who is this guy? b.a. chemistry ‘79 baylor university m.d. and residency ‘87 utmb - galveston...

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Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology University of Arkansas Private Practice Little Rock, Arkansas Scott Dinehart, MD Scott Dinehart, MD QuickTime™ and a decompressor are needed to see this picture.

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Page 1: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Who is this Guy?B.A. Chemistry ‘79

Baylor UniversityM.D. and Residency ‘87

UTMB - GalvestonMohs Fellowship ‘88

Duke UniversityProfessor of Dermatology

University of ArkansasPrivate Practice

Little Rock, Arkansas Scott Dinehart, MDScott Dinehart, MD

QuickTime™ and a decompressor

are needed to see this picture.

Page 2: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Conflict of Interest

Speaker and Consultant for Genentech

Page 3: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Clinical and Practice Management Tips

Scott M. Dinehart, MD

Page 4: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 6: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

“Realize that acne can be made worse by refined carbohydrates and certain dairy products, particularly skim milk”

Page 7: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 8: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 9: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 10: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 11: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

“Facial acne severity improved more on the low glycemic index diet” Reynolds, et al.

Nutrients.Oct 2010;2(10):1060-72.

Page 12: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 13: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

“Glycemic load and frequency of milk and ice cream ingestion were positively associated with acne” Ismail, et al.

BMC Dermatol. 2012;12:13.

Page 14: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

“Subjects adhering to a LGL diet resulted in clinical and histopathological improvements of acne” Kwon, et al.

Acta Derm Vener. 2012;92(3):241-6.

Page 15: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

“Regular consumption of sweets, nuts, chocolate, and oily foods were recognized as risk factors for acne while spicy foods and fasting were not associated with acne severity”

Ghodsi, et al.

J Invest Dermatol. Sep 2009;129(9):2136-41.

Page 16: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Causes

• Lactoferrin, an anti-inflammatory milk protein

• Hormones in milk

• Insulin?

Page 17: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

“Substitute high glycemic index foods for low glycemic index foods, and avoid refined carbohydrates whenever possible” Scott Dinehart, MD

Page 18: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Clinical History

• A 44 year old physician has a changing mole on his back

• You decide to biopsy the lesion using a shave technique

Page 19: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 20: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 21: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 22: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

You Make the CallA. The lesion needs no re-excision

B. The lesion can be re-excised but only needs a wider shave because the deep margin is clear

C. The lesion needs full thickness excision

D. A and B are correct approaches

Page 23: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

You Make the CallA. The lesion needs no re-excision

B. The lesion can be re-excised but only needs a wider shave because the deep margin is clear

C. The lesion needs full thickness excision

D. A and B are correct approaches

Page 24: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Re-excision of Dysplastic Nevi

• Pathologist deserves a vote

• Clinician deserves a vote

• But in general….

Page 25: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

“there is mounting evidence that re-excision of lesions with low-grade atypia (mild and moderate DN) may not be necessary, even when positive margins are found; the recurrence rates of these nevi are low, and there are no reports of subsequent development of melanoma in these lesions” Duffy et al. Arch Dermatol 148:259, 2012

Page 26: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

• May not need to re-excise mild to moderate dysplatic nevi

• If you re-excise it is important to know if deep or lateral margins involved

• If lateral margins present, can re-shave

• Severely dysplastic nevi need full thickness re-excision with minimal margin

Page 27: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Dysplastic Nevi• Tip #1: Trend is not to re-excise mild and

moderate dysplastic nevi

• Tip #2: Work with your dermatopathologist. A shave removal can often work for mild or moderate dysplastic nevi that you want removed if only the lateral margin is involved

• Tip #3: Start the shave removal more lateral to avoid lateral margin positives!

Page 28: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Wet hair in high risk scalp cancer patients

Page 29: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 30: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 31: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 32: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Use of a hair dryerUse of a hair dryer

• Hair dryers on “warm” can dry the Hair dryers on “warm” can dry the scalpscalp

Page 33: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Use of a hair dryerUse of a hair dryer• Hair dryers on “cold” can be used to Hair dryers on “cold” can be used to

EXAMINE the scalpEXAMINE the scalp

Page 34: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Use of a Use of a hair dryerhair dryer

• Only needed on Only needed on selected selected patients to find patients to find lesions on the lesions on the scalpscalp

Page 35: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

“There are only two times when you need to consider doing a KOH examination”

Page 36: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 37: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

KOH Preparation• Use KOH with DMSO (no need to

heat)

• Dip blade in KOH prior to scraping lesion (scale will stick to the blade)

• Look on high power for hyphae (look like thin black lines)

Page 38: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology

Identify the “red dot” Identify the “red dot”

basal cell carcinomabasal cell carcinoma

Page 39: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 40: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 41: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology
Page 42: Who is this Guy? B.A. Chemistry ‘79 Baylor University M.D. and Residency ‘87 UTMB - Galveston Mohs Fellowship ‘88 Duke University Professor of Dermatology