Retrovirus and

HIVBy:

Valentina Benitez Bedoya

Introduction:

Retroviruses are the exception for

the rules of the Central Genome,

because it goes from RNA to DNA

HIV, Human immunodeficiency virus

is the principal retrovirus that can

cause an stage of

immunosuppression in its guests

Discovery of HIV

Feature Provides

New Drug Target

MRC Laboratory of Molecular Biology

2016, August 15

Discovery of HIV Feature

Provides New Drug Target

The virus is not

recognized by the guest’s

immune system because

of the capsid which

doesn’t go away as the

previous thoughts.

Discovery of HIV Feature

Provides New Drug Target

The capsid has capsid pores that regulate the enter of nucleotides to the virus in order to produce de DNA.

Discovery of HIV Feature

Provides New Drug Target

The capsid pores are the new

treatment target, and they were

successfully blocked using

hexacarboxybenzene

The scientist are developing a

component that can go through the

cells membranes and attack the

capsid pores.

Discovery of HIV Feature

Provides New Drug Target

This is a very important discovery,

because each day there are a lot

people getting infected by this virus. If

there is a more efficiently treatment,

there would be better prognostic to

those patients.

HIV-Related

Retroviruses Date

Back 60 Million

Years Ago

Czech Academy of Sciences.

2016, August 11th

HIV-Related Retroviruses Date

Back 60 Million Years Ago

Retroviruses are a

type of lentiviruses

and the oldest one

was target back to 12

million years ago

HIV-Related Retroviruses Date

Back 60 Million Years Ago

The new researched

showed that the

oldest Lentivirus is

back to 60 million

years ago

HIV-Related Retroviruses Date

Back 60 Million Years Ago

They took a genomic

data from the

Malayan flying lemur,

which contains DNA

Lentiviral remnants.

They are going to

study how that

ancient virus has

evolved in order

to understanding

it more.

HIV-Related Retroviruses Date

Back 60 Million Years Ago

By knowing the date were the oldest

lentivirus infected a guest, they can

research about its evolution in order

to know this virus better, and to find

important characteristics which can

lead us to new treatment targets.

Medical

Utility

Medical Utility

Both researches are about HIV, even if they are about a different topic of HIV, they both lead the way to improve the treatments and the way we understand the disease

Medical Utility

Knowing an understanding

how the virus works, and how

the immune system cannot

detect it, is a very important

advance in order to start

thinking in new treatments

Medical Utility

Researching from when and

where the HIV virus comes, is a

very important part of getting to

know this virus because wit that,

we can see how its evolution

process has come and how we

can use it to have new

treatments for HIV disease

Bibliography Czech Academy of Sciences. HIV-Related Retroviruses

Date Back 60 Million Years Ago. Retrieved August 22, 2016 from http://www.natureworldnews.com/articles/26705/20160811/hiv-retroviruses-60-million-years-ago.htm

MRC Laboratory of Molecular Biology. Contagion. Discovery of HIV Feature Provides New Drug Target. Retrieved August 22, 2016 from http://www.contagionlive.com/news/discovery-of-hiv-feature-provides-new-drug-target-

Hope , I said, it is the real

expectation of future glory , both

effect of divine grace as precedent

merits.

Dante Alighieri, Purgatory , Canto

XXV . 067-069

Thanks.