Nano

:ILs and inflammationsWhat nextNeeded a partner for product development through bioequivalent and FDA approvals.Needed a strong marketing partner.22Nano science and technology are advancing quickly; therefore, the status of nano technology commercialization is rapidly changing. Meda Biotech LLC believes that a successful development program using this technology is possible, but it will require an open and honest collaborative relationship with a partner and with a clear understanding of the goals.

We are looking forward to a joint development program with a major partner that will bring ideas, compatibility, aligned interests, complementary experience and skills. The ideal partner would be an industry leader who will give us the opportunity to apply our novel nanotechnology to provide innovative new products to consumers and patients.

You can contact us to discuss ways to work together to pursue current and/or future development opportunities using our new nanotechnology. Proposal: Joint Development Program 23Questions?Please contact Mewa Singh PhD via:

mewasinghsandhu@hotmail.comwww.nanomeda.comTele#: 609-902-7128

Meda Biotech24