Poster Abstracts Thursday, November 10, 2005 $435

lethal outcome. Among 9 TACS 3 had M1 level occlusion, this occlusion was not seen in any of PACS cases.

1314 Tuberculous Carotid Axleritis with Thrombosis of Cerebral Venous sinus

FJ. Rodrfguez de Rivera 1, S. Martin Balbuena 1, R. Regojo 2, J. Salas 1, C.. Morales 2, J. Arpe 1. 1Department of Neurology Hospital Universitario La Paz. UAM. Madrid, Spain; ZDeparttnent of Pathologic Anatomy" Hospital Universitario La Paz. UAM. Madrid, Spain

Objectives: Meningeal vessels arteritis is frequent in tuberculous meningitis, being an uncommon infectious cause of thrombosis of cerebral venous sinus. This is a case of tuberculous carotid and middle cerebral arteries arteritis, with massive cerebral thrombosis. Method: A 58 years-old male, ex smoker, admitted by a self-limiting confusional state (language alteration, headache and nausea). The patient died 5 months late; he was adnfitted twice due to seizures and a hemorrhagic venous stroke. An extensive trial battery was used for the diagnosis (laboratory, MR[, MRA, angiography, carotid Doppler, serologic., immunologic and coagulation analysis). Results: After a CT-scan with a possible right MCA stroke a total vascular study was done (Doppler, echocardiography, coagulation, MRI and MRA), with a possible diagnosis o f vasculitis, but inmmnologic and serologic studies (nomml), Mantoux-test (negative), CSF (minor increase of proteins, normal culture and serology) and angiographic study diagnosed a venous thrombosis of sagittal, recto and both lateral sinus. Autopsy showed a granulomatous meningoencephalitis, with necrotizing ganulomatous arteritis of both carotid siphons and bilateral MCA (PCR tuberculosis +), with an thrombosis evolution of sagittal and both transversal sinus; Sella turcica was fractured. Conclusions: The damage of the large arteries of Circle of Willis without extra-cranial lesions supose primary rhinosinusal tuberculosis with cranial invasion, being uncollmlon its association to a cerebral venous thrombosis. CNS tuberculosis nmst be considered as a cause of craitial venous sinus thrombosis.

1315 Celecoxib trial in Intracerebral Hemorrhage: open label, single center, satiety and I~asibility study

Roh, j1, Chu, K 1, Sitar, D 1, Lee, S 1, Jung, K 1, Park, j1, Kim, M 1. 2Stroke & Neural Stem Cell Laboratory', Department of Neurology, Seoul National University Hospital, Seoul, South Korea

Background: Celecoxib, one of selective cyclooxygenase-2 inhibitors, has been reported to have anti-inflanunatory and anti-apoptotic effects, as well as to induce better functional recovery in the experimental intracerebral hemorrhage (ICH). But there has been no evidence in the clinical setting. In tiffs study, we investigated the safety and the feasibility of celecoxib treatment in the patients with acute [CH. Methods: Study was designed as non-randomized, prospective, open label, and phase I study. Sixteen consecutive ICH patients, who adnfitted within the three days after the onset, were treated with celecoxib (200mg b.i.d) for 14 days. Matched controls (in -- 50) were selected from our database considering age, sex, location of hemorrhage, and the initial NIHSS. We compared NIHSS, modified RankJn Score (mRS) at discharge or 90 days, and NIHSS change from baseline (baseline NIHSS - NIHSS at discharge) between the groups. Results: The basic characteristics including mean age, sex, risk factors, location of hematoma, laboratory findings, baseline NIHSS, and baseline mRS had no significant difference. No treatment-related adverse effect was documented in the celecoxib group. The aggrava- tions of neurologic status, myocardial infarction, cerebral infarction, or death were not found in the celecoxib group. The NIHSS change from baseline was greater in the treatment group than the control group. The celecoxib group showed a larger proportion of those

patients with good outcome (mRS -- 0, 1) compared with the control group. Conclusions: We provide initial evidences that celecoxib adntinistration can be safe and tolerable in acute ICH patients, and that probable better neurologic outcome can be obtained with celecoxib administra- tion. Further studies are warranted with larger scales and randonfized- controlled manners.

1316 The prevalence and clinical significance of Vertebral Artery Hypoplasia M patients with Ischemie Stroke

Roh, j1, Park, j 1 ZDepartrnen t of Neurology, College of Medicine, Seoul National University, SeouL Korea

Background: Hypoplasia of the unilateral vertebral artery (VA) is a congenital variation in the configuration and size. It is frequently seen on cerebral angiography and it seems to possess an increased possibility of ischemic stroke. Objectives: To investigate the prevalence of unilateral VA hypoplasia and to know its significance in ischemic stroke patients with VA territory. Methods: Total 371 patients (mean age 64.5 ± 12.1, male 64.7%) with ischemic stroke were recruited and analyzed according to the location of stroke (1200 anterior and 171 posterior circulation). We investigated prevalence of symptomatic VA hypoplasia and initial stroke scales (NIHSS, mRS) as well as demographic feature, vascular risk factors in patients with lateral medullar (LM) or posterior inferior cerebellar artery (PICA) infarction in the territory of VA. The YA was considered hypoplastic if its diameter was assamnetrically reduced relative to its usual appearance. Results: Unilateral VA hypoplasia was present in 223 (60.1%) of the 371 patients. Patients with posterior circulation stroke showed more significant prevalence of VA hypoplasia (68.4% vs 53.0?::0, p -- 0.002). There were 109 patients with YA territory (156 LM and 53 PICA infarction), among which 81 patients showed unilateral hypoplasia (74.3%). The 58 (53.2"/0) out o f 81 patients showed symptomatic VA territory stroke. The initial NIHSS (3.4 ± 2.1 vs 2.2 ± 1.9) and mRS (13.0 ± 1.2 vs 2.1 ± 1.1) were higher in patients with sympto- matic hypoplasia than in those without symptomatic, hypoplasia (p_ .003, <.oo1). Cotiehision: These results showed that VA hypoplasia has potentially important applications contributing to high probability of ischemic stroke in the elderly. It seems that hypoplastic VA is more susceptible to atherosclerotic change, giving rise to more grave neurological deficit.

1317 Ophthahnologic Ihldings in Cerebral Autosomal Donlinant Atteriopattly with Subcortical Infarcts and Lettkoencephalopathy (CADASIL)

Roine, S l, Harju, M 2, aKivelfi, T 2, PSyhSnen, M 3, Nikoskelainen, E*, Tuisku, S z, Kivel~, H 6'7, Viitanen, M s'~, Sunlnlanen, p2. ZDepartment of Neurology, Turku University Central Hospital, Turku, Finlan& 2Department of Ophthalmology, HdsinM University Hospital, Finland; 3Department of ivledieal Genetics, Family Federation of Finland, Helsinki, Finland; 4Deparmwnt of Ophthalmology, Turku University Central Hospital Turku, Finland; SDepartrnent of Neurology, KesM-Pohjanrnaa Central Hospital Kokkola, Finland; ~Department of Pathology, Helsinki University Hospital, Finland; 7Departrnent of Pathology, University of Helsinki, Helsinki, Finland; SDivision of Clinical Geriatrics, Karolinska University Hospital Huddinge, Stockholm, Sweden; 9Department of Geriatric Medicine, University of Turku, Turku, Finland

Background: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an inherited generalized nonatherosclerotic, nonamyloid arteriopathy, which causes