Abstracts/Lung Cancer I1 (1994) 423-444 433

Single cerebral mehhses of hronchopulmonary cancers Lonjon M, Paquis P, Michiels JF, Frenay M, Bensadoun RJ, Chatel M et al. Service a% Neunxhintrgie. Hopital Parmu, BP 69, O&X72 Nim Ceda. Rev Naurol 1994;150:216-21.

The most frequent brain metastasis originatea from a lung cancer. About halfofthemareunique. Wereportaseriesof36 patients withlung cancer, operated for a single brain lesion. The - age was 57.6 years, most (83.3%) were male. Most of the metastases originated from a primary adenocarcinoma (52.8%), in 10 patients (27.8%) from an epidermoid carcinoma, in 4 patients (11.1%) froma small cell carcin~m

ad in 3 patients from a mixed lesion. The metastatic lesion was detected before the primary lesion in 20 cases (55.5 96). The mean post-operative survival was 9.6 months. 36% were alive one year after surgical treatment. We evaluated our clinical findings, histopathological studies and the type of surgical and medical post-operative management, at the cerebral and pulmonary level, in order to make a possible prognosis. In our series we found that only Post-operative clinical status (Karnofsky ~ore)andthepost-operativeneurologicaIgrading(Orderclaasification) were significant factors @ < 0.001) to determine survival time.

Factors confouttding evnhmtlon of treatment effect in lung cancer Gsterlind K. Deparrmenr of Oncology. Rigshospitalet. ONK5074. DK- 2100 Copenhagen 0. Lung Cancer (Ireland) 1994;lO:Suppl l:S97- s103.

studieaaaaneariydiagnosiswilldrasticallyimpmvethechanceaofcure. Methczirz Twenty-four casea of bronchioloaIve&r cell caminoma for the period of 5 years were studied in terms of incidence, age, sex, underlying diseases, symptoms, radiographic findings, methods of diagnosis, clinical and pathologic staging, methods of treatment, and survival retrospectively. Rcruulrs: No correlation was found between patients’ age, sex, and underlying diseases. Most common symptoms were cough (62.5%). chest pain (29.2%). and sputum (29.2%). Of the 24 cases. 13 patients (54.2 46) had solitary nedule. 6 patients (25 %) had multiple nebules. At the time of diagnosis, 3 patients (12.5%) had the stage I diseases, 3 patients (12.5 %) had the stage II diseases, 4 patients (16.7%)hadthestageIIIadismses,3patients(12.5%)hadthestageIIIb diseasea, and 11 patients (45.8%) had the stage IV diseases. 14 cases (58.3 96) were found inoperable at the time of admission; they all died within 17 months. In 7 casea with stage I, II, 1110 diseasea curative resection were attempted, in 1 case with stage IV disease wedge resection for palliative management was performed, and in 4 cases patients were still alive at the time of conclusion of this study. Conclusion: We conclude that early diagnosis of disease will increase opembilityandimpmvechanceaofsulvivaland thataggreasivediagncstic workupforsuspiciouspulmonaryinfiltrateis-tialasearlyoperation offers the beat chances of cure.

Disease extent, performance status (PS), and serum lactate dehydro- genase (LDH) are the most important prognostic factors in both inoperable non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Hyponatremia and serum alkaline phosphatase play an additional role in SCLC. Many different stratification algorithms have been proposed in SCLC but a generaI B CBnnot be achieved before it is decided whether stage of disease should rank above or be included in an algorithm, along with other pmgnostic factors.

R&x sympathetic dystrophy and lung carcinoma CarlosAcebraJ,PerezR.LlatjosM,OliveA.&ccion&Reumarofogia, Hospital Germans ‘Ikim i Pyiol. &a. de1 Canyet. s/n. OS91 7BaoWona. Rev Esp Reumatol 1994;21:126-7.

A case of reflex sympathetic dystrophy syndrome with unusual lpborntory dates is reported. A lung carcinoma was simultaneously diagnosed. The character of this association is reviewed.

SmaIl oell lung cancer: patients surviving longer thnn thirty months Mom D, Jacoulet P, Quoix E, Ranfaing E, Brambilla E, Capmn F, Lagrange JL. Milleron B. Lebeau B. Ruffie P. Riviete A. Blanchon F. Gemads A. Depierre A. Service & pneumologie, Hopita Michallon, BP217X3W3 Gmwbk cdex 9. Anticancer Rea 1994;14: B 3014.

Two casea of primary lung cancer presenting as nephrotic syndrome anda~~~ofthelitaPhuPinthcpclstl5yePrs Kashiwabara K, Nakamura H, Fukai Y, Semba H, Kurano R. Division of Pathology, Kumamo to Regional Medical Center, Kumamoto. Lung Cancer (Japan) 1994;34:95-102.

The long-term survivors of SCLC are described in 3 different types of study: analysis of prognostic t&tots of phase II and III chemotherapy trials, epidemiological studies and medical registries of LTS. A small number of patients with small cell lung cancer achieve longterm survival. Most of these patients have a disease limited to the chest at the time of diagnosis. The major concems of these LTSs are: the relapse of thesCLc, the occunwtceofasecondPrhnarytumourandtheocc-ce of a disease related to tobacco consumption. About 20% of the LTSs die of noncancer related causes and this exceeds the age adjusted mortality. There is a high risk of relapse in the first 4 years a&the diagnosis; this risk decreases later, but relapses may be seen until 7 years. Nearly 8% of LTSs developed a SPTs are alive at 8 years; this indicates that cure is possible in SCLC, however, these patients account for less than 3% of the overall population.

Two casm of Primary lung cancer presenting as nephrotic syndrome were reported. Case 1 was a 65-year-old male who had squamous cell carcinoma coincident with membranous glomerulonephritis. The nephrotic syndrome was relieved by the resection of the lefi upper lobe and chemotherapy. It did not relapse until he died of pneumonia, which suggested that squamous cell carcinoma had a close relationship with the nephmtic syndrome. Case 2 was a 56-year-old male who had small cell carcinoma metachronous with the membranous glomerulonephritis in the course. of SLE. Small cell carcinoma had been in complete remission when the nephmtic syndrome occurred and appeared to have no relationship with the nephrotic syndrome. It could be considered that lupus nephritis was not ursociated with the nephmtic syndrome because of no recurrence of SLE (anti-Sm antibody: negative). From that point of view, it was suggested that there was no relationship between small cell carcinoma and the nephmtic syndrome.

Clinical signif- of serum BFP and various tumor markers in

Pt-hnpry Iung atncer Clinical study of bronchiui0alV~lar cell carhum8 Horiguchi T, Tachikawa !I, Tam&i S, Kato M, Doi M, Han-no K et Choi JW, Park IS, Kim JH, Yooo HJ, Shin DH, Kim TW et al. al. Department of Internal Medicine, Fugita Health Univ. Sch. of Deparmtent of Internal Medicine, College qf Medicine, Hanyang Medicine, Narita Memorial Hospital, Narita. Lung Cancer (Japan) Uniwrsity, Seoul. Tukc Respir Dis 1994;41:26-35. 1994;34:3745.

Background: Bnmchioloalveolor ceil carcinoma today needs further To ~vestigate the clinical significance of BFP (basic fetoprotein) in