ventricular septal defect dolly mathew. development of ivs muscular septum – primordial iv septum...
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VENTRICULAR SEPTAL DEFECT
Dolly mathew
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Development of IVS
• Muscular septum – primordial IV septum
• Closure of interventricular foramen& membranous septum formation-
Rt & Lt bulbar ridges endocardial cushions
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Anatomy
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• A VSD is a defect in the ventricular septum • The ventricular septum consists of an inferior muscular and
superior membranous portion• The membranous portion -most commonly affected in adults
and older children• most common congenital cardiac anomalies.• 3-3.8 per 1000 live births• 30-60% of all newborns with a CHD
• Prospective studies give a prevalence of 2-5 per 100 births of trabecular VSDs that closes shortly after birth in 80-90% of the cases
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Location of VSDs
Swiss cheese
Muscular
Inlet
outlet
perimembranous
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Classification
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soto et al
• Perimembranous(membranous/• infracristal )-70-80%• Muscular- 5-20% Central- mid muscular Apical Marginal- along RV septal junction Swiss cheese septum – multiple defects• Inlet/ AV canal type-5-8%• Supracrital/ subaortic- 5-7%
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Types of VSD (kirklin)
1
23
4
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Hemodynamic classification
• Restrictive- resistance that limits the shunt at the site of vsd LVSP > RVSP pulm /aortic systolic pressure ratio < 0.3 Qp / Qs<1.4/1• Moderately restrictive - RVSP high, but less than LVSP - Qp/Qs 1.4/2.2• Non restrictive -Shunt not limited at the site of defect RVSP , LVSP, PA , Aortic systolic pressures
equal Qp/Qs >2.2 Flow determined by PVR
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Small VSD in infancy
• <1/3rd size of aortic root• shunt limited by size of the defect• Shunt entirely during ventricular systole• L R shunt <50% LV output• Pulmonary:systemic flow ratio < 2:1
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Medium sized VSD
• VSD size about half – equal to the size of the aortic orifice
• When PA & RVSP are > 50% of systemic arterial pressure
• mod-large L R shunt develops
• p218
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Large VSD
• Size equal to the aortic root
• Equalization of pressures in RV& LV
• Increased LA pressure opening of foramen ovale
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Pathophysiology
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• During systole, blood is shunted from LV to RV• passes through the lungs and re enters the LV via the
pulmonary veins and LA • causes volume overload on the LV• Shunt into the RV elevates RV pressure and volume,
leading to pulmonary hypertension.
• More noticeable in patients with larger defects
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pathophysiology
• Magnitude of shunt: size, PVR• Small defect: large resistance occurs at the
defect• Larger defect: resistance offered by the defect
minimum : Shunt depends largely on PVR• Lower the PVR, greater the LR Shunt
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• Enlargement of LA, LV,PA
• Shunt mainly in systole, when the RV also contracts
• Shunted blood goes directly to PA
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Natural history
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Natural history
• Spontaneous closure :75-85 % all VSDs• :35% perimemb ( 1st 6/12)• More frequent in small defects • Decrease in size with age• Inlet & outlet defects donot become smaller /close spont• Large & nonrestrictive defects : 10- 15%
• endocarditis – risk of endocarditis 4-10% for the first 30 years of life
• High velocity turbulent jet into RV
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• CHF • Large VSDs• Mod sized VSDs survive into adulthood• Increased rt sided flow pulmonary vascular
disease Eisenmenger’s physiology if left untreated
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• Risk factors for decreased survival• Shortness of breath, fatigue, DOE,progressive AR• Cardiomegaly• PASP >60mm Hg/ >1/2 of systemic pressure• Good prognosticators Lack of symptoms normal LV size & function small LR shunt normal pulmonary pressures / resistance Intact vasodilator response in pulmonary
vasculature
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• genetic factors• Affected father- 2%• Affected mother – 6%• 25 yr survival for all pts with a VSD 87%• Mortality increases with the size of VSD
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Mechanisms of closure
• Growth & hypertrophy of septum around the defect• By development of subacute bacterial endocarditis• adherence of STL tissue to the margins • (Negative pressure effect exerted by a high velocity
stream flowing through the defect )• Ventricular septal aneurysm• prolapse of aortic cusp• intrusion of a sinus of valsalva aneurysm
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History & clinical features
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History
• Incidence unrelated to maternal age, sex, birth order
• 3.3% 1st degree relatives of index patients• Among 1st degree relatives with CHD, 1/3rd
have vsd• 30-60% siblings of index patients have vsd• Parents with spontaneously closed vsd can
have offspring with vsd
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Small VSD - infancy
• Normal wt gain & development• 2-8 wks – tachycardia & tachypnea especially
with infection • 2-4/6 systolic mr, medium frequency
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Large VSD - infancy• Infant well in the immediate postnatal period • Systolic mr LLSB after 1-7 days• develop respiratory distress , in 2-8 wks• Cardiomegaly• Systolic thrill , along LSB• S1 normal/ soft: s2loud narrow split• Systolic mr , 2-3/6 intensity at birth, louder & harsh as shunt
increases• S3 & MDM at apex• If the infant survives - subsequent course with persistent dyspnea,
sweating, poor feeding, failure to thrive, LRTI
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Beyond infancy
• Arterial pulse- brisk ( vigorous ejection from a volume overloaded ventricle)
• N pulse in eisenmenger’s - systemic stroke volume maintained
• Cyanosis & clubbing : eisenmenger’s• JVP – N in small defects elevated - Mod restr & nonrestrictive vsd with ccf • Precordial bulge ( large shunt 5-6 months)• Harrison’s sulcus
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• Cardiomegaly• RV heave in pts with RV vol overload• Features of PAH• Grade 2-5/6 systolic regurgitant mrLLSB• MDM preceeded by S3• Infundibular vsd: early diastolic decrescendo
mr of AR
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Improvement of symptoms
• Closing defect findings : soft s2 high frequency & shorter murmur• Increasing PVR findings : increased RV pulsations s2 loud, narrow split• Infundibular hypertrophy decreased LR shunt, findings : s2 decreases in intensity , crescendo-decrescendo systolic murmur in the
ULSB, cyanosis (shunt reversal )
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• Eisenmenger’s • apex by RV • Palpable dilated hypertensive pulmonary trunk• Loud pulmonary closure sound • Very short or no systolic mr of vsd• Short pulmonary ejection mr ULSB• EDM of pulmonary regurgitation • Loud harsh s1 coincident holosystolic mr of
TR
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ECG
• small defects unremarkable• LA enlargement - Mod restrictive, large LR
shunts• left axis deviation Inlet vsd /AV septal defect 5% moderately restrictive vsds Ventricular septal aneurysms multiple vsds
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• LV enlargement in larger defects• RVH - Mild or moderate elevation of RV
pressure (rsR’ in V4R or V1) - Large VSD, equal ventricular
pressures , elevated PVR• RVH , RAD - Eisenmenger’s • RBBB - Surgical repair
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Chest x ray• Small defects that were mod restrictive at birth – increased LV size, dilated
pulmonary trunk & its branches• Large shunts – hyperinflated lungs with flat hemi
diaphragms
• LA enlargement best appreciated in the lateral position
• Increased PVR, decreases LR shunt, decreases heart size, enlargement of pulmonary trunk& its branches persists
• Nonrestrictive vsd with elevated but variable PVR- enlargement of all 4 chambers• Eisenmenger’s syndrome- oligemic lung fields, RA,LA, LV normal, RV occupies the
apex
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Echocardiography
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Common locations of vsd -2d echo
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Echocardiography- doppler• CFM-Direction, timing of flow• IVG (mmHg) = 4v² • PG = LVSP - RVSP
• LVSP - PG jet = RVsp ≈ Pasp• RVSP = cuff systolic BP – 4v² • PVR = TRV / TVI in RVOT x 10 + 0.16• High PA pressure, TRV/TVI rvot < 0.2 ; indicates low PVR, elevated pressure
secondary to the flow
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Cardiac catheterization
Hemodynamic assessments cardiac index oximetry quantification of shunt To assess pulmonary vascular resistance• Pts with increased PVR, with mod or large LR shunt• If PVR is increased, response to 100% oxygen,NO
tested
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cineangiography
• Defect best imaged in LAO(70°)cranial (25°)• Inlet defect - hepatoclavicular view ( 40°LAO,cranial angulation)• Anterior muscular VSD- RAO view• Aortography - r/o PDA ,coarctation
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Other imaging modalities
• Cardiac CT- assess VSD anatomy in suboptimal echo imges
No information about shunt fraction• MRI • delineate vsd location& shunt fraction in
complex associated lesions
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Management
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• Observation & follow up Small VSDs• Medical management Medium sized vsd CCF- treat with diuretics & digitalis, ACEI failure ppted by LRTI- Treat both 2-3 months follow up RV & PA pressures assessed Failure to thrive• Surgical Large vsd
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• drugs digoxin 10-20mcg/kg per day furosemide 1–3 mg/kg per day captopril 0.5–2 mg/kg per day enalapril 0.1mg/kg per day
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Indications of surgical intervention
• Large VSD with pulmonary hypertension • VSD with aortic regurgitation • VSD with associated defects• Failure of congestive cardiac failure to
respond to medications
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Timing of surgery in VSD
• <3months - if symptomatic• 3-6 months - symptomatic, growth failure,
increasing PAH• >6 months – primarily based on PAH • Wait till 1 yr , if no PAH
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• ACC/AHA guidelines 2008 for management of adults with CHD
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Surgical VSD closure
• Surgeons with training & expertise should perform VSD closure surgeries
• Closure of vsd indicated when Qp/Qs
2 or more & clinical e/o LV volume overload
When pt has a history of IE
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
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Surgical VSD closure
• Closure of vsd is reasonable when LR shunt is present at a Qp/Qs >1.5, with a PA pressure <2/3rd of systemic pressure & pulse volume recording < 2/3rd of SVR
• Closure of vsd is reasonable when LR shunt is present at a Qp/Qs >1.5, in the presence of LV systolic or diastolic failure
• Vsd closure not recommended in pts with severe irreversible PAH
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIII
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Interventional Catheterization for VSD
– Device closure of a muscular vsd may be considered,especially if its remote from tricuspid valve & aorta, if the vsd is associated with severe Lt sided chamber enlargement, or if PAH
III IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIII IIaIIaIIa IIbIIbIIb IIIIIIIIIIIaIIaIIa IIbIIbIIb IIIIIIIII
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VSD closure
• Direct closure of the defect• Surgical mortality <1%• Complications – RBBB- direct injury to rt
bundle, disruption of purkinje fibers• Residual shunt (<5% )• Injuries to tricuspid valve & aortic valve
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PA banding
• PA banding- palliative procedure , when additional lesions make repair difficult
• Done in multiple VSDs• 30-50% of original diameter is narrowed• Systolic pressure of 25-30 mmHg beyond the
constriction• RV/PA pressure gradient > 45 associated with
hypoxemia
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Post op follow up
• Every 1-2 yrs• VSD & mild PAH& repair after 3 yrs of age-
watch for progressive pulmonary vascular disease
• long term follow up needed
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Special situations
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VSD with AR
• Peri membranous VSD with AR - 5-8%• Subarterial VSDs – 30%• Sagging or herniation of RCC or RCC+ NCC• May cause RVOT obstruction• Due to morphological abnormality of valve • LV volume – regurgitant volume & shunt volume• VSD murmur dates from infancy• AR murmur appears (5-9 yrs)
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LV RA shunt
• Gerbode defect• Shunt begins inutero• Usually restrictive• Rightward thoracic
position of murmur • X ray – RA enlargement
disproportionate to the size of pulmonary trunk
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Thank you