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Women’s Health Dr. John Bergman

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Women’s HealthDr. John Bergman

Leading Causes of Death for Women• Heart Disease (22.4%)

• 1 in 3 women has some form of Cardiovascular Disease

• Cancer (21.5%) • Chronic Lower Respiratory Diseases (6.1%) • Stroke (5.8%) • Alzheimer’s Disease (4.6%)

Common Disorders and Illnesses in Women• Thyroid disorders (hyper and hypothyroidism) • Gallstone (3-4 times more common in women than men) • Migraine headaches 3:1 ratio, women vs. men • Irritable Bowel Syndrome • Urinary tract infections • Kidney Disease • Autoimmune Diseases:

• Affects 12 million Americans, ¾ of which are women • Osteoporosis

• As many as 1 in 2 women over 50 will suffer a fracture related to osteoporosis

Female Specific Diseases and Disorders• Menstrual irregularities • Urinary tract health

• Urinary incontinence • Urinary Tract infections

• Pelvic floor disorders • Bacterial vaginosis • Vaginitis • Uterine fibroids • Vulvodynia

• Polycystic Ovary Syndrome • Endometriosis • Primary ovarian insufficiency

Cancer •Breast Cancer •Ovarian Cancer •Cervical Cancer

Pregnancy Issues •Preconception and prenatal care •Miscarriages and stillbirths •Preterm labor and premature birth •Breastfeeding •Birth Defects

Is there a Common Link Between All these Problems?• Genetics? • Hormones Imbalances? • Infections? • Does Your Body Randomly decide to Malfunction? • Are these intelligent Responses?

Systems that are “Malfunctioning”• Nervous System • Cardiovascular System • Reproductive System • Respiratory System • Endocrine System • Digestive System • Immune System • Urinary System • Integumentary System • Musculoskeletal System

What do all these Systems have in Common?

Stress involves Every System of the BodyDefinition of Stress: • Any real or imagined threat and your body’s response to it

The Stress Response- First Stage1. The Amygdala

• Area of emotional processing in the brain • Interprets images and sounds • Perceives danger and instantly sends a distress signal to the

hypothalamus

2. Hypothalamus • The Command center of the Body • Controls breathing, blood pressure, heartbeat, and blood vessel

dilation/constriction • Communications with the Autonomic Nervous system • Activates the Sympathetic Nervous System

The Stress Response- First Stage3. Autonomic Nervous System

• Sympathetic: “Fight or Flight” • Parasympathetic: “Rest and Digest” • Stress activates Sympathetic response • The SNS sends signals to the adrenal glands

The Adrenal Glands4. Adrenal Glands

• Secrete Adrenaline (epinephrine)

• Increases heart rate • Increases blood flow to muscles, heart, and other vitals organs

• Increases pulse rate and blood pressure

• Increases Breathing rate and Bronchodilation • Oxygen is sent to the brain to keep it alert

• Sight, hearing and other senses become sharper

• Triggers release of blood sugar from fat storage

The Second Stage of the Stress Response

Hypothalamus-Pituitary-Adrenal Axis • Relies on a series of hormonal signals to keep the SNS active if the brain continues to perceive stress

1. Hypothalamus Releases corticotropin-releasing hormone (CRH) 2. Triggers release of Adrenocorticotropic hormone (ACTH) from

the pituitary 3. Triggers release of cortisol from the adrenal glands 4. When the threat passes cortisol levels fall and the

parasympathetic nervous system decreases the stress response

Functions of Cortisol• Mobilizes and increases amino acids

• the building blocks of protein, in the blood and liver

• Stimulates the liver to convert amino acids to glucose • the primary fuel for energy production

• Stimulates increased glycogen in the liver • Glycogen is the stored form of glucose

• Mobilizes and increases fatty acids in the blood (from fat cells) • to be used as fuel for energy production

• Counteracts inflammation and allergies • Prevents the loss of sodium in urine

• helps maintain blood volume and blood pressure • Maintains resistance to stress

• (e.g. infections, physical trauma, temperature extremes, emotional trauma, etc.) • Maintains mood and emotional stability

The Purpose of the Stress Response•Keeps you Alive during Threatening situations

Fight Flight

Stress has Changed Over the Years

Maladaptation to Chronic Stress• The body can adapt to a state of hyper-stimulation =

Sympathetic Dominance

• The Digestive system, Reproductive system and Endocrine system organs begin to break down from lack of nutrients and blood flow

• Adrenals become exhausted and cortisol levels drop

• Adrenals are usually the first in the order of endocrine function Breakdown, followed by the insulin-producing portion of the pancreas, thyroid, ovaries, parathyroid, pineal, pituitary and finally the link to the autonomic Nervous system the Hypothalamus.  

Effects of Excess Cortisol• Diminishes cellular utilization of glucose • Increases blood sugar levels • Decreases protein synthesis • Increases protein breakdown that can lead to muscle wasting • Causes demineralization of bone that can lead to osteoporosis • Interferes with skin regeneration and healing • Causes shrinking of lymphatic tissue • Diminishes lymphocyte numbers and functions

• Lessens SIgA (secretory antibody productions) which leads to increased susceptibility to allergies, infections, and degenerative disease

Stress and the Adrenals: Adrenal FatigueIf the Adrenals are depleted from chronic stress these are the consequences: • Low body temperature • Nervousness • Depression • Hypoglycemia • Memory loss • Osteoporosis • Weak Immune system • Inflammatory conditions • Vertigo and dizziness • Dry and thin skin • Weakness • Chronic fatigue

• Difficulty gaining weight • Difficulty building muscle • Irritability • Confusion and Cognitive Impairment • Autoimmune hepatitis • Palpitations • Low blood pressure • PMS • Headaches • Unexplained hair loss • Excessive hunger • Indigestion • Alternating diarrhea and constipation • Autoimmune diseases • Insomnia

Stress and the Thyroid• 20 million Americans have hypothyroidism • 10-40% of Americans have suboptimal thyroid function • The thyroid is at the mercy of cortisol

Consequences of an overstimulated and exhausted thyroid:• Depression • Heart disease • Chronic fatigue • Fibromyalgia • PMS (premenstrual syndrome) • Menopausal symptoms • Muscle and joint pains • Irritable bowel syndrome • Autoimmune disease • High cholesterol • Irregular Menstruation

•Low Libido •Infertility •Gum Disease •Fluid retention •Skin conditions such as acne and eczema •Memory problems •Poor stamina •Weight gain •Lethargy •Poor quality hair and nails •Hair loss •Cold hands and feet •Constipation

Stress and The PancreasConsequences of a overstimulated Pancreas due to stress: • Diabetes • Heart disease • Heart attack • Stroke • Glaucoma • Cataracts • Retinopathy • Blindness • Bacterial infections • Fungal infections

• Itchy skin

• Digital sclerosis

• Neuropathy

• Kidney disease

• High Blood pressure

• Foot ulcers

• Gastroparesis

• Hearing loss

• Alzheimer’s disease

Stress and the Heart• 1 in 3 deaths in the U.S. is attributed to heart disease • The most common form of heart disease is Coronary Artery Disease (CAD) • Chronic Epinephrine surges can damage blood vessels and arteries • This increases blood pressure and raises the risk of heart attacks or

strokes

“During moments of high stress, your body releases hormones such as norepinephrine, which the researchers claim can cause the dispersal of bacterial biofilms from the walls of your arteries. This dispersal can allow plaque deposits to suddenly break loose, thereby triggering a heart attack.”

(American Society for Microbiology 65,66)

Other Effects of Chronic Stress• 4 times less blood flow to your digestive system • Decreased metabolism • Decreased enzymatic output in your gut – as much as 20,000-fold!

• Decreased nutrient absorption • Decreased oxygenation to your gut • Elevated cholesterol • Elevated triglycerides • Decreased gut flora populations • Increased food sensitivity

Are we under constant stress?

Annual Stress Survey by the American Psychological Survey

•25% of Americans are experiencing High Levels of Stress

•50% of American experience Moderate stress • Money, Work, and the Economy rank as the Top Sources of Stress

The 3 Types of Stress:

Emotional Physical Chemical

Emotional stress

Physical stress

Chemical stress

Why Women are more susceptible to stress?• Female hormonal imbalances are often related to the stress response

• Chronic Stress imbalances your cortisol levels • Cortisol Imbalance deregulates your female hormones such as Estrogen

• Both Estrogen and Progesterone are necessary in the female cycle and their balance is key for optimal health

• The menstrual cycle further depletes the body of nutrients required for normal function

Female Hormonal Imbalances“People tend to think of women's "hormone problems" as starting in midlife with the onset of menopause. In fact, a dysfunctional pattern can begin during adolescent years or even before birth. The severity of hormonal problems may increase with age, but it is not aging per se that is the root of declining health. It is most often the cumulative physiological effects of stress that cause disruption of the natural rhythms and balancing mechanisms of women's hormones, thereby eventually compromising overall health as well as sexual and reproductive health.”

Michael Borkin N.M.D., Journal of Alternative Medicine 3

The Perfect Recipe for Disaster• Chronic Stress: Chemical, Physical, Emotional • Adrenal Fatigue • Thyroid hyper-stimulation • Pancreatic overload • Hormonal Imbalances • Nutrient Deficient Diet • A Sedentary Lifestyle • Toxic environment • Toxic, processed Food • Antibiotics • Medications • Surgery that removes vital organs

Skid Mark Disease

How do you know you’re stress?Salivary Circadian Test • Chew on a salivette (small dacron roll)- every 4 hours for 24 hours • Results show exact levels of accumulated stress and sex hormone • Saliva contains free fractions of stress and sex hormones • Free fractions are the utilizable hormones that the body has access to

• Can be used along with blood samples that measure total hormone production which includes bound (not free) hormones that are unavailable for use by the body

• Conventional hormone panels usually test only the blood plasma levels of sex hormones and it’s only at the moment of sampling

Steps to Restore Hormonal Health• Support the Endocrine System and allow it time to repair • Support Immune function • Make the proper Dietary and Nutritional changes • Support proper Digestive Function to eliminate any Malabsorption

• Proper Exercise • Reduce Emotional stress

Vitamin D• Vitamin D influences 3,000 or your 24,000 genes • Vitamin D receptors are found throughout your body

• Vitamin D deficiency is directly linked to increased risk of Heart Disease and Cancer

• Deficiency linked to 124% greater risk of dying from all causes 67

• 25% higher risk of dying from heart disease or stroke • Arterial stiffness associated with vitamin D deficiency Proper Vitamin D levels can reduce your risk of Dying by 50%

(American Journal of Cardiology 92,93)

Vitamin DVitamin D Deficiency is linked to: • Digestive disorders • Skeletal disorder including osteoporosis • Depression, mental disorders • Neurodevelopmental disorders (Autism) • Brain Dysfunction, dementia and Alzheimer’s • Chronic infections • Cardiovascular disease • All types of Cancer • Autoimmune Diseases • Premature Aging

Optimize Your Vitamin D levels• UVB exposure from the Sun is the best way to optimize your vitamin D levels

• At least 20 minutes of sun exposure daily during mid day • Your shadow shouldn’t be longer than your height

• Most regions of the planet don’t get proper sunlight for 6 months out of the year • Vitamin D3 supplementation during the winter • Adults required about 8,000IUs per day

Vitamin D and Vitamin K2• Vitamin K2 is essential for proper utilization of vitamin D Sources of Vitamin K2 • Grass-fed organic animal products (eggs, butter, dairy) • Fermented foods • Certain cheeses (Brie, Gouda)

Iodine• The Key to a healthy thyroid and efficient metabolism, and comprises a large part of the thyroid hormone molecule

• T4 has four attached iodine molecules • T3 (the biologically active form of the hormone) has three • Iodine deficiency is one of the three most common nutritional deficiencies, along with magnesium and vitamin D

Iodine has 4 important functions in the body:• Stabilization of metabolism and body weight • Brain Development • Fertility • Optimization of your immune system: iodine is a potent anti-bacterial, anti-parasitic, anti-viral and anti-cancer agent

Factors contributing to Low Iodine levels• In the late 1980’s: The baking industry replaced iodine based anti-caking

agents with bromine-based agents • Competing Halogens which mimic iodine (bromine, fluorine, and chlorine)

• Bromine and fluorine can’t be broken down so they build up in your tissues

• They also grab onto your iodine receptors and block the action of iodide and thyroid hormones

• Fluoridation of water • Diets low in fish, shellfish and seaweed • Vegan and vegetarians diets • Less use of iodide in the food and agricultural industry • Radioactive iodine (medical procedures or environmental exposure)

Sources of Bromine• Pesticides (methyl bromide) used mainly on strawberries in California

• Plastics: used to make computers • Bakery goods and flours often contain a "dough conditioner" called potassium bromate

• Soft drinks: including Mountain Dew, Gatorade, Sun Drop, Squirt, Fresca, and other citrus-flavored sodas – in the form of brominated vegetable oils (BVOs)

• Medications such as Atrovent inhaler, Atrovent Nasal Spray, Pro-Banthine (for ulcers), and anesthesia agents

• Fire retardants: used in fabrics, carpets, upholstery, and mattresses

Detoxing from Fluorine and Bromine• High-dose iodine

• High-dose vitamin C

• Unrefined sea salt

• Epsom salts baths

• Sweating in an Infrared Sauna

Solution For Iodine Deficiency• Iodine supplementation or adding sea vegetables to your diet.   • Non-commercially harvested seaweeds • 5 grams a day or about one ounce per week • Tyrosine, selenium, vitamins A and D, zinc, B vitamins, and omega-3 fats are all needed in order to utilize iodine properly

Magnesium• A mineral used by every organ in your body, especially your heart, muscles, and kidneys

• 80% of Americans are magnesium deficient

• Magnesium is found in more than 300 different enzymes in your body and plays a role in the body’s detoxification process

• Researchers have detected 3,751 magnesium-binding sites on human proteins

• Calcium, vitamin K2 and Vitamin D must be balanced with Magnesium in order to utilize it properly

Magnesium is necessary for:• Activating muscles and nerves • Creating energy in your body by activating Adenosine Triphosphate

• Helping digest proteins, carbohydrates and fats • Serving as a building block for RNA and DNA synthesis • Acting as a precursor for neurotransmitters like Serotonin

Consequences of Magnesium Deficiency:• Hormone imbalance and PMS • Unexplained fatigue and Chronic Fatigue • Weakness • Abnormal heart rhythms • Muscle spasms and twitching • Depression, anxiety, panic attacks • Bowel disorders • Heart disease • Insomnia • Headaches and Migraines • Tooth decay • Blood Clots

• Osteoporosis • Raynaud’s syndrome • Musculoskeletal conditions • Neurological disorders • Kidney Disease • Diabetes • Fibromyalgia • Asthma • Hypertension • Seizures • Coronary Spasms • Personality changes

Natural Sources of Magnesium• Dark Leafy Greens (Raw Spinach) • Nuts and Seeds (Squash and Pumpkin Seeds) • Fish (Mackerel) • Beans and Lentils • Whole Grains (Brown Rice) • Avocados • Bananas • Dried Fruit (Figs, prunes, dates, raisins) • Cacao (Dark Chocolate)

Stress Reduction Breathing ExerciseThe 4-7-8 Breathing Exercise 1. Sit up straight 2. Place the tip of your tongue up against the back of your front

teeth. Keep it there through the entire breathing process 3. Breathe in silently through your nose to the count of four 4. Hold your breath to the count of seven 5. Exhale through your mouth to the count of eight, making an

audible “woosh” sound 6. Repeat the cycle another three times, for a total of four

breaths

Benefits of Nose Breathing• Air is warmed and humidified before entering your lungs • The cilia in your nose trap pathogens, dust and other foreign particles acting as a filter

• Nerves in your nasal passages are connected your hypothalamus which regulates heart and breathing rates

• Nitric Oxide (NO) is made by your sinus mucous membranes • When you breathe through your nose you carry NO into your lungs

• NO is a bronchodilator and vasodilator • NO lowers your blood pressure, increases oxygen absorption, kills bacteria, viruses and boosts your immune system

How breathing affects your Health

• Reduces mental and physical fatigue

• Improves blood circulation and cell oxygenation

• Stimulates the Parasympathetic Nervous System

• Breathing acts as a pump to massage internal organs

• The action of your diaphragm helps push lymph throughout your body, which helps eliminate toxic waste and strengthen your immune system

• Toxic CO2 waste is eliminated directly through your breath

ExerciseProper Exercise helps you: • Get high-quality sleep • Lose, gain, or maintain weight • Improve your resistance to infections • Improve your brain function • Prevent and relieve chronic pain • Improve your Emotional health • Lower your risk of cancer, heart disease, and diabetes

High Intensity Interval Training • Excessive cardio training such marathons or triathlons may actually pose a seven-fold increase in your cardiac risk.

• Extreme cardio puts extraordinary stress on your heart, one that your body is not designed for HIIT is the type of exercise your body is designed for

Steps for HIIT:1. Warm up for 3 minutes 2. Exercise as hard and fast as you can for 30 seconds

By the end of this 30-second period, you should: • Be in oxygen debt, and will have difficulty breathing. • Begin to sweat profusely (around the 2nd or 3rd repetition)

• Feel a muscle "burn" as your lactic acid increases.

3. Recover for 90 seconds 4. Repeat the exercise and recovery 7 more times

How to Deal with Emotional Stress• Daily Prayer and Meditation • Neurolinguistic Programming • Daily Affirmations: ”I Am” statements • Emotional Freedom Technique (EFT) • The Demartini Method: For Traumatic Emotional Events

The 5 Keys to Health and Healing

Proper nerve supply Regular Exercise Proper Nutrition

Sufficient Rest Prayer and Meditation

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References1. https://www.nichd.nih.gov/health/topics/womenshealth/conditioninfo/Pages/whatconditions.aspx

2. http://www.cdc.gov/women/lcod/2013/index.htm

3. Alternative Medicine magazine, September 2000/#37

4. Hoehn K, Marieb EN (2010). Human Anatomy & Physiology. San Francisco: Benjamin Cummings. ISBN 0-321-60261-7.

5. Coderre L, Srivastava AK, Chiasson JL (June 1991). "Role of glucocorticoid in the regulation of glycogen metabolism in skeletal muscle". Am. J. Physiol. 260 (6 Pt 1): E927–32. PMID 1905485.

6. Elenkov IJ (2004). "Glucocorticoids and the Th1/Th2 Balance". Annals of the New York Academy of Sciences 1024 (1): 138–146. Bibcode:2004NYASA1024..138E. doi:10.1196/annals.1321.010. PMID 15265778.

7. Silverthorn, Dee Unglaub (2013). Human Physiology: An Integrated Approach (6th ed.). Glenview, IL: Pearson Education. pp. 850–890. ISBN 0-321-75007-1.

8. Sherwood, Laurelee (2013). Human Physiology: From Cells to Systems (8th ed.). Belmont, California: Cengage. pp. 735–794. ISBN 1-111-57743-9.

9. "Menstruation and the menstrual cycle fact sheet". Office of Women's Health, USA. December 23, 2014. Retrieved 25 June 2015.

10. Women's Gynecologic Health. Jones & Bartlett Publishers. 2011. p. 94. ISBN 9780763756376.

11. Biggs, WS; Demuth, RH (15 October 2011). "Premenstrual syndrome and premenstrual dysphoric disorder.". American Family Physician 84 (8): 918–24. PMID 22010771.

12. Kristin H. Lopez (2013). Human Reproductive Biology. Academic Press. p. 53. ISBN 9780123821850.

13. http://articles.mercola.com/sites/articles/archive/2000/11/12/womens-hormones.aspx

14. The Guardian, March 14, 2013

15. Alcohol Clin Exp Res. 2008 July; 32(7): 1242–1250.

16. NBC News March 10, 2013

17. Circulation 2012 Jan 24;125(3):491-6

18. Circulation 2005; 111: 472-479

19. Harvard Health Beat March 27, 2012

20. Journal of Physiology and Pharmacology 2011 Dec;62(6):591-9.

References21. N Engl J Med September 30, 1999;341:1013-1020,1073-1074.

22. Pediatr Res. 2011 May;69(5 Pt 2):41R-7R 23. J Mol Endocrinol. 2001 Feb;26(1):67-77 24. Endocr Pract. 2006 Sep-Oct;12(5):572 25. Ann N Y Acad Sci. 2006 Jun;1069:322-45.

26. Br Med J. Sep 10, 1949; 2(4627): 555–562. 27. Encephale. 2004 May-Jun;30(3):267-75 28. Encephale. 2004 May-Jun;30(3):267-75 29. European Journal of Endocrinology (1998) 138 1–9

30. Mol Biol Rep. 2014 Apr;41(4):2419-25. 31. Neuro Endocrinol Lett. 2013;34(5):409-17 32. Neurosci Biobehav Rev. 2014 Mar;40:62-79 33. Am J Psychiatry 1 February 2007: 164(2); 201-204

34. Br J Psychiatry. 2011 Apr;198(4):264-8 35. Psychoneuroendocrinology April 2012: 37(4);519–533 36. Acta Endocrinol July 1, 1993 129 26-30 37. Psychoneuroendocrinology. 2013 Jul;38(7):1007-13

38. J Obstet Gynecol Neonatal Nurs. 2013 Jan-Feb;42(1):E26-32. 39. KellyBroganMD.com Predicting Postpartum Depression 40. Eur J Endocrinol November 1, 2001 145 579-584 41. J Am Osteopath Assoc. 2008 Sep;108(9):503-7

References42. Maedica (Buchar). Apr 2010; 5(2): 116–123

43. BMJ2011;342:d2616

44. J Clin Endocrinol Metab. 2007 Apr;92(4):1263-8

45. Bipolar Disord. 2014 Feb;16(1):58-71

46. J Clin Psychiatry. 2014 Feb;75(2):162-8.

47. Indian J Psychiatry. 1980 Apr-Jun; 22(2): 200–202

48. Asian J Psychiatr. 2013 Feb;6(1):42-5

49. Am J Gastroenterol. 2001 Mar;96(3):751-7

50. J Psychosom Res. 2002 Sep;53(3):789-93

51. Environ Res. 2014 Feb;129:47-51

52. Brodal, Per (2004). The Central Nervous System: Structure and Function (3 ed.). Oxford University Press US. pp. 369–396. ISBN 0-19-516560-8.

53. Sympathy, Sympathetic. Evolution of a Concept and Relevance to Current Understanding of Autonomic Disorders

54. Jänig, Wilfrid (2006). The integrative action of the autonomic nervous system : neurobiology of homeostasis. Cambridge: UK. pp. 132–135. ISBN 9780521845182.

55. Moro, C; Tajouri, L; Chess-Williams, R (January 2013). "Adrenoceptor function and expression in bladder urothelium and lamina propria". Urology. 81 (1): 211.e1–7. doi:10.1016/j.urology.2012.09.011. PMID 23200975.

56. Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J (2009). "The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications". J. Am. Coll. Cardiol. 54 (19): 1747–62.

57. http://www.health.harvard.edu/staying-healthy/understanding-the-stress-response

58. Journal of Toxicology and Environmental Health 1992, 37:535-548 "Evidence of Thyroxine Formation Following Iodine Administration in Sprague-Dawley Rats"

59. Journal of Toxicology and Environmental Health 1991, 32:89-101 "Comparison of Toxicity Induced by Iodine and Iodide in Male and Female Rats"

60. Journal of Toxicology and Environmental Health 1998, 55:93-106 "Comparison of the Effects of Iodine and Iodide on Thyroid Function in Humans"

61. Biological Trace Element Research 2006, 110:193-209 "Analyses of Toxic Metals and Essential Minerals in the Hair of Arizona Children with Autism and Associated Conditions, and Their Mothers"

62. Nature Medicine June 22, 2014 [Epub ahead of print]

References63. Techsonia June 25, 2014

64. Natureasia.com June 23, 2014

65. Lanter BB, Sauer K, Davies DG. 2014. Bacteria present in carotid arterial plaques are found as biofilm deposits which may contribute to enhanced risk of plaque rupture. mBio 5(3):e01206-14. doi:10.1128/mBio.01206-14.

66. http://www.asm.org/index.php/journal-press-releases/92974-bacteria-help-explain-why-stress-fear-trigger-heart-attacks

67. Clinical Endocrinology, Volume 71, Number 5, November 2009, pp. 666-672(7)

68. Am J Clin NutrMarch 2004 vol. 79 no. 3 362-371

69. The International Society for Clinical Densitometry, Vitamin D Deficiency: The Silent Epidemic of the Elderly

70. American Journal of Geriatric Psychiatry December 2006; 14(12): 1032-1040

71. Mayo Clinic Proceedings June 21, 2013

72. Orthomolecular Medicine press release January 17, 2013

73. J Biol Chem. 2010 January 22; 285(4): 2227–2231

74. Nutrients 2013, 5(10), 3898-3909

75. PsychCentral.com December 7, 2013

76. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD007470

77. Diabetes Care March 2006; 29(3): 722-724

78. Diabetes Care 2012 Jun 29. [Epub ahead of print]

79. Diabetes Care 2012 Mar;35(3):565-73

80. Science World Report December 2, 2013

81. Am J Clin Nutr. 2007 Jun;85(6):1586-91

82. National Post

83. American Journal of Preventive Medicine March 2007: 32(3); 210-216

References84. International Journal of Cancer 2011 Mar 15;128(6):1414-24

85. American Journal of Clinical Nutrition June 2007: 85(6); 1586-1591

86. Annals of Epidemiology July 2009: 19(7); 468-486

87. DrCarolynDean.com The Magnesium Miracle

88. ADA Diabetes Care October 2, 2013

89. Curr Osteoporos Rep. 2009 Dec;7(4):111-7.

90. Bone November 2013; 57(1):84-91

91. The American Journal of Clinical Nutrition September 2012

92. DOI: http://dx.doi.org/10.1016/j.amjcard.2011.09.020

93. http://www.ajconline.org/article/S0002-9149%2811%2902933-X/abstract

94. The Johns Hopkins University Press ; December 1, 1986

95. Int Arch Allergy Immunol. 2011;156(4):352-61

96. Curr Opin Otolaryngol Head Neck Surg.2007 Aug;(15(4)):258-63

97. Nederlands tijdschrift voor geneeskunde (1998 Dec 26) 142 (52): 2828–30

98. Culotta E, Koshland DE Jr.. NO news is good news. Science.1992 Dec 18;(258(5090)):1862-5

99. Eur J Pharmacol.1992 Jan 14;(210(2)):221-2

100. The Influence of the Carbon Dioxide Content of Blood on its Oxygen Binding.  Bass C. (1989). "The hyperventilation syndrome." Respiratory Disease in Practice 41: 13-16.

101. Ley R, Yelich G. Fractional end-tidal CO2 as an index of the effects of stress on math performance and verbal memory of test-anxious adolescents. The impacts of open-mouth breathing on upper airway space in obstructive sleep apnea: 3-D MDCT analysis.Eur Arch Otorhinolaryngol. 2010 Oct 19

102. American Review of Respiratory Disease 1978

103. American Journal of Orthodontics April 1983

104. The long face syndrome and impairment of the nasopharyngeal airway.

References105. Laryngoscope.2010 Oct;120(10);():2089-93

106. J Otorhinolaryngol.2011;(Sep-Oct;77(5):656-62

107. J Bras Pneumol.2011;(Jul-Aug;37(4)):471-9

108. Journal Pediatrics (Rio J).2011;(Jul-Aug;87(4)):471-9

109. Magarian G. Hyperventilation: a diagnosis begging for recognition

110. Scharf MB, Cohen AP Diagnostic and treatment implications of nasal obstruction in snoring and obstructive sleep apnea. Staevska MT et al. Rhinitis and sleep apnea. Allergy Asthma Report 2004 May;4(3):193-9

111. Acta Otolaryngol Suppl. 1996;523:228-30

112. American Journal of Psychiatry, 149, 1589–1591

113. Conf Proc IEEE Eng Med Biol Soc. 2007: 5323-5325

114. Indian J Med Research 120(2): 115-122

115. Am J Physiol Regul Integr Comp Physiol July 289:R148-R155

116. Journal of Applied Physiology.2001;(Apr;90(4)):1623-9

117. Journal of Applied Physiology.2002;(May;92(5)):2071-9

118. Eur J Appl Physiol 2008;102:609–13. Epub 2007 Dec 19

119. Journal Applied Physiology.1995 ;(Oct;79(4):):1278-85

120. Ageing Res Rev. 2016 Jan ;25:13-23. Epub 2015 Nov 28. PMID: 26607411

121. Int J Sport Nutr Exerc Metab. 2012 Nov 19. Epub 2012 Nov 19. PMID: 23307404

122. Clin Ter. 2009 Mar-Apr;160(2):105-9. PMID:19452097

123. Eur J Cardiovasc Prev Rehabil. 2009 Feb;16(1):47-52. PMID: 19169141

124. PLoS One. 2016 ;11(4):e0154075. Epub 2016 Apr 26. PMID: 27115137

125. Med Sci Sports Exerc. 2001 Apr ;33(4):532-41. PMID: 11283427

126. Br J Nutr. 2002 May;87(5):517-23. PMID: 12010590

127. Med Sci Sports Exerc. 2008 Nov;40(11):1863-72. PMID: 18845966

128. Respirology. 2007 May;12(3):381-8. PMID: 17539842

129. J Int Soc Sports Nutr. 2015 ;12:25. Epub 2015 Jun 4. PMID: 26097440

130. Aging Clin Exp Res. 2009 Nov 6. PMID: 19920410