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Supplemental (Online-Only) Material
Appendix E1. Variables Considered in Multivariable Analyses
DemographicsAge (y), sex, race (white, black, other), weight (kg), height (cm), weight/height ratio,
body surface area (m2), body mass index (kg•m-2)
Status/symptomsNew York Heart Association functional class (I-IV), emergency operation
Cardiac comorbidityPrior myocardial infarction, atrial fibrillation or flutter, heart failure
Noncardiac comorbidityTreated diabetes, peripheral arterial disease, carotid disease, hypertension, history of
smoking, prior stroke, cholesterol (mg•dL-1), triglycerides (mg•dL-1), creatinine (mg•dL-1)
Coronary anatomyNumber of coronary systems diseased (≥50% stenosis), left anterior descending (LAD)
disease (≥50%, moderate [50% to 69%], severe [≥70%]), left circumflex (LCx) system
disease (≥50%, moderate [50% to 69%], severe [≥70%]), right coronary artery (RCA)
system disease (≥50%, moderate [50% to 69%], severe [≥70%]), diagonal (Dg) disease
(≥50%, moderate [50% to 69%], severe [≥70%]), location of moderate CAD (LAD, Dg,
LCx, RCA)
Coronary artery bypass grafting procedures
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Number of internal thoracic artery (ITA) grafts used to graft severely stenosed arteries
(none, 1, 2), conduit used to bypass moderate CAD (none, ITA, saphenous vein [SV]
graft, radial artery, other), graft locations (LAD, LAD diagonals, LCx territory, RCA
territory), interaction terms for conduit used to bypass moderate CAD in each location
(none, ITA, SV)
SupportCardiopulmonary bypass (off-pump versus on-pump), bypass time (min)
ExperienceDate of operation (years since January 1, 1972)
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Table E1. Postoperative Angiograms Available for Analysis
Time from Index CABG>0 ≥3 mo ≥6 mo ≥1 y ≥5 y ≥10 y ≥15 y ≥20 y
Nongrafted native vessel# Patients 489 477 469 422 260 134 66 21
# Angios 683 665 648 578 338 164 72 22
ITA-grafted native vessel# Patients 371 357 351 337 237 112 34 6
# Angios 541 520 509 481 322 141 38 6
SV-grafted native vessel# Patients 957 921 899 842 607 307 100 14
# Angios 1,371 1,325 1,295 1,216 836 402 124 18
Grafts# Patients (ITA) 376 362 357 345 245 118 33 5
# Angios 560 538 527 499 334 149 39 5
# Patients (SV) 1,016 981 959 902 653 325 101 13
# Angios 1,467 1,420 1,390 1,310 907 429 127 17
Angios = angiograms; CABG = coronary artery bypass grafting; ITA = internal thoracic artery;
SV = saphenous vein.
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Table E2. Risk Factors Associated With Higher Likelihood of Having Higher Grade of Postoperative Stenosis (More Progression of Disease) in Left-sided Coronary Arteries versus Right Coronary Artery
Factor Estimate ± SE p
Overall
Younger age -1.00 ± 0.33 .003
Diabetes 0.42 ± 0.195 .03
Peripheral arterial disease 0.53 ± 0.23 .02
No prior stroke -0.79 ± 0.40 .05
Male 0.23 ± 0.16 .17
Comparisons
No graft (left side) reference —
ITA graft (left side) 1.6 ± 0.20 <.0001
SV graft (left side) 2.0 ± 0.19 <.0001
No graft (RCA) 0.97 ± 0.22 <.0001
ITA graft (RCA) 1.7 ± 0.46 .0001
SV graft (RCA) 2.7 ± 0.21 <.0001
Disease progression was similar in ITA-grafted moderately stenosed left-sided vessels and ITA-
grafted moderately stenosed RCAs (0.14 ± 0.45, p = .8).
Disease progression was higher in SV-grafted moderately stenosed RCAs than in SV-grafted
moderately stenosed left-sided coronary arteries (0.75 ± 0.16, p < .0001).
ITA = internal thoracic artery; LAD = left anterior descending coronary artery; SE = standard
error; SV = saphenous vein.
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Fig E1. Frequency of occurrence of graft stenosis (percentage of lumen diameter).
ITAs = internal thoracic artery grafts; SVs = saphenous vein grafts.