University of Groningen

Developmental and pathological roles of BMP/follistatin-like 1 in the lungTania, Navessa

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Citation for published version (APA):Tania, N. (2017). Developmental and pathological roles of BMP/follistatin-like 1 in the lung. [Groningen]:University of Groningen.

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Developmental and Pathological Roles of BMP/Follistatin-like 1 in the Lung

PhD thesis

to obtain the degree of PhD at the University of Groningen on the authority of the

Rector Magnificus Prof. E. Sterken and in accordance with

the decision by the College of Deans.

This thesis will be defended in public on

Friday 6 October 2017 at 12.45 hours

by

Navessa Padma Tania

born on 12 April 1986 in Bandung, Indonesia

Supervisors Prof. R. Gosens Prof. M. Schmidt Co-supervisor Dr. H. Maarsingh Assessment Committee Prof. G. Folkerts Prof. C. Bingle Prof. F.A.E. Kruyt

De rol van BMP/Follistatin-like 1 in de ontwikkeling en de pathologie van de long

door

Navessa Padma Tania

geboren op 12 april 1986 te Bandung, Indonesië

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

vrijdag 6 oktober 2017 om 12.45 uur

Proefschrift

Paranymphs:Christel SeegersThea van den Bosch

The research described in this thesis was carried out at the Department of Molecular Pharmacology (Groningen Research Institute of Pharmacy, University of Groningen, The Netherlands) according to the requirements of the Graduate School of Science (Faculty of Science and Engineering, University of Groningen, The Netherlands).

The research was financially supported by the Lung Foundation Netherlands (grant 3.2.12.083).

Printing of this thesis was financially supported by the University Library of the University of Groningen, the Graduate School of Science, and the Lung Foundation Netherlands.

Cover story: COPD lung vs. developing lung– Putri Astri WulandariPrinting: Ipskamp Printing B.V., Enschede, the Netherlands

ISBN (printed version): 978-94-034-0016-7ISBN (electronic version): 978-94-034-0015-0

Copyright © 2017 by Navessa Padma Tania. All rights reserved. No parts of this thesis may be reproduced or transmitted in any form or by any means without the prior permission from the author.

Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world – Louis Pasteur

1

DEVELOPMENTAL AND PATHOLOGICAL ROLES OF BMP/FOLLISTATIN-LIKE 1

IN THE LUNG

Chapter 1. GeneralIntroduction.

Chapter 2. Endothelialfollistatin-like-1regulatesthepostnataldevelopmentofthepulmonaryvasculaturebymodulatingBMP/Smadsignaling.

Pulm Circ. 2017; 7(1):219-231

Chapter 3. TheeffectofcigarettesmokingonpulmonaryFollistatin-like1expres-sion:potentialimplicationinchronicobstructivepulmonarydisease

Chapter 4. Activin-A:activeininflammationinCOPD.

EurRespir J. 2014; 43: 954–955

Chapter 5. Pro-inflammatoryrolesofFollistatin-like1incoordinatingepitheli-al-mesenchymalcommunicationininflammatorycytokinereleaseinthelung

Submitted

Chapter 6. Regulationofpulmonaryinflammationbymesenchymalcells.

Pulm.Pharmacol.Ther. 2014; 1-10

Chapter 7. Variantclubcelldifferentiationisdrivenbybonemorphogeneticprotein4inadulthumanairwayepithelium:Implicationsforgobletcellmetapla-siaandbasalcellhyperplasiainCOPD.

Chapter 8. Generaldiscussionandsummary.

Chapter 9. Dutchsummary/Nederlandsesamenvatting

Chapter 10. Indonesiansummary/RangkumandalambahasaIndonesia

Acknowledgement

Biographyandlistofpublications