uk – dutch collaboration
DESCRIPTION
Planet 2 /MATISSE. UK – Dutch collaboration. Research staff. Enrico (E) Lopriore Neonatologist Leiden University Medical Center. Anske (JG ) van der Bom Professor of Clinical Epidemiology Leiden University Medical Center Sanquin Blood Supply. Karin (K) Fijnvandraat - PowerPoint PPT PresentationTRANSCRIPT
Planet 2 /MATISSEUK – Dutch collaboration
RESEARCH STAFF
Karin (K) FijnvandraatPediatric hematologistAcademic Medical Center (Amsterdam) Sanquin blood supply
Enrico (E) LoprioreNeonatologistLeiden University Medical Center
Anske (JG) van der BomProfessor of Clinical EpidemiologyLeiden University Medical CenterSanquin Blood Supply
HISTORY OF MATISSE TRIAL• 2011 - 2012: Idea plus funding• 2013: PhD student + Planet-2 • Jan 2014: ethical approval• Feb 2014: start study in Amsterdam
Managing Thrombocyte transfusions In a Special Subgroup: nEonates
STUDY DESIGNS IDENTICAL
Transfusion thresholds
Inclusion criteria
Transfusion dose
?Outcome
PARTICIPATING CENTERSGroningen
Zwolle
Veldhoven
Nijmegen
Maastricht
RotterdamLeiden
Amsterdam
PARTICIPATING PI’S
…
E. Lopriore
A. Kroon
A. Van Kaam
W. de Boode M. vd Hoeven
A. Donker
E. D’Haens
C. Hulzebos
PARTICIPATING CENTERS• 8 level II/III neonatal intensive care units• 4000 admission per year• 2000 < 34 weeks GA
PLANNING• February 18 start in Amsterdam• February – september: start other centers• Datasharing• Expected inclusions: 65 / year
Inclusions
MONET: MONITORING OUTCOME IN NEONATAL THROMBOCYTOPENIA
• Retro/prospective observational cohort• Goal: prediction model neonatal bleeding• Design phase, 1000-2000 inclusions
Questions?
