Type FamilyApprox.

size

Fragmen-

tation

Capsid

shape

Capsid

sizeEnvelope

polyomavirustumours in

rodents

SV40tumours in

rodents

papillomaviruswarts,

carcinoma

adeno-

viridae

35kbp:

medium- icosahedral 80nm - adenovirus resp disease -

herpes simplex,

type 1 + 2

cold sores,

genital lesions

varicella-zosterchicken pox,

shingles

epstein-barr

glandular

fever, burkitt

lymphoma

cytomegalo-

virus

cytomegalic

inclusion

disease in

neonates

human

herpesvirus 8

kaposi's

sarcoma

viriola smallpox

vaccinavaccine against

smallpox

dsDNA

with RNA

intermedi

ate

hepaDNA-

viridae

reversi-

viruses

3kbp:

small- icosahedral 20nm + hepatitis B

acute and

chronic

hepatitis, liver

cancer

- ? nucleus* DNA->RNA-

>cDNA

ssDNA parvo-virus5kb:

small- icosahedral 20nm -

human

parvovirus

childhood rash

(erythema

infectiosum)

- ? nucleus

* most

strands infect

animals

-

-

virion

transcriptase:

DNA-dependent

RNA

polymerase,

capping and

polyadenylating

enzymes

50nm

120nmicosahedral150kbp:

largedsDNA

(lytic!)

-

icosahedral5-8kbp:

small

papova-

viridae(papilloma-

polyoma-

vacuolating)

herpes-

viridae

-

-

+200-

300nmcomplex

200kbp:

largepox-viridae

-

-

1. uncoating

2. Make mRNA

3. translate

4. Assemble

and release

1. uncoating

2. DNA to nuc

3. replication

4. RNA to cp

5. prot.to nuc

6. Assembly

with DNA in nuc

DNA

infectiousnucleus

DNA not

infectious

cyto-

plasm

* produce

EGF that

stimulates

neighbour-

ing cells into

cell cycle!

Genome Coat Additional

proteins

present

Example

species

Resulting

diseaseLife cycle

Genome

infect-

ious?

Replica-

tionOther

* stimulate

cell into cell

cycle!

* herpes

viruses

incease the

prod of

dNTPS

* can cause

latent

infection

* consist of

extrachomos

omal circular

DNA

C.Riedinger Overview of Viruses

Type FamilyApprox.

size

Fragmen-

tation

Capsid

shape

Capsid

sizeEnvelope

-50nm

dsDNA

(lytic!)

icosahedral5-8kbp:

small

papova-

viridae(papilloma-

polyoma-

vacuolating)

--

1. uncoating

2. DNA to nuc

3. replication

4. RNA to cp

5. prot.to nuc

6. Assembly

with DNA in nuc

DNA

infectiousnucleus

Genome Coat Additional

proteins

present

Example

species

Resulting

diseaseLife cycle

Genome

infect-

ious?

Replica-

tionOther

* stimulate

cell into cell

cycle!

* herpes

viruses

incease the

prod of

dNTPS

* can cause

latent

infection

* consist of

extrachomos

omal circular

DNA

dsRNAreo-viridae

(resp. enteric

orphan virus)

20kbp:

medium

10-11

fragmentsicosahedral 70nm -

human

rotavirus

acute infantile

gastro-enteritis

virion

transcriptase

poliovirus poliomyelitis

hepatitis A acute hepatitis

rhinovirus common cold

foot and mouth

disease

foot and mouth

disease

calici-viridae(calyx/goblet)

8kb:

small- icosahedral 35nm

-

lyticnorovirus

winter

vomiting

disease

rubella german

measles

hepatitis C

acute and

chronic

hepatitis

yellow fever

(ZOONOTIC!)

jungle yellow

fever

west nile encephalitis

corona-

viridae

30kb:

medium- helical 140nm + SARS

severe acute

respiratory

syndrome

RNA-dependent

RNA polymerase

+ve

ssRNA

-

-

RNA-dependent

RNA polymerase

-

lytic25nmicosahedral

7kb:

small

picoRNA-

viridae

(small RNA virus)

+60nmicosahedral11kb:

medium

toga-

viridae, flavi-

viridae

1. uncoating

2. Translation

into RNA pol

and capsid

proteins

3. Assembly

and release

RNA

infectious

cytoplas

m,as +ve

RNA

direct

template,

can

replicate

in

enucleate

d cells

* negative

strand is

made to

generate

more

template

* non-

enveloped

RNA-viruses

are lytic

* mRNA is

polycistronic

* picoRNA

viruses

stable

outside the

host

* an get

hepA from

food and

water

C.Riedinger Overview of Viruses

Type FamilyApprox.

size

Fragmen-

tation

Capsid

shape

Capsid

sizeEnvelope

-50nm

dsDNA

(lytic!)

icosahedral5-8kbp:

small

papova-

viridae(papilloma-

polyoma-

vacuolating)

--

1. uncoating

2. DNA to nuc

3. replication

4. RNA to cp

5. prot.to nuc

6. Assembly

with DNA in nuc

DNA

infectiousnucleus

Genome Coat Additional

proteins

present

Example

species

Resulting

diseaseLife cycle

Genome

infect-

ious?

Replica-

tionOther

* stimulate

cell into cell

cycle!

* herpes

viruses

incease the

prod of

dNTPS

* can cause

latent

infection

* consist of

extrachomos

omal circular

DNA

ortho-

myxoviridae(mxyo - mucus)

12kb:

medium8 fragments helical 80nm + influenza influenza

virion

transcriptase

* HA envelope

protein binds

sialic acid

* enters by

endocytosis!

measles measles

mumps mumps

respiratory

synycytial virusbronchitis

rhabdo-

viridae(rhabdo = rod)

10kb:

small-

helical

capsid,

bullet-

shaped

200x80n

m+

rabies

(ZOONOTIC) rabiesvirion

transcriptase

+ve

ssRNA

with DNA

intermedi

ate

retro-

viridae

reversi-

viruses

8kb:

small- ? 100nm +

human

immunodeficie

ncy HIV

Acquired

immuno-

deficiency

syndrome

AIDS

virion

transcriptase

* input RNA

converted to

dsDNA

(provirus) to be

integrated into

host

chromosome

* packaging in

cytoplasm as

RNA packed

* reverse

transcription!

Envelope

protein

GP120 +

CD4/coR on

T-cells/macro

* envelope

protein

enters by

FUSION!

* can spread

as cell-

associated

virus

dsDNA

with RNA

intermedi

ate

hepaDNA-

viridae

reversi-

viruses

3kbp:

small- icosahedral 20nm + hepatitis B

acute and

chronic

hepatitis, liver

cancer

-

* can be

latent if

proviral DNA

not

transcribed

underlined: these viruses cause persisten infection that can lead to neoplasia

+150m

helical (but

pleiomorphi

c, i.e.

different

shapes)

virion

transcriptase-

15kb:

medium

para-

myxoviridae

-ve

ssRNA1. Make mRNA

from -ve strand

2. translation

3. Assembly

and release

* RNA not

infectous

cytoplas

m

* influenza

virus unique:

RNA

processing in

nucleus

C.Riedinger Overview of Viruses