2wl.wum.edu.pl web vieworganisation of tissue and cell banking in poland, eu at the word. ... c3-...

Medical University of Warsaw 2nd Faculty of Medicine - English Division

61 Żwirki i Wigury Street 02-091 Warsaw

Phone: + 48 (22) 5720 502 Fax:+48 (22) 5720 562

e-mail: [email protected]

http: www.wum.edu.pl

2nd YEAR CURRICULUM

6-year program

Warsaw, 2016/2017

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mailto:[email protected]

SCHEDULE – ACADEMIC YEAR 2016/20172nd year 6-year programme

WINTER SEMESTER – 01.10.2016 – 10.02.2017STUDENT’S ACADEMIC CLASSES: 01.10.2016 – 23.12.2016 02.01.2017 – 20.01.2017WINTER HOLIDAYS: 26.12.2016 – 30.12.2016 EXAM SESSION: 23.01.2017 – 27.01.2017DAYS OFF BETWEEN SEMESTER: 30.01.2017 – 3.02.2017RETAKE EXAM SESSION: 06.02.2017 – 10.02.2017

SUMMER SEMESTER – 13.02.2017 – 30.09.2017STUDENT’S ACADEMIC CLASSES: 13.02.2017 – 14.04.2017 24.04.2017 – 28.04.2017

08.05.2017 – 09.06.2017 EASTER HOLIDAYS: 17.04.2017 – 21.04.2017SPRING HOLIDAYS: 01.05.2017 – 05.05.2017 EXAM SESSION: 12.06.2017 – 30.06.2017SUMMER HOLIDAYS: 03.07.2017 – 01.09.2017RETAKE EXAM SESSION: 04.09.2017 – 8.09.2017SUMMER HOLIDAYS: 11.09.2017 – 29.09.2017

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Curriculum of 2nd year of 6-year 2016/2017 ED programme and the list of contents

subject form of credit

semester

Total no of hour

s

includingECT

Slecture

seminar

class

practical

1 Biochemistry with Elements of Chemistry exam c 220 80 50 90 19

2 Cytophysiology exam 1 45 10 10 25 33 Physiology with Pathophysiology exam c 200 65 65 70 194 Immunology exam 2 40 40 35 Hygiene and Epidemiology credit 1 30 30 26 Polish for Medicine credit c 80 80 5

7 Medical Ethics with Elements of Philosophy credit 1 40 24 16 2

8 Medical Genetics credit 2 25 8 17 29 Vocational Training credit 2 160 160 5

10 Optional course credit c 60 60 411 First Aid with the elements of

nursing credit 2 45 13 32 3

945 179 262 344 160 67

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1. Imprint

Faculty name:Second Faculty of Medicine with the English Division and the

Physiotherapy Division, Medical University of Warsaw

Education program (field of study, level and educational profile, form of studies, e.g., Public Health, 1st level studies, practical profile, full time):

English Division, 1st level studies, practical profile, full-time

Academic year:2016/2017

Module/subject name:Biochemistry with elements of chemistry

Subject code (from the Pensum system):29795

Educational units:

Part 1.

Department of Biochemistry, Second Faculty of Medicine with English Division and Physiotherapy Division, and Chair and Department of Biochemistry and Clinical Chemistry02-097 Warsaw, Banacha 1 Str. Phone: +48 (22) 5720735 e-mail: [email protected]

Part 2.

Chair and Department of Biochemistry,

First Faculty of Medicine

02-097 Warsaw, ul. Banacha 1

Phone: +48 (22) 57 20 693

e-mail: [email protected]

Head of the unit/s:

Part 1. Dr hab. Piotr Tomaszewski

Part 2. Prof. dr hab. Anna Barańczyk-Kuźma

Study year (the year during which the respective subject is taught):

second year

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Model syllabus for Biochemistry

Study semester (the semester during which the respective subject is taught):

III and IV semester

Module/subject type (basic, corresponding to the field of study, optional):

basic

Teachers (names and surnames and degrees of all academic teachers of respective subjects):

Part 1: dr hab. Marta Struga, dr hab. Piotr Tomaszewski, prof. dr

hab. Marianna Kańska, dr Bożena Stefaniak-Stiasna, dr Jolanta

Szymańska

Part 2: Prof. dr hab. Anna Baranczyk Kuźma, prof. dr hab. Iwonna

Rahden-Staroń, dr Maria Szumiło, dr Grosicka-Maciąg,

dr Magdalena Mielczarek-Puta, lek. Wojciech Graboń, dr Ewa

Usarek, lek. Leszek Kraj

ERASMUS YES/NO (Is the subject available for students under the ERASMUS programme?):

YES

A person responsible for the syllabus (a person to which all comments to the syllabus should be reported)

Prof. dr hab. Anna Barańczyk-Kuźma, phone: 22 5720693

Number of ECTS credits:19

2. Educational goals and aims

Structures, properties and metabolism of substances present in the body: proteins, carbohydrates, lipids, nucleic acids, vitamins, hormones. Control and integration of metabolic pathways.

Objectives:

1. To develop a solid understanding of the fundamental chemistry2. To provide an introduction to the principles of biochemistry that gives the students a command of its concepts.3. To provide an explanation of the relationship between the three-dimensional structure of macromolecules and

their biological activities.4. To give the insight into understanding how metabolic processes can contribute to explanation of pathological

phenomena.5. To give the students experience in biochemical methodology in order to appreciate the clinical biochemistry

techniques as diagnostic tools, and to be able to interpret the results for appropriate diagnosis and follow up of patients.

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3. Initial requirements

1. It is beneficial to read and understand the chemical and biological background before the seminars and laboratory classes

4. Learning outcomes corresponding to the subject

A list of course learning outcomes

Symbol of course learning outcomes Description of course learning outcomes

The reference to programme learning outcomes (number)

W1 Water and electrolyte balance in biological systems B.W1

W2Acid-base equilibrium and mechanism of buffer action

and their importance in organism homeostasisB.W2

W3Basic reactions of organic and inorganic compounds in

water solutionsB.W4

W4Structure of organic and inorganic compounds present

in cells, extracellular matrix and body fluidsB.W10

W5Structure of lipids and polysaccharides and their roles in

cell structuresB.W11

W6 Primary, secondary, tertiary and quaternary structures

of proteins; posttranslational and functional modifications of proteins and their importance

B.W12

W7 Primary and secondary structures of DNA and RNA B.W13

W8 Stages of expression of genetic information B.W14

W9 Functions of nucleotides B.W13

W10Basic catabolic and anabolic pathways, how are they

regulated by genetic and environmental factorsB.W15

W11 Metabolic profiles of main organs and tissues B.W16

W12 Oxidative stress B.W17

W13Digestive enzymes, mechanism of HCl production in

stomach, role of the bile in lipids digestion, absorption of digestive products

B.W18

W14 Mechanism of hormones action B.W26

U1Calculations of concentrations of solutions (percentage, molar), calculations of pH and osmolality of body fluids

B.U3

U2 Performance of basic laboratory techniques B.U9

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U3Prediction of direction of metabolic processes in term of

energetic state of cellsB.U6

U4Using databases: internet and searching needed

informationB.U11

U5Planning and performance simple research experiments,

results interpretation, and drawing conclusions B.U14

5. Forms of classes

Form Number of hours Number of groups

Lecture 80 1

Seminar 50 4

Practical classes 90 8

6. Subject topics and educational contentsPart 1.

Lectures:

L1 - Structure of an atom, chemical bonding W4

L2 - Solutions, acids and bases, concept of pH, hydrolysis - W1

L3- Volumetric analysis, buffers - W2

L4 - Functional groups in organic chemistry W3, W4

L5 - IUPAC nomenclature, isomerism - W3, W4

L6-8 Characterization of main groups of organic compounds (hydrocarbons, arenes, alcohols, ethers, carbonyl compounds, carboxylic acids and their derivatives, amines) - W3

L9-10 - Structure and chemical properties of amino acids, peptides, proteins, - W6

L10-12 - Nucleosides, nucleotides, nucleic acids, expression of genetic information - W7, W8

L13-14 - Carbohydrates, lipids, and porphyrins - W5

Seminars:

S1 - Chemical calculations (concentrations) - W1, W2, U1

S2 - Biochemical calculations (buffers) –W1, W2, U1

S3 - Analysis of organic compound and inorganic ions - W3

S4 - Amino acids and peptides – W6

S5 - Proteins (isolation and purification) – W6

S6 - Carbohydrates, lipids – W5

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S7 - Nucleosides, nucleotides, nucleic acids - W4, W7, W8

Laboratory classes:

L1 - Basic laboratory technics – U1, U2,

L2 - Qualitative analysis of organic compounds – W3, U2

L3 - Amino acids – W3, W4, U2

L4 - Proteins - W6, U2

L5 - Carbohydrates - W5, U2

Part 2.

Lectures:

L 1 Proteins - W6

L2-3 Enzymes - W10

L4 Tissue oxidation - W12

L5 Generation of ATP from glucose - W10

L6-8 Carbohydrates metabolism - W10

L9 Generation of ATP from lipids - W10

L10-12, Lipids metabolism, lipidoses, atherosclerosis -W10

L13 Digestion of proteins, lipids and carbohydrates - W13

L14-15 Blood - W11

L16 Protein turnover, ureogenesis - W10

L17-19 Amino acids metabolism - W10

L20 Metabolism of purine and pyrimidine nucleotides - W9

L21 Vitamins - W10

L22 Pathobiochemistry of the nervous system - W11

L23. Metabolism in the liver - W11

L24. Biotransformation of xenobiotics - W11

L25. Ethanol metabolism and effects - W11

L26-27. Hormones, regulation of metabolism - W14

Seminars:

S1. Proteins, enzymes - W6; W10

S2. Tissue oxidation - W11

S3 – 4. Metabolism of carbohydrates - W10, W13, U3

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S5 – 6. Metabolism of lipids – W10, W13, U3

S7. Blood - W11

S8 - 9. Ureogenesis, AAs metabolism - W10, U3

S10. Metabolism of purines, pyrimidines - W10, U3

S11. Vitamins - W10

S12. Metabolism in the liver, biotransformation.- W11, U3, U4

Laboratory classes

C1. Proteins - U1, U2

C2. Enzymes - U1, U2

C3. Enzymes - U1, U2

C4. Carbohydrates - U1, U2

C5. Lipids - U1, U2 .

C6. Digestive enzymes - U1, U2

C7. Blood constituents - U1, U2

C8. Urine constituents - U1, U2

C9. Blood and urine nitrogen comp. - U1, U2, U5

7. Methods of verification of learning outcomesLearning outcome

corresponding to the subject (symbol)

Forms of classes (symbol)

Methods of verification of a learning outcome Credit receiving criteria

W1-W14 WFinal exam (MCQ 100 questions)

At least 55% points

W1-W14 S

Continuous assessment,

intermediate assessment tests during the year – first from Part I and two tests from the Part II.

Minimum 60% points (part I)

At least 55% points (Part II)

W1-W14, U1, U2, U3,U4,U5

C Continuous assessment

Minimum 60% points (Part I)

Minimum 70% points from practical classes (Part II)

8. Evaluation criteria Exam MCQ

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Form of receiving credit in a subject: MCQ

grade criteria

2.0 (failed) 0 – 54% of correct answers during final exam.Insufficient learning outcomes

3.0 (satisfactory) 55 – 64% of correct answers during final exam

3.5 (rather good) 65 – 74% of correct answers during final exam

4.0 (good) 75 – 84% of correct answers during final exam

4.5 (more than good) 85 – 93% of correct answers during final exam

5.0 (very good) 94 – 100 % of correct answers during final exam. Outstanding effects of education

9. Literature

Obligatory literature:

1. General Chemistry with Qualitative Analysis – Whitten, Davis, Peck, VI ed., Saunders College Publishing, 2000.2. Introduction to Organic Chemistry – Brown, W.H. Saunders College Publishing, 2000.3. Biochemistry Lippincott’s Illustrated Reviews, D.R. Ferrier (R.A. Harvey ed.), Wolters Kluwer,

Lippincott,Williams & Wilkins, sixth edition.4. Harpers’ biochemistry, R.K. Murray, D.K. Granner, P.A. Mayers, V.W. Rodwell, Appleton & Lange. Last

edition.5. Biochemistry, a practical guide for laboratory classes. A. Barańczyk-Kuźma, I. Rahden-Staroń, ed. Oficyna

Wydawnicza, Medical University of Warsaw, last edition.Supplementary literature:

1. An Introduction to Medicinal Chemistry, L.P. Graham, Oxford University Press, 2009.2. Biochemistry. L. Stryer, W.H. Freeman & Company, New York.3. Principles of Medical Biochemistry, G. Meisenberg, W.H. Simmons, Elsevier (online access + interactive extras,

studentconsult.com).4. Medical Biochemistry, J.W. Baynes, M.H. Dominiczak, Elsevier, (online access + interactive extras,

studentconsult.com). Last edition.5. Textbook of Biochemistry with clinical correlations, T.M. Devlin, Willey-Liss, Inc. Last edition.

10.ECTS credits calculation

Form of activity Number of hours Number of ECTS credits

Direct hours with an academic teacher:

Lectures 80 2

Seminars 50 4


Student's independent work (examples of the form of work):

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Student's preparation for a seminar 70 3

Student's preparation for a class 40 2

Preparation for obtaining credits 80 4

Other (please specify) ----- -----

410 19

11.Additional Information

Rules for Biochemistry Part 1.

Student is obligated to:

- attend all lectures, laboratory classes, seminars and intermediate assessments on time- be prepared and participate in discussions during seminars and laboratory classes.

In case of illness, emergency or other excusable absence student has to contact dr hab. Piotr Tomaszewski ([email protected]) as soon as possible (no later than within a week).

Excused absences will require either prior approval, written verification or doctor’s certificate.

Unexcused absences may result in failing the entire course of biochemistry.

Each students must be familiar with the rules of the workshop and safety regulations prevailed in the biochemistry laboratory, undertake to follow them, and sign a proper declaration before the laboratory classes start.

Evaluation:

Maximal number of points per each laboratory class = 6 (the total: 4 laboratory classes x 6 points = 24). There are no points for the first laboratory class (no 1).

Maximal number of points per each seminar = 3 (7 seminar x 3 points = 21)

Maximal number of points from all seminars and laboratory classes = 45; passing number = 23. Student who obtained less than 23 points has to take the general test.

Student who gained at least 23 points or passed the general test is allowed to take the first intermediate assessment test (MCQ) at the end of the course (Biochemistry Part 1). At least 55% correct answers are needed to pass. Unexcused absence (within a week) means failing.

Retake test is one week after the first intermediate assessment test (MCQ).

Detailed information concerning Biochemistry Part I course can be found on the website of the Department of Biochemistry:

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http://zakladbiochemii-2wl.wum.edu.pl/

Rules for Biochemistry Part 2.

http://biochemia.wum.edu.pl

Attendance:

Student is obliged to:

- attend all lecture, laboratory classes, seminars and intermediate assessments on time- be prepared and participate in discussions during seminars and laboratory classes

In case of illness, emergency or other excusable absence student should contact prof. Iwonna Rahden-Staroń, as soon as possible (no later than within a week).

Excused absences will require either prior approval, written verification or doctor’s certificate.

Unexcused absences may result in failing the entire course of biochemistry.

Evaluation:

Laboratory classes: students’ knowledge, manual skills, participation and preparedness for the laboratory are awarded with points (from 1 to 6), and 70% gained points are needed to get the credit. Written retake from not credited lab/s is taken at the end of the course (in May).

Excused absences may result in the written retake taken at the end of the course (in May).

Seminars: students’ activity is awarded with grades from 2 to 5. Average grade 3 (satisfactory) is needed to get the credit. More than 2 absences (in both winter and spring semesters) may result in the necessity of taken the assessment test from all seminar topics (in May).

Two assessment tests (MCQ) at the end of each semester. Short answer essays, matching and structures may be included. At least 55% of correct answers are needed to pass. Unexcused absence (within a week) means failing.

The first and the second retake test from each assessment test are in May.

Student can take the final exam after getting credit from Biochemistry Part 1 and Part 2.

Final exam (from Part 1 and Part 2) is composed of multiple choice questions, short answer essays, matching and structures may be included. At least 55% of correct answers are needed to pass. The grade obtained from the final exam may be increased for students who are very active during seminars, labs and obtained very good grades from intermediate tests by the head of the Department.

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http://biochemia.wum.edu.pl/

http://zakladbiochemii-2wl.wum.edu.pl/

Academic honesty: Cheating will not be tolerated! The minimum penalty for cheating will be zero points for a test or exam.

12. Imprint

Faculty name:

The English Division of the Second Faculty of Medicine

6-year program

Syllabus (field of study, level and educational profile, form of studies,

e.g., Public Health, 1st level studies, practical profile, full time): Second year, semester I, full-time program


Module/subject name: Cytophysiology

Subject code (from the Pensum system): 29796

Educational units:

Department of Histology and Embryology

Center for Biostructure Research

02-004 Warszawa, Chałubińskiego 5 Str.(Anatomicum bldg.) Web site: http://histologia.wum.edu.pl

Department office is open for students on working days.

Business hours 9: 30 - 14: 00, tel/fax 22 629-5282.

Head of the unit/s: Jacek Malejczyk, Ph.D.

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Syllabus for Cytophysiology

Professor

Study year (the year during which the respective subject is taught):2

Study semester (the semester during which the respective subject

is taught):1

Module/subject type (basic, corresponding to the field of

study, optional):basic

Teachers (names and surnames and degrees of all academic teachers

of respective subjects):

Jacek Malejczyk, Ph.D., Professor

Paweł Włodarski, M.D., D.D.S., Ph.D., Associate professor

Stanisław Moskalewski, M.D., Ph.D., Professor

Wojciech Sawicki, M.D., Ph.D., Professor

Marek Kujawa, M.D., Ph.D.

Anna Hyc, Ph.D.

Anna Iwan, Ph.D.

Izabela Młynarczuk-Biały, M.D., Ph.D.

Łukasz Biały, M.D., Ph.D.

Ewa Jankowska Steifer, Ph.D.

Artur Kamiński, M.D., Ph.D., Associate professor

Jarosław Jóźwiak, Ph.D., Associate professor

Justyna Niderla-Bielińska, Ph.D.

ERASMUS YES/NO (Is the subject available for students under

the ERASMUS programme?):Yes


Jacek Malejczyk, Ph.D.

Professor

Number of ECTS credits: 3

13.Educational goals and aims

1. Presentation of processes concerning differentiation regulation and functioning of different cells and their populations;

2. Presentation of the mechanisms of cell cycle, mechanism controlling cell proliferation and effects of their disturbances, often leading to neoplasm formation;

3. Presentation of molecular mechanisms of apoptosis and external signal reception by the cell,

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signal transduction inside the cell and regulation of intercellular processes;4. Discussion of current views on cell ageing and demonstration why neoplastic cells are thought to

be immortal;5. Presentation of basic histochemical and immunocyteochemical methods used in modern

microscopic diagnosis;6. Presentation of methods for conservation of tissues harvested for grafting for therapeutic

purposes and discussion of functioning of such grafts in the organism. 7. Presentation of basic molecular biology and basic molecular research methods used in modern

medical diagnosis.


2. Credit in histology and embryology

3. Basic knowledge of cell biology, molecular biology and biochemistry from other fields of biomedical sciences

15.Learning outcomes corresponding to the subject

A list of learning outcomes

SymbolDescription

(a number of a learning outcome and its category: W-knowledge, U-abilities,

K-competence)

29796

W1Student describes structure and function of cellular elements

29796

W2

Student knows the structure of lipids and proteins, as well as their function in cellular and extracellular elements

29796

W3

Student knows the mechanisms of intercellular interactions, between the cell and extracellular matrix.

29796

W4

Student knows the structure and function of cellular nucleus, in particular chromatin and its modifications and significance for transcriptional activity.

29796

W5Student describes phenomena of intracellular transport.

29796

W6

Student knows the types of intercellular communication and signal transduction pathways in the cell.

29796

W7

Student knows examples of disturbances in signal transduction with participation of cytokines and hormones, leading to disease appearance in humans.

29796

W8

Student knows the processes of cellular proliferation and mechanisms regulating cellular division and cellular cycle

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29796

W9

Student knows the processes of cellular ageing and cell death – apoptosis, necrosis, and other types of cell death

29796

W10Student knows cellular differentiation

29796

W11

Student knows the mechanisms of disturbances in cellular functioning leading to neoplasm formation

29796

W12Student knows cellular targets of activity of anticancer drugs.

29796

W13Student knows the subject of stem cells and their application in medicine

29796

W14

Student knows the types of cells used in regenerative medicine and possibilities of their application.

29796

W15

Student knows the basic techniques of cell culture and research methods in cytophysiology.

29796

W16Student knows cell and tissue banking methods for the medical purposes

29796

W17

Student knows the basics for running scientific experiments, in particular in vitro studies performed for the purpose of medical development in the field of cytophysiology

29796

U1

Students can plan basic scientific experiments in the field of cytophysiology, interpret their results and draw conclusions

16.Forms of classes


Lecture 10 1

Seminar 10 1


17.Subject topics and educational contents

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Lecture – 1 hour;

W1 - Cyto- & Histochemistry. Marek Kujawa, M.D., Ph.D.

W2 - Cell & Tissue Culture. Cell Ageing. Stanisław Moskalewski, M.D., Ph.D., Professor

W3 - Cell Membranes - Synaptic Transmission. Łukasz Biały, M.D., Ph.D.

W4 - Cell Motility & Intracellular Movement. Stanisław Moskalewski, M.D., Ph.D., Professor

W5 - Cellular Receptors & Signal Transduction. Jacek Malejczyk, Ph.D., Professor

W6 - Cell Cycle. Jacek Malejczyk, Ph.D., Professor

W7 - Apoptosis. Stanisław Moskalewski, M.D., Ph.D., Professor

W8 - Differentiation of Cells. Dr Ewa Jankowska Steifer

W9 - Oncogenes & Antioncogenes. Paweł Włodarski, M.D., D.D.S., Ph.D., Associate professor

W10 - Cell therapy. Marek Kujawa, M.D., Ph.D.

S – seminars – 1 hour; C – Practical class – 2 hours (C11 – 3 hours);

S1. Physiology of selected cytoplasmic processes. Łukasz Biały, M.D., Ph.D.

Physiology of membrane enclosed compartment. Physiology of selected cytosolic processes. Ribosomes, Polisomes. Endo and exocytosis pathways. Interactions between cells and extra-cellar matrix. Cytoskeleton.

C1. Structure and function of cytoplasm and cell membranes. Łukasz Biały, M.D., Ph.D.

Physiology of cell membranes. Structure of lipids and their function In the cell and extracellular matrix. Lipids rafts. Caveolae. Asymmetry of the plasma membrane. Cellular transport. Glucose transporters. ABC transporters and MDR phenomenon.

S2. Cytophysiology of Cell nucleus and function. Jarosław Jóźwiak, Ph.D., Associate professor

Structure of the cell nucleus. Structure of chromatin and its modifications. Tissue specific modifications of chromatin. Transcriptional activity of chromatin. RNA interference Chromosomes. Telomers. Nuclear structures involved in RNA processing.

C2. Structure of nucleus. Jarosław Jóźwiak, Ph.D., Associate professor

Nucleolus- structure and function. Nuclear envelope and nuclear-cytoplasmic transport. Nuclear processes before cell division. RNA interference.

S3. Cell to cell communication. Anna Iwan, Ph.D.

Types of communication between cells in the human body. The answer of cells to extracellular stimuli.

C3. Cell signalling – intracellular pathways. Anna Iwan, Ph.D.

Receptors, second messengers (cAMP, cGMP, Ca2+. IP3, DG at al.), transcription factors (general and specific – ie. CREB, AP-1, NFkB ). Structure and function of G-proteins. Receptor and non-receptor tyrosine kinases. Kinases Src, Jak. MAP, Akt, PI3K pathways.

S4. Cell signalling events. Jacek Malejczyk, Ph.D., Professor

Cell signalling by selected hormones, cytokines, growth factors and extra-cellar matrix components. Pathways activated by insulin, steroid hormones, nitric oxygen.

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C4. Clinical aspect of cell signalling. Jacek Malejczyk, Ph.D., Professor

Abnormalities in the cell signalling in human diseases. Cell signalling pathways as a therapeutic target.

S5. Cell proliferation. Justyna Niderla-Bielińska, Ph.D.

Types of cell division; mitosis, meiosis. Cell cycle. Structure and function of mitotic spindle. Karyo- and cyto- kinesis.

C5. Regulation of the cell cycle. Justyna Niderla-Bielińska, Ph.D.

Cyklins i CDKinases. Role of p53, p21. pRb, Cdc25, Cdc6, APC-complex. Action of drugs interfering with cell division.

S6. Cell senescence and aging. Anna Hyc, Ph.D.

Cellular senescence. Replication senescence. Cell death: apoptosis, necrosis and other types of cell death.

C6. Cell death. Anna Hyc, Ph.D.

Apoptotic pathways. Execution of apoptosis. Caspases. Apoptosis without caspases. Physiological apoptosis. Apoptosis induction as a therapeutic target. Methods of detecting of apoptotic cells.

S7. Cell differentiation. Ewa Jankowska Steifer, Ph.D.

Mechanism of cell differentiation. Genes involved in Cell differentiation. Epigenetic mechanisms. Cell differentiation during embryogenesis and tissue regeneration.

C7 Stem cells. Ewa Jankowska Steifer, Ph.D.

Cell potency. Stem cells, progenitor cells. Cell differentiation of stem cells in the human body.

S8. Mechanisms of oncogenesis. Paweł Włodarski, M.D., D.D.S., Ph.D., Associate professor

Protective cellular mechanisms against cancer transformation. Abnormal gene expression in cancer. Role of p53, p21, Rb, onco mi-RNA. ATM/ATR, BRCA1/2.

C8 Caner transformation. Paweł Włodarski, M.D., D.D.S., Ph.D., Associate professor

Malignant transformation on the example of retinoblastoma, colon cancer, breast cancer, lung cancer, chronic myeloid leukaemia.

S9. Cancer cell biology - selected topics. Łukasz Biały, M.D., Ph.D.

Cancer cells properties. Abnormalities in cellar processes in cancer cells. Abnormal cell growth. Models of cancer evolution. Cancer stem cell theory. Tumor progression. Tumor angiogenesis. Cancer cell – extracellular matrix interactions and metastasis.

C9 Molecular cancer therapy. Łukasz Biały, M.D., Ph.D.

Cellular target of anticancer drugs incl. molecular targets of novel drugs in oncology.

S10. Regenerative medicine and tissue bio- engineering. Marek Kujawa, M.D., Ph.D.

Cells in regenerative medicine. Stem cells – embryonic and somatic. Differenciated cells: autologenic, izogenic (syngenic), allogenic, xenogeneic, primary and secondary. Method of stem generation: embryonic, somatic and induced stem cells. Therapeutic cloning.

C10. Cell therapy. Marek Kujawa, M.D., Ph.D.

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Stem cell therapy possibilities in clinical usage.

C11. Methods of cell culture and techniques used in the medical research. Anna Hyc, Ph.D.

Methods of cell culture for medical research and regenerative medicine. The in vitro experiment on cell cultures. Types of the cell cultures. Cytostatic/cytotoxic tests in a drug discovery. Laboratory methods of cell research in medicine.

C12. Tissue and cell banking for medical proposes.

Rules of tissue and cell banking. Qualification of donors of tissues and cells. Organisation of tissue and cell banking in Poland, EU at the word. Types of transplantation. Clinical usage of transplants. Coordination 2f tissue and cell transplantation. Advanced technology medical products (ATPM) in tissue and cell banking. Types of the scaffolds and cells in tissue engineering. Transplantation in a regenerative medicine.

18.Methods of verification of learning outcomesLearning outcome


Forms of classes (symbol)Methods of verification of

a learning outcomeCredit receiving criteria

26078

W1

S1 – S2,

C1 – C2

intermediate test, intermediate examination, final examination

minimum 60 % of good answers in total, including minimum 65% of good answers to

the questions concerning oral cavity structures

26078

W2

S1

C1

W3

intermediate test, intermediate examination, final examination see above

26078

W3

S1, S9

C1, C9


26078

W4

S2

C2


26078

W5

S1

C1

W4


26078

W6

S3

C3

W5


26078

W7

S4

C4


26078

W8

S5

C5

W6


26078 S6 intermediate test, intermediate examination, final examination

see above

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W9C6

W2, W7

26078

W10

S7

C7

W8


26078

W11

S8

C8

W9


26078

W12

S9

C9


26078

W13

S7, S9, S10

C7, C9, C10

W10


26078

W14

S10

C10


26078

W15C11


26078

W16C12


26078

W17

C11

W11


26078

U1

C11

W2


19.Evaluation criteriaForm of receiving credit in a subject:

grade criteria

2.0 (failed) Up to 59% - insufficient grade; credit not granted

3.0 (satisfactory) 60 – 68%

3.5 (rather good) 69 – 76%

4.0 (good) 77 – 84%

4.5 (more than good) 85 – 92%

5.0 (very good) 93 – 100%

20

20.Literature

ED Textbooks:

Basic Course Textbooks:

Essential Cell Biology by. Alberts at all (ed.)

Medical Cell Biology by Goodman (ed.)

Rewiew:

Cell and Molecular Biology Lippincott’s illustrated Review by Chandar, Viselli

Full Text Books:

Molecular Cell Biology by Albers et all (ed.)

Cell Biology by Karp

The cell – a molecular approach by Cooper, Hausman




Lectures 10

1Seminars 10

Practical classes 25


Student's preparation for a seminar 1

Student's preparation for a class

Preparation for obtaining credits 1

Other (please specify)

Total 3


The student research club is supervised by Izabela Młynarczuk-Biały, M.D, Ph.D. and Ryszard Galus, M.D. Ph.D.

http://histologia.wum.edu.pl - Studenckie Koło Naukowe

21

General regulations – Cytophysiology for students 6 years MD program 2015/2016

Organization of classes

1. Classes begin with the seminar. Presence in the seminar is obligatory.2. Presence in practical classes and seminars is obligatory. Coming late to class by more than 15 minutes

will be treated as an absence.

3. Students have to be prepared for the class. Subject of seminars and classes are specified in the Topics of classes.

4. Proper preparation of the students for the seminar and class is evaluated by the introductory test.

5. During the class, students discuss with their professor topics of the class and inspect microscopic slides, schemes and electronograms.

6. To get the credit for the class, the student has to be present and get a positive grade from the test evaluating his knowledge of the current material.

Presence during the classes and seminars

1. To get the credit for the semester Student must be present in lectures and seminars and get credit in all classes.

2. The prerequisite for getting a credit for the class is a positive note received on the knowledge of the discussed subject.

3. It is permitted to be absent up to 2 times during classes in the semester. Absence at 3 or more classes, regardless of the reason, results in not getting a credit for the semester, hence student will not be admitted to the examination.

4. Classes uncredited because of the absence or being unprepared must be passed in the form established by the Head of the Department. Head of the Department will appoint the date of this test.

Credit and examination

1. In order to get a credit for the course and be admitted to the examination, the student has to get credit for all the classes.

2. Final examination is in the form of a test consisting of 50 questions.

3. Criteria for passing the examination are settled by the Head of the Department after the test. It is as-sumed that at least 60% of good answers are necessary to pass.

4. Any complains on the questions in the tests must be sent via e-mail to the secretary of the Department on the day of the test.

5. In the case of an absence during the final examination caused by medical condition, should present doctor’s leave during three working days from the date of examination, or will receive a failing grade.

22

6. If the student fails retake examination, he can apply to the Dean for the permission for the second retake of the examination.

Position of the Chair regarding cheating during examinations

Cheating on examinations is a breach of ethics and Regulations of Studies at the Warsaw Medical University. Person actively or passively participating in cheating shall be punished by being expelled from the examination and receiving a failing mark. On the top of that, the Department shall institute disciplinary procedure against the cheating students.

Person actively participating in cheating is the one, who copies results from other students or uses illegal notes or electronic devices to communicate or store data. Bringing such devices to examinations is forbidden.

Passive participation in cheating means allowing other students copy one’s own responses. Thus, a student is obliged to behave honestly, not to allow other students copy his/her own responses.

Head of the Department obliges students and examiners to strictly obey these regulations

Position of the Chair regarding the form of crediting

Students, for whom Polish language is not mother tongue are subject to the same criteria as Polish-speaking students and pass tests and examinations in the form of test.

1.

Faculty name: 2nd Medical Faculty with English Division

Education program (field of study, level

and educational profile, form of studies,

e.g., Public Health, 1st level studies,

practical profile, full time):

medicine, master degree, practical profile, full time

Academic year: 2016/2017

23

Sylabus for Physiology with Pathophysiology

Module/subject name: Physiology with pathophysiology elements

Subject code (from the Pensum system):

Educational units:Chair and Department of General and Experimental Pathology

Head of the unit/s: Prof. Dariusz Szukiewicz, MD, PhD

Study year (the year during which the

respective subject is taught):

2

Study semester (the semester during

which the respective subject is taught):

3 and 4

Module/subject type (basic,

corresponding to the field of study,

optional):

basic

Teachers (names and surnames and

degrees of all academic teachers of

respective subjects):

Prof. Dariusz Szukiewicz, MD, PhD, Katarzyna Romanowska-

Próchnicka MD, PhD, Grzegorz Szewczyk MD, PhD, Aleksandra

Stangret MPT, PhD, Mateusz Wątroba MD, PhD, Szymon

Szczepanik MD, PhD, Michał Pyzlak MD, PhD, Dariusz Górko MD,

Marta Skoda MSc, Przemysław Rzodkiewicz PhD

ERASMUS YES/NO (Is the subject

available for students under the

ERASMUS programme?):

yes

A person responsible for the syllabus (a

person to which all comments to the

syllabus should be reported)

Grzegorz Szewczyk MD, PhD



24

8. Explain physiological mechanisms by applying basic principles of physics and chemistry

9. Describe the fundamental mechanisms underlying normal function of cells, tissues, organs, and organ systems of the human body, commensurate with the requirements for a physician providing primary care to patients.

10. Explain the basic mechanisms of homeostasis by integrating the functions of cells, tissues, organs, and organ systems.

11. Apply knowledge of functional mechanisms and their regulation to explain the pathophysiology underlying common diseases.

25


Knowledge of anatomy

Knowledge of histology

Knowledge of cell biology



Symbol of course learning

outcomes

Description of course learning outcomes

The reference to

programme learning

outcomes (number)

W1

to know function and regulatory mechanisms of all organs and systems in human body including: circulatory system, respiratory system, alimentary system, urinary system and skin and understand the relationships between them

B.W25

W2to know and understand definitions: solubility, Osmolic pressure, isotony, coloid solutions; to know metabolic profiles of basic organs and systems

B.W3

W3to know enzymes involved in digestions, gastrin secretion, role of bile, process of digestion and absorption and their pathology

B.W18

W4 to know the implication of malnutriton B.W19

W5to know the implication of vitamin and minerals deficiency

B.W20

W6

to know the action potential, synaptic transmission,

and maintenance of nerve function, smooth and skeletal muscles function and blood function

B.W24

W7to know hormones function and the implication of their dysregulation

B.W26

W8 to know aging processes B.W28

W9to know the relationship between dysregulating factors and physiological and pathophysiological changes

B.W30

W10to describe water-electrolytes homeostasis in biological systems B.W1

W11 to describe acid-base balance, functions of buffer B.W2

26

solutions and their role in homeostasis

W12to trace pathological processes, describe their symptoms and pathogenesis

B.W30, C.U.11, E.W7

U1

to describe changes in organism after homeostasis disturbance, especially after intensive physical effort, exposure to extreme temperatures, water and blood loss

B.U7

U2

to perform simple diagnostics tests which are able to asses human body as a constant regulatory system (exercise test, etc.) to explain basic test results (spirometry, ECG etc)

B.U8

U3to plan and perform basic experiments, explain their results and put the interpretation B.U14

U4to explain results of basic clinical examinations and use the theory in clinical settings

C.U11

K1 to understand the need for continuous education D.U16

K2can cooperate in a team for performing tests, results interpretation, clinical problems solving and critical discussion

D.U11

6. Forms of classes


Lecture 65 1

Seminar 65 4


7. Subject topics and educational contentsLECTURES

L1- Lecture1- The outline of the subject, the history of physiology and pathophysiology: definition, basic concepts, the selected profiles of outstanding Polish and foreign physiologists, current place of physiology and pathophysiology in learning and teaching in medicine. W1

L2- Lecture 2- General Physiology: internal environment of the body, the control of activities of the cell , membrane transports -W1,W2,W10

L3- Lecture 3- Cell physiology: structure of the cell membrane Transport, cell cycle, interactions between cells. Signal transduction in the cell.–W1,W2,W6,W10

L4- Lecture 4- Sensory system. The physiological and pathological pain: definition and classification. Pain receptors (nociceptors), sensory fibers conductive pain stimuli (quick and slow pain). signal transduction of

27

pain. Opioid receptors. The inhibition of pain at the level of the nociceptors. The inhibition of pain on the level of the spinal cord. W1,W6,W9,W12

L5- Lecture 5- Receptor stimuli and the receptors, the distribution of receptors, receptor properties, coding information, exsteroreceptors, interoreceptors, proprioceptors, motor nerves innervation receptors - W1,W6

L6- Lecture 6- Autonomic nervous system: Organization of the autonomic nervous system (ANS). Efferent way in ANS. Effectors, function and distribution of ANS. Neurotransmitters of sympathetic and parasympathetic parts ANS. Clinical evaluation of ANS dysfunction in extrapyramidal diseases.- W1,W6,W7

L7- Lecture 7- The circulatory system – electrical activity of the heart, cardiac arrythmias- W1,W6,W9,W12

L8- Lecture 8- The circulatory system: cardiac muscle mechanics and cardiac pump, hemodynamics, venous return and cardiac output, regulatory mechanism of blood pressure, regulation of tissue blood flow - W1,W6,W9,W12

L9- Lecture 9- physiology of physical effort: The importance of physical activity. The influence of physical exercise on the body. Classification and evaluation of physical efforts. The impact of training on human athletic performance. - W1,W9,W12

L10- Lecture 10- Skeletal muscle physiology, Classification of muscle fibers. The structure of the muscle fibers. Structural differences in skeletal muscle, smooth muscle and myocardial cells. Energyof ATP, the role of ATP, Types of proteins in the sarcomere. the role of dystrophin. Duchenna and Becker dystrophy. Miopathy. disturbance of neuro-muscular junction: types of ACh receptors, pathways of Ach metabolism, miasteny, Lambert-Eaton syndrome- W1,W6,W9,W12

L11-Lecture 11- Kidney function. Renal blood flow and glomeruli filtration, role of kidneys in homeostasis, reabsorbtion processes in proximal tubule, Henle’s loop, distal tubule and collecting ducts. W1,W2,W9,W10,W11

L12- Lecture 12- Respiratory system: function of respiratory system, O2 and CO2 transport and diffusion, gas exchange, control of respiratory pattern, ventilation/perfusion, central and peripheral respiratory centres- W1,W9,W11

L13- Lecture 13- Blood: composition of plasma and morphological elements of blood, hematopoesis, blood groups, hemostasis - W1,W6,W9

L14- Lecture 14- Gastrointestinal system: secretion, digestion and absorption. liver function - W1,W3,W4,W5,W9,W12

L15- Lecture 15- Physiology of pregnancy: fertilization, pregnancy and fetal development - W1,W7,W9

L16- Lecture 16- Endocrine system: male and female reproductive system. W1,W7

L17- Lecture 17- Rheumatic diseases: pathophysiology of rheumatic arthritis, systemie lapus erythematosus, antiphospholipid syndrome, sclerosis, polimyositis, Sjogren syndrome, VasculitisW1,W9,W12

L18- Lecture 18- Pathogenesis of allergic reactions W1,W9,W12

L19- Lecture 19- Inflammatory process as a part of protection strategy. Basic schema of inflammatory process. Adhesive proteins on the circulating blood cells and on epithelium. Chronic inflammatory process.W1,W9, W12

28

L20- Lecture 20- Dietary dysfunctions. Malnutrition. Vitamin deficiencies. Obesity W1,W3,W4,W5,W9,W12

L21- Lecture 21- Respiratory system diseases: cystic fibrosis, COPD, astma, sarcoidosis. W1,W9,W12

L22- Lecture 22- Pathophysiology of cardiovascular system: heart insufficiency, cardiac infarction – patogenesis and symptoms. W1,W6,W9,W12

L23- Lecture 23- Pathology of pregnancy: infertility, induction of fetal malformations, miscarriage and preterm delivery, preeclampsia, diabates in pregnancy, IUGR W1,W7,W9,W12

L24- Lecture 24- Aging: predisposal aging factors, different types of stress, thermodynamic theory, selected aspect of aging. W1,W8,W9,W12

L25- Lecture 25- Biology of cancer. Epidemiology. Definition of oncogens and suppressor genes. Angiogenesis. Inherited predisposition for cancer. Carcinogens. W1,W9,W12

SEMINARS

S1- Seminar 1- Cell physiology: Membrane transport, cell cycle, Signal transduction. W1,W2,W6,W10,K1

S2- Seminar 2- Sensory physiology: Eye as an optical system. Stimulation of photoreceptors. Adaptation of the eye to the world and the dark. Color vision. The field of vision (Stereopsis). Vegetative innervation of the eye (the eye pupil width accommodates). Refractive eye (myopia, hyperopia, astigmatism). Losses in the field of view. Stereoscopic vision disorders. The sense of hearing and balance. The construction of the outer ear, middle ear, inner ear. The conduction way of the sounds. The method of hearing tests (audiometry). Causes of hearing loss. Gustatory and olfactory system -W1,W6,W9,K1

S3- Seminar 3- Nervous system I Neurophysiology; organisation of nervous system, sensory receptors, the motor neurons of the spinal cord and brainstem, sensory and motor pathways that control the functions of upper and lower motor neurons of the spinal cord. Classification of sensory stimuli. transformation of sensory stimulus to electrical signal. Classification of sensory fibres. Somatic sense. The classification of receptors, the structure and mechanism of action of sensory receptors, temperature, deep surface sensation. extero and proprioceptive feeling pathways, Centers of the cerebral cortex, sensory integration. The Organization of motor cortex neurons and connections with other areas of the cerebral cortex stages of creating movement. Efferent motor pathways. The role of cerebellum.. - -W1,W6,W9,K1

S4- Seminar 4- Nervous system II: Action Potential, Synaptic Transmission, and Maintenance of Nerve Function: specificity of neurons, neurotransmitters, ion channels, excitatory postsynaptic potential and inhibitory postsynaptic potential. modulation of synaptic transmission- -W1,W6,W9,K1

S5- Seminar 5- Smooth muscles: differences between smooth and skeletal muscles, regulation of smooth muscles activity, the role of calcium in smooth muscles cells contractions-W1,W6,W9,K1

S6- Seminar 6- Higher cognitive skills: memory, speech, limbic system and emotions, W1,W6,W7,W9,K1

29

S7- CREDIT 1 - W1,W2,W6,W7,W9,W10,W12,U1

S8- Seminar 8- Cardiovascular system I: Spontaneous heart activity, the effect of epinephrine, norepinephrine, ACh, propranolol, atropine, cardiac glicosides and calcium channel inhibitors. Generation of cardiac action potentials. Polarization and repolarization. Effect of autonomic innervation. W1,W2,W6,W7,W9,U1,K1-

S9- Seminar 9- Cardiovascular system II: Physical and electrophysical basics of ECG. W1,W2,W6,W7,W9,U1,K1

S10- Seminar 9- Cardiovascular system III: Cardiac cycle phases. Basic hemodynamics parameters. Preload and afterload. Bowditch’s effect. Frank-Starling law. Systemic circulation. Systolic, diastolic and mean blood pressure. Total peripheral resistance. The rules of blood flow within vessels, turbulent and laminar blood flow. Innervation of blood vessels- W1,W2,W6,W9,U1,K1

S11- Seminar 10- Physical effort physiology I: The kinetics of changes in cardiovascular parameters in response to physical effort..-W1,W6,W9,U1,K1

S12- Seminar 11- Physical effort physiology II: Methods for the assessment of dynamic muscles activity. ECG during stress test. Respiratory responses to exercise. W1,W6,W9,U1,K1

S13- Seminar 13- Skeletal muscles. Structure of skeletal muscles – molecular basis of muscles contractions. Electro-mechanical coupling. Regulation of power of contractions. Mechanics of skeletal muscles contraction. Isotonic/isometric contraction. Metabolism of skeletal muscles. W1,W6,W9,U1,K1

S14- Seminar 14- Respiratory system. Ventilation and the mechanism of breathing. Gas transfer and transport. W1,W6,W9,U1,K1

S15- CREDIT II -W1,W2,W6,W7,W9,U1

S16- Seminar 16- Blood I: Function of blood. Serum proteins function. Erytropoesis. Hemoglobine – ferrum metabolism, types of Hgb, oxyhemoglobin equilibrium curve, CO2 transportation. Blood groups. WBC – role of cytokines, classification, thrombocytes. Hemostasis. W1,W2,W6,W9,W10,U1,K1

S17- Seminar 17- Blood II: Anemias, leucopenias, leucocytoses. Proliferative disorders. W1,W6,W9,U1,K1

S18- Seminar 18- Hormones I : definition of hormones, classification according to structure, regulation of hypophysis activity. Hormones of the anterior pituitary lobeW1,W6,W7,W9,U1,K1

S19- Seminar 19- Acid – base balance. Respiratory and metabolic disorders. W1,W2,W6,W9,W12,W12,U1,K1

S20- Seminar 20- Hormones II: Incretine activity - GIP, glucose-dependent insulinotropicpolypeptide and GLP-1, glucagon-likepeptide 1 - W1,W6,W7,W9,U1,K

S21- Seminar 21- Gastrointestinal physiology: Motility of gastrointestinal tract, digestion and absorption. Liver function. Neurohormonal regulation of food intake. W1,W2,W3,W4,W5,W9,U1,K1

S22- Seminar 22- Electrolytes ( K, Na, Ca, ): The volume and composition of cellular and extracellular compartments. Osmolality of body fluids. the regulatory mechanisms of cell volume, water and electrolytes transportation. Disturbances in electrolytes concentration. W1,W2,W4,W7,W9,W10,U1,K1

S23- Credit III - W1,W2, W3,W4,W5,W6,W7,W9,W10,U1

S24- Seminar 24- Pathophysiology of cardiovascular system: ischemic heart disease, atherosclerosis, heart infarction, pathogenesis of different cardiovascular symptoms: dyspnea, cyanosis etc.

30

W1,W6,W9,W12,U1,U4,K1

S25- Seminar 25- Pathophysiology of reproductive system: infertility: hormonal, tubal and uterine reasons. Endometriosis, Immunological diseases in reproductive system. W1,W7,W9,W12,U1,U4,K1

S26- Seminar 26- Renal insufficiency: Pathogenesis of prerenal, renal and postrenal insufficiency. Complication of acute and chronic disease. W1,W7,W9,W10,W12,W12,U1,U4,K1

S27- Seminar 27- Pathophysiology of endocrine system: pituitary, thyroid gland hyper and hypofunction, adrenal glans – glucorticoids. W1,W7,W9,W10,W12,W12,U1,U4,K1

S28- Seminar 28- Oedema: pathogenesis of different types of oedemas. W1,W2,W3,W4,W5,W6,W7,W9,W10,W12,U1,U4,K1

S29- Seminar 29- Nervous system pathophysiology W1,W6,W7,W9,W12,U1,U4,K1

S30- Credit IV - W1,W2,W3,W4,W5,W6,W7,W9,W10,W12,W12,U1,K1

Classes

C1- Class 1- Ion channels: Simpatch- measurements of Ion channel electrical activity with patch clamp method. - W1,W6,W9,U3,K1,K2

C2- Class 2- Sensory system: examination of superficial sensations: touch (light and deep pressure), pain, and temperature. Examination of pupillary reflexes to the light, examination of air and bone conduction. W1,W6,W9,U1,U2,K1

C3- Class 3- Nervous system physiology: Fizjologia układu nerwowego: Examination of the reflexes to discover the level of peripheral neuron damage. (knee reflex, Achilles tendon reflex). Basic of neurological examination. W1,W6,W9, U1,U2,K1

C4- Class 4- Neuron: SimNerv – examination of action potential in relationship to the stimulus. The threshold for nerves activity. Absolute and relative refraktory period. W1,W6,W9,U3,K1,K2

C5- Class 5- Smooth muscles: Sim Vessel. Spontaneous and induced smooth muscles activity. The influence of sympathetic and parasympathetic system. The functional antagonism of different parts of autonomic nervous system. W1,W6,W9,U3,K1,K2

C6- Class 6- Higher cognitive skills: memory, speech, limbic system and emotions, W1,W6,W7,W9,U1,K1

C7- Credit I - W1,W2,W6,W7,W9,W10,W12,U1

C8- Class 8- Cardiovascular system I: SimHeart . Spontaneous heart muscle activity Cw.2 The effect of epinephrine Cw.3 Functional antagonism of epinephrine and ACh. Cw.4 The effect of: epinephrine, Ach, propranolo, atropine, cardiac glicosides and calcium channel inhibitors - W1,W6,W9,U3,K1,K2

C9- Class 9- Cardiovascular system II: Analysis of normal ECG. Sinus rhytm, QRS morphology. Calculation of electrical axis of the heart. Analysis of basic cardiac arrythmias - W1,W6,W9,U1,U2,U4,K1

C10- Class 9- Cardiovascular system III: Basic diagnostics tools in the assesment of the cardiovascular system: Hearing of heart sounds, blood pressure measurement.- W1,W6,W9,U1,U2,U4,K1

C11- Class 10- Physical effort physiology I: The kinetics of changes in cardiovascular parameters in response to physical effort. W1,W6,W9,U1,U2,K1,K2

C12- Class 11- Physical effort physiology II: Methods for the assessment of dynamic muscles activity. ECG

31

during stress test. W1,W6,W9,U1,K1

C13- Class 13- Skeletal muscles: Sim Muscle; 1 Single contraction isotonic/isometric; Cw.2 Double contraction; Cw.3 tetanus contraction- W1,W6,W9,U3,K1,K2

C14- Class 14- Respiratory system: Spirometry – measurements of VC, FEV.- W1,W6,W9,U1,U2,K1,K2

C15- Credit II -W1,W2,W6,W7,W9,U1

C16- Class 16- Blood I: the assessment of blood smear parameters and coagulation, calculation of GFR (Cockroffa-Gaulta equation - MDRD)- W1,W2,W6,W9,W10,U1,U2,U4,K1

C17- Class 17- Blood: interpration of selected electrolytes levels and biochemical test in some physiological fluids - W1,W6,W9,U1,U2,U4,K1

C18- Class 18- Hormones I: fT3, fT4 – their metabolic effect, excess and deficiency; cortisol – function, excess and deficiency; calcium and phosphate metabolism- W1,W6,W7,W9,U1,U2,U4,K1

C19- Class 19- acidosis,alkalosi: the assesment of kidney function on the base of creatinine clearance. GFR calculation W1,W2,W9,W12,W12,U1,U2,U4,K1

C20- Class 20- Endocrine and exocrine function of the pancreas. Diabetes. Glucose level measurement. Analysis of clinical cases. W1,W6,W7,W9,U1,U2,U4,K1

C21- Class 21- Extremal conditions: high altitude, Monge disease, decompression, the effect of acceleration on human body. Jet-lag effect- W1,W6,W9,U1,K1

C22- Class 22- Kidneys: the composition of urine, creatinine clearence, hormonal and neural regulation of kidneys filtration, role of the kidneys in regulation of blood pressure. Interpretation of urine analysis. W1,W2,W4,W7,W9,W10,U1,U2,U4,K1

C23- Credit III - W1,W2, W3,W4,W5,W6,W7,W9,W10,U1

C24- Class 24- Pathophysiology of cardiovascular system: analysis of clinical cases of patients with: IHD, arterial hypertension and heart abnormalities -W1,W6,W9,W12,U1,U2,U4,K1

C25- Class 25- Reproductive system – analysis of selected reasons of infertility W1,W7,W9,W12,U1,U2,U4,K1

C26- Class 26- Shock: definition, reasons and pathogenesis, ways of compensation, complications.W1,W7,W9,W10,W11,W12,U1,U2,U4,K1

C27- Class 27- Pathophysiology of endocrine disorders: Graves disease, Addison’s disease, acute adrenal gland insufficiency - W1,W7,W9,W10,W11,W12,U1,U2,U4,K1

C28- Class 28- Pathophysiology of the respiratory system: Disorders in ventilation mechanism (restriction, obturation), analysis of spirometry results. W1,W9,W12,U1,U2,U4,K1

C29- Class 29- Liver insufficiency: pathogenesis in different etiological factors, increased portal pressure. Jaundice. W1,W2,W3,W4,W6,W7,W9,W10,W12,U1,U2,U4,K1

C30- Credit IV W1,W2,W3,W4,W5,W6,W7,W9,W10,W11,W12,U1,U4,K1

32

8. Methods of verification of learning outcomesLearning

outcome

corresponding to

the subject

(symbol)

Forms of classes

(symbol)

Methods of verification of

a learning outcome

Credit receiving criteria

W1

L:1-25;

S:1-30;

C:1-30.

credit

Exampresence at all lectures, seminars, classes, positive mark from credits and exam

W2

L:2,3,11;

S:1,7-10,15,16,19,21-23,28,30;

C:7,15,16,19,22,23,29,30

credit


W3

L:14,20;

S: 21,23,28,30;

C:23,29,30.

credit


W4

L:14,20;

S: 21,22,23,28,30;

C:22,23,29,30.

credit


W5

L:14,20;

S: 21,22,23,28,30;

C:22,23,29,30.

credit


W6

L:3,4-8,10,13,21

S:1-20,22-24,28-30

C:1-21,23,24,29,30

credit


W7

L:6,15-19,23

S:6-9,15,18,20,22,23,25-30

C:6,7,15,18,20,22,23,25,27,29,30

credit


W9 L:20 credit presence at all lectures, seminars,

33

Exam classes, positive mark from credits and exam

W9

L:4,7-15,17-25

S:2-30

C:1-30

credit


W10

L:2,3,11

S: 1,7,16,22,23,26-30

C:7,16,22,23,26,27,29,30

credit


W11

L:11,12

S:19,26,27,30

C: 19,26,27,30

credit


W12

L: 4,7-10,14,21-25

S:7,19,24-30

C:7,19,24-30

credit


U1S:7-30

C:2,3,6,7,9-30

active participation in discussion, credit, exam

active participation during seminars and classes, positive mark from credits and exam

U2C:2,3,9-11,14-20,22,24-29

active participation in classesactive participation during seminars and classes

U3 C: 1,4,5,8,13 active participation in classes active participation during classes

U4S:24-30

C:9,10,16-20,22,24-29active participation in classes

active participation during seminars and classes

K1S:1-30

C:1-30

preparation to semianars and classes

active participation in discussion during seminars

active participation during seminars and classes

K2 C: 2,4,5,8,11,13,14active work in subgroups during classes

active participation during classes

9. Evaluation criteriaForm of receiving credit in a subject:EXAM

grade criteria

2.0 (failed)not completing the receiving criteria or getting 50% and less of possible points during the exam.

3.0 (satisfactory) getting more than 50% of possible points during the

34

exam

3.5 (rather good)On the basis of an analysis of the distribution of exam results

4.0 (good)On the basis of an analysis of the distribution of exam results

4.5 (more than good)On the basis of an analysis of the distribution of exam results

5.0 (very good)On the basis of an analysis of the distribution of exam results

10. Literature


Rodney A. Rhoades, David R. Bell : Medical physiology : principles for clinical medicine — 2013, 4th ed. Wolter’s Kluwer

Gary D. Hammer, MD, PhD, Stephen J. McPhee, MD, Pathophysiology of Disease: An Introduction to Clinical Medicine, 2014, 7e, McGraw Hill.

Supplementary literature:

John E. Hall. Guyton and Hall Textbook of Medical Physiology, 13th Edition , 2016, Elsevier




Lectures 65 3

Seminars 65 3



Student's preparation for a seminar 90 3



All 500 19


35

1. Imprint

Faculty name: Second Faculty Of Medicine With The English Division

Syllabus: English Medicine Division, 1st level studies, practical profile, full time, compulsory


Module/subject name: Immunology

Subject code: 29802

Educational unit:

Department of Immunology, Transplantology and Internal Diseases Nowogrodzka 59, building 1A 02-006 Warsaw, phone: +48 22 502 16 41

Head of the unit: Prof. Leszek Pączek, MD PhD

Study year: second year

Study semester: second semester

Module/subject type: basic

Teachers:

Anna Burdzińska, DVM PhDMichał Ciszek, MD PhDKamila Gala, MSc PhDTomasz Pilecki, MD PhD Dariusz Sołdacki, MD PhD Jolanta Żegarska, MD PhD

ERASMUS: YES

A person responsible for the syllabus Dariusz Sołdacki, MD PhD



1. Familiarization with basic immunology in reference to elements of clinical immunology

36

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1. Basic knowledge from anatomy, physiology, cytophysiology



Symbol Description

(a number of a learning outcome and its category: W-

knowledge, U-abilities, K-competence)

C.W20basic knowledge about development and mechanisms involved in innate and adaptive immunity (antibody-dependent and cell-dependent immunity)

C.W21 the major histocompatibility complex

C.W22 hypersensitivity, autoimmune and allergic reactions, types of immunodeficiencies, basic knowledge about immunomodulation

C.W23 The immune response to tumors

C.W24 donor and recipient match genetic bases and transplantological immunology

5. Forms of classes


Lecture 0 -

Seminar 40 4

Practical classes 0 -

6. Subject topics and educational contents

S1- Seminar 1- The complement system - C.W20 – Dariusz Sołdacki, MD PhD S2 – Seminar 2 - Populations of lymphocytes - C.W20 - Tomasz Pilecki, MD PhD S3 – Seminar 3 - The recognition of antigen – Subpopulations of T cells and antigen recognition by T cells - C.W21 - Anna Burdzińska, DVM PhD S4 – Seminar 4 - The major histocompatibility complex and its function - C.W21 - Anna Burdzińska, DVM PhDS5 – Seminar 5 - The recognition of antigen – Antigen presentation to T lymphocytes and dendritic cells -

38

C.W21 – Dariusz Sołdacki, MD PhD S6 – Seminar 6 – T Cell Mediated Immunity - C.W20 - Michał Ciszek, MD PhDS7 – Seminar 7 – Positive and negative selection of T cells - C.W20 - Tomasz Pilecki, MD PhDS8 – Seminar 8 - Pattern recognition and Toll-like receptors - C.W20 - Dariusz Sołdacki, MD PhDS9 – Seminar 9 – Antigen receptor signaling and lymphocyte activation. Immune response to tumors – C.W23 - Dariusz Sołdacki, MD PhDS10 – Seminar 10 - The distributions and functions of immunoglobulin classes - C.W20 - Tomasz Pilecki, MD PhDS11 – Seminar 11 – Structure of antibodies and the humoral immune response - C.W20 - Dariusz Sołdacki, MD PhDS12 – Seminar 12 – Primary Immunodeficiency diseases and immunological aspects of acquired immune deficiency syndrome – C.W22 - Jolanta Żegarska, MD PhDS13 – Seminar 13 - Immunological memory and vaccination – C.W22 - Dariusz Sołdacki, MD PhDS14 – Seminar 14 - Allergy and Allergic Diseases – C.W22- Anna Burdzińska, DVM PhDS15 – Seminar 15 - The mucosal immune system – C.W20 - Anna Burdzińska, DVM PhDS16 – Seminar 16 - Immune response to infection – C.W20 - Anna Burdzińska, DVM PhDS17 – Seminar 17 - Autoimmune diseases and pathogenic mechanisms – C.W22 - Kamila Gala, MSc PhDS18 – Seminar 18 - Evasion and subversion of immune defenses – C.W22 - Tomasz Pilecki, MD PhDS19 – Seminar 19 - The making and breaking of self-tolerance – C.W22 - Anna Burdzińska, DVM PhDS20 – Seminar 20 - Reponses to alloantigens and transplant rejection – C.W24 - Michał Ciszek, MD PhD

7. Methods of verification of learning outcomes

Learning outcome corresponding to

the subject (symbol)



C.W20, C.W21, C.W22, C.W23, C.W24

S (seminars) MCQ

More then 60% positive answers and maximum two inexcusable absences on

seminars

8. Evaluation criteria

Form of receiving credit in a subject:

grade criteria

2.0 (failed) Less then 60% positive answers on MCQ and maximum two inexcusable absences on seminars

3.0 (satisfactory) 60%-65% positive answers on MCQ and maximum two inexcusable absences on seminars

3.5 (rather good) 65%-70% positive answers on MCQ and maximum two inexcusable absences on seminars

4.0 (good) 70%-75% positive answers on MCQ and maximum two inexcusable absences on seminars

4.5 (more than good) 75%-80% positive answers on MCQ and maximum two inexcusable absences on seminars

5.0 (very good) More then 80% positive answers on MCQ and maximum two inexcusable absences on seminars

39

9. Literature

Obligatory literature:“Janeway’s Immunobiology” (8th edition) by K. Murphy. Garland Science 2012, New York Supplementary literature: „Cellular and Molecular Immunology” (8th edition) (Cellular and Molecular Immunology, Abbas)




Lectures - -

Seminars 40 1 and 1/3

Practical classes - -


Student's preparation for a seminar 20 2/3

Student's preparation for a class - -


Total 90 3

11.Additional Information(e.g., information on a scientific association operating within the unit, information on commuting to university, etc.)

40

1. Imprint

Faculty name:The Second Faculty of Medicine

Syllabus (field of study, level and educational profile, form of studies, e.g., Public Health, 1st level studies, practical profile, full time):

English Division

6-year program

Full-time


Module/subject name:BASIC POLISH FOR MEDICINE


Educational units:

Foreign Language Department

The Didactic Center, ul. Trojdena 2a., 02-109 Warsaw

[email protected], tel. 22 5720863

www.sjo.wum.edu.pl/

Head of the unit/s:Maciej Ganczar, PhD


II


Winter and summer semesters


Basic, compulsory


Jolanta Budzyńska, MA

Maciej Ganczar, PhD



Jolanta Budzyńska, MA



1. The II year Polish language course is designed to improve the students' command of the language

41

Syllabus forBASIC POLISH FOR MEDICINE

mailto:[email protected]

and provide them with basic medical terminology and skills to communicate with an adult and paediatric patient at elementary level.

42


1. Successful completion of the I year Polish language course



SymbolDescription

(a number of a learning outcome and its category: W-knowledge,

U-abilities, K-competence)

The successful student should be able to:

D.U.18

• take a patient's history at elementary Polish language level (personal history; chief

complaint (pain): location, radiation, quality, quantity, duration, frequency,

aggravating and relieving factors, associated symptoms; past history; family

history; drug history; social history; the review of systems)

• give simple instructions to an adult and paediatric patient during a physical

examination and explain the doctor's intentions

5. Forms of classes


Lecture

Seminar


6. Subject topics and educational contentsClass duration: 2 hours 15 minutes (winter term) and 1 hour 45 minutes (summer term)

C1/Discussing the syllabus (the course content, learning outcomes and the methods of their verification; rules and regulations; credit receiving criteria)

Parts of the human body • The verb boleć (singular&plural/present&past tense)

C2/Systems and organs • The cases of the noun and adjective in the singular&plural (revision) – forms and uses

C3/The common cold and flu – a patient's description of the symptoms in the present/past tense • Time

43

expressions (revision) • Revision of the tenses (present&past)

C4/Problems with sleep • Questions: jak długo?, jak często?, ile razy?, od jak dawna?, O której godzinie? • The modals móc and musieć (present&past tense)

C5/Diet: pieczywo (białe, ciemne), nabiał, mięso (tłuste, chude), wędlina, owoce, warzywa, napój (słodki, nie/gazowany) • Advising a patient on a healthy diet: proszę jeść/nie jeść … • Containers and quantities: butelka, szklanka, kubek, kieliszek, litr, deka, kilo, dużo, mało, więcej, mniej, trochę, ile, około (+ the genitive case)

C6/Allergies • Common allergens • Medication: lek/lekarstwo (na e.g. serce), tabletka, witamina, suplement diety, lek przeciwbólowy / przeciwgorączkowy / przeciwzapalny / hormonalny, tabletki antykoncepcyjne • The verb brać/wziąć (singular/present&past tense) • Distinction between imperfective & perfective verbs (revision)

C7/Physical activity • The verbs iść, chodzić, pójść, jeździć, po/jechać, ćwiczyć, biec, biegać (present&past tense)

C8&9/Instructions for the clinical examination of adults • Explaining the doctor's intentions to the patient • Future simple tense of selected verbs (e.g. zbadać, osłuchać, zmierzyć, zrobić)

C10&11/Instructions for the clinical examination of children • Explaining the doctor's intentions to the patient • The imperative mood

C12/Revision

C13/Progress test • Common diseases • The verbs chorować (na), leczyć się (na) (present&past tense), umrzeć (na) (past tense)

C14/The medical interview: personal history (name, age, occupation, height, weight, marital/family status)

C15/The medical interview: social history – alcohol, smoking

C16/The medical interview: chief complaint • Common symptoms

C17, 18/The medical interview: past history – surgeries, injuries, hospital admissions, previous illnesses, birth control, pregnancies / births, menstrual periods, allergies

C19/The medical interview: family history

C20, 21, 22/The medical interview: history of present illness (pain) – location, radiation, onset (timing, setting), previous similar pain, duration, character, severity, exacerbating and relieving factors, associated symptoms

C23, 24, 25/The medical interview: systemic inquiry (basic questions)

C26/Revision

C27/Course written test • Speaking practice

C28, 29, 30/Course oral test


corresponding to the subject

(symbol)


Methods of verification of

a learning outcomeCredit receiving criteria

D.U.18 C Written test

Oral test

To successfully complete the I year Polish language course and obtain credit, a student is required to:

• attend all classes (min. 13 out of 15 in a semester)

44

A student who misses more than 2 classes per semester

without a valid excuse will not be allowed to take the course tests and will not receive course credits.

Absences due to illness will be excused on presentation of a valid medical note within one week of return to study. In the case of two or more excused absences per semester the student must make up the missed classes. If a student misses a class, she/he must catch up on the missed material. It is the student's responsibility to communicate with the class teacher as soon as possible about any attendance issues.

• come to classes punctually

If a student arrives less than 15 minutes late three times per semester, it will count as one absence. Arriving to class more than 15 minutes late is counted as an absence.

• actively participate in each class

• complete all the assignments by the due date

• pass the progress test at the end of the winter semester and the course written and oral tests (covering the coursework of both the winter and summer semesters) at the end of the summer semester

A student who fails the course tests can take two resits.

The final course grade a student receives is the average (arithmetic mean) of the written and oral test grades (grades of 2-5), or a grade of 3 for passing a resit. A minimum score of 60% must be obtained on each (written and oral) test to pass the course.

A student who misses a scheduled test will receive a score of 0 unless she/he notifies the class teacher of the reason for her/his failure to take the test within three days of the scheduled test date and makes up the missed test if the reason is justified at the date set by the class teacher.

A student who fails the second resit needs to repeat the course.

Students who are 'independent users' of the Polish language (Level B2 as described in the Common European Framework) may be exempted from attending the second year Polish language course provided they achieve the required score on the B2 level examination administered by the University's

45

Language Centre (Studium Języków Obcych) at the beginning of the academic year. Students interested in taking the exam should check with their class teacher for the exam date, time and location at the first class meeting.

8. Evaluation criteriaForm of receiving credit in a subject:

grade criteria

2.0 (failed) Below 60%

3.0 (satisfactory) 60-69%

3.5 (rather good) 70-79%

4.0 (good) 80-85%

4.5 (more than good) 86-90%

5.0 (very good) 91-100%

9. Literature

Obligatory literature: Maria Janowska, Świetlana Sikorska “Proszę oddychać! Część III Warszawski Uniwersytet Medyczny

Handouts prepared by the teachers

10. ECTS credits calculation



Lectures

Seminars


Student's independent work (examples of the form of work): doing home assignments

Student's preparation for a seminar



46

Other (please specify)

Total 240 5

11. Additional Information(e.g., information on a scientific association operating within the unit, information on commuting to university, etc.)

1. Imprint

Faculty name: Second Faculty of Medicine

Education:2nd Faculty of Medicine, English Division, intramural, full-

time, 6-year Program

Academic year: 2016-17

Module/subject name: Medical Ethics with Elements of Philosophy

Subject code (from the Pensum system): 29797

Educational units:

Zakład Bioetyki i Humanistycznych Podstaw Medycyny

Chair of Bioethics and Medical Humanities

Żwirki i Wigury 63

02-091 Warszawa

tel.: (+48 22) 57 20 568

Head of the unit/s: Prof. dr hab. Tomasz Pasierski

Study year: 1

Study semester: 1

Module/subject type: basic

Teachers: Prof. dr hab. Paweł Łuków; mgr Barbara Fijałkowska

ERASMUS YES/NO: YES

The person responsible for the syllabus Prof. dr hab. Paweł Łuków

47

Syllabus for Medical Ethics with Elements of Philosophy


2. Educational goals and aims12. Lectures : to acquaint students with the philosophical aspects of science and the theoretical-philo-

sophical foundations of medical ethics, together with the basic ethical concepts and standards of physician’s ethic.

13. Seminars : to develop the skills which are necessary for analysis of medical-ethical problems, appreciation of the ethical aspects of medical practice and decision making on the basis of the knowledge acquired during lectures.


None

4. 5. Learning outcomes corresponding to the subject


Symbol of course learning outcomes Description of course learning outcomes

The reference to programme learning outcomes (number)

W1 understands the physician’s social role D.W6.

W2

knows and understands the main concepts, theories, principles and standards that provide a general framework for correct interpretation and analysis of moral-medical problems

D.W13.

W3knows the principles of altruism and clinical responsibility and is aware of the principles of functioning of the therapeutic team

D.W14.

W4appreciates the cultural, ethnic, and national determinants of human behavior

D.W16.

W5knows the philosophical and methodological basic principles of evidence based medicine

D.W20.

U1 observes the ethical standards of professionalism D.U12.

U2can recognize the ethical dimensions of medical decisions and discern their factual from the normative aspects

D.U13.

U3 observes patient’s rights, including: the right to personal data protection, the right to privacy, the right to information concerning the patient’s health, the right to informed consent to treatment or refusal of treatment, the right to death with

D.U14.

48

dignity

U4takes responsibility for his/her own continued education and for dissemination of knowledge

D.U15.

U5recognizes his/her own limitations, determines his/her own educational deficits and needs, plans his/her own educational activity

D.U16.

K1shows respect for others and tolerance towards different views and priorities of others

K2shows compassion with the suffering and readiness to help disinterestedly

K3collaborates with a group at solving medical-ethical dilemmas

K4respects law and ethical guidelines that apply to medicine

5. Forms of classes


Lecture 20 1

Seminar 20 4



L1-Lecture 1: Philosophy and its main subdisciplines. Knowledge and types of science; W1

L2-Lecture 2: Inductive inference. Humanities. Basics of philosophy of science; W1, W5

L3-Lecture 3: Theories of truth. Philosophical and methodological foundations of EBM; W1, W5

L4-Lecture 4: Ethics and medical professionalism; W3, W2, U1

L5-Lecture 5: Philosophical ethical theories; W2, W3, U2

L6-Lecture 6: Ethical regulation in medicine; W1, W3, U2

L7-Lecture 7: Justice in healthcare and patient’s right; W1, W3, U3

L8-Lecture 8: Physician-patient relationship and informed consent. Patient’s decisional competency; W1, W2, U3

L9-Lecture 9: Physician’s professional autonomy. Medical paternalism; W4, U1

L10-Lecture 10: Truthfulness and confidentiality; W2, W4, U3

49

S1-Seminar 1: Medical professionalism; W3; W2, U1, U2, U4, U5, K1, K4

S2-Seminar 2: Informed consent to medical services; W1, W2, U1, U2, U3, K1, K4

S3-Seminar 3: Patient’s autonomy and decisional competency; W1, W2, U3, U5, K1, K3, K4

S4-Seminar 4: Physician’s professional autonomy; W4, U1, U3, U5, K4

S5-Seminar 5: Medical confidentiality; W2, W4, U1, U3, K4

S6-Seminar 6: Patient’s privacy; W2, W4, U1, U3, K2, K4

S7-Seminar 7: Ethics of beginning of life; W2, U1, U3, K1, K2, K3, K4

S8-Seminar 8: Ethical problems in pediatrics; W2, U1, U2, U3, K4

S9-Seminar 9: End of life ethics; W4, U1, U2, U3, K1, K2, K3, K4

S10-Seminar 10: Conflict of interest in healthcare; W1, U2, U3, U5, K3, K4





W1-W5 L1-L10 multiple choice test 65% correct answers

U1-U5 S1-S10correct analysis of a medical ethical case during class presentation

acquisition of skill at acceptable level

K1-K5 S1-S10participation in class discussions of assigned reading materials

acquisition of skill at acceptable level


grade criteria

2.0 (failed) below 60% of correct answers

3.0 (satisfactory) 60% of correct answers

3.5 (rather good) 65% of correct answers

4.0 (good) 70% of correct answers

4.5 (more than good) 80% of correct answers

5.0 (very good) 90% of correct answers

50

9. Literature


1. R. Scruton, Modern Philosophy. An Introduction and Survey, Mandarin 1996, pages: 1-15, 16-20, 23-33, 34-45, 99-111, 183-186, 317-333.

2. T. L. Beauchamp, J. F. Childress, Principles of Biomedical Ethics, Oxford University Press 1994 (fourth edition), chap. 3-7.

Supplementary literature:

Scholarly journal articles selected for particular seminars. List of readings will be provided during first seminar.

10. ECTS credits calculation



Lectures 20 0,8

Seminars 20 0,8


Student's independent work:

Student's preparation for seminars 5 0,2

Preparation for obtaining credits 5 0,2

Other (please specify) 0 0

Total 50 2

11. Additional Information

51

Syllabus for Genetics

1. Course information

Name of the faculty: Second Faculty of Medicine

Mode of study:Medicine

6-year program


Course name: Genetics

Course code:

Department responsible for curriculum:

Department of Medical Genetics

Center for Biostructure Research, First Faculty of Medicineul. Pawińskiego 3c, 02-106 Warszawa

phone: +48 22 572 06 95, fax: +48 22 572 06 96

http://www.genetyka.wum.edu.pl

Head of the Department: prof. dr hab. Rafał Płoski

Year of study: 2 (second)

Semester of study: 4 (fourth)

Course level: mandatory

Teaching staff:

prof. dr hab. Rafał Płoski

dr n. biol. Joanna Kosińska

dr n. med. Małgorzata Rydzanicz

dr n. med. Lech Trzeciak

mgr Konrad Szymański

mgr Piotr Gasperowicz

mgr Anna Walczak

mgr Krystyna Wasilewska

52

Erasmus YES/NO (is the course available for students within Erasmus program):

yes

Person responsible for curriculum (person to whom comments can be made concerning curriculum):

Konrad Szymański

phone: +48 607 49 39 01

[email protected]

Number of ECTS: 2

2. Course aims and objectives The aim of the course is to present theoretical and laboratory basics of medical and clinical genetics. In the course, the main focus is on teaching how to make use of the obtained knowledge in practice. Students will also learn to intepret basic genetic analysis, understand principles of genetics counselling and will be acquainted with basic laboratory and statistical methods used in the research in the field of human genetics.

53

3. PrerequisitesBefore the course a student:

1. knows the function of nucleotides in the cell; describes primary and secondary structure of DNA and RNA; enlists interactions which stabilize these structures; describes chromatine structure (B.W13.);

2. knows functions of human genome, transriptome and proteome as well as basic methods used in studing them; describes processes of DNA replication, repair and recombination, trancription and translation and DNA, RNA and protein degradation; knows basic concepts of gene expression regulation, including epigenetic regulation (B.W14.);

3. knows processes such as cell cycle, proliferation, differentation and aging of cells, apoptosis and necrosis as well as their importance for functioning of the organism; explains the differences between mitosis and meiosis (B.W22.);

4. knows the ways of communication between cells as well as between the cell and extracellular matrix and pathways of transmitting signals in the cell and examples of disruption of these processes leading to cancer and other diseases (B.W21);

5. passed a course in molecular biology.

4. Subject learning outcomes

List of learning outcomes

Learning outcomes symbol Learning outcomes description

Learning

outcomes

reference code

W1 Student knows basic terms in the field of genetics. C.W1.

W2 Student describes phenomena of genes linkage and interactions. C.W2.

W3 Student describes normal human karyotype.

W4 Student describes the structure of chromosomes and molecular basis of mutagenesis. C.W4

W5

Student knows the principles of inheritance different number of traits, inheritance of quantitative traits, independent

inheritance of traits and inheritance of extranuclear genetic information.

C.W5.

W6 Student describes autosomal and heterosomal abberations which cause diseases.

W7Student knows the basics of diagnostics of genetic and chromosomal mutations responsible for inherited and

acquired diseases, including cancers.C.W9.

W8 Student knows factors which influence the primary and secondary genetic balance of population. C.W8.

U1Student analyzes genetic crosses and pedigrees of human

traits and diseases, and estimates the risk of giving birth to a child with chromosomal aberrations.

C.U1.

54

U2Student calculates the risk of occurrence of a particular

disease in the offspring, based on familial predispositions and the influence of environmental factors.

C.U5.

U3Student uses databases, including on-line ones, and finds

information necessary for research (in the field of genetics). C.U28

U4Student critically analyzes medical publications and draws conclusions based on the literature available in the field of

genetics.

K1

Student is able to work in a group in order to solve a problem from the field of genetics.

5. Teaching methods

Form Number of hours Number of groups Minimal number of students in a group

Lecture 0 0 Not applicable

Seminar 8 1 Not applicable

Class 17 1 Not applicable

6. Course content1. Basics of genetic medical history and pedigree analysis. Modes of inheritance in human. Genomic imprinting. Drawing pedigrees based on clinical cases. Analysis of modes of inheritance – W1, W5, K1

2. Calculating genetic risk in multifactorial diseases. Applicability of RR and OR in medical genetics. Calculating reoccurrence risk in monogenic diseases. Empirical estimation of disease likelihood in a family using Bayes theory – W1, W8, U1, U2, K1

3. Usefulnes of LR calculation in medical gentetics. Calculating likelihood of pedigrees – U1

4. De novo mutations. Calculating genetic risk considering mutagenesis – W1, W7, W8, U1, U2

5. Genes identification and mapping. Linkage analysis – W1, W2, U1, U2, U3

6. Introduction to cytogenetic testing. Chromosomal basis of human diseases. Methods in molecular cytogenetics. Analysis of cytogenetic results. Using online databases in CGH analysis – W1, W3, W4, W6, U1, U2, U3, U4

7. Personalized medicine – wholegenome sequencing of DNA. Analysis of DNA sequencing results DNA – W1, U2, U3, U4

7. Methods for evaluation learning outcomesLearning outcomes

symbolSymbols of forms in which

the course is givenMethods for evaluation learning

outcomes Passing criteria

W1 – W8, U1-U4 C, S Report from completed task Solving correctly a given task (drawing a pedigree based on clinical description of a family; interpreting a result of a genetic

55

testing; calculating genetic risk; defining a term; explaining a biological process)

W1-W8, U1-U3 C, S Open question test Solving correctly one out of three tasks

8. Evaluation criteriaForm of passing the course: passing without a grade

Grade Criteria

2,0 (ndst) Not solving at least one out of three tasks

3,0 (dost)

3,5 (ddb)

4,0 (db)

4,5 (pdb)

5,0 (bdb)

9. Literature

Medical genetics

Jorde Lynn B., Carey John C., Bamshad Michael J.

Mosby Elsevier

Edition: 4th

10. ECTS estimation

Form of activity Number of hours Number of ECTS

Contact hours with teaching staff:

Lecture 0 0

Seminar 8 0,5

Class 17 0,5

Student's individual work:

Preparing for the class 15 0,5

Preparing for evaluation 10 0,5

56

Other (which?) 0 0

Total 50 2

11. Additional information

1. Imprint

Faculty name:Second Faculty of Medicine

Education program (field of study, level and educational profile, form of studies, e.g., Public Health, 1st level studies, practical profile, full time):

Medical sciences, Health Sciences, Medicine, Practical profile, Full

time


Module/subject name:First Aid


Educational units:

1. Departament of Paediatric Anesthesiology and Intensive Therapy

Ul. Marszałkowska 24, 00-576 Warsaw, tel.+48 226299418

email: [email protected]

2. I Department of Anesthesiology and Intensive Therapy, ul. Lindeya 4, Warsaw tel. +48 22 5021721

3. II Department of Anesthesiology and Intensive Therapy

ul. Banacha 1a, Warsaw +48 22 5992002

Head of the unit/s:

1. Magdalena Mierzewska-Schmidt MD PhD

2. Janusz Trzebicki MD PhD

3. Grzegorz Niewiński MD PhD


Second year

57

Syllabus for First Aid


Second semester


Compulsory, basic


1. Magdalena Mierzewska-Schmidt MD PhD

Artur Baranowski MD

Karina Baranowska MD

Jakub Kalbowiak MD

Piotr Sawicki MD

2 Małgorzata Mikaszewska-Sokolewicz

Grzegorz Górniewski

Marek Janiak

Mateusz Klukowski

Jan Pluta

Paulina Topka-Cyganecka

Barbara Wrońska-Podstawka

3.Łukasz Wróblewski MD

Paulina Walczak-Wieteska MD

Olga Bartosik MD

Michał Rykowski MD


Yes


Magdalena Mierzewska-Schmidt



14. The aim of the course is to provide sufficient knowledge and skills to enable students to recognise and react appropriately in emergency conditions and life-threatening situations

58

15. The student must be able recognize cardiac arrest and perform cardiopulmonary resuscitation (CPR).

59


11. To know the theory of CPR according to the European Resuscitation Council Guidelines 2015

www.erc.edu ( summary)



Symbol of course learning outcomes

Knowledge-K, Skills-S, Competence-C

Description of course learning outcomesThe reference to

programme learning outcomes (number)

K1S1 The student...knows when the patient should be referred to the hospital E.W20

S2 Knows the algorithm of BLS ( basic life support) D.W46.

K2 Knows life threatening conditions E.W18

K3S3 Knows common life threatening problems in children and knows the rules of first aid management E.W6.

K4 Knows the definition of shock and its causes C.W28.

S4 Performs basic life support, can use AED F.U10

S5 Provides first aid and reacts properly in life threatening situations

F.U10

S6 Can establish peripheral intravenous access on a mannequin F.U5

S7 Can stop external bleeding F.U9

S8, S9 Can assess the patient's general condition and level of consciousness

E.U7

S10 Recognises life threatening conditions E.U14

K5 Provides first aid in poisoning E..U33

K6S11 Provides first aid in fractures and luxations,, prepares the patient for the transportation

D.U14

K7,S12 First aid in bleeding D.U23.

S13 Can assess a trauma patient condition basing on simple vital signs and mechanism of injury

D.U66.

K8S14 i S15 Can recognise signs of shock and acute heart failure E.U9.

C1 Draws conclusions from observation B.K2

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C2 Can work in a team B.K3

5. Forms of classes


Seminar 13

Practical classes 23


e.g.: W1-Lecture 1- Lecture topic…- Educational contents - Symbol of course learning outcome/s….- Lecturer - prof. dr hab. Jan Nowak (teacher name is not obligatory)

W2-Lecture 2- Lecture topic…- Educational contents - Symbol of course learning outcome/s….- Lecturer - prof. dr hab. Jan Nowak (teacher name is not obligatory)

S1-Seminar 1- Topic …- Educational contents - Symbol of course learning outcome/s….- Teacher- prof. dr hab. Jan Nowak (teacher name is not obligatory)

C1-Practical Class 1- Topic…- Educational contents - Symbol of course learning outcome/s….- Teacher- prof. dr hab.

Jan Nowak (teacher name is not obligatory)

S1 Introduction. Organization of the seminar. Why is it important to learn First Aid? First Aid-General Principles. Safety aspects of first aid. Why do we fear to provide first aid. How to recognize and act in life-threatening situations? - EU14

S2 C1 Aseptic, antiseptic. Wounds: type of wounds, identification, inerventions, desinfection. Bleeding and hemorrhage: external and internal: identification, interventions. Luxations and fractures. Identification, interventions. Dressings and immobilization: practical classes (mannequin) CW35, F.U9, DU14 D.U23.

S3 Adult and Paediatric Basic Life Support - theory and algorithm D.W46.

C2 and C3 Cardiopulmonary Resuscitation. Choking in babies and adults : practical classes F.U10BK2, BK3

C4 Injections. Theory. Equipment: syringes, needles, cannulas. IV infusion. Practical training F.U5

S4 First Aid Kit Drugs. Introduction to pain treatment. What is pain? Why should we treat it? How? D.U29.

S5C5Accidental trauma. Drowning and near-drowning. Thermal injury. Burns, frost bites. Heatstroke. Traffic accidents. Spine immobilization- practical training. EW18,EW20 D.U66.EU7, EU14

S6C6 Common paediatric disorders: paediatric emergencies a Breathing difficulties b. Hyperventilationc. Asthma d. Heart problems e. Severe abdominal pain f. Altered level of consciousnessg. Allergic reaction h. Diabetic emergencies (hyperglycaemia and hypoglycaemia).i. Sudden infant death syndrome. Case-based learning.EW6

S7C7 Shock- what is it? How to recognize it? Interventions. Hypovolaemic shock. Septic shock. Anaphylactic shock. Cardiogenic shock. Non- accidental injuries- child abuse. Case-based learning CW 28 EU9 E.U14

S8 Signs and symptoms and first aid techniques for the major medical emergencies Unconsciousness: heart-attack, epilepsy. Stroke . Chemical injury. Electrical shock and lighting. Intoxications. Alcohol. Drugs a poison. Narcotics, drug addiction. EW18 EW20 E.U33

C8 Revision. First aid clinical scenarios ( eg. Cardiac arrest, drowning, haemmorhagic shock…)

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C9 Visit to paediatric intensive care unit. Bedside teaching. EU7 EU9 BK2,

C10 Visit to adult intensive care unit. Bedside teaching. EU7 EU9 BK2

7. Methods of verification of learning outcomes

Learning outcome




DW46, FU10 S2C2C3 MCQ , DOPS The student must be able to perform BLS on a paediatric and adult mannequin

E.W20, E.U9, EU7 E.W6E.U14

S1, S5C5, S6C6, S7C7C8MCQ , observation at the bedside

The student must be able to recognise unconsciousness and react properly.

The student should be able to recognise life-thereatening conditions.

He should know the basic principles in providing first aid in emergency situations


Grade Criteria

FailedAny of the following: more than 2 absences, lack of participation at CPR practical classes, lack of active participation during seminars and practical classes

Pass Active participation during seminars and practical classes

1. Presence, 2 absences are allowed.

2. Being late twice = 1 abscence.

3. Direct observation of student’s performance and his activity during first aid classes

4. Observation and assessment of cooperation in groups in simulated scenarios

5. Credit based on direct observation of performance in clinical scenarios – simple situations requiring first aid.

6. Colloqium: CPR on a manikin and first aid in simulated clinical scenario.

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6. Correct CPR performance is a must to get a pass.

MCQ test

9. Literature


www.erc.edu- European Resuscitation Guidelines Summary 2015

Supplementary literature: PACT –e - learning programme -Main Library: access via SSL-VPN portal (www.wum.edu.pl)

First Aid Manual, British Red Cross 10th Revised Edition,2014

10. ECTS credits calculatio



Lectures 0 0

Seminars 13 1



Student's preparation for a seminar 3

Student's preparation for a class 3

Preparation for obtaining credits 4

Other (please specify)Watching

educational videos - 2

11. Additional InformationPLEASE ADDRESS THE QUESTIONS TO Magdalena Mierzewska-Schmidt: [email protected]

The telephone numbers will be provided later as we are just before displacement to the new location at Żwirki i Wigury Street

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2wl.wum.edu.pl web vieworganisation of tissue and cell banking in poland, eu at the word. ... c3-...

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