Toxicology, 72 (1992) 359-361 359 Elsevier Scientific Publishers Ireland Ltd.

T O X I C O L O G Y

V O L U M E C O N T E N T S

Volume 72 (1992)

Paraquat damage of rat liver mitochondria by superoxide production depends on extramitochondrial NADH (A combined electron microscopy/biochemical study) by K.-I. Hirai, K. Ikeda and G.-Y. Wang (Ishikawa, Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Influence of dietary protein levels on the fate of methylmercury and glutathione metabolism in mice (Low protein diet may decrease urinary Hg excretion by increasing retention of MeHg metabolites in renal cells) by T. Adachi, A. Yasutake and K. Hirayama (Kumamoto, Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . .

Meso-2,3-dimercaptosuccinic acid (DMSA) affects maternal and fetal copper metabolism in Swiss mice (Fetal liver Cu concentrations showed decreases with increasing DMSA doses) by M. Weldon Taubeneck, J.L. Domingo, J.M. Llobet and C.L. Keen (Davis, CA and Reus, Spain)

Effects of dimethylformamide on hepatic microsomal monooxygenase system and glutathione metabolism in rats (Repeated administration of DMF decreases cytochrome P-450 and increases glutathione-s- transferase activity in the liver) by K. Imazu, K. Fujishiro and N. Inoue (Kitalyushu, Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Trichothecene mycotoxins inhibit phosphoinositide hydrolysis in bovine platelets stimulated with platelet activating factor (The lipophilic nature of a trichothecene may be a factor in determining toxicologic potential) by K.M. Grandoni, P.A. Gentry, B.J. Holub and B. Yagen (Guelph, Ontario and Jerusalem, Israel)

The accumulation and metabolism of 3-trifluoromethylpyridine by rat olfactory and hepatic tissues (After oral dosing both tissues show a 4- to 8-fold accumulation within several hours, while other tissues at best show a doubling of tissue concentration) by P.M. Hext and E.A. Lock (Macclesfield, U.K.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Toxicity of monochloroacetic acid administered by garage to F344 rats and B6C3FI mice for up to 13 weeks (Rats are more sensitive than mice and NOEL's are estimated to be 30 mg/kg for rats and 100 mg/kg for mice) by B.J. Bryant, M.P. Jokinen, S.L. Eustis, M.B. Thompson and K.M. Abdo (Research Triangle Park, N C ) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Effects of low-level lead exposure on hypothalamic hormones and serum progesterone levels in pregnant guinea pigs (Lead exposure lowered serum progesterone in the dams but failed to affect litter size or organ and body weight of the fetuses) by E.M. Sierra and E. Tiffany-Castiglioni (College Station, TX) . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Comparison of several oximes against poisoning by soman, tabun and GF (Two effective compounds are identified) by P.M. Lundy, A.S. Hansen, B.T. Hand and C.A. Boulet (Ralston, Alberta) . . . . . . . . . . . . . . . . .

Book Reviews . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Announcements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Neurotoxicity of acute and repeated treatments of tabun, paraoxon, diisopropyl fluorophosphate and

isofenphos to the hen Only hens treated with diisopropyl fluorophosphate developed signs of organo- phosphate-induced delayed nenropathy) by J.D. Henderson, R.J. Higgins, J.C. Dacre and B.W. Wilson (Davis, CA and Frederick, MD) .

Protective antioxidant mechanisms in rat and guinea pig tissues challenged by acute exposure to cigarette smoke (Both mainstream and sidestream cigarette smoke elicit a transient depletion of pulmonary glututhione; however, tissue stores are replaced again rapidly) by M.H. Bilimoria and D.J. Ecobichon (Montreal, Quebec) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

1-16

17-26

27-40

41-50

51-60

61-75

77-87

89-97

99-105 107-109 111-115

117-129

131-144

360

Lipid peroxidation and loss of potassium from red blood cells produced by phototoxic quinolones (Increased cation permeability is attributed to photooxiflation of amino acid residues of erythrocyte membrane proteins) by A.M. C~irdenas D., M.P. Cort6s, E. Fernfindez B. and W. Pefia (Valparaiso, Chile) . . . . . . . . . 145-151

Free radical-mediated lung response to the monofunctional sulfur mustard butyl 2-chloroethyl sulfide after subcutaneous injection (Biochemical signs of oxidative stress are found in the lung) by N.M. Elsayed, S.T. Omaye, G.J. Klain and D.W. Korte, Jr. (San Francisco and Los Angeles, CA) 153-165

Cadmium effect on zinc metabolism in human trophoblast cells: involvement of cadmium-induced metallothionein (Metailothionein may play an important role in the regulation of materno-fetal transport of zinc) by A, Torreblanca, J. Del Ramo and B. Sarkar (Toronto, Ontario) . . . . . . . . . . . . . . . . . . . . . . . . . . 167-174

A primary culture system of adult rat heart cells for the evaluation of cocaine toxicity (Acute toxic effects are demonstrated at a concentration of 10 -5 M) by A.A. Welder (Oklahoma City, OK) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175-187

Etiology of sarcoplasmic reticulum calcium release channel lesions in doxorubicin-induced cardiomyopathy (A possible mechanism for doxorubicin-indoced cardiomyopathy) by I.N. Pessah, M.J. Schiedt, M.A. Shalaby, M. Mack and S.N. Girl (Davis, CA and Giza, Egypt) 189-206

DNA damage induced by alachlor after in vitro activation by rat hepatocytes (An account of the complex metabolism of this herbicide and its action on DNA) by M. Bonfanti, P. Taverna, L. Chiappetta, P. Villa, M. D'lncalci, R. Bagnati and R. Fanelli (Milan, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207-219

Effect of avarol and avarone on in vitro-induced microsomal lipid peroxidation (Inhibition of peroxidative process by avarol and avarone) by M.A. Belisario, M. Maturo, R. Pecce, S. De Rosa, G.R.D. Villani (Naples, Italy) . . . . . . . . . . . 221-233

Book Review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235-236 Announcements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237-238 Action of allopurinol and aspirin on rat whole-embryo cultures (The embryotoxic effects in vitro can be

moderately modified through metabolic activation by microsomal oxidase from rat and man) by F. Sp6zia, R. Fournex and B. Vannier (Romainville, France) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239-250

Effect of ethanol on the distribution of cadmium between the cadmium metallothionein- and non- metallothionein-bound cadmium pools in cadmium-exposed rats (Ethanol alters the proportion of the non-MT-associated Cd in a complex manner) by G. Sharma, R. Nath and K. Dip Gill (Chandigarh, India) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251-263

Hematotoxic effects of benzene analyzed by mathematical modeling (Time-curve and steady-state analysis were applied to data from studies on in viva benzene toxicity) by S. Scheding, M. Loeffier, S. Schmitz, H.-J. Seidel and H.-E. Wichmann (Wuppertal, Koeln and

Ulm/Donau, Germany) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265-279 Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium (Metallothionein may

protect against Cd toxicity even when intracellular glutathione levels are low) by H. Man Chan and M.G. Cherian (London, Ontario) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281-290

Sub-acute toxicity of piperonyl butoxide in F344 rats (Signs of toxicity were found in liver and kidney) by T. Fujitani, H. Ando, K. Fujitani, T. lkeda, A. Kojima, Y. Kubo, A. Ogata, S. Oishi, H. Takahashi, O. Takahashi and M. Yoneyama (Tokyo, Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291-298

Acute effects of carboxyatractyloside and stevioside, inhibitors of mitochondrial ADP/ATP transloca- tion, on renal function and ultrastructure in pentobarbital-anesthetized dogs (Carboxyatractyloside affects primarily S t and S 2 cells of the proximal tubules) by M.E. Krejci and D.A. Koechel (Toledo, OH) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299-313

Importance of hepatocyte culture conditions in dimethylnitrosamine-induced suppression of antibody response in the mixed cultures of murine hepatocytes and splenocytes The activation of DMN to immunosuppressive forms can be modulated by different culture conditions) by T.-C. Jeong, K.-H. Yang and M.P. Holsapple (Richmond, VA and Taejon, Korea) . . . . . . . . . . 315-327

Roles of active oxygen species in glomerular epithelial cell injury in vitro caused by puromycin aminonucleoside (Hydrogen peroxide and hydroxyl radical are implicated in poromycin toxicity) by M. Kawaguchi, M. Yamada, H. Wada and T. Okigaki (Hyogo and Okayama, Japan) . . . . . . . 329-340

361

Involvement of glutathione in cis-platinum toxicity in Escherichia coli KI2 (In bacterial mutants as procaryotic models for eukaryotic cells GSH protects DNA against nucleophilic attack) by B. Salles and P. Calsou (Toulouse, France) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341-350

Contents of journals relating to Toxicology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351-352 Subject Index Volume 72 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 353-355

Author Index Volume 72 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 357 Contents Volume 72 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359-361