yukihiko nosé: mr artificial organs

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In Memoriam

Yukihiko Nosé: Mr Artificial Organs

Dr Yukihiko Nosé passed away on 13 October2011 at the age of 79 after a long battle with coloncancer. He was a loving and devoted husband to Ako,loving father to Kevin, Ken, and Kimi, medical tech-nology pioneer and educator. He was well recognizedworldwide as a leader, statesman, and pioneer in arti-ficial organs (Figs 1,2).

Yukihiko Nosé MD, PhD was born in Hokkaido,Japan on 7 May 1932 as the seventh of 10 children toMinoru and Haru Nosé and was raised in the city ofIwamisawa. From an early age, his mother desiredthat her son become a doctor and it was his ambitionto be a first-class physician and dedicate his life totreating people with severe diseases. In 1953 hegraduated from the University of Hokkaido’s Schoolof Basic Science and in 1957 from the University’sSchool of Medicine with his MD degree (No. 257,Igakushi). After serving a rotating internship hereceived his medical license to practice in 1958.Through 1962 he served under Professor Jiro Mikamiin the First Department of Surgery. Dr Mikami was aleading physician in the field of liver surgery butencouraged Dr Nosé to pursue a career in substitu-

tive medicine and transplantation. He appointed himas Chief of the Artificial Organ Research Divisionwhere Dr Nosé devoted his efforts on the develop-ment of various artificial organs including the artifi-cial kidney and the hybrid artificial liver. He receivedhis PhD on the development of a miniaturized hemo-dialyzer. During this time he served in the Depart-ment of Mechanical Engineering at the University ofTokyo headed by Professor Shigeru Watanabe.

From 1962 to 1964 Dr Nosé was a Research Asso-ciate in the Surgical Research Laboratory of DrAdrian Kantrowitz at Maimonides Hospital inBrooklyn, New York (Figs 3–5). While working therethe team developed the Series-Type ventricular assistdevice. In 1967 this device was successfully implantedin a patient who was discharged from the hospitaland maintained his life at home. In 1984 Dr Noséreceived the Maimonides Medical Center Award ofRecognition for his outstanding research work. In1964 he was invited by Dr Willem Kolff to join histeam at the Cleveland Clinic as a postgraduateFellow with an initial focus on the development of a

FIG. 2. Yukihiko and Ako Nosé.

FIG. 1. Yukihiko Nosé, MD, PhD.

Therapeutic Apheresis and Dialysis 2012; 16(1):1–10doi: 10.1111/j.1744-9987.2011.01049.x© 2012 The AuthorsTherapeutic Apheresis and Dialysis © 2012 International Society for Apheresis

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total artificial heart (Fig. 6). Under Dr Kolff’s leader-ship Dr Nosé developed various artificial heartdesigns and was appointed to the Associate Staff.In 1967 Dr Kolff moved to the University of Utahand Dr Nosé, with very few resources, took overas Department Head of Artificial Organs at the

Cleveland Clinic Foundation. He served in this lead-ership position until 1989 and built a world class firstrate department in artificial organ technologies. Heexpanded the activities with governmental grants andcommercial support including developments on theartificial heart, dialyzers (artificial kidney), artificial

FIG. 3. Adrian Kantrowitz with his team circa 1963 or 1964.

FIG. 4. Yuki with Adrian Kantrowitz. FIG. 5. Yuki with Jean Kantrowitz

In Memoriam2

© 2012 The AuthorsTherapeutic Apheresis and Dialysis © 2012 International Society for ApheresisTher Apher Dial, Vol. 16, No. 1, 2012

uterus, blood oxygenators (artificial lung), artificialblood, artificial bladder, liver support devices, blooddetoxification by sorption and tissues, blood andplasma filtration technologies, and neuroprostheses.The Department of Artificial Organs grew to includeover 70 persons in research and development as wellas clinical programs (Fig. 7). In addition to theseactivities at this time, Dr Nosé was the drive behind

the organization and formation of many interna-tional societies and other organizations including theInternational Society for Artificial Organs in 1977,Artificial Organs in 1977, the International Center forArtificial Organs and Transplantation in 1979, theWorld Apheresis Association in 1983, the Interna-tional Society for Rotary Blood Pumps in 1992,Fairway Medical Technologies in 1994, the Interna-tional Society for Apheresis in 1995, the InternationalCenter for Medical Technologies in 2002, and theInternational Academy for Artificial Organ Pioneersin 2002 (Figs 8–10). Dr Nosé served as Editor-in-Chief of Artificial Organs from 1977–1999 as well as

FIG. 6. Dr Larry Tretbar, Steven Topaz, Yuki Nosé, and DrWillem Kolff in the laboratory at the Cleveland Clinic.

FIG. 7. Department of Artificial Organs at the Cleveland Clinic.

FIG. 8. Drs Y. Nosé and V. Shumakov at the ICAOT.

In Memoriam 3

© 2012 The AuthorsTherapeutic Apheresis and Dialysis © 2012 International Society for Apheresis Ther Apher Dial, Vol. 16, No. 1, 2012

Editor for Therapeutic Apheresis and Dialysis from1997. In the 1980s he was actively involved in theCleveland Revival Project and the HIMEX (Hok-kaido International Medical and Industrial Complex)Project.

While on sabbatical leave from the ClevelandClinic in 1990 he accepted an appointment at BaylorCollege of Medicine as Professor of surgery inJanuary 1991, working with Dr Michael DeBakey.There he continued his work on pulsatile and non-pulsatile pumps while continuing his activities inthe preservation of artificial organs technologiesartifacts.

Dr Nosé was President of various Societies includ-ing the International Society for Artificial Organs in1985, the American Society for Artificial InternalOrgans in 1993, and the International Society forRotary Blood Pumps in 1996. In 1993 he was awardedthe Cleveland Clinic Foundation’s “Man HelpingMan Award” as only one of three individuals havingreceived this highly prestigious recognition awardover the Clinic’s 75 year history (Fig. 11).

FIG. 9. ISAO founders: From the left:Drs Atsumi, Funck-Brentano, Klinkmann,Kolff, Gurland, Nosé and Friedman.

FIG. 10. Drs Horst Klinkmann, Kazuhiko Atsumi, YukihikoNosé at the sake ceremony on the occasion of the first ISAOCongress in Japan.

FIG. 11. Man Helping Man Award pre-sented by Dr Bill Kiser to Dr Nosé.

In Memoriam4


Dr Nosé had received many honors for his worksincluding in 1984 the Maimonides DistinguishedFellow’s Award, in 1985 the ICAOT Cleveland awardfrom the International Society for Artificial Organs,the Hastings Lecture Award in 1989, FoundingFellow of the American Institute for Medical andBiological Engineering in 1991, and the Barney ClarkAward in 2003. In 2004 he was awarded “The Orderof the Sacred Treasure”Award and the Sacred Medalof Honor,“Zuiho Sho” from the Emperor Akihiko ofJapan. The award and medal is given to an individualwho has provided lifelong service to the Governmentof Japan. It is the highest honor for a Japanese citizenwho resides outside Japan. To celebrate this occasionhis students prepared a special book for him, “Yuki-hiko Nosé: Life Long Dream.”

Dr Nosé’ contributions to medical science are welldocumented. He authored or co-authored chapters inover 100 books covering various types of experimen-tal and clinical artificial organs, biomaterials, trans-plantation, and surgery. His list of publicationsincludes over 1200 on these topics and he alsoauthored or edited 20 books.

While he made a great impact in various areas ofresearch and development on artificial organ tech-nologies, his biggest impact may be the legacy that hehas left in the over 600 individuals, Nosé alumni, thathe involved in his research activities. He gratefullyrecognized their efforts over the years. Dr Nosé alsofostered friendship and collaboration through hisefforts with the Japan-America Society of Houston,which later became the Japan America Society ofGreater Houston (Fig. 12).

PERSONAL REMEMBRANCES

Dr. Paul S. Malchesky notes “It was with greatsadness that I heard the passing of Dr Yukihiko Nosé.In recalling his life it was always directed to the newand exciting prospects for treating organ systemfailure.He was always enthusiastic and forward think-ing.Whether through teaching the many collaboratorsthat he had, his writings, his presentations at confer-ences, his organization of scientific conferences, hispreservation of historical artifacts, or his founding ofsocieties and journals, his life had the focus and pro-motion of artificial organ technologies. I recall inmeeting some earlier researchers, they referred to himas “Mr Artificial Organs,” a title befitting him.

I first met Yuki in the New Year of 1969 when I wasa graduate student in Cleveland. By some surprisingconnection I was introduced to him and he offeredme a job (that I was not sure I wanted) in his smallbut growing Department of Artificial Organs at the

Cleveland Clinic. I accepted the position thinking I’llgive it a try for a year or two. At the time I could nothave known the impact on my life made by that deci-sion. I directly worked with him for over 20 years.Yuki was first a teacher. I recall his work at that timein writing and illustrating his manuals on the artificialkidney and the oxygenator and of the daily morningconferences that he would convene. His manualswere easy reads and demonstrated the straightforward approach to his work. His constant challeng-ing forced others to research their positions and readthe literature (which at that time was without thebenefit of the internet and on-line journals). Therewere few if any excuses that he would acknowledge. Irecall one time he noted “that too much researchfunding is not good, it only holds you back.” Whilefunding is important, its focus took away the innova-tion that is much needed in developing this field andat times clouds the direction. He also believed thatthe contributions can come from many, not onlythose with MDs and PhDs. Being in an institutionthat highly valued the medical degree he fought hardto have those recognized that had knowledge andexperience and reached out beyond the walls ofthe institution to enrich his team. He built multi-disciplinary groups focused on organ system devel-opment and recognized the contributions of all. He

FIG. 12. Dr and Mrs Nosé with President George H.W. Bush andfirst Lady Barbara Bush at a gathering of the Japan AmericaSociety of Houston.

In Memoriam 5


saw the utility of bringing together people from otherregions around the world as well as from differentscientific disciplines. This mix created an environ-ment of learning and developments spanning manyorgan systems.

The Department of Artificial Organs at the Cleve-land Clinic was the premier group of its kind in theworld and stimulated a competitive environmentworldwide. His publication list and long list of formercolleagues is but one reflection of the breadth andscope of his influence. Many others followed his leadand tried to imitate. I know he found a sense of pridein this. When organizing the Second Congress of theInternational Society for Artificial Organs in NewYork City he helped organize the social program thatincluded a trip to the play “They Are Playing OurSong” for the attendees. The music for this was alsoincluded in his musical production for the 6th Anni-versary and Kick Off Ceremony for the InternationalCenter for Medical Technologies Museum GrandRe-Opening and ISRBP Presidential Reception inhonor of Dr Michael DeBakey.

I think he felt most productive in creating newthings whether they were new approaches/conceptsto treating organ disease states or organizations fortheir purpose. He was a fighter and not much couldstand in his way of fulfilling that goal. I can recall thestart of the journal Artificial Organs as an example.He felt strongly about the need to provide a forum toall artificial organ researchers in the world that wasnot bound by national borders that led to the birthof the International Society for Artificial Organs(ISAO) (now the International Federation for Arti-ficial Organs). Of course he needed to establish ajournal to be the official voice of this Society andArtificial Organs was born. Some would say “how doyou finance and operate such an endeavor” but tohim these were minor details. The “minor details”such as journal logo, initial funding, advertising andarticle solicitations, proof reading, typesetting, pro-duction, and shipping were worked out in a very shortperiod of time. In August 1977 the first issue wascreated and delivered to the attendees of the SecondInternational Symposium for Artificial InternalOrgans in Tokyo, Japan which became the First Con-gress of the ISAO. He traveled and lectured exten-sively sharing knowledge and maintaining personaland professional contacts throughout the world(Figs 13–16).

Dr Nosé lived his credo of “Unlimited Curiosity,Unlimited Enthusiasm, Unlimited Optimism, andUnlimited Friendship.” My best wishes to his familyare that they remember him in this light. His impactwas great and far reaching.We are thankful to you for

sharing him with us. We are certainly better personsas a result of knowing him.”

In the following paragraphs we have includedsome selected comments from his former colleaguesand friends.

Dr Yoshinori Mitamura, Professor of Tokai Uni-versity in Sapporo, Japan and Emeritus Professor ofHokkaido University, writes “Dr Yukihiko Noséintroduced me to a world of artificial organs andtaught me not only scientific and technologicalaspects but also how to break through a new researchfield. We need unlimited curiosity, enthusiasm andoptimism. I am proud of working with him. I miss DrNosé. Please rest peacefully.”

Professor Horst Klinkmann, Dean of INFA andHonorary President of ESAO from Rostock,Germany writes “I have been a long time profes-sional and personal friend of Professor Nosé. Wefounded together several international medicalsocieties such as the International Society for Arti-ficial Organs (ISAO), the International Faculty ofArtificial Organs (INFA), and the InternationalSociety for Apheresis (ISFA) in which both of usreceived the Honorary Membership together inSeptember. Professor Nosé was one of the last pio-neers in the field of artificial organs, an ingeniousinventor, and great academic teacher; moreover, hewas an outstanding personality with great humanityand love of his wife, children, and family. Themedical world has lost one of its greatest personali-ties and leaders, who will always remain in ourmemory” (Fig. 17).

Dr Jan Wojcicki, Director of the InternationalCenter for Biocybernetics of the Polish Academy ofSciences, in Warsaw, Poland commented “It was notpossible for me and also for many of his coworkersand students to be with him during his last days butwe all remember his great personality and charisma.Many biomedical engineers and medical doctorsprofited a lot from his advice.”

Dr Rolf Bambauer (Fig. 15, third from the left)from Homburg, Germany notes “Yukihiko Nosé wasa fantastic man, a great scientist, and a pioneer inartificial organs and medical technology. He partici-pated in three international congresses in my area, inHomburg (1985, 1988), and in Saarbrücken (2ndISFA Congress, 1999) with excellent presentations(Fig. 18). I learned a great deal from him at variousinternational symposia around the world. He hadmany friends across the world, because he was anexcellent educator, who tremendously influencedmedical technology. He made great progress in thefield of artificial organs over 40–50 years. I miss himvery much. My condolences to his wife and family.”

In Memoriam6


Drs Wolfgang Ramlow and Professor Dr PeterSchuff-Werner from Rostock, Germany noted “therewill remain an irreplaceable gap inside our apheresiscommunity although many of us had the privilege to

learn from Professor Nosé how apheresis “should”work. With great creativity and concentrated passionhe put things forward. Japanese by heart he became acosmopolitan influencing physicians and scientistsfrom around the world.”

Dr Isamu Koshino writes: “Yuki, thank you foreverything you did and taught me.I will be missing youfor the rest of my life. The calf #75052 shall remainforever in my mind as one of the best gifts and memo-ries you had ever given to me in my time at theDepartment of Artificial Organs at the ClevelandClinic.”

Dr Peter Ivanovich, Past President of the Interna-tional Society for Artificial Organs “extends hisdeepest condolences to Mrs Nosé and his family. Thescientific world has lost a true leader in the field ofartificial organs,Yuki will be ever remembered for hisinventive and generous spirit and his dedicatedservice by his contributions to artificial organsscience and for training and mentoring so many fromall parts of the world. They and everyone influencedby his work and deeds will strive to carry on his spiritto the benefit of mankind.”

FIG. 13. At the 3rd Congress of the International Society for Apheresis held in 2001 in Taipei, Taiwan.

FIG. 14. Drs Akira Yamamoto and Yukihiko Nosé at the Japa-nese Society for Apheresis held in Kyoto, Japan in 1999.

In Memoriam 7


Professor Kazuhiro Atsumi, Emeritus Professor,University of Tokyo, writes “it was with great sorrowthat I received the sad news of the sudden passing ofProfessor Nosé. Professor Nosé was one of the greatpioneers in the field of artificial organs. He was a rivaland also a close friend of mine for many years. He hashad many great achievements and has many follow-ers. I am certain that his passing must be a great lossto Mrs Nosé as he has been such a capable and cheer-ful person and had made so much contribution to thefamily and society. On behalf of all of his colleaguesin the world, I tender deepest sympathy and condo-lences on the passing of Professor Nosé.”

Ji Feng Chen of the Cleveland Clinic recalls “I wishto express my deepest regrets and prayers to the

family and friends of Dr Nosé. Dr Nosé brought meto this country from China to work in his laboratoryas a polymer engineer; a job I have just recentlyretired from after 26 years working in the field ofcardiac assist devices at the Cleveland Clinic. As hisgreatest legacy, Dr Nosé’s leadership and inspirationhas guided the careers of many scientists, engineersand physicians who have contributed greatly to thisfield. He was a mentor to us all and was personallyinvolved in facilitating the reunion of myself with mywife and son at a time when this was not possible forChinese nationals working in the US. Teacher, coun-selor, scientist, physician, international spokesman,these all describe a great man whose memory willlive on in history and in the hearts of those he hastouched.”

FIG. 15. Attending the ISFA 2001 held in Taipei, Taiwan.

FIG. 16. Professor Nosé with Ako Nosé and Tadao Akizawa atthe 6th ISFA, 11th WAA and 27th JSFA meeting held in Yokohama,Japan in 2007.

FIG. 17. Dr Kolff’s “most obnoxious pupils,” Drs Horst Klink-mann and Yukihiko Nosé at Pim Koff’s memorial in Kampen, theNetherlands (quote from Dr Nosé).

In Memoriam8


Dr Yoshi Asanuma of Akita, Japan writes: “DrNosé, I have never forgotten the beautiful days Ispent at the Department of Artificial Organs, Cleve-land Clinic, from 1978 to 1981. You and Dr Paul Mal-chesky are so gifted that we could develop the systemof plasma separation and perfusion over multiplesorbents for the treatment of fulminant hepatitis,and cryofiltration for rheumatoid arthritis. Our paperentitled ‘Macromolecule removal from blood’appearing in the original ASAIO Transactions in 1981was selected as one of the top 25 papers of majorhistorical significance, on the occasion of the 50th

anniversary meeting of ASAIO held in Washington,DC in 2004. All of us (DAO members) have admiredand respected you very much both as a boss and as ahuman being.”

Dr Takashi and Kazue Horiuchi from Mie, Japanwrite: “We didn’t want to accept this sad news.Nothing could fill our emptiness. Nosé Sensei wasalways a big boss for us who possessed a huge energyand power to go forward, not only for himself butalso all of us. He made a big family and kept themgoing to much higher peaks of the academic moun-tains. There are so many memories of Nosé Sensei; Istill remember his footsteps in the early morningwhen I stayed at the overnight experiments. My wifestill remembers his lovesome escort as a father of thebride in our wedding ceremony. Our students stillremember his hearty care when they visited his labo-ratory. To meet him itself lead us to happiness andsatisfaction in our life. We appreciate him forever. Indeepest sympathy.”

Mr Raymond Kiraly, Emeritus Staff at the Cleve-land Clinic notes:“in 1971 Dr Nosé invited me to joinhis group of about a dozen people working on artifi-cial organs at the Cleveland Clinic.Through his vision

and leadership, a multi-disciplinary team grew toover 50 scientists, engineers, technicians, researchfellows, and students and made significant contribu-tions to virtually all artificial organ technologies overthe next 25 years. I remember him as a dedicatedteacher, leader, colleague, and friend. I am thankfulthat I accepted his invitation and started on a new,interesting and exciting career and had the opportu-nity to work daily with this unique and remarkableman who devoted his life to developing lifesavingtherapies for mankind.”

Dr Patrick Moriarty of the University of KansasMedical Center in Kansas City, MO, USA extends“my sympathy and condolences to the family andfriends of Professor Nosé. A legend in the field ofapheresis has passed away but his immeasurable con-tributions to humanity lives on.”

Dr Andre Kaplan of the University of Connecticutin Farmington, CT, USA and the President of the 7th

World Congress of the International Society for Aph-eresis recounts “it is with great sadness that I hear ofYuki’s passing. He was a great innovator and mentorin the field of artificial organs. He will be sorelymissed.”

Dr Floyd D. Loop, Chief Executive officer andChairman, Board of Governors (1989–2004) of theCleveland Clinic Foundation writes “Yuki Nosé wasboth a pioneer and an icon during his tenure at theCleveland Clinic. He broadened the scope of Artifi-cial Organs, recruited an outstanding group of scien-tists and represented the Cleveland Clinic worldwide.He is a great part of the history of the ClevelandClinic and his achievements will not be forgotten.”

Dr Tohru Tani, President of the InternationalSociety for Apheresis and Dr Yoshihiro Endo, Secre-tary Treasurer of the International Society for Aph-eresis write “we are deeply saddened to learn of theuntimely death of Professor Yukihiko Nosé onOctober 13. The medical world has lost an importantleader. At the Congress, he always used to keep afront row seat available throughout a whole day ofmeeting sessions. There is no doubt that manyyounger researchers were encouraged by ProfessorNosé’s positive attitude towards presentations anddiscussions. Professor Nosé was one of the fewfamous Japanese researchers for his work in theUnited States and the rest of the world. As a pioneer,Professor Nosé inspired and taught researchers howthey should be and his entire success stories providedhope and motivation, as well as shared enthusiasmfor hard work.Whenever we met, it gave us an oppor-tunity to renew our understanding of the mission hewished to accomplish. He was a true gentleman, gen-erous and always willing to extend a helping hand for

FIG. 18. Attending the 1999 ISFA Congress in Saarbrücken,Germany.

In Memoriam 9


younger researchers. The cause of apheresis and arti-ficial organs has lost an eloquent spokesman.We whoknow of the great work of Professor Nosé shall misshis wise counsel.We offer our deepest condolences tothe family of Professor Nosé.”

Dr Akif Undar wrote “With great sorrow, I learnedthat Yukihiko Nosé is no longer with us. I express mysincere condolences to Yuki’s family, colleagues andfriends. We have lost not only a pioneer of the artifi-cial organs community, but a great friend and an edu-cator. He will be greatly missed by his family, friends,and colleagues. To keep his legacy, I have created aYoung Investigator Award in his name. The firstYukihiko Nosé Young Investigator Award will bepresented at the 8th International Conference onPediatric Mechanical Circulatory Support Systems &Pediatric Cardiopulmonary Perfusion, June 13–15,2012, Istanbul, Turkey.”

Mrs Jean Kantrowitz offered the following fondremembrance of Dr Yuki Nosé. “In 1961 ProfessorMikami, head of the artificial organs laboratory atHokkaido University, recommended Yukihiko Noséfor a Research Fellowship in Adrian Kantrowitz’slaboratory at Maimonides Hospital in Brooklyn, NewYork. When I learned that we had lost Yuki, I pulledout his file. In it, as part of his application, Yuki sent apresentation on ‘Mikami’s Frame Coil Dialyser—asimple, portable set of the Artificial Kidney.’ Eachpage had a photograph and a beautiful illustration. Itis a 1960 power point, all by his hand. I will be sure itis preserved, perhaps at the National Library ofMedicine, as part of Adrian’s papers, or wherever thefamily chooses. In 1962, Research Fellows were paidabout $3600 for the year, and travel from home wasreimbursed. Yuki arranged his own travel. He wroteus his itinerary and arrival time so we could meet himat the airport. He used this paid-for ticket to go firstto Dow Corning in Midland, Michigan to talk aboutmaterials, and then to stop at the Cleveland Clinic tomeet Dr Kolff. It was a tip-off of his ingenuity. He gotthings done. Adrian was then collaborating with hisbrother Arthur, who headed the AVCO EverettLaboratory in Everett, Massachusetts. Adrian andArthur were collaborating on a mechanical auxiliaryventricle designed for chronic heart failure. Shortlyafter Yuki arrived, Adrian asked him to go to theAVCO laboratory to meet and work with the AVCOengineers. After Yuki arrived, Arthur called Adrian.He was irate. He said he intended to send Yuki backto Brooklyn: ‘He can’t speak English.’ Adrian

insisted that Yuki understood everything, that hecould draw pictures of anything he didn’t have thewords to describe, and that the meeting should con-tinue. . . . WITH Yuki. It did. The collaboration cul-minated in a U-shaped auxiliary ventricle implantedin the ascending aorta of a woman in terminal heartfailure. When activated, the device took Mrs LouiseCerasso out of heart failure.When it was deactivated,she went back into heart failure. This cycle wasrepeated over and over again. . . . In 1966, it was thefirst demonstration that a left ventricular assist devicecould be effective in the treatment of chronic heartfailure. It caused a flurry of excitement at NIH; adelegation came to see the patient. Yuki Nosé hadperformed critical preclinical experiments thathelped determine the design of this U-shaped auxil-iary ventricle. It marked the beginning of a long, pro-ductive research career in the US. Yuki never lost hisroots or relationships in Japan. He was a man for allseasons, for all countries, for all people.”

To those wishing to contribute in the memory ofDr Yukihiko Nosé, a fund has been established inhis name.Donations may be sent by Wire Transfer to:

Account name: Yuki Nosé Charity FoundationJP Morgan Chase Bank, NAAccount number: 912193729SWIFT: CHASUS33Routing number: 111000614

Donations may also be made by sending a checkpayable to:Yuki Nosé Charity Foundation1111 Herman, Suite 26FHouston, TX 77004 USA

Paul S. Malchesky, D.Eng.Managing Editor

Email: [email protected]

and

Tadashi Motomura, MDDepartment of Cardiovascular Surgery and

Transplant SurgeryThe Methodist Hospital Research Institute,

The Methodist Hospital,Texas Medical Center, Houston, TX 77030, USA

Email: [email protected]

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yukihiko nosé: mr artificial organs

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