3 7 9

Tamaro, M., see Venturini, S. Tew, K.D., see Jump, D.B. Tisdale, M.J., The effect of cyclic nucleo-

tides on DNA polymerase, thymidy- late synthetase, thymidine kinase and deoxynucleoside levels of Walker carci- noma, 115

Tomatis, L., see Margison, G.P.

Umezawa, K., M. Sawamura, T. Matsu- shima and T. Sugimura, Inhibit ion of chemically induced sister chromatid exchanges by protease inhibitors from Streptomyces, 247

Vecchi, A., A. Mantovani, M. Sironi, W. Luini, M. Cairo and S. Garattini, Effect of acute exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin on humo- ral antibody production in mice, 337

Venturini, S., M. Tamaro, C. Monti- Bragadin, F. Bordin, F. Baceiechetti

and F. Carlassare, Comparative muta- genicity of linear and angular furocou- matins in E. coli strains deficient in known repair functions, 203

Virkki, L., see Hemminki, K.

White, I.N.H. and M. Suzangar, Cytotoxic effects of norethindrone-4~,5/~-epoxide to Walker cells in culture and to rat liver in vivo, 355

Willis, R.J., see Kratzing, C.C. Wolf, W., see Cole, W.C.

Yamazoe, Y., K. Ishii, T. Kamataki, R. Kato and T. Sugimura, Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, TRP-P-2, formed by rat liver micro- somes, 125

Zheljazkov, L., see Kaneti, J.

CHEMICO-BIOLOGICAL INTERACTIONS

VOLUME 30 (1980)

CONTENTS

On the fidelity of DNA synthesis: ~effects of steroids and intercalating agents by M.A. Sirover and L.A. Loeb (Philadelphia, PA) . . . . . . . . . . . . . . . . . . . . . 1

Mutagenicity of halogenated aliphatic hydrocarbons in Salmonella typhimurium, Streptomyces coelicolor and Aspergillus nidulans by M. Bignami, G. Conti, L. Conti, R. Crebelli, F. Misuraca, A.M. Puglia, R. Randazzo, G. Sciandrello and A. Carere (Rome and Palermo, Italy) . . . . . . . . . 9

Interaction of zinc ions with electron carrying coenzymes NADPH and NADH by J.C. Ludwig, R.L. Misiorowski, M. Chvapil and M.D. Seymour (Tucson, A Z ) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25

Probes to study the effect of methyl nitrosourea on ADP-ribosylation and chromatin structure at the subunit level by D.B. Jump, S. Sudhakar, K.D. Tew and M. Smulson (Washington, DC) . . . . . 35

Decreased levels of ascorbic acid in lung following exposure to ozone by C.C. Kratzing and R.J. Willis (St. Lucia, Australia and Cleveland, OH) . . . . . . 53

In vitro metabolism of n-nitrosopyrrolidine by rat lung subcellular fractions: a-hydroxylation in a non-target tissue by L.I. Hecker (Frederick, MD) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57

Binding specificity of chemically and enzymatically activated anthracycline anti- cancer agents to nucleic acids by B.K. Sinha (Research Triangle Park, NC) . . . . . . . . . . . . . . . . . . . . . . . . . 67

380

Quantum mechanical conformational analysis of heterocyclic analogues of noreph- edrine by J. Kaneti, D. Mihailova, K. Faitondzieva and L. Zheljazkov (Sofia, Bulgaria). . 79

Molecular models of induced DNA premutational damage and mutational pathways for the carcinogen 4-nitroquinoline 1-oxide and its metabolites by R.L. Ornstein and R. Rein (Buffalo, NY) . . . . . . . . . . . . . . . . . . . . . . . . . 87

Effect of 2,3-dinitrilo-l,4-dithia-9,10-antraquinone on Ehrlich ascites carcinoma and yeast cells by E. Sturd[k and I~. Drobnica (Bratislava, Czechoslovakia) . . . . . . . . . . . . . . . 105

The effect of cyclic nucleotides on DNA polymerase, thymidylate synthetase, thymidine kinase and deoxynucleoside levels of Walker carcinoma by M.J. Tisdale (London, United Kingdom) . . . . . . . . . . . . . . . . . . . . . . . . . 115

Isolation and characterization of active metabolites of tryptophan-pyrolysate muta- gen, TRP-P-2, formed by rat liver microsomes by Y. Yamazoe, K. Ishii, T. Kamataki, R. Kato and T. Sugimura (Tokyo, Japan) . . 125

Effects of sulfhydryl reagents on phagocytosis and exocytosis in rabbit polymorpho- nuclear leukocytes by J.G.R. Elferink and J.C. Riemersma (Leiden, The Netherlands) . . . . . . . . . . 139

Kinetic analysis of the in vitro binding of radioactive cis- and t rans-dichlorodiam- mineplatinum(II) to DNA by N.P. Johnson, J.D. Hoeschele and R.O. Rahm(Oak Ridge, TN) . . . . . . . . . . 151

The interaction of [ 3H ] TPA with bovine lymph node lymphocytes in vitro by A.M. Mastro and K.G. Pepin (University Park, PA) . . . . . . . . . . . . . . . . . . 171

9-Hydroxyellipticine: inhibitory effect on skin carcinogenesis induced in Swiss mice by 7,12-dimethylbenz[a] anthracene by P. Lesca and D. Mansuy (Toulouse and Paris, France) . . . . . . . . . . . . . . . . . 181

The electronic structure of platinum-guanine complexes by T.P. Carsey and E.A. Boudreaux (New Orleans, LA) . . . . . . . . . . . . . . . . . 189

Comparative mutagenicity of linear and angular furocoumarins in Escherichia coil strains deficient in known repair functions by S. Venturini, M. Tamaro, C. Monti-Bragadin, F. Bordin, F. Baccicchetti and F. Carlassare (Trieste and Padua, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203

The effects of tetraalkylammonium salts on helix-coil transition parameters in natural and synthetic ribo- and deoxyribo-polynucleotides by T. Golag, M. Miller and D. Shugar (Warsaw, Poland) . . . . . . . . . . . . . . . . . . 209

Preparation and metabolism of a cisplatin/serum protein complex by W.C. Cole and W. Wolf (Los Angeles, CA) . . . . . . . . . . . . . . . . . . . . . . . . 223

S h o r t C o m m u n i c a t i o n s Isolation of lead-resistant cells from an established rat glioma cell line

by L.M. Lake, S. O'Cheskey, H. Masuji and L.E. Gerschenson (Denver, CO and Los Angeles, CA) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237

Benzene is metabolized and covalently bound in bone marrow in situ by R.D. Irons, J.G. Dent, T.S. Baker and D.E. Rickert (Research Triangle Park, NC) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241

Inhibition of chemically induced sister chromatid exchanges by protease inhibitors from S t r e p t o m y c e s by K. Umezawa, M. Sawamura, T. Matsushima and T. Sugimura (Tokyo, Japan) . 247

Urinary excretion of methylated purines and 1-methylnicotinamide following administration of methylating carcinogens by B. Shaikh, S.-K. S. Huang and N.J. Pontzer (Frederick, MD) . . . . . . . . . . . .

Corrigendum

253

257

3 8 1

Alkylation products of DNA bases by simple epoxides by K. Henm~inki, J. Paasivirta, T. Kurkirinne and L. Virkki (Helsinki and Jyv~skyl~/,~Finland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259

Polychloriflated biphenyls as inducers of hepatic microsomal enzymes: structure- ~activity rules

by A. Parkinson, L. Robertson, L. Safe and S. Safe (Ontario, Canada and Ann Arbor, MI) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271

Unusual patterns of benzo [a ] pyrene metabolites and DNA-benzo [a ] pyrene adducts produced by human placental microsomes in vitro by O. Pelkonen and H. Saarni (Oulu, Finland) . . . . . . . . . . . . . . . . . . . . . . . . 287

Incorporation of 5-bromodeoxyuridine into DNA in newborn rat tissues by G.P. Margison, A.J. Likhachev and L. Tomatis (Lyon, France) . . . . . . . . . . . 297

Development of a papillary thyroid carcinoma in a patient while on high dosage ascorbic therapy by A. Campbell (East Kilbride, Scotland) . . . . . . . . . . . . . . . . . . . . . . . . . . . 305

Permeability of lipid bilayers to methylmercuric chloride: quantification by fluo- rescence quenching of a carbazole-labeled phospholipid by J.R. Lakowicz and C.J. Anderson (Navarre, MN) . . . . . . . . . . . . . . . . . . . . 309

Antimitot ic activity of dehydroretronecine, a pyrrolizidine alkaloid metabolite, and some analogous compounds, in a rat liver parenchymal cell line by A.R. Mattocks and R.F. Legg (Carshalton, United Kingdom) . . . . . . . . . . . . 325

Effect of acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral anti- body production in mice by A. Vecchi, A. Mantovani, M. Sironi, W. Luini, M. Cairo and S. Garattini (Milan, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337

The induct ion of benzo[a]pyrene-3-mono-oxygenase by singlet oxygen in liver cell culture is mediated by oxidation products of histidine by A.J. Paine and J.E. Francis (Carshalton, United Kingdom) . . . . . . . . . . . . . 343

Cytotoxic effects of norethindrone-4f3,5~poxide to Walker cells in culture and to rat liver in vivo by I.N.H. White and M. Suzangar (Carshalton, United Kingdom) . . . . . . . . . . . 355

Short Communication Inhibit ion of benzo[a ] pyrene metabolic activation in the livers of rats treated with

acetylsalicyllc acid by F. Decloitre and J. Benrekassa (Villejuif, France) . . . . . . . . . . . . . . . . . . . 367

Subject Index Volume 30 (1980) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 373

Author Index Volume 30 (1980) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377

Volume Contents Volume 30 (1980) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379