Y.S.P..Vol. 831st Oct 2020

xxxxx Printing code xxxxx

Strictly for Healthcare Professionals Continued on page 2Strictly for Healthcare Professionals

Sodium Hyaluronate 48mg/6mL in Pre-�lled Syringe

1Reg No: PP11312 / 03 / 2013 (032051) Publisher: Y.S.P. Industries (M) Sdn. Bhd. (199001001034)Company Address: Level 22, Menara LGB, No. 1 Jalan Wan Kadir, Taman Tun Dr. Ismail, 60000 Kuala Lumpur.Tel: +603 - 7727 6390 (14 lines) Fax: +603 - 7727 6701 Ordering line: 1 800 88 3027 Product Info Line: 1 800 88 3679 Website:http://www.yspsah.comMCI (P) 145 / 02 / 2014 (Singapore Publication Permit)PERCETAKAN ZANDERS SDN. BHD.: No. 16, Jalan BK 1/11, Bandar Kinrara, 47180, Puchong, Selangor Darul Ehsan, Malaysia.

A Subsidiary of

Osteoarthritis (OA) is a progressive degenerative joint disease due to progressive breakdown of the joints' natural shock absorbers, resulting from an imbalance between the synthesis and degradation of articular cartilage, leading to the classic pathologic changes of wearing away and destruction of cartilage. This can cause discomfort when using the affected joints – perhaps an ache when bending at the hips or knees (knee OA), or sore �ngers when typing (hand OA). 1,2

Viscosupplementation arti�cially supplements the joint �uid's natural viscosity. By injecting a man-made hyaluronan into the knee and temporarily lubricating the knee joint, pain reduction and function improvement can be achieved and perhaps even slow the degeneration process.

Hyorth XL has been tested in an open-label, multicenter study to evaluate the ef�cacy and safety of single intra-articular injection of Hyorth XL in patients with knee OA. Patients were injected with Hyorth XL intra-articularly and followed up for a period of 26 weeks.

Patients have experienced a signi�cant improvement of pain, stiffness, and physical function disability, there is also improvements in the physician and patient slobal impression of change scale (PGIC) and visual analogue score (VAS) from baseline to subsequent visits during post therapy. Hyorth XL was well tolerated and no serious adverse event was observed.

*P<0.001

0

2

4

6

8

10

12

14

Baseline 8 12 18 264

Mea

n W

OM

AC

Pai

n S

core

Weeks

12.2

6.3 6.1 5.96.4 6.6

*P<0.001

0

10

20

30

40

50

60

70

80

Baseline 8 12 18 264

Mea

n V

isua

l Ana

log

ue S

core

(mm

)

Weeks

72.2

32.229.7 29.2 30.4 31.5

Significant reduction in mean pain score from baseline in mean pain score from baseline (12.2 ± 1.7) to week 26 (6.6 ± 1.3); (p<0.01) and percentage of reduction was 45.9%. 69% patients responded to treatment with regard to WOMAC pain scores at week 8.

Figure 1: Changes In Western Ontario And McMasterUniversities Osteoarthritis Index (WOMAC) Pain ScoresFigure 1: Changes In Western Ontario And McMasterUniversities Osteoarthritis Index (WOMAC) Pain Scores

Significant reduction in pain in terms of visual analogue scale (72.2 ± 10.4 to 31.5 ± 5.8) from baseline to week 26 and percentage of reduction was 56.4%.

Figure 2: Changes In Current Pain Scores On VASFigure 2: Changes In Current Pain Scores On VAS

Dosage/ Direction for Use:A single injection of Hyorth XL is administered by intra-articular route. Inject the full Hyorth XL in one knee only. If treatment is bilateral, a separate syringe should be used for each knee.

References:1. Malaysia Clinical Practice Guidelines: Management of Osteoarthritis (Second Edition). Dec 2013.2. Zelman D, MD. Visual Guide to Understanding Osteoarthritis [Internet]. WebMD; 2005 [update 2020 January 15; cited 2020 July 29]. Available from: https://www.webmd.com/osteoarthritis/ss/slideshow-osteoarthritis-overview

How to use SensiLacer® Toothgel for rapid reduction in dental hypersensitivity: Brush teeth after every meal.

2

Strictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare Professionals

Dedicated to

Improving Oral Health

®TOOTHGELTOOTHGEL

Ingredients: Potassium nitrate, Sodium mono�uorophosphate, Silicon dioxide obliterans, Aldioxa, Fluoride ion

After BlockedDentine TubulesAfter BlockedDentine Tubules

Before ExposedDentine TubulesBefore ExposedDentine Tubules

Figure 1: The close-up images of the tooth surface after using SensiLacer® Toothgel. The repeated application has increased the percentage of closed tubules.

The toothgel containing potassium nitrate and �uoride has been shown to reduce post-bleaching sensitivity. The silicon dioxide contained in the toothgel has been proven helpful in signi�cantly strengthening the dentine which resulted in tubule occlusion. SensiLacer® Toothgel provides rapid and long-lasting protection for sensitive teeth.

Dentine hypersensitivity is de�ned as a short sharp pain arising from exposed dentine in response to stimuli that cannot be ascribed to any other form of dental defect or pathology.1 Although many people have dentine that are exposed, only a percentage present with symptoms of dentine hypersensitivity. There are many treatment options that either occlude the dentine tubules or desensitise the nerve �bres to block neural transmissions.

Fast-acting Rescue for Sensitive TeethThis study examines the morphological changes of etched and unetched dentine in vitro. A total of 96 etched and 96 unetched human dentine specimens were brushed with various toothpastes and water for 1, 2, 5 or 10 min periods and subsequently examined under scanning electron microscopy for surface changes.2 The time and treatment showed a signi�cant interaction (P < 0.05), with the arti�cial silica-based paste showing signi�cantly better dentine tubule occlusion for all time intervals.

3

Strictly for Healthcare ProfessionalsStrictly for Healthcare Professionals

®

BIOADHESIVE GELBIOADHESIVE GEL

Ingredient: 0.20% Chlorhexidine digluconate

Benefit of Bioadhesive Gel formulation

Enhances the adhesion of Chlorhexidineto oral surface

BIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GELBIOADHESIVE GEL

Ingredient:

Benefit of Bioadhesive Gel formulation

Worry No More About YourWorry No More About YourDRY SOCKETSDRY SOCKETSDRY SOCKETS Alveolar osteitis (AO) or more simply known as ‘dry socket’ is said to be the most common

postoperative complication encountered following tooth extraction.

A meta-analysis study on ten articles involving 862 participants showing signi�cant reduction of AO incidence was found; 0.60 (95% CI: 0.41, 0.87; p = 0.05) in the intervention. The study concludes that chlorhexidine gel (0.2% or 1%) is superior to placebo in AO reduction after mandibular third molar extraction.3

While it may seem that a higher chlorhexidine concentration yields greater AO effectiveness, a study comparing 1% versus 0.2% chlorhexidine gel proves otherwise. A randomized, double-blind clinical trial comparing the effectiveness of the gels with the two chlorhexidine concentrations in postoperative AO after surgical extraction of mandibular third molars and assessing the impact of treatment on the Oral Health-related Quality of Life produced a statistically insigni�cant results between the two chlorhexidine gel concentrations.4 The week-long follow-up of baseline subjective pain sensation, in�ammation and evolution showed no signi�cant difference between two groups.

References:1. Gillam D. Dentine Hypersensitivity. Advances in Diagnosis, Management and Treatment, 2015. 2. West NX, Hughes JA, Addy M. Dentine hypersensitivity: the effects of brushing toothpaste on etched and unetched dentine in vitro. J Oral Rehabil, 2002 Feb; 29(2):167-74. 3. Teshome A. The efficacy of chlorhexidine gel in the prevention of alveolar osteitis after mandibular third molar extraction: a systematic review and meta-analysis. BMC Oral Health, 2017.4. Rodriguez-Perez M, Bravo-Perez M, Sanchez-Lopez J et al. Effectiveness of 1% versus 0.2% chlorhexidine gels in reducing alveolar osteitis from mandibular third molar surgery: A randomized, double-blind clinical trial. Med Oral Patol Oral Citr Bucal, 2013 Jul; 18(4): e693-e700.

Graph 1: Pain and in�ammation, from pre-extraction (day 0) to day 7.

pre-extraction pre-extractionDays0

0

5

20

25

30

35

40

15

10

1 2 3 4 5 6 7

Inflammation

Pain

3h 7h2 3 4 5 6 71

60

6570

75

80

85

90

95

100

105

110MAB: Mandibular angle-Nasal base

MAPO: Mandibular angle-Pogonion

MAC: Mandibular angle-Cantus

MACO: Mandibular angle-Commisure

MAT: Mandibular angle-Tragus

Days

Graph 2: Different facial measurement from mandibular angle, from pre-extraction (day 1) to day 7.

The application of 0.2% chlorhexidine may result in the formation of relatively stable monolayer of retained chlorhexidine in the oral mucosa, while the higher concentration of 1% chlorhexidine may have given only an oversaturation of chlorhexidine with a rapid release of its excess.

How to use PerioLacer® Bioadhesive Gel to prevent dry sockets: • After extracting the tooth, clean the alveolus (the socket), smoothen the bone edges, and remove any follicular remnants and granulation tissue• Apply the 0.2% bioadhesive gel inside the alveolus• Suture the wound• Continue to apply the bioadhesive gel on the surgical wound twice daily (after brushing teeth) for 7 days.

(discontinuos lines) : Chlorhexidine 0.2%(continuous line) : Chlorhexidine 1%

(discontinuos lines) : Chlorhexidine 0.2%(continuous line) : Chlorhexidine 1%

Strictly for Healthcare ProfessionalsStrictly for Healthcare Professionals

Pediculosis capitis infestation is endemic in both developing countries leading to various physical, economical and psychological consequences. The overall prevalence of Pediculosis capitis among the primary school students in Hulu Langat, Selangor is high (15.3%) in an analytical cross-sectional study conducted in 2015.

Strictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare ProfessionalsStrictly for Healthcare Professionals

Head lice Head lice is a parasitic, tiny insect that feeds on blood from the human scalp.

Nit Lice eggs, called nits, are glued onto hairs near the scalp and can be even harder to see.

Head Lice (Pediculus Humanus)

NITOLIC® wash 20 mlA laundry additive to wash personal items (clothes, bed linens etc.) that may have come in contact with the head of the person with lice

NITOLIC® fine-tooth lice combFor visual diagnosticexamination of the hair and removal of lice, eggs and nits after the treatment

NITOLIC® protective shower capTo cover the hair during treatment

Tracking listTo trace back close contact

NITOLIC® bookletTo make time pass more pleasantly for children during treatment

NITOLIC® nitremover 20 mlAn emulsion for removing lice eggs from hair

E�cacy in Lice and Nits Elimination

The female lice live for about 40 days and lay up to 330 eggs (7-10 eggs a day). These eggs (called nits) look like tiny yellow, tan or brown oval dots and have a special lid on the eggshell, which the young lice leaves when it hatches.

Life Cycle of the Head Lice

egg (7-8 days) egg (13 days) female or male lice

The One and Only, Comprehensive Head Lice TreatmentAdditionally contains

Directions For UseDirections For Use

Divide the hairinto four sections.

Apply NITOLIC®

on dry hair fromroot to end of hair.

Put on the NITOLIC®

protective cap onhead for 1 hour.

Saturate the hairand scalp withNITOLIC®.

Remove theprotective capand wash thehair with waterand shampoo.

Dry the hair andapply NITOLIC®

nit remover for5-10 mins. Then,rinse & dry again.

Wash all clothes, bed linens orblankets withNITOLIC® wash.

Dry the hair and®

5-10 mins. Then,rinse & dry again.

Remove the liceand nits from thehair using NITOLIC®

removal comb.

Dry the hair andapply nit remover for5-10 mins. Then,rinse & dry again.

4

Strictly for Healthcare ProfessionalsStrictly for Healthcare Professionals

HIGH EFFICIENCY & COST EFFECTIVE 2

Rapid Action of NITOLIC®1

Triple Action

HOW NITOLIC® WORK?

IMMOBILIZATIONLice are immobilized, increasing their exposure to NITOLIC®.

DEHYDRATIONThe lice experience uncontrollable and irreversible loss of water, which leads to their death.

O-E�ect®NITOLIC® ef�ciently covers the scalp and hair with parasite and suffocating them by blocking their spiracles.

WHY CHOOSE NITOLIC®?

1 HOUR SINGLE APPLICATION 100% EFFICACY

60mins

30mins

Adult Head Lice100% Kill

Lice Eggs100% Kill

• After 30 mins of exposure, NITOLIC® is able to eliminate all active developmental stages of head lice. • After 1 hour of exposure, NITOLIC® can eliminate all lice eggs (nits).

1 x long hair 2 x medium-length hair 4 x short hair

OR ORNITOLIC® is a highly ef�cient product. Just 50ml of the solution is enough for a single long hair application or two medium-length hair treatments or four short hair treatments.

SAFE, PESTICIDE-FREE 3

NITOLIC® does not contain pesticides but works through physical mode of action and is safe for children over the age of two. It has passed dermatological and toxicological clinical safety tests.

COMPLETE ERADICATION OF THE HEAD LICE PROBLEMS 4

NITOLIC® is the only brand providing a complete head lice treatment system. It does not only eliminate lice and eggs from head but also supports lice and eggs elimination from clothing and bedding.

COMPLETE GUIDE 5

Each pack also contains information for the whole family designed to overturn myths and misunderstanding about the head lice.

With the O-effect® technology, NITOLIC® allows a quick, larger and even area of coverage of the scalp and hair which is able to reduce cost of treatment.

Chart shows NITOLIC® spreading ef�ciency through spreadability test of same volume (5μl) of product 30 mins after spotting onto a test surface.

5

S 0,3 cm2 MINERAL OIL + SURFACTANTS 1,3 cm2 MINERAL OIL + DIMETHICONE DIMETHICONE + PEG/PPG DIMETHICONE-CO-POLYMER + SiO2

S 2,0 cm2 CAPRYLIC/CAPRIC GLYCERIDES + H2OS 2,3 cm2 OCTANE-1,2-DIOL + PEG/PPG S 2,8 cm2 D5 (96%) + DIMETHICONE (4%) S 3,5 cm2 DIMETHICONE (92%)

S 36,4 cm2 NITOLIC®

= HIGHEFFICIENCY TECHNOLOGY

EVENING PRIMROSE OIL1,000mg + Vitamin E Softgel

Nutritional Oil for Optimal Women HealthEvening Primrose Oil (EPO) is cold pressed from the seeds of the Evening Primrose plant and contain essential omega-6 fatty acids including linoleic acid (LA) and gamma-linoleic acid (GLA). These essential fatty acids are needed by our body for growth and development. Human body can convert GLA into prostaglandins which have anti-in�ammatory properties and maintain hormone balance.

Health Benefits of Evening Primrose Oil

Product Features: Contains top-quality source of cold-pressed EPO that helps lock in all the nutrients High in natural source of 10.5% GLA Added with Vitamin E that acts as antioxidant for skin health and preserves the freshness of EPO

Available in blister packaging that helps to protect the softgel capsules from external environment until they are ready to use, thus reducing the risk of oxidative rancidity

Suitable for:

20 70

30 6040 50

∗ Women who suffer from PMS or menopause

∗ Women who want to maintain their general health and well-being

∗ Those with skin problems such as dry or itchy skin, acne and eczema

∗ Those with arthritis related conditions

Each softgel contains:Evening Primrose Oil (equivalent to 105mg GLA) ... 1,000mg

Vitamin E ....................................................................... 13IU

Dosage and Administration:1 softgel to be taken once daily, preferably after meal or as required.

6

Strictly for Healthcare ProfessionalsStrictly for Healthcare Professionals

Enhances overall skin healthand maintain youthful skin

Reduces rheumatoid arthritisand joint pain by reducingin�ammation

20 7020 70

30 6030 6040 5040 5040 5040 5040 5040 50

Regulates hormone balance

Relieves symptoms of premenstrual syndrome (PMS),menstruation and menopause (including menstrual cramps,depression, breast pain and hot �ashes)

Slows progression of diabetes-related complications such as nerve damage

Relieves dry eye condition

Improves cardiovascular health

Allertoin® cream is a series of Ectoin®-containing products which are safe and without steroid that can be used in long term for dermatitis symptoms. Ectoin® is an extremolyte produced by the bacterium Halomonas elongata which lives in harsh environments such as high UV radiation, extremely saline, heat or dryness. It is able to stabilize the skin barrier and protect the cells from allergens, in�ammation or other harmful substances. It is also recommended for use on all parts of the body in both children and adults.

Allertoin® CreamAllertoin® Cream for Kids

A Non-Steroidal Solution for Eczema & Psoriasis A Non-steroidal Solution for Eczema & Psoriasis

Strictly for Healthcare ProfessionalsStrictly for Healthcare Professionals

A randomized, comparator-controlled , intra-individual, double-blind, multicenter trial, showed that topical application of Ectoin®-containing cream to lesional skin of patients with mild to moderate AD significantly reduced the clinical severity of the AD.1

• For the treatment and prevention of psoriasis and dermatitis symptoms

• Contains 5% Ectoin® and urea

• Suitable for psoriasis and eczema in adults

• For topical use on dry, irritated and sensitive skin associated with various types of dermatoses

• Contains 3.5% Ectoin®

• Suitable for atopic eczema in infants and children

Allertoin® Cream Allertoin® Cream for Kids

Reductionof in�ammation

Symptom relief

Ectoin®

Stabilization of cell membranes and biomolecules

In�uenceon water structure

Reductionof in�ammation

Symptom relief

Ectoin®

Stabilization of cell membranes and biomolecules

In�uenceon water structure

Pru

ritu

s [m

m V

AS

]

20

Day 0 Day 7 Day 28

-37%

-49%-48%

-51%

40

60

Active Comparator Ectoin®-containing cream

day 0 day 7 day 28

0

2

4

6

8

9

Mo

difi

ed S

CO

RA

D

Active Comparator Ectoin®-containing cream

-24%* -29%

* -41%* -50%

*

Graph 1: This shows 49% improvement of pruritus after treatment with Ectoin®-containing cream in day 7.

Graph 2: This shows Ectoin®-containing cream improves SCORAD up to 50%.

Ectoin® - Mode of Action

Improvement of overall skin condition

Enhancement in skin hydration and long lasting moisturizing effect

Has anti-inflammatory properties and improves skin barrier repair

An effective topical treatment for atopic dermatitis (AD) without side effects

Benefits of Allertoin® Cream and Allertoin® Cream for Kids

Reference:1. Marini A, Reinelt K, Krutmann A, Bilstein A. Ectoine-Containing Cream in the Treatment of Mild to Moderate Atopic Dermatitis: A Randomised, Comparator-Controlled, Intra-Individual Double-Blind, Multi-Center Trial. Skin Pharmacol Physiol 2014; 27:57–65.

• For topical use on dry, irritated and sensitive skin associated with various types

Cream for Kids

• For topical use on dry, irritated and sensitive skin associated with various types

Cream for Kids

Graph 2: This shows Ectoin®-containing cream improves SCORAD up to 50%.

NONO• Steroid • Fragrance• Preservative• Paraben• Mineral oil

• Steroid • Fragrance• Preservative• Paraben• Mineral oil

7