Poster Abstracts Wednesday, November 9, 2005 $345

gene expression from SHR and SD rats was analyzed using eDNA array strategy. Hippocampal expression of the gene-encoding ghicose- dependent insulinotropic polypeptide (GIP) varied strongly in parallel with cell-proliferation rates in the DG. GIP immunoreactivity could be detected in the DG. The GIP receptor is expressed by cultured adult hippocampal progenitors and throughout the granule cell layer of the DG, including progenitor cells. Thus, these cells have the ability to respond to GIP. Exogenously delivered GIP induced proliferation of adult-derived hippocampal progenitors in viva and in vitro, and adult GIP receptor knock-out mice exhibit a lower number of newborn cells in the hippocampal DG compared with wild-type mice. This investigation demonstrates the presence of GIP in the brain for the first time and provides evidence for a regulatory function for GIP in progenitor cell proliferation.

GIP stimulation might be a putative target in the treatment of neurodegenerative disorders.

0963 Effects of rehabilitation on physical activities of chronic stroke patients with hemiplegia

Itiraoka, T, Tsubahara, A, Seki, S, Nishikawa, M, Osugi, A, Yokoyanla, M. Kawasaki Medical School Hospital, Japan

Objective: This study was carried out to clarify the role of rehabi- litation care in our hospital for the patients with hemiplegia during maintenance period, and to evaluate its effectiveness and problems. Methods: Subjects were 100 stroke patients with hemiplegia discharged from our department between January 1, 2000 and April 1, 2004. FIM scores at discharge were compared to the one at least 1 year after discharge. Differences of the FIM score are analyzed according to severity of hemiplegia, housing after discharge, contents of physical training, and examinations at the out patient clinic, of the fixed physi- atrist. FIM after discharge was evaluated by using telephone FIM.

The motor function was evaluated by using Brunnstrom Recovery Stage (BRS). Results: Patients whoes BRS was 5 or 6, maintained their functions and abilities sufficiently. The function in the patients whoes BRS was less than 4, however, was effected by some factors. The FIM score was significantly higher in the patients who continued training under the guidance of physiatrists than the other patients. Conclusions: The participation of physiatrists is extremely important for the maintenance of functions and abilities particularly in chronic patients with low stage.

0964 NoriilOXie Curative compression in Baroehaulber in eOulbinafion with Cyelosporin a ill tile rehabilitation of patients with severe stroke

Kazantseva, NV, Volkova, NA, Timofeev, VT. Russian Institute of Cardio- Vaseular Surgery, Moscow, Russia

Introduction: The use of Cyclosporin A in combination with normoxic compression in the narrow range of surplus pressure values in chamber was accompanied by a pronounced curative effect in the treatment of neurodegenerative disorders that go with expressed autoinnnune inflammation (multiple sclerosis, Ahheimer 's disease, ALS). PCT/RU 02/00070. The aim of the study was to analyze the effectiveness of the method in the rehabilitation of patients with severe stroke. Material and Methods: We observed 10 patients aged 4%85 who had had an ischemic stroke with a pronounced residual neurological deficit and cogtfitive impairment. Duration of the disease was one month three years. Previously all patients had course of normoxic compres- sion in a barochamber (11.05 -1.1 ATA 20 rnin) without Cyclosporin A. For two to four weeks all the patients received Cyclosporin A in the dose of 2-5 mg/kg a day in combination with daily treatment in a barochamber. Complex investigations included: the score estimation of the neurological status, MMCE test, innnunological status (lympho- cyte subpopulations, including CD25, CD 95 and Ig A, M, G).

Results: The use of Cydosporin A in combination with baro- chamber sessions was accompanied by a more significant regress of neurological symptoms and improvement of cognitive functions (MMSE), as compared to the previous course in a barochamber without Cyclosporin A. We also observed the normalization of the inlnlUne status. Discussion: A pronounced curative effect of the method is based on retarding apoptosis pathologically activated in severe ischernia.

0965 The EfficiencTf of Impulse Magneto Stimulation in Rehabilitation of the Patients with Movement Disorders after Discectomy

Daminov, V, Lyadov, K, Lavrentiev, K, Manevsky, A, Kuznetsov, A. National Pirogov Centre of Therapy and Surgery, Moscow, Russia

Purpose of this study is estimation of efficiency of impulse magneto stimulation in the patients within early period after discectomy. Material and methods: Magneto stimulation was applied as additional rehabilitation method in 104 patients with paresis of foot flexor or extensor on the 2th 5th day after discectonry (L5 or S1) (Group 1). Stable and scamfing methods were used with induction 0.5 1.7 TI daily during 1~18 days. The control group consisted of 62 patients with similar severity of disease (Group 2). The patients of Group 2 were conducted only by usual rehabilitation (massage, kinesiotherapy, laser therapy). We used Muscular Force Scale of R. Braddom, MOS SF-36 and neuromJography before and after treatment. Results: There was decrease of degree of paresis in 74% of the patients of Group 1 (p < 0.05). Only 51% of the patients of Group 2 had the same changes. S F 3 6 scores were considerably improved in Group 1. The patients o f Group 2 had not considerably improved dynamics of these scores. Significant increase of initially reduced peak parameters was registered in stimulating neuromiography in 45% o f the patients of Group 1 and in 29% of the patients of Group 2. In Group 1 motor nerve conduction velocity on fibular nerve increased in 42% of the patients, on ribial nerve-in 51%. Significant changes of nerve conduction parameters were not registered in the patients of Group 2. Conehisions: Additional magneto stimulation therapy heightens the efficiency of rehabilitation in the patients within early postoperative period after discectomy.

0966 The Influence of Rehabilitative Treatments to the Prognosis of Middling- Severe Cerebral Vascular Diseases

l iang Rtfi, Xu Eli, Deng Bingnlei, Liu Zuyou, Lu Xuefen. Institute of Neuroscience, the 2nd Affiliated Hospital of Guangzhou Medical College, Guangzhou, China

Background: To investigate the influence of rehabilitative treatments to the prognosis of middling-sever cerebral vascular diseases at acute phase and long term results. Methods: All the charged cerebral in 2001 patients, whose NIHSS were higher than 7 and score for paralyzed limbs was higher than 2, received combined rehabilitative therapy, such as acupuncture, exercise therapy and helium- neon laser therapy were recorded with the B[ scale, MRs and NIHSS at the onset t ime, date of discharge, 3 months, 6 months after discharge and the final date at intervew. All the scales were also recorded at the final checking in. The patients were divided according to the length of time of committing rehabilitative therapy, the time when the treatment began. Results: All 397 patients were collected. The patients received rehabilitative therapy got better results than that of those didn't have therapy (p < 0.05). At 6 month after onset, the patients could gain the best recover level. When compared with the shorter period of therapy groups, the scales of longer period group were better (i3 < 0.05), no mater how early the therapy was began.