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Under the direction of Rebecca Gruchalla, M.D., Ph.D., the Division of Allergy and Immunology in the Department of Internal Medicine (IM) and the Division Pediatric Allergy and Immunology in the Department of Pediatrics work as one team. While administratively separate, the two Allergy and Immunology divisions function as one, blending teaching, clinical, and research. Patient care and clinical activities are based at the Asthma, Allergy and Immunology, and Immunodeficiency Clinics at Children’s Health, Parkland Memorial Hospital and the James W. Aston Ambulatory Care Center, where division faculty provide comprehensive evaluation, diagnostic, and management services for children and adults, respectively, with allergy, asthma, and immunological disorders. Faculty members participate in both clinical and basic science research efforts. As both a clinical and mechanistic site in the National Institutes of Health (NIH) Inner City Asthma Consortium (ICAC), the Division continues to expand research efforts in pediatric asthma. Moreover, Drs. Bird and Parrish perform important clinical research in food allergy and Dr. Khan in drug allergy and asthma.
The Division has one of only 71 ACGME-accredited programs for fellowship training in allergy and immunology. Division faculty also provide the major instruction to pediatric and internal medicine residents in the evaluation and management of children and adults with allergic diseases, asthma, and immunodeficiency diseases.
Division Faculty
Allergy and immunology spans both Pediatrics and Internal Medicine, with four pediatric-based and four internal medicine-based faculty members who are all certified by the American Board of Allergy and Immunology. All division faculty are clinically active and firmly committed to clinical teaching. Volunteer faculty members in private practice also participate in clinical and educational activities.
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Rebecca Gruchalla, M.D., Ph.D. Profesor, Division Chief
Drew Bird, M.D. Associate Professor
Jeffrey Chambliss, M.D. Assistant Professor
Shelley Harvey, M.D. Faculty Associate
Christopher Parrish, M.D. Assistant Professor
Min Lee, M.D. Assistant Professor
David Khan, M.D. Professor
Christian Wysocki, M.D., Ph.D. Associate Professor
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Honors / Awards Best Doctors/Pediatric Specialists in Dallas, D Magazine
Drew Bird
Rebecca Gruchalla
David Khan
Christopher Parrish
Christian Wysocki
Texas Super Doctors, Texas Monthly
Drew Bird
David Khan
Rebecca Gruchalla
Christopher Parrish (2019 Texas Rising Star)
Exceptional Women in Medicine, Castle Connolly Top Doctors
Rebecca Gruchalla
Invited Lectures
Drew Bird
NYU Winthrop Hospital Internal Medicine Grand Rounds, Long Island, NY, April 2019
“Food Allergies, Not Just for Kids”
Food Allergy: From Primary Prevention to Treatment and Intervention, AAAAI Course, Chicago, IL, September 2019
“Epicutaneous Immunotherapy”
3rd Annual BJ Ferguson Memorial Lecture, American Academy of Otolaryngic Allergy Annual Meeting
New Orleans, LA, September 2019
“Is the Proof in the Pudding: Update on Novel Food Allergy Therapies”
American Academy of Otolaryngic Allergy Annual Meeting, New Orleans, LA, September 2019
“Food Allergies: Are They Driving You Nuts? Updates in Food Allergy Diagnosis & Management”
American College of Allergy, Asthma and Immunology Annual Meeting, Houston, TX, October 2019
“Evolution of Food Allergy Therapies: Efficacy and Safety of OIT and EPIT”
“7 for 11: Hot Topics in Pediatric A&I: Food Allergy Treatment”
TexMed 2019, Texas Medical Association, Dallas, TX, May 2019
“Food Allergies: Are They Driving You Nuts? Updates in Food Allergy Diagnosis and Prevention”
51st Annual Kenneth C. Haltalin Pediatrics for the Practitioner, Children’s Medical Center, Grapevine, TX, June 2019
“Approach to Diagnosis of Food Allergy in a Patient with Atopic Dermatitis”
Kelsey-Seybold Pediatric Department Meeting, Houston, TX, December 2019
“Is the Proof in the Pudding: Update on Novel Food Allergy Therapies”
Jeffrey Chambliss
Pediatric Hospitalist Medicine Conference, Annual Meeting, Seattle, WA, July 2019
“Keeping Your Hives at Bay: Key Strategies for the Allergic Reaction Admission”
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David Khan
AAAAI Annual Meeting San Francisco, CA, February 2019 “JACI In Practice Year In Review: Drug Allergy, Urticaria, & Angioedema”
Texas Allergy, Asthma, and Immunology Meeting, Bastrop, TX, April 2019 “Updates on the New Drug Allergy Practice Parameter”
UTSW Internal Medicine Grand Rounds, Dallas, TX, April 2019 “Tackling the Epidemic of Penicillin Allergy”
Eastern Allergy Conference, Palm Beach, FL, May 2019 “Proactive management of antibiotic allergies” “Advances in the Diagnosis and Treatment of HAE”
UTSW Pediatrics Research Conference, Dallas, TX June 2019 “Implementing a Proactive Penicillin Allergy Testing Program”
Cleveland Allergy Society Meeting, Cleveland, OH, July 2019 “Refractory Chronic Urticaria: Beyond Omalizumab”
Cleveland Clinic Internal Medicine Grand Rounds, Cleveland, OH, July 2019 “Dealing with Antibiotic Allergies”
Cleveland Clinic Allergy & Immunology Grand Rounds, Cleveland, OH, July 2019 “Advances in the Diagnosis and Treatment of HAE”
Intermountain West Allergy Association, Coeur D’Alene, ID, July 2019 “Refractory Chronic Urticaria: Beyond Omalizumab”
Primary Care Conference, Skagway, AL, July 2019 “Drug Allergy Cases and Management” “Anaphylaxis Fact and Fiction” “Allergic Rhinitis Update” “Asthma Update” “Allergy Cases”
TAAIS Primary Care Resident’s Conference, Lakeway, TX, August 2019 “Drug Allergy”
University of Nebraska Internal Medicine Grand Rounds, Lincoln, NE, September 2019 “Practical Approaches for Dealing with Antibiotic Allergies”
Univ of Nebraska Pulmonary/Allergy Grand Rounds, Lincoln, NE, September 2019 “Refractory Chronic Urticaria”
Advanced Academic Rheumatology Review Course, Abu Dhabi, UAE, October 2019 “Drug Allergy Updates for Rheumatologists” “Urticarial Vasculitis”
ACAAI Annual Meeting, Houston, TX, November 2019 “Literature Review: The Year’s Best Articles” “Cutaneous Drug Eruptions” “Owning Penicillin Allergy”
Infectious Diseases in Children Symposium, New York, NY, November 2019 “Assessing Antibiotic Allergies”
WAO World Allergy Congress, Lyon, France, December 2019 “Risk factors for biphasic anaphylaxis”
Min Jung Lee
TexMed 2019, Allergy, Asthma, Immunology CME Program, Dallas, TX, May 2019
“An Update on Biologics for Allergic Diseases”
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Christopher Parrish
Physician Education Resources CME Program in conjunction with TAAIS Annual Meeting, Lost Pines, TX, April 2019
“From Diagnosis to Emerging Immunotherapeutic Options: Understanding the Burden and Risks of Peanut Allergy”
TexMed 2019, Allergy, Asthma, Immunology CME Program, Dallas, TX, May 2019
“Eosinophilic Esophagitis: What Primary Care Providers Should Know”
Physician Education Resources CME Program in conjunction with meeting of Hawaii Society of Allergy Asthma and
Immunology, Honolulu, HI, November 2019
“Immunotherapy Best Practice™ Peanut Allergy”
Christian Wysocki
TAAIS Primary Care Resident’s Conference, Lakeway, TX August 2019
“Diagnostic evaluation of Primary Immunodeficiencies”.
Education and Training
The Division of Pediatric Allergy and Immunology is committed to providing quality medical education for medical students, residents, and fellows. It has an active fellowship program and also provides inpatient and outpatient opportunities for residents and medical students.
Fourth-Year Medical Students
Pediatric Allergy and Immunology offers a fourth-year clerkship for medical students. This course provides an in-depth exposure to pediatric allergy and immunology via:
Clinical experience
One-on-one discussions between student and faculty regarding pre-determined topics outside of the clinic
Attending structured didactic sessions/conference
Self-study through prepared curriculum material
Residents
The Pediatric Allergy and Immunology Division provides the major instruction to pediatric and internal medicine residents in the evaluation and management of children and adults with allergic diseases, asthma, and immunodeficiency diseases. It also provides didactic teaching for the residents on the basics of allergy and immunology and directs teaching for the residents in the regular departmental clinical conferences and as part of the inpatient consultation service.
An Allergy and Immunology elective is available for pediatric and internal medicine residents, and fourth-year medical students. The objectives of the elective are to:
Develop a working differential diagnosis of allergies, asthma, and primary immunodeficiency disorders.
Learn how to conduct a complete physical exam including the upper and lower airways.
Examine and discuss patients from all major allergy and immunology categories: allergic rhinitis, asthma, urticaria, drug allergy, food allergy, and primary immunodeficiency.
Residents see outpatients in the clinics under the supervision of one of the members of the Division faculty. Relevant articles about specific allergic and immunologic disorders are provided to residents at the beginning of each rotation, and residents attend clinical conferences offering didactic teaching for fellows.
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Fellows
Although recognized for its scientific achievements, the Division of Pediatric Allergy and Immunology is committed to excellence in clinical care and teaching. Toward this end, the Allergy and Immunology Training Program, directed by David Khan, M.D., has grown in both size and stature with four funded fellowship positions since it enrolled its first fellow in 1982.
Balanced Clinical Experiences
Successful training in Allergy and Immunology should consist of balanced exposure to training experiences involving adults and children, no matter what the training background or the long-term plans of any particular fellow in training. Drs. Rebecca Gruchalla, David Khan and Chris Wysocki oversee the adult teaching clinics at Parkland Memorial Hospital and the University West Campus, while Drs. Drew Bird, Parrish, Lee and Chambliss oversee the teaching clinics at Children’s Health™.
Further staffing of both adult and pediatric clinics is provided by our 15 volunteer clinical faculty. Approximately 40 percent of Allergy fellows have come from pediatric house staff programs, and approximately half of the outpatient clinics required of Allergy and Immunology fellows primarily involve children.
Diversified Training Experiences
The UT Southwestern program offers a diversity of clinical experiences in Allergy and Immunology. It has a strong primary immunodeficiency program and is one of the Diagnostic and Research Centers for the Jeffrey Modell Centers Network. In addition, a Food Allergy Center has been established for clinical and research purposes at Children’s Health™. The Food Allergy Center has been recognized as a FARE Clinical Network Center of Excellence since 2015.
The Adult Allergy Division operates the Parkland Asthma Clinic, which oversees the care of adult patients with moderate to severe asthma, and the Parkland Allergy Clinic and the clinics at the University’s West Campus are tertiary/quaternary referral centers for patients with chronic urticaria, drug allergies, hereditary angioedema, common variable immunodeficiency, mastocytosis, and anaphylaxis.
Fellows also have exposure to other common conditions including rhinitis, asthma, sinusitis, and atopic dermatitis in both the pediatric and adult clinics.
Research
All fellows are required to participate in at least one research project. Current and past projects have been extremely diverse – most are clinically oriented and some are basic science-oriented – a reflection of the differing interests of the past and current fellows. Because training positions are fully funded by Parkland Memorial Hospital and Children’s Medical Center, and not by federal training grants, fellows are encouraged to consider research opportunities in a diversity of fields.
Fellows are encouraged to present the results of their research studies at national meetings. The majority of fellows are able to publish at least one manuscript based on their fellowship training. Fellows in training are encouraged to travel to one national meeting during each of the two training years and are provided financial support for this purpose.
Success of Training Program Graduates
Within the past 16 years, 100 percent of the graduates of UT Southwestern’ s Allergy and Immunology training program have passed the American Board of Allergy and Immunology certifying examination. Most graduates are currently in private or group practice settings; however, a few have become full-time medical school faculty members. More than half of our clinical faculty are prior graduates of the Allergy and Immunology training program.
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Research Activities
Since 1994, Dr. Gruchalla has had sustained NIH funding for research in inner-city pediatric asthma. In 1996, she became a member of the Inner-City Asthma Multicenter Study group (Dallas-site PI), which became an NIH-sponsored contract (Inner City Asthma Consortium – ICAC) in 2002. The initial contract was a six-year contract for $55.8 million, and its purpose was to investigate the mechanisms of asthma in inner-city children, as well as to develop novel treatments for this disease. The contract has been renewed for the third time and now extends through 2021.
UT Southwestern Medical Center is once again a participating site, along with Boston University, Children’s Memorial Hospital in Chicago, Cincinnati's Children's in Cincinnati, Children’s National Medical Center in Washington, D.C., Henry Ford Health System in Detroit, National Jewish Health in Denver, Johns Hopkins University in Baltimore, Columbia University in New York, St. Louis Children’s Hospital in St. Louis, and the University of California, San Francisco.
UT Southwestern continues to be one of the top recruiting sites for ICAC.
In addition to the asthma clinical studies that have been, and that are being done, as a part of ICAC, basic mechanistic studies are being conducted as well.
Drs. Rebecca Gruchalla and Michelle Gill, Professor of Pediatrics, Immunology and Internal Medicine, are involved in research that suggests allergic reactions to cockroaches, pet dander, dust mites, and mold may prevent people with allergic asthma from generating appropriate immune responses to respiratory challenges like the flu virus.
Dr. David Khan is conducting various research projects in adults focused on drug allergies, refractory chronic urticaria, mood disorders and asthma, and rush immunotherapy.
Dr. Bird continues conducting active research into interventional therapeutics for treatment of life-threatening food allergies. In 2019, Dr. Bird was invited to participate in the NIH/NIAID-funded Consortium for Food Allergy Research. He and his team managed eleven active clinical trials in 2019.
Clinical Activities
Faculty cover an active consult service at Children’s Health, Parkland Memorial Hospital, and UT Southwestern University Hospitals, as well as outpatient clinic services in Asthma, Allergy, and Immunology at Children’s and the University’s West Campus.
Clinical Immunology Program
The Clinical Immunology Program was awarded recognition by the Jeffrey Modell Foundation as a Diagnostic and Research Center primary immunodeficiency diseases. Directed by Dr. Christian Wysocki, the Clinical Immunology Program serves a large geographical referral area encompassing North Texas, eastern New Mexico, Oklahoma, western Louisiana, and southern Arkansas. This comprehensive program provides both diagnostic and state-of-the-art treatment opportunities for patients with primary immunodeficiency diseases. The clinical program also partners with members of the basic Immunology department at UT Southwestern in research and educational efforts.
Furthermore, Dr. Wysocki staffs adult Immunodeficiency clinics at UT Southwestern and Parkland Hospital. This allows state of the art treatment of adult patients with immunodeficiency disorders, and importantly, allows effective transitioning of adolescent and young adult patients from the pediatric immunodeficiency clinics, to the adult clinics, while maintaining continuity of care.
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Food Allergy Center
Under the direction of Dr. Drew Bird, Dedman Family Scholar in Clinical Care, the Food Allergy Center treats a broad range of allergic diseases in both inpatient and outpatient settings and will be conducting research that is instrumental in developing treatments and therapies. This Center opened in 2010 and is the only academic-affiliated pediatric food allergy center in North Texas. Since 2015 the Food Allergy Center has been recognized as a FARE Clinical Network Center of Excellence.
The Food Allergy Center is also home to the Dallas Eosinophilic Esophagitis Program (DEEP) at Children’s Health. Dr. Christopher Parrish is Co-Director of this multidisciplinary program, which utilizes a team approach to the management of eosinophilic esophagitis involving a pediatric allergist, pediatric gastroenterologists, a dietitian and a child psychologist with expertise in feeding problems.
Asthma Clinic
In addition to other allergic diseases, Drs. Min Lee and Jeffrey Chambliss evaluate and care for children with persistent allergic asthma along with a volunteer faculty member, Dr. William Neaville. The targeted therapies for these patients may include biologic therapies and/or allergy shots offered through the immunotherapy clinic.
Patient Visits Dallas 2017 2018 2019
Food allergy new patient visits 956 912 740
Food allergy follow up visits 719 752 819
Food allergy challenge visits 524 429 652
Allergy new patient visits 677 777 1294
Allergy follow up visits 724 830 1079
Immunology new patient visits 339 251 242
Immunology follow up visits 495 468 465
Total Dallas Visits 4,434 4,419 5,291
Legacy 2017 2018 2019
Food allergy new patient visits 423 632 654
Food allergy follow up visits 241 275 397
Food allergy challenge visits 25 9 13
Total Legacy Visits 689 916 1,064
THD 2018 2019 Food allergy new patient visits 112 127
Food allergy follow up visits 109 133
Total THD Visits 221 260
Total All Locations 2017 2018 2019
Total New, follow up, and challenge visits 5,123 5,556 6,615
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Current Grant Support
Drew Bird
Grantor: NIH-NIAID and Genentech Title of Project: Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen OIT in Food Allergic Children and Adults (OUtMATCH) Role: Site Principal Investigator Dates: 03/2019 – 02/2024 Grantor: Food Allergy Research and Education Title of Project: Peanut Sublingual Immunotherapy Induction of Clinical Tolerance in Newly Diagnosed Peanut Allergic 12 to 48 month-old Children Role: Site Principal Investigator Dates: 05/2014 – 12/2019 Grantor: DBV Technologies Title of Project: A Double-Blind, Placebo-Controlled Randomized Trial to Study the Viaskin Milk Efficacy and Safety for Treating IgE-Mediated Cow’s Milk Allergy in Children (MILES study) Role: Site Principal Investigator Dates: 07/2015 – 06/2020 Grantor: DBV Technologies Title of Project: Open-label Follow-up Study of the PEPITES Study to Evaluate the long-term efficacy and safety of Viaskin Peanut (PEOPLE Study) Role: Site Principal Investigator Dates: 04/2017 – 03/2020 Grantor: Aimmune Therapeutics Title of Project: Peanut Oral Immunotherapy Study of AR101 for Desensitization in Children and Adults (PALISADE) Role: Site Principal Investigator Dates: 04/2016 – 04/2021 Grantor: DBV Technologies Title of Project: Long-term Assessment of Safety and Therapeutic Benefit of Viaskin Peanut Epicutaneous Treatment in Peanut-Allergic Children: A 6-Month Randomized, Double-Blind, Placebo-Controlled Phase III Study Followed by an Open Label Active Treatment (REALISE Study) Role: Site Principle Investigator Dates: 12/2016 – 12/2021 Grantor: Aimmune Therapeutics Title of Project: Real-world AR101 market supporting experience study in peanut-allergic children ages 4 to 17 (RAMSES) Role: Site Principal Investigator Dates: 03/2016 – 6/2020 Grantor: Astellas Pharma Title of Project: A Phase 1, Randomized, Placebo-Controlled Study to Evaluate Safety, Tolerability and Immune Response in Adolescents Allergic to Peanut after Receiving Intradermal Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Role: Site Principal Investigator Dates: 05/2019 – 10/2021
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Grantor: DBV Technologies Title of Project: A double-blind, placebo-controlled, randomized phase III trial to assess the safety and efficacy of Viaskin Peanut in peanut allergic young children 1 to 3 years of age Role: Site Sub-Investigator Dates: 02/2019 – 01/2024 Grantor: DBV Technologies Title of Project: A Double-Blind, Placebo-controlled, Randomized Phase III Pivotal Trial to Assess the Efficacy and Safety of Peanut Epicutaneous Immunotherapy with Viaskin Peanut in Peanut-Allergic Children (PEPITES Study) Role: Site Principal Investigator Dates: 02/2016 – 02/2019
Rebecca Gruchalla
Grantor: University of Wisconsin / NIAID Title of Project: Inner City Asthma Consortium Role: Principal Investigator Dates: 2014 – 2021
Christopher Parrish Grantor: DBV Technologies Title of Project: A Double-Blind, Placebo-Controlled, Randomized Phase Iii Trial to Assess the Safety and Efficacy of Viaskin Peanut in Peanut-Allergic Young Children 1-3 Years of Age (Epitope) Role: Principal Investigator Dates: 02/2019 – 02/2024
Grantor: Regeneron Pharmaceuticals, Inc. Title of Project: A Phase 3, Randomized, 3 Part Study to Investigate the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients with Eosinophilic Esophagitis (R668-EE-1774) Role: Principal Investigator Dates: 07/2019 – 12/2040 Grantor: NIH-NIAID and Genentech Title of Project: Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen OIT in Food Allergic Children and Adults (OUtMATCH) Role: Site Sub-Investigator Dates: 03/2019 – 02/2024 Grantor: Food Allergy Research and Education Title of Project: Peanut Sublingual Immunotherapy Induction of Clinical Tolerance in Newly Diagnosed Peanut Allergic 12 to 48 month-old Children Role: Site Sub-Investigator Dates: 05/2014 – 12/2019 Grantor: DBV Technologies Title of Project: A Double-Blind, Placebo-Controlled Randomized Trial to Study the Viaskin Milk Efficacy and Safety for Treating IgE-Mediated Cow’s Milk Allergy in Children (MILES study) Role: Site Sub-Investigator Dates: 07/2015 – 06/2020
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Grantor: DBV Technologies Title of Project: Open-label Follow-up Study of the PEPITES Study to Evaluate the long-term efficacy and safety of Viaskin Peanut (PEOPLE Study) Role: Site Sub-Investigator Dates: 04/2017 – 03/2020 Grantor: Aimmune Therapeutics Title of Project: Peanut Oral Immunotherapy Study of AR101 for Desensitization in Children and Adults (PALISADE) Role: Site Sub-Investigator Dates: 04/2016 – 04/2021 Grantor: DBV Technologies Title of Project: Long-term Assessment of Safety and Therapeutic Benefit of Viaskin Peanut Epicutaneous Treatment in Peanut-Allergic Children: A 6-Month Randomized, Double-Blind, Placebo-Controlled Phase III Study Followed by an Open Label Active Treatment (REALISE Study) Role: Site Sub-Investigator Dates: 12/2016 – 12/2021 Grantor: Aimmune Therapeutics Title of Project: Real-world AR101 market supporting experience study in peanut-allergic children ages 4 to 17 (RAMSES) Role: Site Sub-Investigator Dates: 03/2016 – 06/2020 Grantor: Astellas Pharma Title of Project: A Phase 1, Randomized, Placebo-Controlled Study to Evaluate Safety, Tolerability and Immune Response in Adolescents Allergic to Peanut after Receiving Intradermal Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Role: Site Sub-Investigator Dates: 05/2019 – 10/2021
David Khan
Grantor: NHLBI-National Heart, Lung and Blood Institute Title of Project: Treating Caregiver Depression to Improve Childhood Asthma: Impact and Mediators Role: Principal Investigator Dates: 09/2015 – 06/2020 Grantor: NHLBI-National Heart, Lung and Blood Institute Title of Project: The Dallas Asthma Brain and Cognition Study Role: Principal Investigator Dates: 07/2018 – 05/2022 Grantor: NATIONAL INSTITUTE OF HEALTH Title of Project: Penicillin Allergy: Prediction, Outcomes, and Phenotypes Role: Principal Investigator Dates: 07/2020 – 06/2025 Grantor: NATIONAL INSTITUTE OF HEALTH Title of Project: Determining the Accuracy of Cephalosporin Allergy Testing Role: Principal Investigator Dates: 06/2019 – 05/2020
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Christian Wysocki Grantor: Jeffrey Modell Foundation Title of Project: Primary Immune Deficiency Diagnostic and Research Center Title: Director Dates: 09/2019 – 09/2020
Journal Publications
1. Altman MC, Gill MA, Whalen, E, Babineau DC, Shao B, Liu AH, Jepson B, Gruchalla RS, et al. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. Nat Immunol. 2019 May;20(5):637-651. PMID: 30962590
2. Bird JA, Clark A, Dougherty I, Brown LS, Arneson A, Crain M, Parrish C. Baked egg oral immunotherapy desensitizes baked egg allergic children to lightly cooked egg. J Allergy Clin Immunol Pract. 2019 Feb;7(2):667-669.e4. PMID: 30053593
3. Bird JA, Parrish C, Patel K, Shih JA, Vickery BP. Prevention of food allergy: Beyond peanut. J Allergy Clin Immunol. 2019 Feb;143(2):545-547. PMID: 30611674
4. Brown ES, Kulikova A, Van Enkevort E, Nakamura A, et al, Khan DA, et al. A randomized trial of an NMDA receptor antagonist for reversing corticosteroid effects on the human hippocampus. Neuropsychopharmacology. 2019 Dec;44(13):2263-2267. PMID: 31181564
5. Brown ES, Sayed N, Choi C, Tustison N, Roberts J, et al, Khan DA, et al. A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus. Eur Neuropsychopharmacol. 2019 Mar;29(3):376-383. PMID: 30612854
6. Castells M, Khan DA, Phillips EJ. Penicillin Allergy. N Engl J Med. 2019 Dec 12;381(24):2338-2351. PMID: 31826341
7. Chamseddin B, Marks E, Dominguez A, Wysocki C, Vandergriff T. Refractory macrophage activation syndrome in the setting of adult-onset Still disease with hemophagocytic lymphohistiocytosis detected on skin biopsy treated with canakinumab and tacrolimus. J Cutan Pathol. 2019 Jul;46(7):528-531. PMID: 30927277
8. Chiriac AM, Banerji A, Gruchalla RS, et al. Controversies in Drug Allergy: Drug Allergy Pathways. J Allergy Clin Immunol Pract. 2019 Jan;7(1):46-60.e4. PMID: 30573422
9. Dorman SM Jr, Regan SB, Khan DA. Effectiveness and safety of oral tacrolimus in refractory chronic urticaria. J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):2033-2034.e1. PMID: 30641147
10. Dreskin SC, Germinaro M, Reinhold D, Chen X, et al, Chambliss JM, et al. IgE binding to linear epitopes of Ara h 2 in peanut allergic preschool children undergoing oral Immunotherapy. Pediatr Allergy Immunol. 2019 Dec;30(8):817-823. PMID: 31437325
11. Du Q, Huynh LK, Coskun F, Molina E, King MA, Raj P, Khan S, Dozmorov I, Seroogy CM, Wysocki CA, et al. FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans. J Clin Invest. 2019 Nov 1;129(11):4724-4738. PMID: 31566583
12. Fleischer DM, Greenhawt M, Sussman G, Begin P, et al, Bird JA, et al. Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial. JAMA. 2019 Mar 12;321(10):946-955. PMID: 30794314
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13. Fox A, Bird JA, Fiocchi A, Knol J, Meyer R, Salminen S, et al. The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions. World Allergy Organ J. 2019 Jun 4;12(5):100034. PMID: 31194186
14. Garvey LH, Dewachter P, Hepner DL, Mertes PM, et al, Khan DA, et al. Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations. Br J Anaesth. 2019 Jul;123(1):e50-e64. PMID: 31130272
15. Garvey LH, Ebo DG, Kroigaard M, Savic S, Clarke R, et al, Khan DA, et al. The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions: current status. Br J Anaesth. 2019 Jul;123(1):e126-e134. PMID: 31027914
16. Har D, Lee MJ. Systemic reaction rates with omalizumab, subcutaneous immunotherapy, and combination therapy in children with allergic asthma. Allergy Asthma Proc. 2019 Jan 1;40(1):35-40. PMID: 30582494
17. Hopkins PM, Cooke PJ, Clarke RC, Guttormsen AB, et al, Khan DA, et al. Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions. Br J Anaesth. 2019 Jul;123(1):e29-e37. PMID: 31029409
18. Kercsmar CM, Sorkness CA, Calatroni A, Gergen PJ, Bloomberg GR, Gruchalla RS, et al. A computerized decision support tool to implement asthma guidelines for children and adolescents. J Allergy Clin Immunol. 2019 May;143(5):1760-1768. PMID: 30529451
19. Khan DA, Banerji A, Bernstein JA, Bilgicer B, Blumenthal K, et al. Cephalosporin Allergy: Current Understanding and Future Challenges. J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2105-2114. PMID: 31495420
20. Khan DA, Knowles SR, Shear NH. Sulfonamide Hypersensitivity: Fact and Fiction. J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2116-2123. PMID: 31495421
21. Lutfeali S, Khan DA. Pediatric Drug Allergies: Updates on Beta-Lactam, Nonsteroidal Anti-Inflammatory Drug, and Chemotherapeutic Reactions. Pediatr Clin North Am. 2019 Oct;66(5):1035-1051. PMID: 31466678
22. Mertes PM, Ebo DG, Garcez T, Rose M, et al, Khan DA, et al. Comparative epidemiology of suspected perioperative hypersensitivity reactions. Br J Anaesth. 2019 Jul;123(1):e16-e28. PMID: 30916015
23. Remington BC, Krone T, Kim EH, Bird JA, Green TD, Lack G, Fleischer DM, Koppelman SJ. Estimated risk reduction to packaged food reactions by epicutaneous immunotherapy (EPIT) for peanut allergy. Ann Allergy Asthma Immunol. 2019 Nov;123(5):488-493.e2. PMID: 31442495
24. Ritz T, Kroll JL, Patel SV, Chen JR, et al, Khan DA, et al. Central nervous system signatures of affect in asthma: associations with emotion-induced bronchoconstriction, airway inflammation, and asthma control. J Appl Physiol (1985). 2019 Jun 1;126(6):1725-1736. PMID: 30920889
25. Savic LC, Khan DA, Kopac P, Clarke RC, Cooke PJ, et al. Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations. Br J Anaesth. 2019 Jul;123(1):e82-e94. PMID: 30916014
26. Togias A, Gergen PJ, Hu JW, Babineau DC, et al, Gruchalla RS, et al. Rhinitis in children and adolescents with asthma: Ubiquitous, difficult to control, and associated with asthma outcomes. J Allergy Clin Immunol. 2019 Mar;143(3):1003-1011.e10. PMID: 30213627
27. Torres MJ, Adkinson NF, Jr., Caubet JC, Khan DA, Kidon MI, Mendelson L, et al. Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing. J Allergy Clin Immunol Pract. 2019 Jan;7(1):40-45. PMID: 30245291
28. Wheatley LM, Wood R, Nadeau K, Liu A, et al, Gruchalla R, et al. Mind the gaps: Clinical trial concepts to address unanswered questions in aeroallergen immunotherapy-An NIAID/AHRQ Workshop. J Allergy Clin Immunol. 2019 May;143(5):1711-1726. PMID: 30731123
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29. Wood RA, Khan DA, Lang DM, Fasano MB, Peden DB, et al. American Academy of Allergy, Asthma and Immunology response to the EAACI/GA2 LEN/EDF/WAO guideline for the definition, classification, diagnosis, and management of Urticaria 2017 revision. Allergy. 2019 Feb;74(2):411-413. PMID: 30338538
30. Yeh CY, Wheeler A, Bethea L, Bird JA, et al. Identifying barriers to implementation of emergency epinephrine bills: The Texas experience. J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2875-2877.e2. PMID: 31059827
Book Chapters
1. Bird JA, Jones S, Burks W. (2019). Food Allergy. In: Rich RR, Fleisher TA, Shearer WT, Schroeder H, Frew AJ, Weyand CM (Eds.), Clinical Immunology: Principles and Practice, (5th ed., pp. 625-631). China, Elsevier.
2. Joshi SR, Nicolaides RE, Bird JA. (2019). Acute Food Protein-Induced Enterocolitis Syndrome. In: Brown-Whitehorn T, Cianferoni A (Eds), Food Protein Induced Enterocolitis (FPIES): Diagnosis and Management, (1st ed., pp. 31-67). Springer.