uc san diego jacobs school of engineering enhancing...

UC San Diego Jacobs School of Engineering

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George R. Tynan, Ph.D. Associate Dean - Research, Jacobs School of Engineering University of California, San Diego Professor, Mechanical and Aerospace Engineering & Center for Energy Research

UC San Diego Jacobs Hall, 7th Floor 9500 Gilman Drive #0403 La Jolla, CA 92093-0403 USA [email protected] Tel: +1 858 822-4444

Enhancing Industry-focused Research with Agile Centers

Jacobs School of Engineering UC San Diego


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Jacobs School is Largest Engineering School in California

214 Faculty 1,850 Graduate Students 6,830 Undergraduates


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Rankings

13th among World’s for Engineering, Technology and Computer Science Academic Ranking of World Universities, 2013

8th among U.S. best public engineering schools U.S. News ranking of graduate schools, 2013

1st in the U.S. for biomedical engineering National Research Council, 2010


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Six Academic Departments

Mechanical/ Aerospace

Electrical Engineering

Computer Science

Bio Engineering

Structural Engineering

Nano Engineering


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Jacobs School Strategic Vision

Focus

Look, Think and Act as a Top 10 Professional Engineering School Joint Institutes • Education/Research collaborations with campus partners • Faculty cluster hires build UC San Diego strengths in unique strategic

themes Agile Research Centers • Jacobs School faculty/industry research partnerships • Leverage federal investment with applied research Experience Engineering • Design-build-test project courses, beginning in freshman year • Inspire students and enhance career preparation Engineering for the Global Good Exponential Impact through Entrepreneurism

Strategies

Values


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What is an Agile Center?

• Focused on issues and challenges of interest to industry and/or non-traditional public sector funding sources

• Composed of multidisciplinary research team

• Launch quickly under oversight of Dean

• Quickly and nimbly respond to evolving industry research needs


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• Agile Center: two or more faculty from various disciplines who collaborate to be highly responsive to industry needs for innovation and talent.

• The Dean’s Initiative:

• Research Reviews twice each year • Student Resume Database • Website, Press Releases by expert Communications and Marketing staff • Password protected access to technical papers

• Sponsored Research w/ Fast-Track Agreements

• Recruit the new faculty talent with corporate collaboration • Visiting Industry Fellows • Corporate Affiliates Program membership

The Jacobs School’s Agile Center Initiative


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• Center for Wearable Sensors • Center for Extreme Events Research • Sustainable Power & Energy Center • In Development:

– Visual Computing – Genomic Engineering for Rational

Biotherapeutics Design – Science & Technology for Hazard Response – Unmanned Aerial Systems

New Agile Centers Launched in 2014


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Motivation for the Center for Wearable Sensors (CWS)


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Research Vision


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CWS – Our Unique Expertise


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Focus Areas


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Center Research Structure


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Center for Extreme Events Research (CEER)

Founding Members


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CEER Mission

• Extreme event protection: to provide damage assessment of infrastructure and bio-systems subjected to extreme events for effective protection and vulnerability reduction.

• Extreme event mitigation and recovery: to provide fast estimation of damage and vulnerability to first responders after extreme events for disaster mitigation and recovery.


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CEER Capabilities & Facilities

The CEER’s Blast Simulator is the first of its kind in the world, situated at UCSD’s Englekirk Structural Engineering Center of the Charles Lee Powell Laboratories. The UCSD blast facility is unique due to the capability of the blast simulator with its six blast generators, its wide range of simulated blast load parameters, and the large number of possible test set-up configurations. The CEER’s Impact Testing Facilities include a 79 mm gas gun (250 m/s) and a 25 mm gas gun (over 1000 m/s) for research on impact effects on composite materials and aerospace structures, composite structures subjected to penetration and high velocity impacts, and a Split-Hopkinson pressure bar for measuring pressure wave propagation under various impact loading conditions.


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CEER Capabilities & Facilities (cont’d)

The unique computational capabilities for Penetration, Fragmentation, and Shock Modeling developed at CEER have been successfully applied to various fragment-impact modeling of high velocity impact and penetration processes, vehicle crash simulation, landslide modeling, homeland security applications and other extreme events simulations. The Meshfree Method and Isogeometric Analysis developed at CEER are new frontiers in computational science and engineering, which allow multi-scale, multi-physics investigation of damage and failure processes in infrastructure as well as damage to the human brain and body due to considerable mobility and shocks, in a wide range of extreme events such as manmade disasters, car crashes, sports injuries, among others.


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CEER Research Topics

Blast effects

Armor performance

Unique Modeling Capabilities -Mesh free

Energy Systems Response To Extreme Natural Events

Multi-phase Material Modeling

Biomedical device modeling

Single-surface contact algorithm


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CEER Opportunities

• Protecting infrastructure (e.g., key bridges or government buildings) from terrorist attacks and natural disasters

• Protecting brain and body injury from extreme loading (due to bomb blast, car crash, or collision on the football field) and its prevention or mitigation, is of great importance to the military as well as civilian sectors.

• Protection of nation’s energy generation facilities (wind turbines, nuclear power plants, hydraulic power plants, dam and water supply systems, mining tunnels) against natural and manmade disasters are of critical importance.


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Primary Focus: A multidisciplinary initiative dedicated to advancing the frontiers of energy technologies，focusing primarily on forward-looking renewable energy conversion and storage, its distribution and power integration. Goals: • Make UC San Diego a global leader in renewable energy research

and integration • Promote interdisciplinary energy research, education and training

program • Expedite Lab-to-Market transitions and support local Clean Tech

industry


Energy Landscape of USA in 2008


Change is Hard to Come


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The Challenge of Power vs. Energy


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Truly Interdisciplinary Research


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Unique Assets

• A micro-grid designed for testing disruptive new technology

• Right location/climate

• Faculty members who have the right combination of skills

• Students who are enthusiastic and eager to change the world


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NE: Joseph Wang*, Shyue Ping Ong, Darren Lipomi, Jian Luo, Kesong Yang, David Fenning (incoming faculty) ECE: Eric Fullerton, Vitaliy Lomakin, Paul Yu, Yuhwa Luo MAE: Renkun Chen, Prab Bandaru, Sungho Jin*, Olivia Graeve, Carlos Coimbra SE: Yu Qiao CSE: Rajesh Gupta, Tajana Rosing BE: Ted Coleman Chemistry: Michael Sailor, Seth Cohen, Francesco Paesani, Clifford Kubiak Physics: Oleg Shyprko, Ivan Schuller*, Sunil Sinha* Economics: Graham Elliott, Mark Jacobson, Richard Carson CER: William Torre VC Office: Byron Washom

Possible Participants


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Advanced Lithium Ion Batteries – Safer and More Powerful


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Sodium Ion Battery for MWh Large Grid Storage - Novel Materials


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1 Abilify $6,885,243,368

2 Nexium $6,271,376,299

3 Humira $5,936,288,498

4 Crestor $5,502,148,010

5 Advair Diskus $5,112,576,549

6 Enbrel $4,896,267,318

7 Remicade $4,235,535,358

8 Cymbalta $4,095,537,942

9 Copaxone $3,679,837,035

10 Neulasta $3,634,919,067

11 Lantus Solostar $3,375,632,862

12 Rituxan $3,320,475,967

CHO: Design of Biotherapeutics

6 of the top 12 drugs are recombinant proteins

Produced in living cells, such as Chinese hamster ovary (CHO) cells

Top 12 drugs in 2013 by sales

http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&docid=aQTBl1besclOhM&tbnid=WHIsSBZESeMqnM:&ved=0CAcQjRw&url=http://absoluteantibody.com/about-us/&ei=IJIhVJ7oMseVoQTwu4LIBg&psig=AFQjCNG8HZBGLXY44HhJvcMxnCIGqFDSgQ&ust=1411572558004476


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CHO has a rich history in the biopharmaceutical industry

• 1987 – – 1st FDA-approved

mammalian recombinant protein: tissue plasminogen activator produced in CHO

• Today – – 70% of

biotherapeutics made in CHO

– Global spending on biologics passed $140 billion in 2013


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Why CHO?

• Robust over-expression of recombinant protein • Human-friendly protein modifications • Virus-resistant • Bioprocessing-friendly • High-density suspension growth • Selection systems • Strong precedent set at the FDA

• Primary limitation: • Little governmental funding

support for research and training in mammalian bio processing


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Challenges

• Challenges facing the biopharmaceutical industry

– Making vs.

• More challenges

– Increasing protein yield – Controlling protein modifications – Maintaining product purity (contaminants, mutations, heterogeneity)

• Challenges can be met by engineering improved CHO cells as we

have seen in microbial metabolic engineering

http://en.wikipedia.org/wiki/File:Aripiprazole2D1.svg


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Three Key Elements:

Engineering via Genome editing systems (Datsenko and Wanner, 2000)

Parts: Genomic sequence (E. coli K-12 MG1655, 1997)

Interactions: Genome-scale systems biology models

(Edwards and Palsson, 2000)


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Resources that we have developed or are developing that allow rational engineering of CHO

Core tools from UCSD for genome-scale engineering of CHO cells

Genome-scale resources for rationally designing CHO cells

Now we can start rationally engineering CHO


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Benefits of Joining a Center

• Access to UC San Diego faculty, researchers, and graduate students who are transforming their technology domain.

• Access to multidisciplinary innovation in wearable sensing through bi-annual workshops and research reviews

• Student recruiting: Access to the most promising students • One-on-one collaborations with faculty, researchers and graduate

students • Visiting-scholar opportunities for your research staff • Directed research projects and non-directed research gifts • Branding for your company • Continuing education for your employees • Help shape the research agenda in your technology space • Access to our commercialization engine: the von Liebig Center of

Entrepreneurism


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Multiple Engagement Mechanisms

• Basic Membership • Pooled Research Support • Individual Research Support • Directed Research • Visiting Industry Fellows • Access Spin-outs thru von Liebig Center

of Entrepreneurism


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Contact Info:

• George Tynan, Associate Dean – Research, Jacobs School of Engineering – [email protected] – +1.858.534.9724 (faculty office) – +1.858.822.4444 (Dean’s office) – +1.619.840.6678 (mobile)

• Anne O’Donnell, Executive Director for Corporate Research Partnerships – [email protected] – +1.858.822.5963

mailto:[email protected]

mailto:[email protected]


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Thank You!

uc san diego jacobs school of engineering enhancing...

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