use of psoas muscle size as a frailty assessment tool for open and transcatheter aortic valve...
TRANSCRIPT
![Page 1: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/1.jpg)
Use of Psoas Muscle Size as a Frailty Assessment Tool for Open
and Transcatheter Aortic Valve ReplacementRaghavendra Paknikar BS
Jeffrey Friedman BSDavid Cron BS,
G. Michael Deeb MDStanley Chetcuti MD
P. Michael Grossman MDStewart Wang MD
Michael Englesbe MDHimanshu J. Patel MD
University of Michigan Medical Center
![Page 2: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/2.jpg)
Author Disclosures
• None
![Page 3: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/3.jpg)
Background
• AVR is most common valve procedure in US
• Landmark studies evaluating TAVR have revolutionized treatment for patients deemed “inoperable” or at high risk for AVR
• High rates of 1 year mortality in these cohorts regardless of treatment
![Page 4: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/4.jpg)
Background
• Concepts of frailty and futility have become increasingly important
• Frailty has been independently associated with higher risk for mortality and institutional care requirement after cardiac surgery
- Lee DH et. al. Circulation 2010
![Page 5: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/5.jpg)
Background
• Current risk assessment evaluates comorbidities not frailty
• Typical tests include:• “eyeball test”
• Gait speed
• Grip strength
• Subjective, effort dependent, cumbersome and therefore likely underutilized
• riskcalc.sts.org
![Page 6: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/6.jpg)
Background
• Prior work has evaluated use of core muscle mass loss as a measure of frailty
• Uses routinely available CT scan testing to assess core muscle mass
• Sarcopenia is not subject to acute changes in health status or effort
• Measurement can be standardized
• Lee DH et. al JVS 2011
![Page 7: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/7.jpg)
Study Objective
To evaluate the use of core muscle loss (sarcopenia) as a frailty assessment tool in determining therapeutic options for aortic valve disease
![Page 8: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/8.jpg)
Determination of Total Psoas Major Muscle Area
Inferior border L4
Patient A
Patient B
STS 2.4%TPA -1.7
STS 2.4TPA 2.1
![Page 9: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/9.jpg)
Patients and Methods
• Inclusion criteria• Either AVR ± CABG or TAVR
• Adequate preoperative CT scan (within 90 days) with imaging from L1 to L4
• January 2011 through December 2013
• Primary endpoint: Late survival
![Page 10: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/10.jpg)
Patients and Methods
TAVR
(47.1%)
710 Patients
SAVR
(52.9%)
Excluded for inadequate CT scan (n=414)
![Page 11: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/11.jpg)
Overall AVR Clinical Profile
• Mean age 70.7 years• SAVR 70 yr vs. TAVR 79 yr: p<0.001
• Mean STS-PROM 4.4%• SAVR 3.0% vs. TAVR 6.5%: p<0.001
• Gender standardized total psoas area:• SAVR 0.25 above mean vs.
TAVR -0.29 below mean: p<0.001
![Page 12: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/12.jpg)
Relationship of Total Psoas Area to STS risk score
-4-2
02
4G
ende
r Sta
ndar
dize
d TP
A
0 .05 .1 .15 .2 .25STS Mortality Risk Score
95% CI Fitted values
Standardized values of TPA
R-Squared=0.0078
-2-1
01
23
Gen
der S
tand
ardi
zed
TP
A0 .1 .2 .3 .4
STS Mortality Risk Score
95% CI Fitted values
Standardized values of TPA
R-Squared=0.0137
• SAVR • TAVR
• R2= 0.0078 • R2=0.0137
![Page 13: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/13.jpg)
Total Psoas Area By Gender
• SAVR• TAVR
• Because of baseline differences between gender, TPA reported as number of standard deviations from gender specific mean
![Page 14: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/14.jpg)
Early Outcomes
• 30-day mortality• SAVR 0% vs. TAVR 4%: p=0.022
• Stroke• SAVR 1% vs. TAVR 4%: p=0.154
• Renal Failure (STS version 2.73)• SAVR 0% vs. TAVR 2%: p=0.1
![Page 15: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/15.jpg)
Early Poor Composite Outcome
• Composite measure of :
1) 30-day mortality
2) stroke
3) renal failure
4) prolonged ventilation
5) deep wound infection
• 25 patients (8.4%)
![Page 16: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/16.jpg)
Early Poor Composite Outcome
Independent predictors OR p ValueBody mass index 1.1 < 0.001
STS M and M score 91.1 0.02
Tobacco use 5.0 0.03
Presence of mitral stenosis 7.8 0.03
Total psoas area 0.5 0.02
![Page 17: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/17.jpg)
Late Survival—Entire Cohort
2 yr survival 91.9%
![Page 18: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/18.jpg)
Late Survival According to Sarcopenia (lowest tertile)
2 yr survival
Sarcopenia 85.7%
Non-sarcopenia 93.8%
p=0.02
![Page 19: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/19.jpg)
Late Survival
Independent predictors HR p ValueMI within 21 days 9.2 0.009
Total psoas area 0.5 0.02
![Page 20: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/20.jpg)
High Resource Utilization
• Composite measure of :
1) length of stay > 14 days
2) ICU stay > 7 days
3) readmission within 30 days
• 68 patients (23.1%)
![Page 21: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/21.jpg)
High Resource Utilization—Entire Cohort
Independent predictors OR p ValueMale gender 0.5 0.04
Presence of aortic insufficiency 0.4 0.01
Total psoas area 0.6 0.001
![Page 22: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/22.jpg)
High Resource Utilization—Stratification by Treatment Type
• SAVR group
- Total psoas area independently predictive (OR 0.4, p<0.001)
• TAVR group• total psoas area not
predictive (p=0.66)
Bel
ow m
edia
n T
PA
Abo
ve m
edia
n T
PA
0
20
40 35.2
16.3
• SAVR Group
![Page 23: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/23.jpg)
High Resource Utilization Stratified By Sarcopenia and STS Score in SAVR Group Alone
Sarc
o H
i ST
S
Sarc
o L
o ST
S
Non
-sar
co H
i ST
S
Non
-sar
co L
o ST
S
0
20
40
60
80 66.7
3721.7 19.1
![Page 24: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/24.jpg)
Study Limitations
• Exclusion of fraction of initial cohort due to inadequate available imaging
• Need larger sample size and prospective analysis to determine differential effects on SAVR vs. TAVR mortality
• Sarcopenia does not evaluate other important cognitive and social aspects of frailty
![Page 25: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/25.jpg)
Summary
1. CT scan derived assessment of sarcopenia as an easily obtained objective frailty test predicts early morbidity and mortality, high resource utilization and late survival after AVR.
2. Sarcopenia along with STS risk score is important predictor of high resource utilization after SAVR but not TAVR
![Page 26: Use of Psoas Muscle Size as a Frailty Assessment Tool for Open and Transcatheter Aortic Valve Replacement Raghavendra Paknikar BS Jeffrey Friedman BS David](https://reader035.vdocuments.mx/reader035/viewer/2022062715/56649d755503460f94a565d9/html5/thumbnails/26.jpg)
Conclusion
Use of conventional risk calculators along with heart team evaluation and assessment for sarcopenia may provide optimal selection of therapy for aortic stenosis in transcatheter era