**********************************************************...neuroscience program, she has increased...

October 2019 **********************************************************************************************************

CURRICULUM VITAE

Jill B. Becker **********************************************************************************************************

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PERSONAL INFORMATION

Name: Jill B. Becker Office Address: The University of Michigan Molecular & Behavioral Neuroscience Institute 1050 MBNI 205 Zina Pitcher Place Ann Arbor, MI 48104-1109 Office: 734/763-4363 Lab: 734/936-3670 fax: 734/936-2690 email: [email protected] PRESENT POSITION:

Biopsychology Area Chair Patricia Y. Gurin Collegiate Professor of Psychology Research Professor of Psychiatry Research Professor Molecular and Behavioral Neuroscience Institute Senior Scholar Neuroscience Program, Reproductive Sciences Program.

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ACADEMIC BACKGROUND

University of Kansas, Lawrence, Kansas 1969-1976 B.A. (1973) Department of Human Development

M.A. (1976) Department of Human Development Thesis Advisor: Dr. E. K. Michaelis Thesis Title: The effect of cycloheximide on a positively reinforced discrimination task compared to the non-specific effect of satiation.

University of Illinois, Urbana, Illinois 1976-1980

Ph.D. (1980) Neuroscience Program; School of Life Sciences Dissertation Advisor: Dr. V. D. Ramirez, Dept. Physiology & Biophysics Dissertation Title: Sex differences in catecholamine release from brain tissue in vitro.

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RESEARCH AND PROFESSIONAL EXPERIENCE

Patricia Y. Gurin Collegiate Professor of Psychology 2009-present Research Professor 2007-present The University of Michigan Medical School, Department of Psychiatry, Molecular & Behavioral Neuroscience Institute, Senior Neuroscience Scholar, Professor 1997-present The University of Michigan, Department of Psychology, Reproductive Sciences Program, Neuroscience Program Ann Arbor, MI Sabbatical with Drs. Thomas Insel and Larry Young 2001-2002

Viral vector development for over-expression of estrogen receptors Center for Behavioral Neuroscience, Emory University, Atlanta, GA

Sabbatical with Dr. Michael D. Uhler 1994-1995 Molecular biology of membrane-associated steroid hormone receptors in MCF-7 cells The University of Michigan, Department of Biological Chemistry, Ann Arbor, MI Associate Professor 1992-1997 The University of Michigan, Department of Psychology, and Associate Research Scientist in the Reproductive Sciences Program

member Neuroscience Program Faculty Ann Arbor, MI Assistant Professor 1987-1992 The University of Michigan, Department of Psychology, Reproductive Sciences Program and Neuroscience Program Faculty Ann Arbor, MI Lecturer and Assistant Research Scientist 1983-1987 The University of Michigan, Department of Psychology, Ann Arbor, MI. Post-Doctoral Fellow, Department of Psychology, MI 1980-1983 The University of Michigan, Ann Arbor,

****************************************************************** HONORS OR DISTINCTIONS

Neal Miller Distinguished Lecture – American Psychological Association 2019 Graduate Mentoring Award – UM Psychology Dept. 2018 Winter Conference on Brain Research Pioneer Award 2017 Ting-Kai Li Lecture Award from the Research Society on Alcoholism 2016 Endowment for the Basic Sciences, Faculty Recognition Award 2015

University of Michigan Medical School Sarah Goddard Power Award, University of Michigan 2011 Award for promoting women in every aspect of her work as a scientific researcher, leader and mentor. In her neuroscience research, she has focused on such areas as understanding the interaction between neuroscience and endocrinology in the modulation of female behavior, and the difference in the release of dopamine and its role in the female brain. Her work has resulted in an acceptance that female and male brains work differently At U-M, she was instrumental in improving both mentoring and promotion processes, resulting in formal mentoring plans in departments and more transparent promotion reviews, both of which create a more open and supportive faculty environment. As associate director of the Neuroscience Program, she has increased flexibility for students who need to cope with birth, illness and other complications. Louise Hanson Marshall Special Recognition Award, Society for Neuroscience 2010 This award recognizes an individual for significant contributions to promoting the professional advancement of women in neuroscience through teaching, public advocacy, and organizational leadership. Patricia Y. Gurin Collegiate Professor of Psychology 2009 Excellence in Research Award, College of Literature, Science and the Arts 1998 Faculty Recognition Award, Horace H. Rackham School of Graduate Studies, University of

Michigan 1997-98 Research Career Development Award, National Institute of Neurological and Communicative Disorders and Stroke, "Brain Tissue Transplantation Studies of Functional Activity", #KO4 NS01056. 1986-1991 National Research Service Award, National Institute of Child Health and Human Development, "Gonadal Steroid Modulation of Striatal Activity", #HD05997. 1980-1983 NIH Pre-doctoral Traineeship, Systems and Integrative Biology Training Grant 1978-1980 Dept. Physiology and Biophysics, University of Illinois, Urbana, IL. James Scholar Program, Early Admissions Program for High School Seniors, University of Illinois, University High School Urbana, IL. 1969

PROFESSIONAL ACTIVITIES

SOCIETY MEMBERSHIPS Fellow of the American College of Neuropsychopharmacology Fellow International Behavioral Neuroscience Society Michigan Society for Neuroscience

Organization for the Study of Sex Differences Society for Neuroscience

Society for Behavioral Neuroendocrinology

EDITORIAL CONSULTING (Journals) Editorial Board: Biology of Sex Differences (2010 – present)

Endocrinology (2008-2017) Journal of Neuroscience (1993-2002)

Neuroscience and Biobehavioral Reviews (1992-present) Restorative Neurology and Neuroscience (1990-1998) Journal of Neural Transplantation and Plasticity(1990-1998) Guest Editor: Brain Research Special Issue: Sex, Genes and Steroids Vol. 1126, Dec 18, 2006 Guest Editor with David C.S. Roberts: Neuroscience & Biobehavioral Reviews, Special Issue Honouring Ann Kelley, Volume 37 (9), Part A, November 2013. Guest Editor with Carla Segura-Sanchis: Addiction Biology, Special Issue of Gender and Addiction Research (2016) AD-HOC consulting: Brain Research Brain Research Bulletin Behavioral and Brain Sciences Behavioral Brain Research Behavioral Neuroscience European Journal of Pharmacology Experimental Neurology Hormones and Behavior Journal of Neuroendocrinology

Journal of Neuroscience Journal of Pharmacology and Experimental Therapeutics Life Sciences Neuroscience Neuroendocrinology

Neuropsychopharmacology Pharmacology, Biochemistry and Behavior Physiology and Behavior Proceedings of the National Academy of Science, USA Psychopharmacology Science Steroids Leadership

Chair, Isis Fund network on “Sex, Gender Drugs and the Brain” (2002-2007) Society for Women’s Health Research. Description: Understanding the impact of sex differences on health requires contributions from disciplines in basic biological research and in clinical research. The Society has established the Isis Fund for Sex-Based Biology Research (the Isis Fund) to promote collaborations among scientists in diverse areas by supporting the development of interdisciplinary research Networks. The mission

of the Network on Sex, Gender, Drugs and the Brain is to “Promote research and education in the area of sex/gender differences in brain health and disease. In order to achieve this goal, the Network will educate and advocate for the importance of sex differences among research funders, scientists, reviewers, regulators, the public and learners in all disciplines.” As chair of the network I lead the presentation of workshops and symposium at a number of international meetings including a satellite symposium at the Society for Neuroscience in 2003 on “Sex Differences in the Brain”, presentation of a Symposium at the Society for Neuroscience in 2004 on “Sex, Gender, Drugs and the Brain”, and the writing of a major article on “Strategies and Methods for Research on Sex Differences in Brain and Behavior”, Endocrinology, 146 2005, 1650-1673. We formed a new scientific society, the Organization for the Study of Sex Differences and published a book on “Sex Differences in the Brain: From Genes to Behavior, Oxford University Press (I am senior editor for the book).

Neuroscience Graduate Program (NGP), Faculty Ally for Diversity (2009-2014). As

the Faculty Ally for the NGP, I wrote a grant proposal that was funded. This funding provided additional external mentoring for our diverse graduate students to improve time to completion of the PhD. The funding also allowed us to conduct the first NGP Preview weekends to further increase the population of diverse students in the NGP.

Society for Neuroscience: Committee on Women in Neuroscience,

(member 2004-07, Chair-Elect 2007-08, Chair 2008-2009) Professional Development Committee Co-Chair (2009-2011) Initiated funding from the National Science Foundation through the ADVANCE program: Department Chair Training to Increase Women in Neuroscience (IWIN). The overall and long-term goal of IWIN was to increase the number of women, including underrepresented minority (URM) women among faculty in neuroscience.

Associate Director Neuroscience Graduate Program (2007-2010)

The Associate Director is responsible for staffing the courses taught for the graduate students in Neuroscience, filling committee assignments and running the colloquium series, as well as other duties to assist the Director.

Interim Director Neuroscience Graduate Program (2010-2011)

The Director is responsible for overseeing the Graduate Program in Neuroscience.

Biopsychology Area Chair, Psychology Dept. (2005-2007; 2017-present)

The Biopsychology Area of the Psychology Department is one of 6 subfields in the Department of Psychology at the University of Michigan. Area chairs are chosen by the Department chair after soliciting recommendations from the faculty. As Biopsychology Area Chair I am responsible for coordinating the teaching of 15 faculty, negotiating space needs, overseeing the Graduate Program in Biopsychology (Admissions, Funding, Preliminary Exams, Fellowship and Award competitions, Student progress), I am liaison to the Department for the Area, and deal with day-to-day problems within the Area.

Chair, Gordon Research Conference on Catecholamines 2007

Vice-Chair Gordon Research Conference on Catecholamines 2005 At the 2003 Gordon Research Conference on Catecholamines I was elected to these positions. The Chair is responsible for assembling the program and obtaining funding for speaker travel through grants and donations.

Organizing Committee, Workshop on Steroid Hormones in the Brain (2001-2006)

As a member of the organizing committee for this meeting I was responsible for soliciting proposals, obtaining feedback from the committee on the proposals, assembling the program, fundraising, and helping to run the meeting on site.

Associate Dean for Academic Affairs, College of Literature, Science and the Arts

(2003-2004). As Associate Dean for Academic Affairs I was responsible for oversight of hiring as well as promotion and tenure review at the College. This involved chairing the reading committees who evaluate the scholarship of all individuals hired with tenure or promoted to or with tenure in the College, and I was responsible for official offer letters as well communication with the Provost about the faculty. I was liaison to the Department Chairs, and responsible for Chair training on issues of faculty hiring, departmental climate, and many other issues.

Assistant to the Dean of LSA (1998-2000). In this capacity, I dealt with issues of

sexual harassment, faculty-partner hiring, and student-faculty complaints. Graduate Program Chair, Psychology Department (1996-1999, 2000-2001)

The Psychology Department Graduate program consists of a total 180-200 graduate students. As graduate program chair I negotiated with the Dean of the Graduate School for the first 5-year funding package for our graduate students and managed a budget of $2.5 million, annually.

National Service National Advisory Council on Alcohol Abuse and Alcoholism (2018-2022)

Advisory Council to Office of Research on Women’s Health (2014-2018) Tourettes Syndrome Scientific Advisory Board (1994-2009) President, Organization for the Study of Sex Differences (2008-2010) Chair, Search Committee for new Editor-in-Chief of Biology of Sex Differences,

flagship journal for the Organization for the Study of Sex Differences (2017) Winter Conference on Brain Research

Travel Fellowship Chair (2005-2007) Conference Chair-Elect (2009-2010)

Conference Chair (2010-2012) Society for Neuroscience

Committee on Women in Neuroscience, (member 2004-07, Chair-Elect 2007-08, Chair 2008-2009) Professional Development Committee Co-Chair (2009-2011) Awards Selection Committee (2012-2014)

Biobehavioral Regulation, Learning and Ethology Study Section (NIH): Ad hoc Member (2011-2014)

Neuroendocrinology, Neuroimmunology, and Behavior Study Section (NIH): Member 2004-2006.

Integrative and Fundamental Cognitive Neuroscience-2 Study Section (NIH); 2000-2003 Ad- Hoc Member

Neurology B1 Study Section Ad-Hoc member (1989, 1990, and 1991) Grant applications for NSF, NSERC (Canada), MRC (Canada) Board of Directors, Winter Conference on Brain Research (1992-1996; 2001-2004) Program Committee, Winter Conference on Brain Research (1992-2002) Program Committee, International Behavioral Neuroscience Society (1993-95) Nominations Committee, Int. Behavioral Neuroscience Society (1994-97; Chair, 1997)

Ethics Committee, American Society for Neural Transplantation (1995-1998)

DEPARTMENT AND UNIVERSITY SERVICE ADVANCE LSA Advisory Board

Biopsychology/Systems Neuroscience search committee for 2 faculty members (2016-17)

Provost’s Review of Promotions and Tenure Casebooks (2017) MBNI Diversity, Equity and Inclusivity Lead (2015-present) Interim Director Neuroscience Program (2010-2011)

Associate Director Neuroscience Program (2007-2010) Rackham Faculty Ally for students of diversity in Neuroscience Program (2009-2014) Executive Committee, College of Literature, Science and the Arts (2000-2003; 2005-2006) Neuroscience Initiative Committee, Univ. Michigan (2000-present; Co-Chair 2004-) Associate Dean for Academic Affairs, College of Literature, Science and the Arts (2003-2004). Assistant to the Dean of LSA (1998-2000) Psychology Department Graduate Program Chair (1996-1999, 2000-2001) Neuroscience Program Preliminary Exam Chair (1997-1999) (2002-2004)

Executive Committee, Psychology Department (1995-1996) Executive Committee, Reproductive Sciences Program (1991-1995) Executive Committee, Neuroscience Program (1990-1992, 1996) Biopsychology Faculty Search Committee (1995; 2003) Rackham Graduate School Divisional Board I, Chair (1993) Rackham Graduate School Divisional Board I, member (1991-1992; 2005-2006)

Biopsychology Graduate Student Recruitment/Admissions (1983, 1989, 1990, 1996, 2014, 2015, 2017)

Psychology Department Tenure and Promotions Committee (1993-1994) Neuroscience Graduate Student Recruitment/Admissions (1990, 1991) Member of Reproductive Sciences Program Training Grant Committee (1990-1991) Psychology Department Graduate Committee (1991-1993) University Committee for the Use and Care of Animals (1986-1989)

****************************************************************** CURRENT RESEARCH SUPPORT

1R01DA046403 (Becker) 7/15/19-4/30/24 NIDA: Social support, oxytocin and motivation for methamphetamine These experiments will investigate the effects of social housing on motivation for methamphetamine and methamphetamine-induced increases in dopamine in the nucleus accumbens using fast scan cyclic voltammetry. We will also determine whether there are sex differences in effects of social housing on methamphetamine self-administration and the role of oxytocin in this regard.

IOS 7383675 (Becker) 7/1/2014-12/31/2019 National Science Foundation: Neural Mechanisms of Female Motivation For all animals there is a constant competition among motivational forces for food, shelter, and reproduction. An animal must balance priorities so that motivation is directed towards resources at appropriate times. Neural mechanisms assign priorities to specific rewards and an animal’s choices change with the internal state of the animal. In the female rat, estradiol (E) decreases food intake and the motivation for food while enhancing female reproductive motivation. Further, dopamine (DA) increases in the nucleus accumbens (NAc) upon the presentation of a cue that has been previously paired with a reward, and NAc DA is implicated in attribution of incentive salience for that reward. How DA signaling is affected by reward-related cues under different hormonal states, and the mechanism through which E affects the incentive salience of these cues, is critically important to our understanding of motivation in the female rat. Experiments will use fast scan cyclic voltammetry (FSCV) to measure spontaneous DA release in the core and shell of the NAc during responding for a mate or food under different hormone conditions, using our novel paradigm to quantify female reproductive motivation. We will investigate possible neural mechanisms mediating the switch between choosing food vs. a mate. The experiments proposed herein will investigate how E affects DA neurotransmission (i.e., release and reuptake) in the female to affect the incentive salience of food- and reproduction-related cues and, ultimately, change behavior. R01DA039952-01 9/1/2015-7/31/2020 National Institutes of Health: Neural Mechanisms of Propensity for Drug Taking Females (women and laboratory rats) exhibit more rapid escalation of drug taking than do males and estradiol enhances acquisition of drug taking and motivation for drugs of abuse. Experiments will investigate the role of attenuation of cocaine-induced dopamine release in nucleus accumbens relative to striatal dopamine release in the propensity to develop a preference for cocaine over palatable food pellets in both males and females. The mechanisms mediating estradiol’s action striatum of females to enhance the cocaine-induced dopamine increase and cocaine-taking behavior will also be investigated as will the role of the indirect pathway to enhanced motivation for cocaine over pellets in both males and females. Social Sciences Annual Institute 9/1/2016-8/31/2020 Gender, Microhistories and Epigenetics: Focus on Stress and Addiction In the proposed study, we will use an innovative combination of methods to gather new findings and conclusions from an ongoing longitudinal study of alcoholism in families. We will create “microhistories” of the communities in which study participants lived to allow us to closely link individuals and families with their social and economic environments. We will analyze the familial and environmental patterns together across generations to reveal evidence for stress as well as opportunities in the community throughout the years. This will allow us to investigate how historical events such as economic crises (e.g., the closure of a local manufacturing plant) have impact upon the risk that later generations will develop alcoholism and how these relationship interactions are affected by gender. Second, we will examine whether there is evidence of epigenetic mechanisms at work mediating sex differences in risk and protective factors for addiction using saliva samples and blood samples (when available). For this initial investigation of potential epigenetic influences, we have decided to investigate epigenetic changes in methylation of two genes: FKBP5 and BDNF. The FKBP5 gene is a regulator of the receptor for the stress hormone, cortisol. Changes in the methylation of this gene have been found in blood from Holocaust survivors and their children, as well as in individuals suffering from PTSD and major depression. Epigenetic changes in BDNF methylation have been implicated in early trauma

as well as in major depression. The social factors that are most likely to trigger these heritable epigenetic effects on risk for substance addiction are the topic of this proposal. U01NS007659 (Chestek) 9/30/2018-9/29/2021 NIH/National Institute of Neurological Disorder and Stroke Optimization and Distribution of High Density Cellular Scale Carbon and Silicon Arrays This project is a collaboration on experiments implementing the 16-channel carbon fiber arrays. My research program is interested in addressing questions related to how changes in dopamine function mediate changes in behavior. I see this new electrode as a logical extension of methods I have used in the past (in vivo microdialysis and fast scan cyclic voltammetry), that will allow us to take our questions to the next level by investigating changes in dopamine function in multiple adjacent brain regions simultaneously. Role: Co-Investigator

Completed Research Support Diamond M-Cubed 1/1/2015-6/30/2016 Bringing Big Data to Studies of the Epigenetics of Gender and Addiction Addiction is a complex compulsive behavior that can affect men and women differently and arises from complicated interactions between the individual and environment. In this project we will articulate an ontology and develop models and strategies to investigate evidence for epigenetic transmission of vulnerability for substance abuse using data from the Michigan Longitudinal Study (MLS), the world’s longest-running study on the development of substance abuse, particularly alcoholism To link individuals and families more closely with their social and economic environments, we will develop “microhistories” of the communities. Analysis of the familial and environmental patterns and effect of these across generations may reveal possible epigenetic mechanisms mediating sex differences in risk and protective factors for addiction. R21 DA032747 (Becker) 8/1/2012-1/31/2015 NIH/National Institute on Drug Abuse Social Support and Addiction: cross talk between oxytocin and dopamine Effective treatments for cocaine addiction are limited, and appear to be more successful in men than women. Even though more men are addicted to cocaine, drug use in women is increasing, and the addictive effects of drugs of abuse are greater in women. This research is important for mental health as it will investigate the impact of social factors on the effects of drugs of abuse in males and females, and how this affects neural function. Insight into the protective properties of social support could ultimately lead to improved treatment options for cocaine addiction in both women and men. R21 DA-032856 (Becker) 3/1/12-2/28/14 NIH/National Institute on Drug Abuse $ Norepinephrine and dopamine: mediating drug vs. natural rewards The central hypothesis is that the reinforcing effects of drugs (and other rewards) are mediated primarily by dopamine signaling, and the attenuation of alternative motivated behaviors is mediated by drug-induced changes in noradrenergic signalling, within the nucleus accumbens. Sex differences in the noradrenergic system contribute to the enhanced vulnerability of females following chronic drug use. Experiments will use self-administration of cocaine vs palatable food and in vivo microdialysis to investigate this hypothesis. R01 DA 12677-10 (Becker) 6/1/09-3/31/14

NIH/National Institute on Drug Abuse Gender differences in drug abuse Women are more vulnerable to becoming addicted to cocaine than are men. The experiments being conducted investigate the neurodevelopmental processes that contribute to sex differences in drug abuse using a preclinical model. We are also investigating drug taking behavior during adolescence and whether drug exposure during adolescence affects adult drug taking behavior. The long-term goal of this project is to develop better intervention and treatment protocols for both men and women based on an improved understanding of neural basis of vulnerability to addiction. NSF #0930184 (Becker) 9/01/09-8/31/13 National Science Foundation ADVANCE/PAID Department Chair Training to Increase Women in Neuroscience (IWIN) The overall and long-term goal of IWIN is to increase the number of women, including underrepresented minority (URM) women, among faculty in neuroscience. This will be accomplished by effecting change in behavior and practice related to recruitment, promotion and work climate for women within academic neuroscience and neuroscience-related departments. The IWIN project strategy will allow SfN to reach up to 300 department chairs and to influence over 50 institutions. The project includes: a training intervention in the form of eight regional interactive workshops; development of institution-level implementation plans; ongoing support to participants through peer-to-peer interaction and online resources; and dissemination of lessons learned and best practices. For each workshop, SfN will invite three-five chairs from 5-10 institutions. R21 DA-027924-01 (Becker) 8/1/10-7/31/12 NIH/National Institute on Drug Abuse Protective benefits of maternal behavior on susceptibility for drug abuse The experiments presented in this proposal will determine whether some aspect of motherhood helps to reduce a female’s drug abuse liability. The results from these studies could aid in tailoring treatments for women and, potentially, the development of methods or treatments to reduce a woman’s susceptibility to drug abuse.

P.I. National Institute on Drug Abuse. R01 DA 23990-01 “Drug Abuse: Sex differences and developmental influences” $175,000/yr direct costs 7/1/09-7/30/11. Experiments to investigate the effects of prenatal stress on sex differences in drug abuse. P.I. Pfizer Inc. “Determination of the efficacy of Pfizer compounds for treatment of female sexual dysfunction.” $183,788, 4/1/2008-6/30/2009. Studies to develop and validate an animal model for female sexual dysfunction. P.I. National Institute of Neurological Disorders and Stroke, 1 R01 NS048141 “Rapid Effects of Estradiol in the Brain” $225,000/yr total direct costs 4/1/04-3/31/09. Principal Investigator, National Science Foundation #IBN-9816673 Title: Gonadal Hormone Involvement in Brain Activity $285,000 in Total Costs 1999-2003

Principal Investigator, National Science Foundation #IBN-9514888 Title: Gonadal Hormone Involvement in Brain Activity $237,357 in Total Costs 1996-1999

Principal Investigator, National Institute of Neurological Disorders and Stroke #NS22157

Title: Brain Tissue Transplantation: Neurochemical Studies of Functional Activity $152,000/yr Direct Costs 1985-1996

Co-Principle Investigator, Hereditary Disease Foundation, Title: Chronic intrastriatal infusion of

quinolinic acid $20,000/year. [Dr. Roger L. Albin, PI]. 1990-1991 NIH Research Career Development Award, National Institute of Neurological Disorders and

Stroke #NS01056, Title: Brain Tissue Transplantation Studies of Functional Activity $199,607 1986-1991 Principal Investigator, National Institute of Neurological Disorders and Stroke #NS25662,

Title: Gonadal hormone involvement in brain activity $190,754 over 3 yr. 1988-1991

Principal Investigator, National Science Foundation #BNS 84-11763, Title: Gonadal Hormone Involvement in Brain Activity $100,000 over 2 years. 1985-1988 Principal Investigator, National Institute of Mental Health #MH39438

Title: Psychomotor Stimulants: Dopamine Release Mechanisms $15,000 1984-1985

Co-Investigator (J.E. Eccles, PI), National Science Foundation #BNS84-10777, Title: Hormones and Psychosocial Development in Early Adolescence $160,000 over 2 years. 1985-1988 Co-Investigator (T.E. Robinson, PI), National Institute of Mental Health #MH37277

Title: Plasticity in brain catecholamine systems $77,895 (Direct Costs) 1982-1985

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TEACHING Biopsychology Graduate Seminar Hormones and Behavior Sex, Gender and Addiction Introduction to Biopsychology Laboratory in Biopsychology Behavior and the Menstrual Cycle Principles in Neurochemistry for Psychobiologists Sex Differences in Brain Organization and Behavior Recovery of Function and Neuronal Plasticity Biopsychology of Eating and Eating Disorders Neuoendocrinology Module Neuroscience Graduate Program History and Biology of Women and Addiction ****************************************************************** SERVICE ON DOCTORAL COMMITTEES (Ph.D.'s awarded)

1987 Jill Roberts-Lewis, Psychology (Co-Chair with M. Gnegy) Edward Castaneda, Psychology (Co-Chair with T. E. Robinson) Therese Ryan-Jastrow, Neuroscience (M. Gnegy, Chair) Dianne Camp, Psychology (T. E. Robinson, Chair)

1988 Christy Miller, Psychology (J. Eccles, Chair) Mary Lou Tucker, Education and Psychology (J. Eccles, Chair)

1992

Eileen J. Curran, Neuroscience (Chair) Xiaojuan Xu, Biopsychology (R. E. Davis, Chair)

1993

Kevin Davis, Chemistry (M. Morris, Chair) Stephen Asmus, Anatomy and Cell Biology (S. Newman, Chair) Margaret Forgie, Psychology Dept., Concordia Univ., Montreal (J. Stewart, Chair)

1994

Stacy Castner, Biopsychology (Chair) Pamela Paulson, Biopsychology (T. E. Robinson, Chair)

1995

Paul Mermelstein, Neuroscience (Chair)

1996 Namni Goel, Biopsychology (T. Lee, Chair) Laurise Mead, Psychology Dept, University of Western Ontario, (E. Hampson, Chair)

1997 Li Xiao, Biopsychology (Chair)

Avris Genene Holt, Neuroscience (S. Newman, Chair) Jennifer Feeley Kearney, Neuroscience (R. Albin, Chair)

1998

Rowena Johnston, Biopsychology (Chair) Kaitlin Browman, Biopsychology (T. E. Robinson, Chair) Diana Palmiere Hunt, Combined Program in Education and Psychology (J. Eccles, Chair) Mei-Chuan Ko, Biopsychology (J. H. Woods, Chair)

2000

Carrie Ann Zimmer, Neuroscience (E. Young, Chair) Karen Parker, Biopsychology (T. Lee, Chair)

2001

Michelle Ostrander, Neuroscience (T. Robinson, Chair)

2002

Tammy Jo Jechura, Biopsychology (T. Lee, Chair)

2003 William Jenkins, Biopsychology (Chair) Lisa Jackson, Biopsychology (Chair) Shelley Flagel, Neuroscience (T. Robinson, Chair)

2004 Graham Flory, Biopsychology (J. Woods, Chair) Anne-Noel Samaha, Biopsychology (T. Robinson, Chair)

2005

Amy Tindell, Biopsychology (Berridge/Aldridge, Chairs) Elizabeth Lapoczka, Pharmacology (J. Traynor, Chair) Daniel Hummer, Biopsychology (T. Lee, Chair)

2006 Evelyn Field, Neuroscience, University of Lethbridge Outside Examiner 2008

Kelly Bosse, Pharmacology Dept. (John Traynor, Chair) Wei Zhou, Biopsychology (Chair)

2009

Kristin Schultz, Chemistry (Robert T. Kennedy, Chair) Jakub Jedynak, Neuroscience (Terry Robinson, Chair) Tiffany Love, Neuroscience (Jon-Kar Zubieta, Chair) Ken Wakabayashi, Neuroscience (Terry Robinson, Chair)

2010

Megan Hagenauer, Neuroscience (Theresa M. Lee, Chair) Darren Oppland, Neuroscience (Martin Myers, Chair)

2012 Mark B. Thomas, Biopsychology (Chair)

2013 Shanna Harkey Resendez, Neuroscience (Chair)

2014

Kirsten Porter-Stransky, Biopsychology (Brandon Aragona, Chair) Patricia Clark, Nursing, (Bernadine Cimprich, Chair)

2015 Jessica Adams, Neuroscience (Malcolm Low, Chair) Katharine Goldey, Biopsychology (Sari van Anders, Chair)

2016

Sarah Mikelman, Pharmacology (Margaret Gnegy, Chair)

2017 Natalie Nevarez, Biopsychology (Chair)

2018 Katie Yoest, Biopsychology (Chair) Ashley Schmelling Keiser, Biopsychology (Natalie Tronson, Chair) Brittany Kuhn, Neuroscience (Shelly Flagel, Chair)

Ph.D.'s in progress, doctoral committees Jacqueline Quigley, Biopsychology (Chair) Pavlo Popov, Biopsychology (Chair) Yanaira Alainso, Neuroscience (Carrie Ferrario, Chair) Christopher Turner, Biopsychology (Chair) Crystal Carr, Biopsychology (Terry Robinson, Chair)

INVITED ADDRESSES OUTSIDE THE UNIVERSITY OF MICHIGAN (Last 5 years) Winter Conference on Brain Research, Steamboat Springs, CO, January 26-30, 2014. Session organizer and Speaker “Individual variation in development of compulsive behaviors: the search for a common mechanism”. Invited Speaker, Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany March 10, 2014. Invited Speaker, University of Minnesota Specialized Center of Research on Sex Differences in Addiction, Sex and Gender Differences in Addiction, April 23, 2014 Keynote speaker, Society for Behavioral Neuroendocrinology, Asilomar Conference Center, CA. June 10-14, 2015, “SEX DIFFERENCES IN MOTIVATION: NEUROCHEMISTRY AND BEHAVIOR”.

American College of Neuropsychopharmacology, Hollywood, Florida Dec. 6-10, 2015. Participant in Study Group: The Future of Sex Difference Research in Neuropsychopharmacology Winter Conference on Brain Research, Breckenridge, CO January 2016. Session Chair and Speaker: How and Why to study both sexes in basic neuroscience research. Plenary Speaker, Research Society on Alcoholism, “Sex Differences in Addiction: insights from animal models”, 8th Annual Ting-Kai Li Plenary Lecture, June 26, 2016. Invited Speaker, Department of Behavioral Neuroscience, Oregon Health Sciences University, June 2-3, 2016. International Society for Biological Research on Alcohol and Alcoholism / European Society for Biological Research on Alcohol and Alcoholism, World Congress on Alcoholism. Berlin, Germany. September 2-5, 2016. Invited speaker in “Hot Topics” session: Sex and Gender Differences in Addiction Research. Dopamine 2016, Vienna, Austria Sept 5-12, 2016. Session Chair: Sex Differences in Dopamine and Reward. American College of Neuropsychopharmacology, Hollywood, Florida Dec. 4-8, 2016, Session Chair: Stress, Anxiety and Decision-Making: New Insights From Animal Models. American College of Neuropsychopharmacology, Hollywood, Florida Dec. 4-8, 2016, Invited Speaker in session: Hormonal Regulation of Neural Circuit Organization and Function: Implications for Neuropsychiatric Illnesses. Winter Conference on Brain Research, January 28- February 2, 2017, Big Sky Montana, WCBR Pioneer Lecture College on Problems of Drug Dependence, June 17-22, 2017, Montreal, Canada, Invited Speaker: Sex as a Biological Variable: research findings from the NIH Office of Research on Women’s Health and the NIDA center grants – ahead of its time or long overdue? University of Washington, Neuroscience Program, October 16, 2017 Invited speaker: Sex differences in addiction and the role of estradiol: evidence from preclinical studies. University of Texas, Austin, TX, Neural Mechanisms of Sex Differences in Addiction, Toxicology Seminar Speaker, University of Texas at Austin, Austin, TX, 3/29/2018. SEX DIFFERENCES AND ADDICTION: PRECLINICAL STUDIES OF NEURAL MECHANISMS AND DEVELOPMENTAL INFLUENCES, Annual Meeting, FETAL ALCOHOL SPECTRUM DISORDERS STUDY GROUP, San Diego, CA, 6/15/2018. Women & Addiction: Treatment Differences & Challenges, 2ND ANNUAL ADDICTIONS UPDATE CONFERENCE, University of Utah Medical School, Salt Lake City, UT, 6/8/2018.

Why Are There Sex Differences in Addiction? Lessons From Animal Models, 2ND ANNUAL ADDICTIONS UPDATE CONFERENCE, University of Utah Medical School, Salt Lake City, UT, 6/8/2018. Sex differences in motivation and addiction, Keynote Speaker, International Behavioral Neuroscience Society, Boca Raton, FL, 6/29/2018. Sex differences in motivation and addiction, Ohio State University, Columbus Ohio, Departmental Colloquium, 10/18/2018. How to Study Sex Differences in Rodents, Society for Neuroscience Short Course, Society for Neuroscience, San Diego, CA, 11/2/2018. Course organizer and speaker. POPOV, P. R. PATEL, C. M. CALDWELL, E. J. Welle, D. CAI, J. D. BERKE, J. B. BECKER, C. A. CHESTEK, Chronic Dopamine Detection with a 16-Channel Carbon Fiber Microelectrode Array, American College of Neuropsychopharmacology, American College of Neuropsychopharmacology, Hollywood, FL, 12/12/2018. Sex Differences in Motivation and Addiction, Harvard Medical School, McLean Hospital, Boston, MA, February 19, 2019. Sex Differences in Motivation and Addiction, Temple University, Philadelphia, PA, March 19, 2019. Sex Differences in Addiction: lessons from animal models. Neal Miller Distinguished Lecture at 2019 American Psychological Association Convention, Chicago, Illinois, Aug 8-12, 2019. PUBLICATIONS 1. Becker, J.B. and Michaelis, E.K. Comparison of the cycloheximide and food satiation

effects on a discriminative task. Pharmacology, Biochemistry and Behavior, 6 (1977) 631-635.

2. Becker, J.B. and Ramirez, V.D. Dynamics of the release of endogenous norepinephrine

and dopamine from brain fragments in perifusion. Neuroendocrinology, 31, (1980) 18-25.

3. Robinson, T.E., Becker, J.B., and Ramirez, V.D. Sex differences in rotational behavior

and the lateralization of striatal dopamine in rats. Brain Research Bulletin, 5 (1980) 539-545.

4. Becker, J.B. and Ramirez, V.D. Sex differences in the amphetamine stimulated release

of catecholamines from striatal tissue fragments in vitro. Brain Research, 204 (1981) 361-372.

5. Becker, J.B. and Ramirez,, V.D. Experimental studies on the development of sex

differences in the release of dopamine from striatal tissue fragments in vitro. Neuroendocrinology, 32, (1981) 168-173.

6. Robinson, T.E., Camp, D.M., and Becker, J.B. Gonadectomy attenuates turning behavior produced by electrical stimulation of the nigrostriatal dopamine system in female but not male rats. Neuroscience Letters, 23 (1981) 203-208.

7. Robinson, T.E., and Becker, J.B. Variation in lateralization: selected samples do not a

population make. Behavioral and Brain Sciences, 4 (1981) 34-35 (invited commentary). 8. Becker, J.B., Robinson, T.E., and Lorenz, K.A. Sex differences and estrous cycle

variations in amphetamine-elicited rotational behavior. European Journal of Pharmacology, 80, (1982) 65-72.

9. Robinson, T.E., Camp, D.M., Jacknow, D.S., and Becker, J.B. Sex differences and

estrous cycle dependent variation in rotational behavior elicited by electrical stimulation of the mesostriatal dopamine system. Behavioral Brain Research, 6 (1982) 273-287.

10. Sutherland, R.J., Kolb, B., Whishaw, I.Q. and Becker, J.B. Cortical noradrenaline

depletion eliminates sparing of spatial learning after neonatal frontal cortex damage in the rat. Neuroscience Letters, 32 (1982) 125-130.

11. Robinson, T.E., and Becker, J.B. Behavioral sensitization is accompanied by an

enhancement in amphetamine-stimulated dopamine release from striatal tissue in vitro. European Journal of Pharmacology, 85 (1982) 253-254.

12. Robinson, T.E., Becker, J.B., and Presty, S.K. Long-term facilitation of amphetamine-

induced rotational behavior and striatal dopamine release produced by a single exposure to amphetamine: Sex differences. Brain Research, 253 (1982) 231-241.

13. Whishaw, I.Q.,, Kolb, B., Sutherland, R.J. and Becker, J.B. Cortical control of claw

cutting in the rat. Behavioral Neuroscience, 97 (1983) 370-380. 14. Robinson, T.E., and Becker, J.B. The rotational behavior model: Asymmetry in the

effects of unilateral 6-OHDA lesions of the substantia nigra in rats. Brain Research, 264 (1983) 127-131.

15. Robinson, T.E., Becker, J. B., and Camp, D.M. Sex differences in behavioral and brain

asymmetries. In M. Myslobodsky (Ed.), Hemisyndromes: Psychobiology, Neurology, Psychiatry. New York: Academic Press, 1983, pp. 91-128.

16. Camp, D.M., Robinson, T.E., and Becker, J.B. Sex differences in the effects of early

experience on the development of behavioral and brain asymmetries. Physiology and Behavior, 33 (1984) 433-439.

17. Becker, J.B., Castaneda, E., Robinson, T.E., and Beer, M. A simple in vitro technique

to measure the release of endogenous dopamine and dihydroxyphenylacetic acid from striatal tissue using high performance liquid chromatography with electrochemical detection. Journal of Neuroscience Methods, 11 (1984) 19-28.

18. Becker, J.B., Beer, M.E., and Robinson, T.E. Striatal dopamine release stimulated by

amphetamine or potassium: influence of ovarian hormones and the light/dark cycle. Brain Research, 311 (1984) 157-160.

19. Lin-Chu, G., Robinson, T.E., and Becker, J.B. Rotational behavior in animals with 6-OHDA lesions. Acta Psychologica Sinica, 4 (1984) 416-421 (In Chinese).

20. Castaneda, E., Robinson, T.E., and Becker, J.B. Involvement of nigrostriatal dopamine

neurons in the contraversive rotational behavior evoked by electrical stimulation of the lateral hypothalamus. Brain Research, 327 (1985) 143-151.

21. Lin-Chu, G., Robinson, T.E., and Becker, J.B. The effects of cocaine on rotational

behavior in rats with unilateral lesions of the substantia nigra. Acta Psychologica Sinica, 5 (1985) 101-107 (In Chinese).

22. Lin-Chu, G., Robinson, T.E., and Becker, J.B. Sensitization of rotational behavior

produced by a single exposure to cocaine. Pharmacology, Biochemistry and Behavior, 22 (1985) 901-903.

23. Robinson, T.E., Becker, J.B., Moore, C.J., Castaneda, E., and Mittleman, G. Enduring

enhancement in frontal cortex dopamine utilization in an animal model of amphetamine psychosis. Brain Research, 343 (1985) 374-377.

24. Robinson, T.E., Angus, A.L., and Becker, J.B. Sensitization to stress: the enduring

effects of prior stress on amphetamine-induced rotational behavior. Life Sciences, 37 (1985) 1039-1042.

25. Robinson, T.E., Becker, J.B., Camp, D.M., and Mansour, A. Variation in the pattern of

behavioral and brain asymmetries due to sex differences. In S.D. Glick (Ed.), Cerebral Lateralization in Non-Human Species. [Part of "Behavioral Biology: An International Series", J.L. McGaugh and W.T. Greenough (Series Editors)]. New York: Academic Press, 1985, pp. 185-231.

26. Robinson, T.E. and Becker, J.B. Enduring changes in brain and behavior produced by

chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Research Reviews, 11 (1986) 157-198.

27. Wilcox, R.A., Robinson, T.E. and Becker, J.B. Enduring enhancement in amphetamine-

stimulated striatal dopamine release in vitro produced by prior exposure to amphetamine or stress in vivo. European Journal of Pharmacology, 124 (1986) 375-376.

28. Becker, J.B. and Beer, M.E. The influence of estrogen on nigrostriatal dopamine

activity: behavioral and neurochemical evidence for both pre- and post-synaptic components. Behavioral Brain Research, 19 (1986) 27-33.

29. Camp, D.M., Becker, J.B. and Robinson, T.E. Sex differences in the effects of

gonadectomy on amphetamine-induced rotational behavior in rats. Behavioral and Neural Biology, 46 (1986) 491-495.

30. Whishaw, I.Q., Sutherland, R.J., Kolb, B. and Becker, J.B. Effects of neonatal forebrain

noradrenaline depletion on recovery from brain damage: Performance on a spatial navigation task as a function of age of surgery and post-surgical housing. Behavioral and Neural Biology, 46 (1986) 285-307.

31. Becker, J.B., Snyder, P.J., Miller, M.M., Westgate, S.A. and Jenuwine, M.J. The

influence of estrous cycle on sensorimotor performance in female rats. Pharmacology, Biochemistry and Behavior, 27 (1987) 53-59.

32. Robinson, T.E., Becker, J.B., Young, E., Akil, H. and Castaneda, E. The effects of

footshock stress on regional brain dopamine metabolism and pituitary ß-endorphin release in rats sensitized to amphetamine. Neuropharmacology, 26 (1987) 679-691.

33. Becker, J.B., Adams, F. and Robinson, T.E. Intraventricular microdialysis: a new

method for determining monoamine metabolite concentrations in the cerebrospinal fluid of freely moving rats. J. Neuroscience Methods, 24 (1988) 259-269.

34. Becker, J.B. and Freed, W.J. Adrenal medulla grafts enhance functional activity of the

striatal dopamine system following substantia nigra lesions. Brain Research, 462 (1988) 401-406.

35. Becker, J.B. and Freed, W.J. Neurochemical correlates of behavioral changes following

intraventricular adrenal medulla grafts: intraventricular microdialysis in freely moving rats. Progress in Brain Research, 78 (1988) 527-533.

36. Castaneda, E., Becker, J.B., and Robinson, T.E. The long-term effects of repeated

amphetamine treatment in vivo on amphetamine, KCl and electrical stimulation evoked striatal dopamine release in vitro.. Life Sciences, 42 (1988) 2447-2456.

37. Becker, J.B. and Freed, W.J. Recovery of function after tissue transplantation in the

nigrostriatal dopamine system. IN: Cell Function and Disease (L.E. Canedo, L. Todd, L. Packer and J. Jaz, Eds.), Plenum Publ. Co., New York. 1988 pp 225-233.

38. Becker, J.B. and Cha, J.-H. Estrous cycle dependent variation in amphetamine-induced

behaviors and striatal dopamine release assessed with microdialysis. Behavioural Brain Research, 35 (1989) 117-125.

39. Gordon, K., Statman, D. Johnston, M.V., Robinson, T.E., Becker, J.B. and Silverstein,

F.S. Transient hypoxia alters striatal catecholamine metabolism in immature brain: an in vivo microdialysis study. Journal of Neurochemistry, 54 (1990) 605-611.

40. Becker, J. B., Robinson, T. E., Barton, P., Sintov, A., Siden, R. and Levy, R. J.

Sustained behavioral recovery from unilateral nigrostriatal damage produced by the controlled release of dopamine from a silicone polymer pellet placed into the denervated striatum. Brain Research, 508 (1990) 60-64.

41. Becker, J. B. A direct effect of 17ß-Estradiol on striatum: sex differences in dopamine

release. Synapse, 5 (1990) 157-164. 42. Becker, J. B., Curran, E. J., and Freed, W. J. Adrenal medulla graft induced recovery of

function in an animal model of Parkinson's Disease: Possible mechanisms of action. Canadian Journal of Psychology , 44 (1990) 293-310.

43. Freed, W. J., Poltorak, M., and Becker, J. B. Intracerebral adrenal medulla grafts: a

review. Experimental Neurology, 118 (1990) 139-166.

44. Becker, J.B., Curran, E.J., Freed, W.J., and Poltorak, M. Mechanisms of action of

adrenal medulla grafts: the possible role of peripheral and central dopamine systems. Progress in Brain Research , 82 (1990) 499-507.

45. Freed, W.J. and Becker, J.B. Mechanisms of action of substantia nigra and adrenal

medulla grafts. Progress in Parkinson Research. F. Hefti and W.J. Weine (Eds.) Plenum Publ. Corp, 1990.

46. Becker, J. B. Estrogen rapidly potentiates amphetamine-induced striatal dopamine

release and rotational behavior during microdialysis. Neuroscience Letters, 118 (1990) 169-171.

47. Becker, J. B. and Ariano, M. A. Behavioral effects of fetal substantia nigra tissue grafted

into the dopamine-denervated striatum: responses to selective D1 and D2 dopamine receptor agonists. Restorative Neurology and Neuroscience 3 (1991) 187-195.

48. Curran, E.J. and Becker, J. B. Changes in blood-brain barrier permeability are

associated with behavioral and neurochemical indices of recovery following intraventricular adrenal medulla-la grafts in an animal model of Parkinson's Disease. Exp Neurol, 114 (1991) 184-192.

49. Bazzett, T., Becker, J.B. and Albin, R.L. A novel device for chronic intracranial drug

delivery via microdialysis. J. Neuroscience Methods ,40 (1991) 1-8. 50. Buchanan, C.M., Eccles, J.S. and Becker, J.B. Are adolescents the victims of raging

hormones? Evidence for activational effects of hormones on moods and behavior at adolescence. Psychological Bulletin , 111(1992) 62-107.

51. Becker, J. B., Breedlove, S. M., and Crews, D. (Eds.) Behavioral Endocrinology, MIT

Press, Cambridge, MA, 1992. 52. Becker, J. B. Hormonal influences on extrapyramidal sensorimotor function and

hippocampal plasticity. IN: Behavioral Endocrinology, Becker, J. B., Breedlove, S. M., and Crews, D. (Eds.) MIT Press, Cambridge, MA, 1992, pp. 325-356.

53. Becker, J. B.and Breedlove, S. M. Introduction to Behavioral Endocrinology. IN:

Behavioral Endocrinology, Becker, J. B., Breedlove, S. M., and Crews, D. (Eds.) MIT Press, Cambridge, MA, 1992, pp. 3-37.

54. Takashima, H., Poltorak, M, Becker, J. B., and Freed, W. J. Effects of adrenal medulla

grafts on plasma catecholamines and rotational behavior. Experimental Neurology, 118 (1992) 24-34.

55. Curran, E.J., Albin, R.L. and Becker, J.B. Adrenal medulla grafts in the hemiparkinsonian rat: profile of behavioral recovery predicts restoration of the symmetry between the two striata in measures of pre- and post-synaptic dopamine function J Neurosci. 1993 Sep;13(9):3864-77.PMID:8103552

56. Bazzett, T.J., Becker, J.B., Kaatz, K.W., and Albin, R.L. Chronic intrastriatal dialytic admistration of quinolinic acid produces selective neural degeneration. Experimental Neurology, 120 (1993) 177-185.

57. Castner, S.A., Xiao, L., and Becker, J.B. Sex differences in striatal dopamine: in vivo

microdialysis and behavioral studies. Brain Research , 610 (1993) 127-134. 58. Bazzett, T.J. and Becker, J. B. Sex differences in the rapid and acute effects of

estrogen on striatal D2 dopamine receptor binding. Brain Research, 637 (1994) 163-172.

59. Bazzett, T.J., Becker, J.B. and Albin, R.L. Construction and implantation of a chronic

intracranial dialytic delivery system. Neuroscience Protocols, 060 (1994) 1-9. 60. Bazzett, T.J., Becker, J.B., Falik, R.C. and Albin, R.L. Chronic intrastriatal quinolinic

acid produces reversible changes in perikaryal calbindin and parvalbumin immunoreactivity. Neuroscience 60 (1994) 837-841.

61. Xiao, L and Becker, J. B. Sex differences and estrous cycle dependent variation in

extracellular dopamine concentrations in striatum. Neuroscience Letters, 180 (1994) 155-158.

62. Bergdall, V.K. and Becker, J. B. Effects of nerve growth factor infusion on behavioral

recovery and graft survival following intraventricular adrenal medulla grafts in the unilateral 6-hydroxydopamine lesioned rat. Journal of Neural Transplantation and Plasticity, 5 (1994) 163-167.

63. Mermelstein, P. G., and Becker, J. B. Increased extracellular dopamine in the nucleus

accumbens and striatum of the female rat during paced copulatory behavior. Behavioral Neuroscience, 109 (1995) 354-365.

64. Bazzett, T. J., Falik, R. C., Becker, J. B., and Albin, R. L. Chronic administration of

malonic acid produces selective neural degeneration and transient changes in calbindin immunoreactivity in the rat striatum. Experimental Neurology, 134 (1995) 244-252.

65. Galasso, J. M., Bazzett, T. J., Becker, J. B., and Albin, R. L. Synergistic effect of

intrastriatal co-adminsitration of L-NAME and quinolinic acid. NeuroReport, 6 (1995) 1505-1508.

66. Castner, S. A. and Becker, J. B. Sex differences in the effect of amphetamine on

immediate early gene expression in the dorsal striatum of the rat Brain Research, 712 (1996) 245-257.

67. Mermelstein, P.G., Becker, J.B., and Surmeier, D.J. Estradiol reduces calcium currents

in rat neostriatal neurons through a membrane receptor. Journal of Neuroscience 16 (1996) 595-604.

68. Bencsics, C., Wachtel, S. R., Milstien, S., Hatakeyama, K., Becker, J. B., Kang, U. J.

Double transduction with GTP cyclohydrolase 1 and tyrosine hydroxylase is necessary for spontaneous synthesis of L-dopa by primary fibroblasts. Journal of Neuroscience 16 (1996) 449-4456.

69. Bazzett, T. J., Falik, R. C., Becker, J. B., and Albin, R. L. Chronic intrastriatal

administration of quinolinic acid produces transient nocturnal hypermotility in the rat. Brain Research Bulletin 39 (1996) 69-73.

70. Bazzett, T. J., Falik, R. C., Becker, J. B., and Albin, R. L. Synergistic effects of chronic

exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum. Brain Research 718 (1996) 228-232.

71. Johnston, R. E., Hu, X-T, White, F. J., and Becker, J. B. Intrastriatal grafts of ventral

mesencephalic tissue restore quantitative and qualitative D1/D2 dopamine receptor synergism in the striatum. Restorative Neurology and Neuroscience 11 (1997) 13-20.

72. Johnston, R. E. and Becker, J. B. Intranigral grafts of fetal ventral mesencephalic tissue

in adult 6-hydroxydopamine lesioned rats can induce behavioral recovery. Cell Transplantation, 6 (1997) 267-276.

73. Xiao, L and Becker, J. B. Hormonal activation of the striatum and the nucleus

accumbens modulates paced mating behavior in the female rat. Hormones and Behavior 32 (1997) 114-124.

74. Xiao, L and Becker, J. B. Effects of estrogen agonists on amphetamine-stimulated

striatal dopamine release. Synapse, 29 (1998) 379-391. 75. Kearney, J. A., Frey, K. A., Becker, J. B. and Albin, R. L. The role of nigrostriatal

dopamine in metabotropic glutamate agonist-induced rotation. Neuroscience 87 (1998) 881-891.

76. Becker, J. B. and Rudick, C. N. Rapid effects of estrogen and progesterone on

dopamine in the striatum are enhanced by priming with estrogen: a microdialysis study. Pharmacology, Biochemistry and Behavior 64 (1999) 53-57.

77. Johnston, R. E. and Becker, J. B. Behavioral changes associated with grafts of fetal

ventral mesencephalon tissue into the striatum and/or substantia nigra in a rat model of Parkinson’s Disease. Behavioral Brain Research 104 (1999) 189-196.

78. Johnston, R. E., Schallert, T and Becker, J. B. Akinesia and postural abnormality after

unilateral dopamine depletion. Behavioral Brain Research 104 (1999) 179-187. 79. Bazzett, T. J., Becker, J. B. and Albin, R. E. Malonic acid and the chronic administration

of excitotoxicity. IN: Mitochondrial inhibitors as a tool for neurobiology”, Sanberg, P, Nishino, H. and Borlongan, C. V. (Eds) Human Press, Inc, Totowa, NJ 1999 pp. 219-231.

80. Becker, J. B. Gender differences in dopaminergic function in striatum and nucleus

accumbens. Pharmacology, Biochemistry and Behavior 64 (1999) 803-812. 81. Becker, J. B. Oestrogen effects on dopaminergic function in striatum. IN: Neuronal and

Cognitive Effects of Oestrogens. (Novartis Foundation Symposium 230) Wiley, Chichester, UK, 2000, pp 134-151.

82. Becker, J. B., Molenda, H. A. and Hummer, D. L. Gender differences in the behavioral responses to cocaine and amphetamine: implications for mechanisms mediating gender differences in drug abuse. IN: The Biological Basis of Cocaine Addiction (V. Quinones-Jehad (Ed). Ann. N. Y. Acad. Sci. 937 (2001) 172-187.

83. Becker, J. B., Rudick, C. N. and Jenkins, W J The Role of Dopamine in the Nucleus

Accumbens and Striatum during Sexual Behavior in the Female Rat. Journal of Neuroscience 21(2001) 3236-3241.

84. Jenkins, W. J. and Becker, J. B. Role of the Striatum and Nucleus Accumbens in Paced

Copulatory Behavior in the Female Rat. Behavioural Brain Research 120 (2001) 119-128.

85. Becker, J. B., Breedlove, S. M, Crews, D., and McCarthy, M. M. (Eds.) Behavioral

Endocrinology, 2nd Edition, MIT Press, Cambridge, MA, (2002) 86. Becker, J. B. Hormonal Influences on Sensorimotor Function. IN: Behavioral

Endocrinology, 2nd Edition, Becker, J. B., Breedlove, S. M., Crews, D., and McCarthy, M. M. (Eds.) MIT Press, Cambridge, MA, (2002).

87. Becker, J. B.and Breedlove, S. M. Introduction to Behavioral Endocrinology IN:

Behavioral Endocrinology, 2nd Edition, Becker, J. B., Breedlove, S. M., Crews, D., and McCarthy, M. M. (Eds.) MIT Press, Cambridge, MA, (2002).

88. McCarthy, M. M. and Becker, J. B. Neuroendocrinology of Sexual Behavior in the

Female. . IN: Behavioral Endocrinology, 2nd Edition, Becker, J. B., Breedlove, S. M., Crews, D., and McCarthy, M. M. (Eds.) MIT Press, Cambridge, MA, (2002).

89. Hu, M. and Becker, J. B. Effect of sex and estrogen on behavioral sensitization to

cocaine in rats. Journal of Neuroscience, 23 (2003) 693-699. 90. Jenkins, W. J. and Becker, J. B. Female rats develop conditioned place preferences for

sex at their preferred interval. Hormones and Behavior 43 (2003) 503-507. 91. Xiao, L., Jackson, L. R. and Becker, J. B. The effect of estradiol in the striatum is

blocked by ICI182,780 but not tamoxifen: pharmacological and behavioral evidence. Neuroendocrinology 77 (2003) 239-245.

92. Hu, M., Crombag, H. C. Robinson and Becker, J. B. The biological basis of sex

differences in the propensity to self-administer cocaine. Neuropsychopharmacology 29 (2004) 81-85.

93. Jenkins, W. J. and Becker, J. B. Dynamic increases in dopamine during paced

copulation in the female rat. European Journal of Neuroscience. 18 (2003) 1997-2001. 94. Jenkins, W. J. and Becker, J. B. Sexual behavior in the rat. IN: The Behaviour of the

Laboratory Rat: A handbook with tests. Eds.: Whishaw, I. Q. and Kolb, B. Oxford University Press, Oxford, UK (2004).

95. Becker, J. B. Rapid effects of estradiol on motivated behaviors. Pp 155-172. IN:

Hormones and the Brain. Ed.: Kordon et al., Springer-Verlag, Berlin/Heidelberg (2004)

96. Becker, J. B., Arnold, A., Berkeley, K. J., Blaustein, J. D., Eckel, L. A., Hampson, E.,

Herman, J. P., Marts, S., Sadee, W., Steiner, M., Taylor., J., Young, E. Strategies and Methods for Research on Sex Differences in Brain and Behavior., Endocrinology, 146 2005, 1650-1673.

97. Jackson, L. R. Robinson, T. E. and Becker, J. B. Sex differences and hormonal influences on acquisition of cocaine self-administration in rats. Neuropsychopharmacology 2006, 31: 129-138.

98. Hu, M., Watson, C. J., Kennedy, R. T. and Becker, J. B. Estradiol attenuates the K+-induced increase in extracellular GABA in dialysate from striatum in the rat. Synapse, 2006, 59: 122-124.

99. Becker, J. B. and Meisel, R. L. Neurochemistry and Molecular Biology of Reward. IN: Handbook of Neurochemistry and Molecular Neurobiology, 3rd Edition. Editor in Chief: A. Lajtha. Volume 21, Ed: J. Blaustein. (2007) pp 739-774.

100. Becker, J. B. Introduction to the Special Issue: Sex Genes and Steroids, Brain Research 2006, 1129:1.

101. Becker, J. B. and Taylor, J. R. Sex Differences in Motivation. IN: Sex Differences in the Brain: from Genes to Behavior, ED: J. B. Becker, K. Berkley, N. Geary, E. Hampson, J. P. Herman, and E. A. Young. Oxford University Press, 2008, pp. 177-200.

102. Eckel, L., Arnold, A. P., Hampson, E, Becker, J. B., Blaustein, J., and Herman, J. P. Research and Methodological Issues in the Study of Sex Differences and Hormone-Behavior Relations. IN: Sex Differences in the Brain: from Genes to Behavior, ED: J. B. Becker, K. Berkley, N. Geary, E. Hampson, J. P. Herman, and E. A. Young. Oxford University Press, 2008, pp. 35-62.

103. J. B. Becker, K. Berkley, N. Geary, E. Hampson, J. P. Herman, and E. A. Young (EDS). Sex Differences in the Brain: from Genes to Behavior, Oxford University Press, 2008.

104. Yang, H, Zhao, W, Hu, M and Becker, J B Interactions Among Ovarian Hormones and Time of Testing on Behavioral Sensitization and Cocaine Self-Administration. Behavioral Brain Research, 2007, 184: 174-184.

105. Becker JB, Monteggia LM, Perrot-Sinal TS, Romeo RD, Taylor JR, Yehuda R, and Bale TL. Stress and disease: is being female a predisposing factor? J Neurosci. (2007) 27(44):11851-5.

106. Becker, J. B. and Hu, M. Sex differences in drug abuse. Frontiers in Neuroendocrinology, (2008) 29: 36-47.

107. Hu, M. and Becker, J. B. Acquisition of cocaine self-administration in ovariectomized female rats: effect of estradiol dose or chronic administration. Drug and Alcohol Dependence (2008) 94: 56-62.

108. Davis, B. A., Clinton, S. M., Akil, H., and Becker, J. B. Sex differences and individual differences in acquisition of cocaine self-administration in selectively-bred High-Responder and Low-Responder rats. Pharmacology, Biochemistry and Behavior (2008) 90:331-8.

109. Young EA, Becker JB. Perspective: sex matters: gonadal steroids and the brain. Neuropsychopharmacology. (2009) 34(3):537-8.

110. Schultz, K.N., von Esenwein, S. A., Hu, M., Bennett, A. L., Kennedy, R. T., Musatov, S., Toran-Allerand, C. D., Kaplitt, M. G., Young, L. J., and Becker, J. B. Viral Vector-Mediated Over-Expression of Estrogen Receptor–a �in Striatum Enhances the Estradiol-induced Motor Activity in Female Rats and Estradiol Modulated GABA Release, Journal of Neuroscience, (2009) 29(6):1897-1903

111. Thomas, M. B., Hu, M., Lee, T. M., Bhatnagar, S., Becker, J. B. Sex-specific susceptibility to cocaine in rats pre-exposed to prenatal stress, Physiology and Behavior 2009; 97(2):270-7.

112. Becker, J.B. Sexual Differentiation of Motivation: a novel mechanism? Hormones and Behavior (2009) 55:646-654.

113. G. M. Leinninger, Y.-H. Jo, R. L. Leshan, G. W. Louis, J. G. Barrera, H. Wilson, H. Yang, M. L. Perry, J. C. Jones, Y. Gong, C. J. Rhodes, S. Chua, Jr., R. T. Kennedy, R. J. Seely, J. B. Becker, H. Munzberg, M. G. Myers, Jr. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metabolism (2009) 10(2):89-98.

114. Becker, J. B. Sex Hormones. IN: Ian P. Stolerman (ed.), Encyclopedia of Psychopharmacology, DOI 10.1007/978-3-540-68706-1,# Springer-Verlag Berlin Heidelberg (2010).

115. Becker, J. B. Stress and Reward. IN: Encyclopedia of Behavioral Neuroscience, Elsevier (2010).

116. Zhao W, Becker JB. Sensitization enhances acquisition of cocaine self-administration in female rats: Estradiol further enhances cocaine intake after acquisition. Horm Behav. (2010) 58: 8-12.

117. Cummings, J. A, Gowl, B. A., Westenbroek, C., Clinton, C. M., Akil, H. Becker, J. B. Effects of a Selectively-Bred Novelty-Seeking Phenotype on the Motivation to Take Cocaine in Male and Female Rats. Biology of Sex Differences. (2011) 2(1): 3-10.

118. Peckham, E., Graves, S, Jutkiewicz, E., Becker, J.B., Traynor, J. Role of gonadal hormones on mu-opioid stimulated [35S]GTPγS binding and morphine-mediated antinociception in male and female Sprague-Dawley rats. Psychopharmacology, (2011) 218(3):483-92.

119. Leinninger GM, Opland DM, Jo YH, Faouzi M, Christensen L, Cappellucci LA, Rhodes CJ, Gnegy ME, Becker JB, Pothos EN, Seasholtz AF, Thompson RC, and Myers MG Jr. Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab. (2011) Sep 7;14(3):313-23.

120. Cummings, J. A, and Becker, J. B. Quantitative Assessment of Female Sexual Motivation in the Rat: Hormonal Control of Motivation. Journal Neuroscience Methods, (2012) 204(2):227-233.

121. Becker, J. N., Perry, A. N., and Westenbroek, C. Sex Differences in the Neural Mechanisms Mediating Addiction: A new synthesis and hypothesis. Biology of Sex Differences (2012) 3(1):14-49.

122. Cummings, J. A., Clinton, S. M., Perry, A. N., Akil, and Becker, J. B. Male rats that differ in their response to novelty demonstrate differences in sexual behavior and motivation. Behavioral Neuroscience (2013) Feb;127(1):47-58.

123. Becker, J.B. Commentary: Puberty and shifting values (invited commentary on Bell et al) European Journal of Neuroscience (2013) 37: 455-456.

124. Meitzen, J., Perry, A.N., Westenbroek, C., Hedges, V.L., Becker, J.B., and Mermelstein, P.G., Enhanced striatal β1-adrenergic receptor expression following hormone loss in adulthood is programmed by both early sexual differentiation and puberty: a study of humans and rats. Endocrinology (2013) 154(5):1820-31.

125. Westenbroek, C., Perry, A. N. and Becker, J. B. Pair housing attenuates the motivation to take cocaine in female rats. Behavioral Brain Research (2013) 252:68-71.

126. Perry, A. N., Westenbroek, C., Becker J. B. Impact of pubertal and adult estradiol treatments on cocaine self-administration, Hormones and Behavior (2013) Sep;64(4):573-8. doi: 10.1016/j.yhbeh.2013.08.007. Epub 2013 Sep 5.

127. Perry, A. N., Westenbroek, C., and Becker, J. B., The Development of a Preference for Cocaine Over Food Identifies Individual Rats with Addiction-like Behaviors (2013) PlosOne 2013 Nov 18;8(11):e79465. doi: 10.1371/journal.pone.0079465.

128. Foreword. Becker JB, Roberts DC Neurosci Biobehav Rev. 2013 Nov;37(9 Pt A):1917. doi: 10.1016/j.neubiorev.2013.08.009. Epub 2013 Aug 29.

129. Cummings, J.A., Jagannathan, K., Jackson, L., Becker, J.B., Sex differences in the effects of estradiol in the nucleus accumbens and striatum on the response to cocaine: neurochemistry and behavior, Drug and Alcohol Dependence (2014) 135:22-28. PMCID: PMC3947194

130. McCullough, L.D., de Vries, G.J., Miller, V.M., Becker, J. B., Sandberg, K. L. and McCarthy, M.M. NIH initiative to balance sex of animals in preclinical studies: Generative questions to guide policy implementation and metrics (2014) Biology of Sex Differences, 2014 Oct 3;5:15. doi: 10.1186/s13293-014-0015-5

131. Yoest, K.E. Cummings, J.A. and Becker, J.B. Estradiol, dopamine and motivation. Cent Nerv Syst Agents Med Chem. 2014;14(2):83-9. PMID:25540977.

132. Perry, A. N., Westenbroek, C., Jagannathan, L and Becker, J. B., The roles of dopamine and a1-adrenergic receptors in cocaine preferences in female and male rats. Neuropsychopharmacology, 2015; 40(12):2696-704. doi: 10.1038/npp.2015.116. PMCID: PMC4864645

133. Becker, J.B. and Koob, GF.. Sex Differences in Animal Models: Focus on Addiction. Pharmacological Reviews, 2016 Apr;68(2):242-63. PMCID:PMC4813426

134. Becker J.B., McClellan, M.L., Reed, B.G. Sociocultural context for sex differences in addiction. Addict Biol. 2016 Sept 21(5): 995-1006. doi: 10.1111/adb.12383. PMID:26935336.

135. Sanchis-Segura, C., Becker, J.B. Why we should consider sex (and study sex differences) in addiction research. Addict Biol. 2016 Sep;21(5):995-1006. doi: 10.1111/adb.12382. Epub 2016 Mar 31.

136. Becker, J.B., Prendergast, B.J., Liang, J.W. Female rats are not more variable than male rats: a meta-analysis of neuroscience studies, Biology of Sex Differences, 2016 7:34 DOI 10.1186/s13293-016-0087-5.

137. Becker, J.B., McClellan, M. L, Reed, B.G. Sex Differences, Gender and Addiction, Journal of Neuroscience Research, (2017). Jan 2;95(1-2):136-147. doi: 10.1002/jnr.23963. PMID: 27870394

138. Becker, J.B., Sex Difference in Addiction, Dialogues in Clinical Neuroscience 71 (Vol 18, No 4 395-403, 2016).

139. Miller LR, Marks C, Becker JB, Hurn PD, Chen WJ, Woodruff T, McCarthy MM, Sohrabji F, Schiebinger L, Wetherington CL, Makris S, Arnold AP, Einstein G, Miller VM, Sandberg K, Maier S, Cornelison TL, Clayton JA. Considering sex as a biological variable in preclinical research. FASEB J. 2016 Sep 28. Jan;31(1):29-34. doi: 10.1096/fj.201600781R

140. Li, P., Becker, J.B., Heitzeg, M.M., McClellan, M.L., Reed, B.G. & Zucker, R.A. Gender differences in the transmission of risk for antisocial behavior problems across generations, Plos One 2017 May 15;12(5):e0177288. doi: 10.1371/journal.pone.0177288.

141. Kerver, H.N. and Becker, J.B., Sex Differences in the Effects and Actions of Cocaine. In: Victor R. Preedy, editors, The Neuroscience of Cocaine: Academic Press, 2017, pp. 11-20.

142. Westenbroek, C., Perry, A.N., Jagannathan, L. and Becker, J.B. Effect of Social Housing and Oxytocin on the Motivation to Self-Administer Methamphetamine in Female Rats. Physiology Behavior (2019) 203:10-17. doi: 10.1016/j.physbeh.2017.10.020. Epub 2017 Oct 18. PMID 29055749.

143. Thomas MB, Becker JB. Sex differences in prenatal stress effects on cocaine pursuit in rats. Physiology & Behavior (2019) 203: 3-9. Oct 18 Epub ahead of print. PMID: 29055747

144. McClellan, M.L., Reed, B.G., Becker, J.B. Worlds Colliding: Trans-Disciplinary Approaches to Gender and Addictions. Social History of Alcohol & Drugs (2017) 31: 107-125.

145. Song, Z., Kalyani, M. and Becker, J.B. Sex differences in motivated behaviors in animal models, Current Opinion in Behavioral Sciences (2018) 23: 98-102.

146. Fitzpatrick CJ, Jagannathan L, Lowenstein ED, Robinson TE, Becker JB, Morrow JD. Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking. Behav Brain Res. 2018 [Epub ahead of print].

147. Yoest, K.E., Quigley, J.A. and Becker, J.B. Rapid Effects of Ovarian Hormones in Dorsal Striatum and Nucleus Accumbens, Hormones and Behavior, 2018 104:119-129. PMID:29626485

148. Becker, J.B. and Chartoff, E. Sex Differences in Neural Mechanisms Mediating Reward and Addiction, Neuropsychopharmacology, 2019 Jan;44(1):166-183. doi: 10.1038/s41386-018-0125-6. Epub 2018 Jun 19. PMID:29946108.

149. Yoest, K.E., Cummings, J.A. and Becker, J.B. Estradiol influences on dopamine release from the nucleus accumbens shell: Sex differences and the role of selective estradiol receptor subtypes. British Journal of Pharmacology (2018) Epub ahead of print PMID:30381823.

150. Song, Z, Yang, H, Elizabeth M. Peckham, E.M., Becker, J.B. Estradiol-induced potentiation of dopamine release in dorsal striatum following amphetamine administration requires estradiol receptors and mGlu5 (2019) (2019) eNeuro 29 January 2019, ENEURO.0446-18.2019; DOI: https://doi.org/10.1523/ENEURO.0446-18.2019.

151. Becker, J. B. and Mazure, C.M. The federal plan for health science and technology's response to the opioid crisis: understanding sex and gender differences as part of the solution is overlooked. Biol Sex Differ. 2019 Jan 7;10(1):3. doi: 10.1186/s13293-018-0215-5.

152. Beltz, A. M*., Beery, A. K.* and Becker J. B. Analysis of sex difference in pre-clinical and clinical data sets. Neuropsychopharmacology. 2019 Sep 17. doi: 10.1038/s41386-019-0524-3. [Epub ahead of print]. * co-first authors.

153. Yoest, K. E., Cummings, J. A. and Becker, J.B. Ovarian hormones mediate changes in adaptive choice and motivation in female rats (submitted).

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