의료 빅데이터와 인공지능의 현재와 미래
TRANSCRIPT
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의료 빅데이터와 인공지능의 현재와 미래
서울대 최형진
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Contents
1. What is Healthcare Big Data? 2. Healthcare Big Data
① Genetic Data② Electrical Health Records③ National Healthcare Data④ Medical Images⑤ Sensor/Mobile Data⑥ Data Integration
3. Healthcare Big Data + Artificial Intelligence
3
Contents
1. What is Healthcare Big Data? 2. Healthcare Big Data
① Genetic Data② Electrical Health Records③ National Healthcare Data④ Medical Images⑤ Sensor/Mobile Data⑥ Data Integration
3. Healthcare Big Data + Artificial Intelligence
$215MPrecision Medicine Initiative
2015/1/30
Integration of Multi-Big-Data
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미국 내분비 학회
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미국 골대사 학회
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Big Data Dimensions
New Analysis Tool (R, Python, Matlab)New Approach
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( 중환자실 심전도 )
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Data Variety
Tipping Point for Big Data Healthcare
2013 McKinsey The big data revolution in healthcare
Hypothesis Driven Science Data Driven Science
Hypothesis
Collect Data
Data
GenerateHypothesis
Analyze
Analyze
Candidate GeneApproach
Genome-wideApproach
Choose a Gene from Prior Knowledge
Analyze the Gene
Analyze ALL Genes
Discover Novel Findings
GWAS (Genome wide association study)
SNP chipWhole Genome SNP Profiling (500K~1M SNPs)
Common Variant
Choi HJ, Doctoral Thesis
Estrada et al., Nature Genetics, 2012
+ novel targets for bone biology
Recent largest GWASGEFOS consortium
2010 An Environment-Wide Associ-ation Study (EWAS) on Type 2 Dia-betes Mellitus
Environment-Wide Association Study (EWAS)
다양한 환경인자들
GWAS PheWAS Phenotype-wide Association Study
1000 개의 질병들Bioinformatics. 2010 PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations.
Phenotype-wide Association Study
Genome-Envirome-Phenome-wideAssociation Study
Phe
nom
e-w
ide
(Lab
, Dia
gnos
is)
Proposal (Choi)
Genome-wide
Environment-wide(Life style, diet, exercise, pollution)
Anatome-Phenome-wideAssociation Study
2015.2.19. Nature. Genetic and epigenetic fine mapping of causal autoimmune disease variants
Phenome
Ana
tom
e
의료 빅데이터의 새로운 역할전통적인 관점 연구
Large scale(unstructured)data
Summary(Modify)
Classical hypothesis driven study
새로운 관점 연구
Hypothesis Generating Study
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Contents
1. What is Healthcare Big Data? 2. Healthcare Big Data
① Genetic Data② Electrical Health Records③ National Healthcare Data④ Medical Images⑤ Sensor/Mobile Data⑥ Data Integration
3. Healthcare Big Data + Artificial Intelligence
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저의 유전자 분석 결과를
반영하여 진료해주세
요 !!헠 ?
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DNA
mRNA
Protein
Metabolite
Epigenetics
Genetics Information and OMICs
Genomics
Epigenomics
Transcriptomics
Proteomics
Metabolomics
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DNA
mRNA
WBC Liver CancerGermline mutation Somatic mutation
Epigenomics
Proteomics
Metabolomics
Epigenomics
Proteomics
Metabolomics
Epigenomics
Proteomics
Metabolomics
Metabolomics
GermlineGenomics
CancerGenomics
Transcriptomics Transcriptomics Transcriptomics
Proteomics
Promise of Human Genome Project
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Tissue Specific Expression
Comprehensive Catalogues of Genomic DataVariation in the human genome
Mendelian (monogenic) diseases (N=22,432)
Whole genome sequencing (N=1,000)
Four ethnic groups (CEU, YRI, JPT, CHB, N=270)
GWAS catalogComplex (multigenic) traits(1926 publications and 13410 SNPs)
Disease-related variations
Functional elements
2014-06-29
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All Major Tissues/OrgansAll Proteins + All RNAs
2015 Science Tissue-based map of the human proteome
1. Immunohistochemistry (IHC)24,028 antibodies (16,975 proteins) >13 million IHC images
2. RNA-sequencing
(N=44)
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111 Reference Human Epigenomes
2015.2.19. Nature. Integrative analysis of 111 reference human epigenomes
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Data Dimensions
2015.2.19. Nature. Integrative analysis of 111 reference human epigenomes
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Building the Interactome
2015 Science Uncovering disease-disease relationships through the incomplete interactome
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Network-based Model of Disease-disease Relationship
2015 Science Uncovering disease-disease relationships through the incomplete interactome
Disease genetic susceptibility Cancer driver somatic mutation
Pharmacogenomics
Targeted Cancer Treatment
(EGFR)
Causal Variant
Targeted Drug(MODY-SU)
Drug Efficacy/Side Effect Related Genotype
(CYP, HLA)
Genetic Diagnosis(Mendelian,
Cystic fibrosis)Molecular
Classification- Prognosis(Leukemia)
Hereditary Cancer(BRCA)
Microbiome(Bacteria,
Virus)
Genomic Medicine
Risk prediction(Complex disease,
Diabetes)
Germline Variants
Fetal DNA
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1) Cancer Genome
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Cancer Targeted Therapy
Targeted TherapyGenetic TestCancer
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Cancer Rebiopsy
2013 JCO Genomics-Driven Oncology- Framework for an Emerging Paradigm
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Liquid Biopsy
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2) Common Complex Disease Susceptibility
Influence of Genetics on Human Disease
For any condition the overall balance of genetic and environmental determinants
can be represented by a point some-where within the triangle.
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Single Locus /
Mendelian
Multiple Loci or multi-chromosomal
Environmental
Cystic FibrosisHemophilia A
Examples:Alzheimer’s Disease
Type II Diabetes
Cardiovascular Disease
DietCarcinogensInfectionsStressRadiationLifestyle
Gene = F8Gene= CFTR
F8 = Coagulation Factor VIIICFTR = Cystic Fibrosis Conductance Transmembrane Regulator
Lung Cancer
49 2008 HMG Genome-based prediction of common diseases- advances and prospects
50 2008 HMG Genome-based prediction of common diseases- advances and prospects
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Diabetes ≠ Genetic Disease? • Familial aggregation
– Genetic influences?– Epigenetic influences
• Intrauterine environment– Shared family environment?
• Socioeconomic status• Dietary preferences• Food availability• Gut microbiome content
• Overestimated heritability– Phantom heritability
2012. Drong AW, Lindgren CM, McCarthy MI. Clin Pharmacol Ther. The genetic and epigenetic basis of type 2 diabetes and obesity.2012. PNAS The mystery of missing heritability- Genetic interactions create phantom heritability
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Genetics of eating behavior
2011 Genetics of eating behavior
Gene-Environment Interaction
Gene Environment
Disease
Genetic Predisposition Score Sugar-Sweetened Beverages
Soda School
No-Soda School
Obese Family Lean Family
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3) Rare Mendelian Disease Susceptibility
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Mendelian (single-gene) genetic disorderKnown single-gene candi-
dates testingWhole Genome or Whole Ex-
ome Sequencing
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Laboratory Director강현석
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4) Pharmacogenomics
65 2012 European Heart Journal. Personalized medicine: hope or hype?
Herceptin
Glivec
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Pharmacogenomic Biomarkers in Drug Labeling (N=166)2015.9.14.Atorvastatin, Azathioprine, Car-bamazepine, Carvediolol, Clopidogrel, Codein, Di-azepam…..
Large Effect Size Variant?
Disease susceptibility variant Pharmacogenetic variant
EnvironmentalExposure
DrugExposure
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5) Other GenomeFetal DNA
Microbiome (Bacteria, Virus DNA)
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30 만원 -200 만원
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73 ( 출처 : 금창원 대표님 블로그)
$99
TV CF
Pharmacogenetic Tests: 최형진
No Drug(N= 10)
Gene(6 genes=8
biomarkers)
Target SNPs (N=12)
#5(HJC) Genotype Interpretation Clinical Interpretation
1 Clopidogrel CYP2C19rs4244285 (G>A) GG
*1/*1(EM) Use standard dosers4986893 (G>A) GG
rs12248560 (C>T) CC
2 WarfarinVKORC1 rs9923231 (C>T) TT
Low dose(higher risk of bleeding) Warfarin dose=0.5~2 mg/dayCYP2C9 rs1799853 (C>T) CC
rs1057910 (A>C) AC3 Simvastatin SLCO1B1 rs4149056 (T>C) TT Normal
4 Azathioprine (AP), MP, or TG TPMT rs1142345 (A>G) AA Normal
5 Carbamazepine or Phenytoin HLA-B*1502 rs2844682 (C>T) CT Normalrs3909184 (C>G) CC
6 Abacavir HLA-B*5701 rs2395029 (T>G) TT Normal7 Allopurinol HLA-B*5801 rs9263726 (G>A) GG NormalClopidogrel1): UM/EM=standard dose, IM/PM= consider alternative antiplatelet agent (eg. prasugrel/ticagrelor)Warfarin2): high dose=5~7 mg/day, medium dose=3~4 mg/day, low dose=0.5~2 mg/day
=0최형진+1,000,000?
2014 NEJM Genotype–Phenotype Correlation — Promiscuity in the Era of Next-Generation Sequencing
Future of Genomic Medicine?
Test when neededWithout information Know your type
Bloodtype
Genotype
Here is my sequence
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Contents
1. What is Healthcare Big Data? 2. Healthcare Big Data
① Genetic Data② Electrical Health Records③ National Healthcare Data④ Medical Images⑤ Sensor/Mobile Data⑥ Data Integration
3. Healthcare Big Data + Artificial Intelligence
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Electronic Health Records
2012 NRG Mining electronic health records- towards better research applications and clinical care
Common EHR Data
Joshua C. Denny Chapter 13: Mining Electronic Health Records in the Genomics Era. PLoS Comput Biol. 2012 December; 8(12):
International Classification of Diseases (ICD)Current Procedural Terminology (CPT)
Medication Data
Lab Data
Big Data Analysis
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
1.8 1/Creatinine
한 환자의 10 년간 신장기능의 변화전체 환자의 당 조절 정도 분포
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PCA Analysis혈당
신장기능
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Machine Learning
2014 Big data bioinformatics
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Clinical Notes
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밤동안 저혈당수면 Lt.foot rolling Keep 떨림 , 식은땀 , 현기증 , 공복감 , 두통 , 피로감등의 저혈당 에 저혈당 이 있을 즉알려주도록 밤사이 특이호소 수면유지상처와 통증 상처부위 출혈 oozing, severe pain 알리도록 고혈당 처방된 당뇨식이의 중요성과 간식을 자제하도록 . 고혈당 ,, 관리 방법 . 당뇨약 이해 잘 하고 수술부위 oozing Rt.foot rolling keep 드레싱 상태를 고혈당 고혈당 의식변화 BST 387 checked. 고혈당으로 인한 구강 내 감염 위해 식후 양치 , gargle 등 구강 위생 격려 . 당뇨환자의 발관리 방법에 . 목표 혈당 , 목표 당화혈색소에 . 식사를 거르거나 지연하지 않도록 . 식사요법 , 운동요법 , 약물요법을 정확히 지키는 것이 중요을 .처방된 당뇨식이의 중요성과 간식을 자제하도록 . 고혈당 ,, 관리 방법 . 혈당 정상 범위임 rt foot rolling 중으로 pain 호소 밤사이 수면양호걱정신경 예민감정변화 중임감정을 표현하도록 지지하고 경청기분상태 condition 조금 나은 듯 하다고 혈당 조절과 관련하여 신경쓰는 모습 보이며 혈당 self 로 측정하는 모습 보임혈당 조절에 안내하고 불편감 지속알리도록고혈당 고혈당 의식변화 고혈당 허약감 지남력 혈당조절 안됨고혈당으로 인한 구강 내 감염 위해 식후 양치 , gargle 등 구강 위생 격려 . 당뇨환자의 정기점검 내용과 빈도에 .BST 140 으로 저혈당 호소 밤동안 저혈당수면 Lt.foot rolling Keep 떨림 , 식은땀 , 현기증 , 공복감 , 두통 , 피로감등의 저혈당 에 저혈당 이 있을 즉알려주도록 pain 및 불편감 호소 WA 잘고혈당 고혈당 의식변화 고혈당 허약감 지남력 혈당조절 안됨식사요법 , 운동요법 , 약물요법을 정확히 지키는 것이 중요을 . 저혈당 / 고혈당 과 대처법에 . 혈당정상화 , 표준체중의 유지 , 정상 혈중지질의 유지에 . 고혈당 ,, 관리 방법 . 혈당측정법 , 인슐린 자가 투여법 , 경구투약 ,수분 섭취량 , 대체 탄수화물 , 의료진의 도움이 필요한 사항에 교혈당 정상 범위임수술부위 oozing Rt.foot rolling keep 수술 부위 ( 출혈 , 통증 , 부종 ) 수술부위 출혈 상처부위 oozing Wound 당겨지지 않도록 적절한 체위 취하기 설명감염 발생 위험 요인 수술부위 출혈 밤동안 저혈당 호소 수면 양상 양호 rt foot rolling유지하며 감염이나 심한 통증등 침상안정중임BST 420 checkd. R1 알림 obs 하자 Rt DM foot site pain oozing 없는 상태로 저혈당 은 낮동안에는 . BST BST 347 mg /dl checked. R1notify 후 apidra 10U sc 주사 . 안전간호 시행안전간호 시행
간호기록지 Word Cloud
Natural Language Processing (NLP)
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Contents
1. What is Healthcare Big Data? 2. Healthcare Big Data
① Genetic Data② Electrical Health Records③ National Healthcare Data④ Medical Images⑤ Sensor/Mobile Data⑥ Data Integration
3. Healthcare Big Data + Artificial Intelligence
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Number of patients with medical treatments related to os-teoporosis in each calendar year
2005 2006 2007 20080
500
1000
1500MaleFemale
Calendar year
Num
ber
(tho
usan
d)
2011 JBMM Burden of osteoporosis in adults in Korea- a national health insurance database study
Korean Society for Bone and Mineral Research
Anti-hypertensive prescrip-tions
(2008-2011)N = 8,315,709
New usersN = 2,357,908
Age ≥ 50 yrsMonotherapy
Compliant user (MPR≥80%)No previous fracture
N = 528,522
Prevalent usersN = 5,957,801
Excluded
Age <50Combination therapy
Inadequate compliancePrevious fracture
N = 1,829,386
Final study population
심평원 빅데이터 연구고혈압약과 골절
Choi et al., 2015 International Journal of Cardiology
98
Compare Fracture Risk Comparator?Hypertension
CCB HighBlood Pressure
FractureRisk
BB
Non-user
Healthy
Non-user
Cohort study (Health Insurance Review & Assessment Service)New-user design (drug-related toxicity)Non-user comparator (hypertension without medication)
2007 20112008Choi et al., 2015 International Journal of Cardiology
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100
Distribution of ARB MPR(Histogram)
ARB Non-user
20
Freq
uenc
y D
ensi
ty
ARB user
80 120
Medication Possession Ratio (MPR)Total prescription days
Observation days
350 days (Prescription)
365 days (Observation)MPR96%
MPR (%)Choi et al., 2015 International Journal of Cardiology
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Data Variety
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Overview of secondary data in public health by data source
보험청구자료 건강검진
NHIS (National Health Insurance Corporation): 국민건강보험공단 ( 보험공단 )HIRA (Health Insurance Review and Assessment Service) : 건강보험심사평가원 ( 심평원 )
통계청 암센터
J Korean Med Assoc 2014 May; 근거중심 보건의료의 시행을 위한 빅데이터 활용
Big data platform model by Korea Institute of Drug Safety and Risk Management
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Contents
1. What is Healthcare Big Data? 2. Healthcare Big Data
① Genetic Data② Electrical Health Records③ National Healthcare Data④ Medical Images⑤ Sensor/Mobile Data⑥ Data Integration
3. Healthcare Big Data + Artificial Intelligence
Heart
SIMENS: CT Cardio-Vascular Engine
2013 Science Structural and Functional Brain Networks- From Connections to Cognition
fMRI analysis
2013 Science Functional interactions as big data in the human brain
2013 Science Functional interactions as big data in the human brain
1132013 Science Functional interactions as big data in the human brain
2012 Decoding subject-driven cognitive states with whole-brain connectivity patterns
114
Obesity fMRI ResearchPreliminary Pilot Results
p<0.005 uncorrected
Activation of visual, motor and prefrontal brain area in response to visual food cue
3
+
Food presentation max 4sec
Feedback 1sec
Fixation1~10sec
Choi et al., on going
Resting state fMRI analysisComplex network approach
Parcellation 116 brain regions by AAL map
Adjacency matrix Network properties
node degree, clustering coefficient
Choi et al., on going
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Genome Big Data + Brain Big Data
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Connectome-wide GWAS
2014 Nature Neuroscience. Whole-genome analyses of whole-brain data- working within an expanded search space
118 2015 Nature. Common genetic variants influence human subcortical brain structures
Published online 21 January 2015
119 2015 Nature. Common genetic variants influence human subcortical brain structures
2014
Radiomics
2014 Nature Communications. Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
Quantitative nuclear morphometry
2015 Laboratory Investigation. Novel genotype-phenotype associations in human cancers enabled by advanced molecular platforms and computational analysis of whole slide images
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딥러닝으로 폐암 진단을 돕는다 , 의사를 위한 인공 지능 ‘뷰노 메드 (Vuno-Med)’
Artificial Intelligence for Doctors and Patients
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Contents
1. What is Healthcare Big Data? 2. Healthcare Big Data
① Genetic Data② Electrical Health Records③ National Healthcare Data④ Medical Images⑤ Sensor/Mobile Data⑥ Data Integration
3. Healthcare Big Data + Artificial Intelligence
1282015 Sci Transl Med. The emerging field of mobile health
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131 삼성서울병원 ( 홍승봉 신경과 교수 , 전홍진 정신건강의학과 부교수 ) 협업
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피부 사진 원격 진단 / 처방
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심전도 원격 진단 / 처방
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NFC 혈당측정기
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데이터베이스 기반 혈당관리
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혈당 변화 실시간 모니터링
저녁 식사전 고혈당
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Date Time name foodType calories unit amount2014-08-
09 0 미역국 0 23 1 국그릇 (300ml) 105 g2014-08-
09 0 잡곡밥 0 80 1/4 공기 (52.5g) 52 g2014-08-
09 0 열무김치 0 3 1/4 소접시 (8.75g) 9 g2014-08-
09 0 파프리카 0 6 1/2 개 (33.25g) 35 g2014-08-
09 0 토란대무침 0 28 1/2 소접시 (46.5g) 46 g2014-08-
09 1 복숭아 0 91 1 개 (269g) 268 g2014-08-
09 2 마른오징어 2 88 1/4 마리 (25g) 25 g2014-08-
09 2 파프리카 0 6 1/2 개 (33.25g) 35 g2014-08-
09 2 저지방우유 1 72 1 컵 (200ml) 180 g2014-08-
09 2 복숭아 0 183 2 개 (538g) 538 g2014-08-
09 3 복숭아 0 91 1 개 (269g) 268 g2014-08-
09 3 파프리카 0 6 1/2 개 (33.25g) 35 g2014-08-
09 4 파프리카 0 6 1/2 개 (33.25g) 35 g2014-08-
09 4 식빵 1 92 1 장 (33g) 33 g2014-08-
09 4 삶은옥수수 1 197 1 개 반 (150g) 150 g2014-08-
09 4 복숭아 0 91 1 개 (269g) 268 g2014-08-
09 4 저지방우유 1 72 1 컵 (200ml) 180 g2014-08-
10 0 복숭아 0 91 1 개 (269g) 268 g2014-08-
10 0 저지방우유 1 36 1/2 컵 (100ml) 90 g2014-08-
10 0 두부 0 20 1/4 인분 (25g) 25 g2014-08-
10 0 견과류 2 190 1/4 컵 (50g) 31 g2014-08-
10 0 파프리카 0 11 1 개 (66.5g) 65 g2014-08-
10 2 방울토마토 0 8 4 개 (60g) 60 g2014-08-
10 2 방울토마토 0 8 4 개 (60g) 60 g2014-08-
10 2 방울토마토 0 8 4 개 (60g) 60 g2014-08-
10 2 김밥 1 318 1 줄 (200g) 200 g2014-08-
10 3 복숭아 0 91 1 개 (269g) 268 g2014-08-
10 4 잡곡밥 0 161 1/2 공기 (105g) 105 g2014-08-
10 4 복숭아 0 91 1 개 (269g) 268 g2014-08-
10 4 김치 0 3 1/4 소접시 (10g) 12 g2014-08-
10 4 장조림 1 66 1/2 소접시 (45g) 45 g2014-08-
10 4 콩나물국 0 14 3/4 국그릇 (187.5ml) 83 g2014-08-
10 5 포도 0 45 3/4 대접시 (75g) 75 g
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식사량 실시간 모니터링아
침아
침간
식점
심점
심간
식저
녁저
녁간
식아
침아
침간
식점
심점
심간
식저
녁저
녁간
식아
침아
침간
식점
심점
심간
식저
녁저
녁간
식아
침아
침간
식점
심점
심간
식저
녁저
녁간
식아
침아
침간
식점
심점
심간
식저
녁저
녁간
식아
침아
침간
식점
심점
심간
식저
녁저
녁간
식아
침아
침간
식점
심점
심간
식저
녁저
녁간
식
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500
600점심 과식
저녁 금식
143
운동량 실시간 모니터링
8/9/20
14
8/10/2
014
8/11/2
014
8/12/2
014
8/13/2
014
8/14/2
014
8/15/2
014
0
5000
10000
15000
20000
25000
걸음 수
운동 X
144
145
운동
식사
스마트폰 활용 당뇨병 통합관리
의사
상담 교육
조회 /분석
교육간호사
매주 / 필요시
진료 처방
2-3 달 간격
평가 회의매주 / 필요시
식사 /운동
스마트폰
데이터베이스 서버
자가관리
전송
분석
혈당측정
혈당측정기
Social Network and Obesity Prevalence
2013 PLOS One. Assessing the Online Social Environment for Surveillance of Obesity Prevalence
2013 PLOS CB Reassessing Google Flu Trends Data for Detection of Seasonal and Pandemic Influenza
Google Flu Trends
150
151http://startupbank.co.kr/board/board_view.html?ps_boid=75&ps_db=report_s
152 2015 Cell Metabolism. A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits
November 3, 2015
153 2015 Cell Metabolism. A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits
154
Personalized Nutrition by Prediction of Glycemic Responses
2015 Cell. Personalized Nutrition by Prediction of Glycemic Responses
Received: October 5, 2015; Received in revised form: October 29, 2015;
Accepted: October 30, 2015;
1552015 Cell. Personalized Nutrition by Prediction of Glycemic Responses
1562015 Cell. Personalized Nutrition by Prediction of Glycemic Responses
1572015 Cell. Personalized Nutrition by Prediction of Glycemic Responses
158
Contents
1. What is Healthcare Big Data? 2. Healthcare Big Data
① Genetic Data② Electrical Health Records③ National Healthcare Data④ Medical Images⑤ Sensor/Mobile Data⑥ Data Integration
3. Healthcare Big Data + Artificial Intelligence
159
2014 JAMA Finding the Missing Link for Big Biomedical Data
electronic medical records (EMRs) and genotype data from 11,210 indi-viduals
2015 STM Identification of type 2 diabetes subgroups through topological analysis of patient similarity
2015 Sci Rep. Repurpose terbu-taline sulfate for amyotrophic lateral sclerosis using electronic medical records
2015 Sci Rep. Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records
164
Apple Health App
2015 Nature Immunology. A vision and a prescription for big data–enabled medicine
http://hineca.tistory.com/entry/Vol11-3%EC%9B%94%ED%98%B8-%EB%B3%B4%EA%B1%B4%EC%9D%98%EB%A3%8C%EC%9D%B4%EC%8A%88-%EA%B7%BC%EC%8B%9C%EA%B5%90%EC%A0%95%EC%88%A0
2014.3.
169
국가기관
의료기관
연구기관
개인
개인식별정보통합
정보저장 통계인공지능
건강관리
정보공개
수집 분석 활용
개인집단
Overview of Healthcare Data
170
Contents
1. What is Healthcare Big Data? 2. Healthcare Big Data
① Genetic Data② Electrical Health Records③ National Healthcare Data④ Medical Images⑤ Sensor/Mobile Data⑥ Data Integration
3. Healthcare Big Data + Artificial Intelligence
171
Healthcare Big Data + Artificial Intelligence
Healthcare Big Data Machine Learning
Novel Insights and Applications
172
175
176
In a scan of 3,000 images, IBM technology was able to spot melanoma with an accuracy of about 95 percent, much better than the 75 percent to 84 percent average of today's largely manual methods.IBM Research will continue to work with Sloan Kettering to develop additional measure-ments and approaches to fur-ther refine diagnosis, as well as refine their approach through larger sets of data.
Dec 17, 2014
177
Aug. 11, 2015
IBM is betting that the same technology that recog-nizes cats can identify tumors and other signs of dis-eases. In the long run, IBM and others in the field hope such systems can become reliable advisers to radiolo-gists, dermatologists and other practitioners who analyze images—especially in parts of the world where health-care providers are scarce.While IBM hopes Watson will learn to interpret Merge’s images, it also expects the combination of imagery, medical records and other data to reveal patterns relevant to diagnosis and treatment that a human physician may miss, ushering in an era of computer-assisted care. Two other recent IBM ac-quisitions, Phytel Inc. and Explorys Inc., yielded 50 million electronic medical records.
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Dec. 10, 2015
Novo Nordisk A/S is teaming up with IBM Watson Health, a divi-sion of International Business Machines Corp., to create a “vir-tual doctor” for diabetes patients that could dis-pense treatment advice such as insulin dosage.
180
Environment
Gene
Eat
Exercise
Metabolism
Brain
GlucoseDM
Blood PressureHTN
CardiovascularDisease
Cognitive
Hormone
Behavior
Psychotherapy
Behavior Therapy
Policy Making
Genetic TestingNeuroimaging
Neuromodulation
Drug
Drug
Lab
Survey
Survey
Sensor
DrugDiagnosis
EMR
Government
DataMining
181
Environment Survey
NeuroimagingGenetics Lab/Hormone Hospital
Cognitive
Personalize
Psychotherapy
DietaryIntervention
ExerciseIntervention
Food
Exercise
Glucose
Mobile
Drug
Neuromodulation
Monitoring
182
Multidimensional ArchitectureGene
Hormone
Psychology
Behavior
Phenotype
Outcome
MetabolicDisease Vascular
Disease
Env
ironm
ent
183
The FUTURE MEDICINEis already
at PRESENT