vertebrate closed circulatory systems closed circulatory systems cardiac anatomy & its o 2...
TRANSCRIPT
![Page 1: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/1.jpg)
Vertebrate Closed Circulatory Systems
• Closed circulatory systems• Cardiac anatomy & its O2 supply• The myogenic heart & the cardiac cycle• Blood pressure• Anatomical variations• Other ‘hearts’
![Page 2: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/2.jpg)
Hearts
Cardiac cycle – pumping action of the heart
Two phases• Systole – contraction
• Blood is forced out into the circulation• Diastole – relaxation
• Blood enters the heart
![Page 3: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/3.jpg)
Closed vertebrate circulatory system
• Multi-chambered heart• Capillaries connect arterial & venous systems• Respiratory pigments present in red blood cells
Tunica media = vascular smooth muscle + elastin fibres
Lower BP,thinner walled
![Page 4: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/4.jpg)
Anatomy of the chambered heart
Fish: The simplest/earliest design•Four cardiac chambers• All contain muscle (cardiac & smooth)• Surrounded by a pericardial sac• Atrium & ventricle propel blood• Venous BP atrial contraction ventricular contraction
All vertebrates• Similar developmental pathway• Myogenic contractions• Similar intrinsic properties
Variations• Hagfishes: incomplete pericardial sac• Sharks & Rays: pericardial sac is stiff; conus arteriosus has cardiac muscle• Primitive Fishes: conus is reduced & bulbus also present• Teleosts: bulbus arteriosus (VSM & elastin fibres)
bulbus/conus arteriosus
Venousbloodpressure
Arterialbloodpressure
![Page 5: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/5.jpg)
Advantages•Blood pressure can be regulated, even venous blood pressure • High blood pressure, high flow rate & faster circulation time• Exquisite control of blood flow distribution at arterioles (VSM)• High capillary density reduces blood velocity & the diffusion
distance to cells
Disadvantages•High resistance to flow b/c of small diameter arterioles (R = r4)•High resistance high blood pressure thicker-walled
hearts & higher cardiac O2 needs
Closed vertebrate circulatory system
![Page 6: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/6.jpg)
Adult mammalian cardiomyocyte
Fish cardiac myocytes also have a reduced sarcoplasmic reticulum (SR), & lack an extensive t-tubular system
Consequence: Ca2+ handling during excitation-contraction varies
Myocardial cells
• Striated cells• Electrically connected (desmosomes)• ‘Unstable’ membrane potential
Adult fish cardiomyocyte
![Page 7: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/7.jpg)
Myocardium
Two types• Compact – tightly packed cells arranged in a regular pattern• Spongy – meshwork of loosely connected cells
Relative proportions vary among species• Mammals: mostly compact• Fish and amphibians: mostly spongy
• Arranged into trabeculae that extend into the heart chambers
![Page 8: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/8.jpg)
Cardiac muscle O2 supply
• A working muscle requires ATP• ATP requirement proportional to cardiac power output
Phylogeny & Ontogeny• Hagfishes & Lampreys: spongy• Sharks & Rays: spongy plus variable compact (athletic ability)• Teleosts: most spongy; some have variable compact (athletic/hypoxia)• Amphibians & reptiles: spongy; some have compact (athletic/hypoxia)• Neonatal birds & mammals: spongy• Adult birds & mammals: 99% compact
Compact•Coronary blood supply•Compact design•First organ supplied with O2
Spongy •Venous blood supply•Simplest, but intricate design•Last organ supplied with O2
![Page 9: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/9.jpg)
Most fish = Trabeculae = venous
Mammals = compact = coronary Octopus coronaries
Variable compact/spongy
Cardiac muscle blood & O2 supply
![Page 10: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/10.jpg)
Initiation of cardiac contraction
Neurogenic pacemakers: rhythm generated in neurons(some invertebrates)
Myogenic pacemakers: rhythm generated in myocytes(vertebrates and some invertebrates)
Artificial pacemakers:rhythm generated by device
![Page 11: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/11.jpg)
Control of Contraction
• Vertebrate hearts are myogenic – cardiomyocytes produce spontaneous rhythmic depolarizations
• Cardiomyocytes are electrically coupled via gap junctions to insure coordinated contractions
• Pacemaker – cells with the fastest intrinsic rhythm• Fish: located in the sinus venosus• Other vertebrates: sinoatrial (SA) node in the right
atrium
![Page 12: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/12.jpg)
Myogenic contractions
• All cardiomyocytes can contract without an external stimulus• Resting membrane potential is ‘unstable’ = Pacemaker potential• Specialised cells (pacemaker) set intrinsic heart rate• Relative timing & speeds of opening of specific ion channels
Increasing heart rate• Norepinephrine is released from
sympathetic neurons and epinephrine is released from the adrenal medulla
• More Na+ and Ca2+ channels open• Rate of depolarization and action
potentials increaseDecreasing heart rate
• Acetylcholine is released from parasympathetic neurons
• More K+ channels open• Pacemaker cells hyperpolarize• Time for depolarization takes longer
![Page 13: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/13.jpg)
Increasing Heart Rate
![Page 14: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/14.jpg)
Decreasing Heart Rate
![Page 15: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/15.jpg)
Modulation of heart rate
![Page 16: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/16.jpg)
Depolarization travels through heart in two ways
![Page 17: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/17.jpg)
1. Directly between cardiomyocytes
• Cardiomyocytes are electrically connected via gap junctions
• Electrical signals can pass directly from cell to cell
![Page 18: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/18.jpg)
2. Specialized conducting pathways
• Modified cardiomyocytes that lack contractile proteins
• Specialized for electrical impulse conduction
![Page 19: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/19.jpg)
• All cardiomyocytes of a chamber contract together• Electrically coupled cells (desmosomes)• Specialized conduction fibres• Cardiac chambers contract sequentially, after blood has moved• Delays in electrical conduction between chambers
Syncitial & sequential cardiac contractions
(EKG)
• Sums all the electrical activity of syncytial contractions & relaxations
• P wave: atrial depolarization• QRS complex: ventricular depolarization• T wave: ventricular repolarization
![Page 20: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/20.jpg)
Impulse conduction – step 1
![Page 21: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/21.jpg)
Impulse conduction – step 2a
![Page 22: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/22.jpg)
Impulse conduction – step 2b
![Page 23: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/23.jpg)
Impulse conduction – step 3
![Page 24: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/24.jpg)
Impulse conduction – step 4
![Page 25: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/25.jpg)
Conducting Pathways
![Page 26: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/26.jpg)
EKG
![Page 27: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/27.jpg)
Myogenic contractions
• All cardiomyocytes can contract without an external stimulusBut• Different myocardial cells activate different ion channels • Plateau phase – extended depolarization that corresponds to the
refractory period and last as long as the muscle contraction• Prevents tetanus
Absence of funny channelsFast Na+ channelSlow L-type Ca2+ channel
![Page 28: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/28.jpg)
Excitation-contraction coupling
![Page 29: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/29.jpg)
Cardiac action potentials
![Page 30: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/30.jpg)
Cardiac pumping cycle
• ATP muscle contraction blood pressure blood flow• Isometric contraction blood pressure (wall tension) until valves open• Isotonic contraction blood flow (cardiac output) after valves open• Muscle thickness determines pressure
![Page 31: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/31.jpg)
Vertebrate Hearts
Vertebrate hearts have 3 main layers•Pericardium•Myocardium•Endocardium
Myocardium
![Page 32: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/32.jpg)
Vertebrate Hearts
Have complex walls with four main parts• Pericardium – sac of connective that surround the heart
• Two layers: parietal (outer) and visceral (inner) pericardium
• Filled with a lubricating fluid• Epicardium – outer layer of heart made of connective tissue
• Continuous with visceral pericardium
• Contain nerves that regulate the heart
• Contain coronary arteries• Myocardium – the middle layer of heart muscle• Endocardium – innermost layer of connective tissue covered by
epithelial cells (called endothelium)
![Page 33: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/33.jpg)
Vertebrate hearts - Myocardium
• Muscle layer• Composed of cardiomyocytes• Specialized type of muscle cell
![Page 34: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/34.jpg)
Oxygen supply to heart
• Myocardium extremely oxidative; has high O2 demand• Coronary arteries supply oxygen to compact myocardium• Spongy myocardium obtains oxygen from blood flowing through the heart
![Page 35: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/35.jpg)
Mammalian cardiac anatomy
Two atria Two ventricles
![Page 36: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/36.jpg)
Mammalian cardiac cycle
• Step 1: Late diastole, chambers relaxed, passive filling• Step 2: Atrial systole, EDV• Step 3: Isovolumic ventricular contraction• Step 4: Ventricular Ejection• Step 5: Early diastole, semilunar valves close
![Page 37: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/37.jpg)
Electrical and Mechanical Events in the Cardiac Cycle
• Heart sounds: opening and closing of valves
Figure 9.26
![Page 38: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/38.jpg)
Heart Pressures
• The two ventricles contract simultaneously, but the left ventricle contracts more forcefully and develops higher pressure
• Resistance in the pulmonary circuit is low due to high capillary density in parallel
• Less pressure is needed to pump blood through this circuit• The low pressure also protects the delicate blood vessels of the lungs
![Page 39: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/39.jpg)
Heart Pressures
![Page 40: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/40.jpg)
Heart Pressures
![Page 41: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/41.jpg)
Cardiac Output
• Cardiac output (CO) – amount of blood the heart pumps per unit time
• Stroke volume (SV) – amount of blood the heart pumps with each beat
• Heart rate (HR): rate of contraction• CO = HR X SV• Bradycardia – decrease in HR• Tachycardia – increase in HR
![Page 42: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/42.jpg)
Modulating cardiac output
• By changing heart rate• By changing stroke volume
Concept check: How would you modulate heart rate?
Slow heart rate = bradycardiaFast heart rate = tachycardia
Stroke volume is regulated in two ways:
1) Extrinsically (by nervous system and hormones)2) Intrinsically (via local mechanisms)
![Page 43: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/43.jpg)
Modulation of cardiac output
![Page 44: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/44.jpg)
Control of cardiac output: Intrinsic control mechanisms
• The importance of cardiac output (Q)• Heart rate
Pacemaker rate: temperature; body size • Cardiac stroke volume
Species variabilityEffects of filling (venous) pressure
![Page 45: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/45.jpg)
The importance of cardiac output (Q)
Flow (output) of blood per unit time from the heart (ml/min/kg)
Cardiac power output (= ATP need = O2 need)
Power output = Q x [blood pressure developed]
Right vs left
Atrium vs ventricle
![Page 46: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/46.jpg)
Respiratory function:
O2 uptake = Q x (A-V O2 difference)
Species variability in routine & maximum Q valuesHumans @ 37oC 70-300 ml/min/kgHagfish @ 10oC 10-30 ml/min/kgTrout @ 10oC 15-50 ml/min/kgTuna @ 28oC 100-200 ml/min/kgIcefish @ 0oC 100 ml/min/kg
(Cao2-Cvo2); tissue O2 extraction
[Hb] is a primary determinant of Cao2
Q10 effect~ x8~ x8~ x2~ x16
Q10 effect: O2 uptake doubles for +10oC
The importance of cardiac output (Q)
![Page 47: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/47.jpg)
Human exercising
Contribution of Q during exercise
O2 uptake = Q x (A-V O2 difference)
10-fold increase
Q = 3-fold increaseHR = 2.5-fold increaseSVH = 20% increaseA-VO2 = 3-fold increase
Volume = O2 delivery to tissues
Q = [heart rate] x [cardiac stroke volume]
![Page 48: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/48.jpg)
Q = [heart rate] x [cardiac stroke volume]
Regulation of Q during exercise
![Page 49: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/49.jpg)
Acute temperature effect on heart rate
HR,bpm
Temperature, oC0 4020
60
20
Ectotherms & Endotherms
Cooling by10oC 2x decrease
Q10 ~ 2
humantrout
![Page 50: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/50.jpg)
Temperature acclimation (resetting of pacemaker rate)
HR,bpm
Temperature, oC0 4020
60
20
Ectotherms
Acute Q10 ~ 2
1. Compensationeg, trout, Q10 = 1-2
2. Downregulationeg, turtles, Q10 > 3
trout
![Page 51: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/51.jpg)
Control of intrinsic pacemaker rate
Body mass & heart rate
Rate,bpm
Body Mass
1,000
hummingbird (1 g)
whale20 bpm
human60 bpm
HR = k . BM-0.25
Ectotherms120 bpm is maximumfor many ectotherms
Endotherms
![Page 52: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/52.jpg)
Intrinsic control of stroke volume
How? The Frank-Starling mechanism:
2. Varying stroke volume Alter cardiac emptying (end-systolic volume) = D muscle contraction Alter cardiac filling (end diastolic volume) = D venous pressure
Roles
1. Automatic matching output of chambersventricular output must match atrial output – all vertebratesright & left ventricular matching – crocodiles, birds & mammals
Many fishes (2-3x increase)Small increases (<50%) other vertebrates
![Page 53: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/53.jpg)
Control of Stroke Volume
Frank-Starling effect – an increase in end-diastolic volume results in a more forceful contraction of the ventricle and an increase in SV• Due to length-tension relationship
for muscle• Allows heart to automatically
compensate for increases in the amount of blood returning to the heart (autoregulation)
Level of sympathetic activity shifts the position of the cardiac muscle length-tension relationship
![Page 54: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/54.jpg)
Venous pressure cardiac filling myocyte stretch stronger contraction
Frank-Starling mechanism:
passive stretch
z
actin
contractile unit z
myosin
Venous filling pressure
SV
An intrinsic property of all vertebrate cardiomyocytes
![Page 55: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/55.jpg)
Control of Stroke Volume
The nervous and endocrine system can cause the heart to contract more forcefully and consequently pump more blood with each beat
![Page 56: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/56.jpg)
Control of stroke volume
![Page 57: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/57.jpg)
Control of cardiac output & flow distribution
• Cardiac stroke volumeChange in contractility
- importance of calcium
•Heart rateSympathetic & parasympathetic neural controls
- mechanisms- species diversity
• Blood flow distributionArteriolar controls
neural, humoral, paracrine, autocrine
Extrinsic control mechanisms
![Page 58: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/58.jpg)
Changing heart rate (vagal inhibition)
Pacemaker rate rarely equals measured HR
Inhibition & excitation
Vagus innervation of pacemaker & atriumAll vertebrate heartsExcept hagfish & lampreys
Sympathetic innervation of pacemaker, atrium & ventricleSome advanced, athletic teleost fishes,Amphibians, reptiles, birds & mammals
Cardiac stores: primitive fishInnervated Chromaffin tissue: other fishesAdrenal medulla
![Page 59: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/59.jpg)
Negative chronotropic effects (vagal inhibition)
0 mV
-60 mV
![Page 60: Vertebrate Closed Circulatory Systems Closed circulatory systems Cardiac anatomy & its O 2 supply The myogenic heart & the cardiac cycle Blood pressure](https://reader031.vdocuments.mx/reader031/viewer/2022013001/56649cc25503460f94989d34/html5/thumbnails/60.jpg)
Positive chronotropic effects (adrenergic stimulation)
0 mV
-60 mV