viruses208.93.184.5/~jones/bio161/virus.pdf · for viruses •non-living •smaller than bacteria...
TRANSCRIPT
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Viruses
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General Information for Viruses
• non-living
• smaller than bacteria
• only perform one life function;
reproduction. But they require
the help of living cells to
replicate.
– These living cells where
viruses replicate are called
host cells.
• named for diseases they cause or the
tissue they infect
• viruses that infect bacteria are called
bacteriophages
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Structure of a Virus
• inner core of nucleic acid: RNA or DNA
• outer protein coat called a capsid
– Composed of protein complexes called
capsomers Ex: TMV and adenoviruses
• some larger viruses have an envelope
outside of the capsid with
glycoproteins used to attach
to host cells Ex: herpes & HIV
• viruses are grouped based
on their shape and structure
• outside a host a virus is called
a virion
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Virus Classification • By the presence/absence of an envelope
• Type of nucleic acid
– DNA or RNA Retrovirus- RNA viruses with complex replication cycles;
RNA cannot be integrated into DNA, so a virus that has RNA as
its nucleic acid must first make its RNA into DNA before
meshing with the DNA. To make DNA from RNA an enzyme
must be present: reverse transcriptase. Ex: AIDS
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Retroviruses
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Virus Classification • Type of nucleic acid
– DNA or RNA (on previous slide)
– Single stranded or double stranded
– Positive (+) sense or negative (-) sense
• Positive sense- genome is the same sequence as
the mRNAs
• Negative sense- mRNAs have complementary
sequences to the DNA
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Virus Classification • Viral shape
– Shape of virus & composition of the protein coat
enables viral penetration into the host cell
• Type of host cell
– Bacteriophages
– Rhinoviruses- infect epithelial
cells of the respiratory system
– Different kinds of organisms a virus can infect
constitute a host range
• Zoonosis- multiple species Ex: influenza, rabies
• Reservoirs- species that harbor the virus but show no
symptoms Ex: ducks for influenza
– These species can act like vectors to transmit disease
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Viral Infection • Epidemic- a disease that afflicts a large
population at once
• Pandemic- a worldwide epidemic
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Lytic Cycle
1. Viral Recognition
2. Attachment and Entry into cell
3. The virus takes over the cell to
make more viruses.
4. The virus destroys the cell and
releases tons of new viruses
(progeny virions) to invade
nearby cells.
View Lytic Cycle
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Lytic Cycle
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Lytic Cycle
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Lysogenic Cycle Also called "temperate viruses“
1. Entry
2. Viral nucleic acid (prophage in bacteria) is
integrated into cell’s DNA
All cells produced by this cell will have the
virus- now call a provirus
3. Provirus is activated (days to years after
infection – latent infection)
4. Provirus takes over cell processes (lytic cycle
entered)
5. Cell is destroyed thereby releasing viruses to
infect nearby cells
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Lysogenic Cycle
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Viroids
• smallest known
particles that
are able to
replicate
• short, single
strand, highly
wound RNA
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Prions Proteinaceous Infectious Particles
• Abnormal forms of
misfolded proteins
that clump together
inside cells
• Can cause other
proteins to misfold
• Ex: mad cow
disease
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Prions Proteinaceous Infectious Particles
• Abnormal forms of
misfolded proteins
that clump together
inside cells
• Can cause other
proteins to misfold
• Ex: mad cow
disease
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Vaccines Inactivated- do not replicate in a
host system
Attenuated- genetically altered virus
that cannot cause
disease – provides
greater protection
and lasts longer