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Use of Ozone In Clinical Practice
Dr. David I. Minkoff M.D.
Lifeworks Wellness Center
BodyHealth Inc
Nearly Every Patient Gets Ozone
• CFS – mitochondrial dysfunction – virus/fungus/bacteria/parasite
• Cancer
• Athletic Performance – Anti-aging
• GI problems
• Wound care
• Dental Infections
• Macular Degeneration
• Pain – Prolozone
Why? Because……
• “Ultimately, it is a decrease in oxygen utilization that is responsible for the beginnings of degenerative disease, and the very process of aging itself.”
• And OZONE can be a critical factor in reversing that.
From Principles and Applications of Ozone Therapy, A Practical Clinical Guideline for Physicians
Frank Shallenberger MD, HMD, ABBAM
Decreased O2 Utilization Leads to:
• Decreased anti-oxidant buffering AND
• Increased ROS production
• Leads to:
• MITOCHONDRIAL DECAY that leads to
• AGING AND DEGENERATIVE DISEASE
Most Patients Have The Following Factors That Block O2 Utilization
1. Genetic SNIPs –e.g. Methylation defects
2. Nutritional deficiencies –EAA, EFA, Vit/Min
3. Toxin Load
4. Infections
5. Hormonal deficiencies
CORRECT THESE FOR OPTIMUM RESULTS
What Does Ozone Do? Kills bad stuff….
• Inactivates bacteria, viruses, fungi and protozoa by:
• Disrupting the integrity of bacterial cell envelope through oxidation of the phospholipids and lipoproteins.
• Damaging the viral capsid by disrupting virus-to-cell contact with peroxidation.
• Inhibiting cell growth at certain stages in fungi
• (V. Bocci & R. Viebahn)
What Does Ozone Do? Restores flow……
• Enhances Circulation by:
• Reducing clumping of red cells and restoring their flexibility and oxygen carrying ability.
• Increasing arterial oxygen partial pressure and reducing viscosity leading to better tissue oxygenation
• Oxidizing plaque in arteries allowing removal of the breakdown products.
What Does Ozone Do? Oxygenates…..
• Stimulates oxygen metabolism by:
• Increasing red blood cell glycolysis rate → stimulation of 2,3-diphosphoglycerate
• (2,3-DPG) → increase of oxygen released to tissues.
• Activating Krebs cycle by enhancing oxidative carboxylation of pyruvate → stimulating production of ATP.
What Does Ozone Do? Enzyme activation…
• Stimulates of the production of free radical scavenging enzymes and cell wall protectors: Glutathione Peroxidase, Catalase, and Superoxide Dismutase.
• Dissolution of malignant tumors: Ozone inhibits tumor metabolism, oxidizes the outer lipid layer of malignant cells and destroys them through cell lysis.
What Does Ozone Do? Activates cells and DNA• Induces cytokines in monocytes and lymphocytes)
• H2O2 crosses the cell membrane and activates the cytoplasmic gene-regulatory nuclear factor kappa B, which results in the transcription of mRNAs of several cytokines {interleukins (IL 1,2,4,6,8,10), tumor necrosis factor (TNF-∝) and interferons (IFN β and γ)}. (V. Bocci 2002)
The StrongestOXIDANTS
1. FLUORINE- rxns leave toxic byproducts
2. PERSULFATE- rxns leave toxic byproducts
3. OZONE- rxns leave O2, H2O, peroxides and lipoperoxides – “The clean killer!”
Important Aspect to Consider
Bacteria, Virus, Fungi, Parasites and free
radicals are all positively charged
Ozone is negatively charged
4500
BACTERIA
4500
MOLECULES
OF
CHLORINE
TOTAL
KILL
TIME
3500
SECONDS
4500
BACTERIA
ONE
MOLECULE
OF
OZONE
TOTAL
KILL
TIME
ONE
SECOND
Properties of Ozone
In Vitro Powerful Oxidizer
–Kills bacteria, fungi and viruses at lower concentrations than chlorine (1 molecule of ozone = 3,000 to 10,000 molecules of chlorine) AND kills 3500 times faster than chlorine.
Also oxidizes phenolics (poisonous compounds of methanol and benzene), pesticides, detergents, chemical manufacturing wastes and aromatic compounds more rapidly and effectively than chlorine, yet WITHOUTchlorine’s harmful residues (Trihalomethanes, etc.).
Silver Hydrosol
Silver Hydrosol Properties:Purity, Particle Size and Energy• Positively charged silver nanoparticles (Ag(n)
1+) 96%+.
• Particles measured on the nano/pico-scale.
• Uniform dispersion.
• Unprecedented surface area means that you can achieve with microgram doses what even gram doses of drugs cannot – without toxicity!
• At only 23 parts per million (ppm), there may be over 300,000,000 particles of active silver in every drop of pharmaceutical-grade purified water (H2O).
A B C
D E
Silver Hydrosol is different from colloidal silvers by virtue of particle size and energy (resulting in uniform dispersion).
Transmission Electron Micrographs at 100,000x magnification
F
The Silver Hydrosol is (C)
D E
Bio-Active Silver
Hydrosol
Label: 50 ppm; Actual: 60 ppm Label: 30 ppm; Actual: 34.2 ppm Label: 23 ppm; Actual: 23.2 ppm
Label: 200 ppm; Actual: 71 ppmLabel: 50 ppm; Actual: 54.8 ppm
Colloidal SilverColloidal Silver
Citrate
Nov. 2007
Colloidal Silver
Citrate
April 2009
Colloidal Silver
A B C
F
Label: 400 ppm; Actual: 393 ppm
Mild Silver
Protein
Electrical Charge
• The electrical charge is the effective anti-microbial mechanism of action rather than the element itself.
E Coli with Silver Ions on Surface
*3 teaspoons a day for
70 years (76,650
teaspoons) of a 23 ppm
silver hydrosol falls
under the oral RfD for
lifetime exposure
according to the U.S.
EPA.
76,650 teaspoons does
not even come close to
the Lowest Observed
Adverse Event Level
(LOAEL).
Silver
Hydrosol Safety
KAQUN WATER
KAQUN - ATTRIBUTES
• Non-carbonated
• Medical scientific research results
• Made of spring water with extremely high purity
• Low mineral content
• High oxygen content, its oxygen content is many fold of that of the normal drinking water
• Does not contain preservatives, flavorings and any other additives
• PH value of KAQUN water: 7.6-8.0
• Total mineral dissolved substance content: 180-220mg/l
• KAQUN has extra high stable dissolved Oxygen content
• Dissolved Oxygen reaches and enters cells regardless of hemoglobin level
• KAQUN triggers redox reactions in seconds as a proof of mitochondrial activity
• KAQUN triggers apoptosis as a proof of increased cell energy level and increased membrane potential
• KAQUN triggers cell redifferentiation as a proof of mitochondrial activity
What do we know about KAQUN water?
• Healthy cells: -70mV
• Chronic inflammation: < -50 mV
• Cancer: < -20 mV
• Death: 0 mV
Membrane potential
• -If toxins block ox-phos then CO2 is notproduced.
• -If no pCO2 then Oxygen remainsattached to Hemoglobin and the cellsremain hypoxic.
• -If O2 can be delivered to mitochondriaox-phos can be restarted.
• Any method what brings Oxygen intocells and restarts mitochondria iscurative.
KAQUN – RECOMMENDED AMOUNTS
• To preserve health: 0,5 litre
• In case of chronic illnesses: 0,75–1 litre
• In case of excessive mental burden: 1 litre
• In case of a weak immune system: 1–1,5 litre
• For sportsmen: 1,5–2 litre
• For children, pregnant and nursing mothers: 0,2–0,5 litre
ILLUSTRATIVE CASES
• Lifeworks treatment protocols for Lyme and chronic illness…..
Joseph
• 19 y/o male
• Symptoms: incapacitating fatigue, generalized pain and fibro, brain fog, lost hope of ever getting better.
• Began having problems years before and never was sure what was going on.
• Diagnosis: Lyme
Abnormal Borrelia burgdorferi (Lyme) Western Blot IgG
Nutrient/Toxic Elements
Deficient in Potassium, Copper and Selenium
Toxic in Aluminum, Arsenic and Mercury
Serum/Urine
Serum/Urine
CoQ10 plus vitamins mostly low
DNA/Oxidative Stress marker in urine high
Vit D low
Fatty Acids Profile (Plasma)
Deficient in Omega-3, Omega-6 and monounsaturated fats
Daniel G.
• 19 y/o male
• Symptoms: Incapacitating fatigue, fibro, can’t study or think, can’t pitch any more for his high school team.
• Diagnosis: Lyme
Positive Western Blot specific for B. burgdorferi
Low WBC count
Low Vitamin D
Heavy growth of bacteria
Positive H. Pylori
Low SIgA
Tapeworm detected
MTHFR, DNA Analysis shows abnormal C677T/A1298C mutations
Nutrient/Toxic Elements
Deficient in Potassium, Magnesium and Copper
Toxic in Aluminum, Arsenic, Cadmium and Lead
Zorica S.
• 48 y/o female
• PhD in Mechanical Engineering Ohio State
• Dx: “Rheumatoid Arthritis”
• Sx: Severe joint pain and swelling and deformity hands, knees, ankles, neck.
• Fatigue, abdominal pain, extreme weight loss, cachectic.
Positive Candida
Heavy growth of bacteria
Positive Toxoplasma
Equivocal Ameba histolytica
Positive H. Pylori Low SIgA Borderline Elevated Alpha
Anti-Chymotrypsin Low Chymotrypsin Positive Occult Blood Sensitive to milk, soy, egg Roundworm detected
Low essential amino acids Lysine Methionine Tryptophan Isoleucine Leucine Valine Histidine Threonine Arginine
Multiple abnormal Functional Categories
Low Potassium and Magnesium
Low Vitamin A
High Lipid Peroxides
High 8-Hydroxy-2 deoxyguanosine in urine
High Cell Regulation Markers Neuro-transmitter
Metabolism Markers Oxidative Damage and
Antioxidant markers Detoxification Indicators
Low Sulfate detox indicator
High Benzoate, Hippurate, P-Hydroxybenzoate, P-Hydroxyphenylacetate
High Fibrinogen Platelets
Low Hemoglobin Hematocrit MCV MCH MCHC
High Hemoglobin A1C
High CRP!
Low Vitamin D
Low IGF-1
Saliva Hormones
Low Estrogen(s) Progesterone DHEA
• High Sed- Rate
Doreen
• 51 years old
• Lives in San Diego
• Chronic severe fatigue/Fibro years
• Diagnosis: RA, CFS
• Bed ridden
Saliva Hormones
Low Estrogen(s) Progesterone DHEA
High
Benzoate, Phenylacetate, P-Hydroxyphenylacetate D-Lactate
Low Potassium and Magnesium
High Calcium
Low essential amino acids Lysine Methionine Tryptophan Threonine Glycine Serine
Low IGF-1
Low Vit D
High Ferritin
High CRP
Abnormal Borreliaburfdorferi (Lyme) Western Blot IgG
Low CD8-CD57
How Do We Use Ozone?
• Major Auto Hemotherapy (MAH) as extracorporeal blood treatment with O3 and reinfusion of activated blood
• Direct Ozone IV
• Rectal Insufflation of O3-O2 mixture = Rozone
• Prolozone injected for pain in joints or soft tissue
• HOCATT
• OTOZONE
The Safety and Benefits of Direct Intravenous Ozone Therapy (DIV)Howard F. Robins, D.P.M. Founding member AAO, IAOHD
• Abstract: Direct Intravenous Ozone Therapy (DIV) has been a method of treating diseases and conditions for many years. Internationally this method has been discouraged due to supposed risks and lack of benefits. Contrary to this opinion held by many, there is no scientific support of these allegations as there is no apparent record of injuries caused by this method or proven lack of benefits, just supposition, rumors and “medical urban myths”. In fact, over the last 17 years DIV has been performed over 150,000 times at the clinic with virtually no adverse reactions of any consequence. The supposed criticisms are either academic belief that are contrary to clinical experience, or at best, based on improper method of administration elsewhere. This paper will discuss the supposed risks and show through clinical experience the fallacies and misunderstandings that exist along with the benefits of the Robins Method Protocol for DIV compared to Major Autohemotherapy (MAH).
Direct Ozone Protocol
• We start with 20 gamma 20 cc via 27 g needle or PICC.
• Then increase by 20 cc at 20 gamma until 60 cc of gas reached or saturation.
• Then increase by 10 gamma/ 60 cc of each treatment until 55 gamma and 60 cc.
• Then we hold them there for a week to make sure they are stable.
• If so, we then start increasing to a total of 120 cc (as 60 cc ozone/1000 glutathione/ 60 cc ozone), based on their symptoms and tolerance.
• Usually after 60 cc we give 1000 mg of glutathione.
• For Lyme patients I do a treatment 5 days a week and in some twice a day (10) if they can take it without too much Herx.
• Most patients will feel well within 20-40 DIV treatments.
• We do Argentin 23 IV 3x per week with this.
• A daily Myer’s cocktail is also given.
HOCATT PLUS™
Hyperthermic Ozone & Carbonic Acid Transdermal Therapy
PLUS Other Natural Therapy Modalities
Whole Body Hyperthermia
It utilizes the following modalities as its fundamental therapies:Ozone in oxygen therapy as its main therapy
Carbonic Acid Therapy (CO2 Therapy)
Whole Body Hyperthermia
Ultrasonic Cavitation
Electrotherapy
Ultraviolet Irradiation
Summary of What We Do
• 1. Extensive labs to find toxicities and deficiencies.
• 2. Dental handling if needed
• 3. Scars and Autoimmune if needed
• Paleo Diet, ALCAT if needed
• 4. IV vits and minerals, usually Myers + Glutathione
• 5. Gut restoration, hormone balancing, metal detox (when ready),oral supplements (everyone gets BHC+D, MAP, Vit D, Iodine, Nanogreens, Mag)
• 6. Ozone: Direct IV, MAH, Rozone, HOCATT, Otozone, Frankenzone,
• 7. IV Silver 1-3 per week
• 8. Kaqun water
