trinity college institute of neuroscience

TRINITY COLLEGE INSTITUTE OF NEUROSCIENCE

ANNUAL REPORT 2013

TCIN Annual Report 2013

Directors Report ................................................................................................................................................ 3 Mission Statement ........................................................................................................................................................... 5 TCIN STAFF .................................................................................................................................................................. 6 TCIN EXECUTIVE MANAGEMENT COMMITTEE .................................................................................................. 6 MRI STAFF .................................................................................................................................................................... 6

NEW APPOINTMENTS AND ARRIVALS.......................................................................................................... 7 Visiting Researchers........................................................................................................................................................ 7

RESEARCH ACTIVITY IN TCIN ....................................................................................................................... 8 RESEARCH HIGHLIGHTS ............................................................................................................................... 9 GRANT FUNDING IN TCIN ........................................................................................................................... 24

1. NEIL, NeuroEnhancement for Independent Lives .................................................................................................... 24 2. SFI Infrastructure award 2012 & OpportunisticFunding award 2013 ....................................................................... 24 4. The TRIL programme ............................................................................................................................................... 24 5. PRTLI 5-PhD Programme ......................................................................................................................................... 24 6. TILDA....................................................................................................................................................................... 24 7. Science Foundation Ireland ....................................................................................................................................... 24 Funding Breakdown ...................................................................................................................................................... 25

PROMOTIONS AND AWARDS ....................................................................................................................... 27 PROMOTIONS ................................................................................................................................................ 27 AWARDS .......................................................................................................................................................... 27 EDUCATION & OUTREACH AT TCIN .......................................................................................................... 28

PhD Programmes .......................................................................................................................................................... 28 MSc Programs ............................................................................................................................................................... 28 Societies and Outreach Activities .................................................................................................................................. 30 Neuroscience Prizes 2013 ............................................................................................................................................. 31

MEETINGS ...................................................................................................................................................... 32 Meetings Held: .............................................................................................................................................................. 32 Planned Meetings: ......................................................................................................................................................... 32 Lecture Series:............................................................................................................................................................... 32

INNOVATION .................................................................................................................................................. 36 Industrial Collaborations ............................................................................................................................................... 36 Commercialisation Activities ........................................................................................................................................ 36

MEASURING RESEARCH OUTCOMES ........................................................................................................ 39 Research, Innovation, Education & Outreach ............................................................................................................... 39 TCIN Publications Analysis .......................................................................................................................................... 40

PERSONNEL IN TCIN 2013 (APPENDIX 1) .................................................................................................. 44

TCIN Annual Report 2013 2

Directors Report TCIN was very active in 2013 in looking to increase non-exchequer funding sources including EU, Philanthropic, and Industrial grant funding to sustain our research programs. Our Grants officer, Laura Bertolini has been busy supporting our PIs in the complexities of EU grant applications. In the past year, we have been successful in establishing a number of new collaborative research programs with contracts funded or pending of €6.8 million. We will continue to support our PIs to maximise funding opportunities in 2014. We are delighted that one of Our PIs, Prof Michael Gill is leading the new 1,300sqm Wellcome Trust/HRB Clinical Research Facility (CRF) at St. James’s Hospital. This €7 million facility is a joint initiative between Trinity College Dublin and St James’s Hospital, and is funded by a partnership between the Wellcome Trust and the Health Research Board. TCIN was successful in December 2012 in winning major funding of €1.34 million to upgrade both of our MRI systems under the SFI Infrastructure Grant 2012. The awards will double resolution and speed on both systems and should enhance our international competiveness for grant applications. The 3T system was fully upgraded in June 2013 and has been running well for many new studies. We expect the 7T system which is a major and state of the art system upgrade should be completed by June 2014. In addition in 2013, under the SFI opportunistic funding programme, we were able to acquire MRI compatible physiological monitoring equipment, a crash trolley and additional MRI coils for Aging studies. I am pleased to say that several new industrial programs commenced in 2013 with a number of partners including Alkermes, Opsona and Transpharmation UK. TCIN has also generated 2 spinouts in the last 12 months: (i) Trinity Brain Health Ltd is an educational services company formed by Dr Sabina Brennan arising out of work from her EU funded research, (ii) Transpharmation Ireland offers translational medicine services to Pharma and was developed by Prof Shane O’Mara and colleagues formerly from GSK. We have applied for a number of ITN programmes in 2013 and plan to develop new training programmes at professional and PhD levels over the coming years. These initiatives will build on the highly successful HRB integrated PhD program in Neuroscience and current HEA-PRTLI 5 structured PhD program ‘Molecular and Cellular Mechanisms underlying inflammatory processes’, led in TCD by Professor Marina Lynch of TCIN. http://www.tcd.ie/Graduate_Studies/PRTLI/cellular.php We continue to be involved in several technology platform programs with partners in Molecular Medicine Ireland (MMI) and the National Bio-photonics Imaging Program (NBIP) to share our EEG, MRI and Confocal Microscopy technology and expertise both nationally and within Europe. We are also part of the ESFRI Eurobioimaging Initiative. The NEIL program funded initially by Atlantic Philanthropies and run by Dr Sabina Brennan, Assistant Director, Prof. Brian Lawlor, Clinical Director and Prof. Ian Robertson as Director


http://www.tcd.ie/Graduate_Studies/PRTLI/cellular.php

has leveraged a large amount of external funding (€6m+) from the EU, NGOs and Industry and is a model for the types of programmes we intend to develop in TCIN in the future. In terms of outreach and public engagement we held two conferences, 6 TV/Radiointerviews, 5 press articles, 3 TEDx talks and had over 100 enrolments in CPD and extramural courses. We also held the 2013 TCIN Symposium on November the 5th with several international keynote guest speakers and a fulllecture theatre of distinguished guests & colleagues. Our research has generated over 600 publications in the last 3 years with 25% of our publications having an impact factor greater than 7. We’d like to thank all our staff and researchers for their strong contributions during the year. We also acknowledge the strong support of College officers, the TCIN board, our Chairman Mr Alan Cooke and our Dean Prof Clive Williams during the year. Prof Shane O’Mara Director TCIN Dec 2013


Mission Statement

‘Understanding the brain from molecules to mind’

Through our research and teaching in neuroscience, we engage students and society in the quest for knowledge about the human brain and mind, and seek to achieve excellence in all we do. We respond with creativity and imagination to the challenges and opportunities of a shared future, by developing and applying our fundamental scientific knowledge for the benefit of human health, welfare and knowledge.


TCIN STAFF

Prof. Shane O’Mara Director [email protected] Mr. Ciaran Conneely Operations Manager [email protected] Ms. Barbara Hewitt Accountant [email protected] Ms Katy Cagney Executive Officer Ms Susan Cantwell Executive Officer [email protected] Ms Denise O’Connor Executive Officer

TCIN EXECUTIVE MANAGEMENT COMMITTEE

The members of TCIN’s Executive Management Committee and their affiliations Prof. Shane O’Mara Director of TCIN Professor Ruth Byrne Deputy Director of TCIN, School of Psychology Prof Veronica Campbell Head of Physiology Prof Declan McLoughlin Consultant Psychiatrist, St Patrick’s Hospital Prof Mani Ramaswami School of Genetics, Dept of Zoology Prof Richard Reilly School of Engineering, School of Medicine Mr. Ciaran Conneely Operations Manager Ms. Barbara Hewitt TCIN Accountant

MRI STAFF

Dr. Christian Kerskens Lead Physicist [email protected] Mr. Sojo Joseph Radiographer [email protected] Rustam Rakhmatullin Animal specialist [email protected]


mailto:[email protected]

NEW APPOINTMENTS AND ARRIVALS

Dr’s Sabina Brennan, Matthew Campbell and Marian Tsanov were appointed as TCIN PIs in 2013. Katy Cagney was appointed as Executive Officer in 2013. Denise O’Connor has joined for 2014. Visiting Researchers Marta Couto and Celia Rasga, PhD students from Lisbon visited TCIN in May, 2013. Prof Orlando Espino from the University of La Laguna, Tenerife, was a visiting fellow from September 2012-December 2012; he is a collaborator of Professor Ruth Byrne.


RESEARCH ACTIVITY IN TCIN One of the core ideas of the Institute of Neuroscience was creating multidisciplinary translational research teams. Our PIs are drawn from all the faculties of the university and there are important translational links between our researchers, clinicians, affiliated hospitals and industrial partners which enable improvements in scientific understanding of basic mechanisms and the development of new therapies for human health. Three research foci describe the broad interdisciplinary nature of our research in the table below and PIs are listed under these as follows.

1. Neurodegeneration, neuroprotection & neuroplasticity

2. Synapses, cognition & behaviour

3. Neuropsychiatry & neurodevelopmental disorders

Prof. Marina Lynch Prof. Mani Ramaswami Prof. Declan McLoughlin Dr. Colm Cunningham Dr. Paul Dockree Dr. Andrew Harkin Dr. Arun Bokde Prof. Khurshid Ahmad Prof. Veronica Campbell Dr. Sabina Brennan Prof. Ruth Byrne Prof Mary Cannon* Dr. Matthew Campbell Dr. Sabina Brennan Prof. Aiden Corvin Prof. Veronica Campbell Dr. Matthew Campbell Prof. Kumlesh Dev Prof. Richard Carson Prof. Richard Carson Dr. Gary Donohue Dr. Colm Cunningham Prof. Aiden Corvin Prof. Thomas Frodl Dr. Gavin Davey Prof. Kumlesh Dev Prof. Louise Gallagher Prof. Kumlesh Dev Dr. Paul Dockree Prof. Hugh Garavan* Dr. Colin Doherty* Prof. Jane Farrar Prof. Michael Gill Prof. Gary Donohue* Prof. John Foxe* Dr. Andrew Harkin Prof. Jane Farrar Prof. Thomas Frodl Prof. Brian Lawlor Prof. Orla Hardiman Prof. Hugh Garavan* Prof. Pat McKeon* Prof. Pete Humphries Dr. James Gibney* Prof. Declan McLoughlin Dr. Aine Kelly Prof. Pete Humphries Prof. Veronica O’Keane Dr. Julie Kelly Dr. J. Pablo Labrador Prof. Shane O’Mara Dr. Paul Kenna Dr. Ed Lalor Prof Mani Ramaswami Prof. Rose-Anne Kenny Prof. Brian Lawlor Prof. Richard Reilly Prof. Brian Lawlor Dr. Kevin Mitchell Prof. Ian Robertson Prof. Marina Lynch Prof. Fiona Newell Dr. Astrid Sasse Dr. Aileen Lynch Dr. Redmond O’Connell Dr. Jogin Thakore* Dr. Connail McCrory Prof. John O'Doherty* Prof. Declan McLoughlin Prof. Shane O'Mara Prof. Kingston Mills Prof. Desmond O'Neill Prof. Shane O’Mara Dr. Niall Pender* Prof. Desmond O’Neill Prof. Mani Ramaswami Prof. Mani Ramaswami Prof. Richard Reilly Prof. Richard Reilly Prof. Ian Robertson Prof. Ian H. Robertson Prof. Michael Rowan Prof. Michael Rowan Dr. Marian Tsanov Dr. Marian Tsanov Dr. Daniel Ulrich

Dr. Alice Witney

Dr. Michael Wride

NOTE: Details of team members for all PIs are given in Appendix 1; External or Adjunct PIs denoted by *asterix.


RESEARCH HIGHLIGHTS Arun Bokde research group Brain training interventions have attracted intense interest in recent years due to an increasingly older population and a desire to retain and promote cognitive stability in later years. Dr Bokde’s group participated in a brain training study, called Senior Adult inteGrated Executive function training study (SAGE), in which older healthy participants participated in a 6-week training program with an online adaptive training task. The placebo arm consisted of a non-adaptive task. The intervention group improved their performance after training, and the placebo arm group showed more limited improvements. Even though there were improvements in a single cognitive domain, adaptive cognitive training failed to provide strong evidence of transfer effects to other cognitive domains. We concluded that brain training required a good deal more research before claims could be made regarding the potential positive effects such interventions may yield. One question that was investigated in older subjects was (a) the stability and reproducibility of the resting state networks (RSN) in older populations and (b) the overlap between resting state networks and neural network activated by cognitive task. We found that different analysis methods lead to different results when examining stability of RSN. This is an important issue if neuroimaging is to be used in a longitudinal study, or as a diagnostic biomarker or as a marker to quantify pharmacological effectivity. In the second study we found that individual RSN can be thought, in part, as building blocks to the neural network that is recruited to support cognition. Dr Bokde’s group is lead partner of the NeuroSKILL project (a project involving TCCD, UCD and Bangor Univ (Wales)) and in 2013 the partners developed optimised diffusion imaging and spectroscopy sequences to investigate normal ageing and neurodegeneration. In addition, as part of NeuroSKILL learning resources were developed for clinical groups on the use of neuroimaging in the diagnostic process. In addition, Dr Bokde is member of a large multi-centre European neuroimaging consortia investigating Alzheimer's disease (European DTI Study on Dementia - EDSD). One study found that APOE genotype modulated white matter integrity in healthy subjects but not in manifest Alzheimer’s disease. Dr Bokde joined a multi-centre study on impulsivity and brain development in adolescents (IMAGEN). This was a longitudinal study to investigate brain development in adolescents and the clinical, neuropsychological and behavioral factors that may increase the risk of developing psychiatric disorders. In 2013 Dr Bokde and his team held continuing education courses on neuroimaging to health care professionals and post-graduate students.


Dr Sabina Brennan, Assistant Director of the NEIL Programme and Prof Brian Lawlor, Clinical Director of NEIL and Prof. Ian Robertson as Director have had continued success in leveraging additional funding and developing novel research programmes under the overall NEIL programme with the following highlights for 2013. ACAD – Automated Cognitive Assessment Delivery; NEIL – PhD Stipend This brief cognitive assessment has been validated and the paper published. We are currently seeking collaborators who may wish to help develop the use of this further. (Di Rosa et al, in press) Active Body, Active Brain.; Coca Cola Thank-You Fund. Coordinated course to train 30 ASI staff in Cognitive Stimulation Therapy (CST). Approx 18 CST groups developed by trained staff, 127 people with dementia attend groups and 13 new staff trained as facilitators. Learnning event hosted and outcomes report delivered to ASI senior management recommending further development in community and day care settings. EIC funding expired – hand-over to ASI Alertness Training For Focused Living (ATFL); TRIL and NEIL This study has been published. This alertness training is one of two training programmes (the other is also our programme - Working Memory Training WMT – see below) which have been adopted for a proposed EU–funded multi centre rehabilitation trial with older people with and without amyloid protein in their brains. The proposed Horizon 2020 study has got through to the second round and the extended proposal is being currently written. (Pub: Milewski-Lopez et al., in press) ASAPS – A Sharing Approach to Promoting Science – Sharing Age; EC– FP7 Outputs from this study include: A brain health awareness campaign (Hello Brain), a multi-lingual website which provides easy-to-understand information and short films about brain health and brain research, an app to support users to be proactive about brain health and a 60 minute documentary highlighting the importance of brain research. In addition, the project has engaged in extensive outreach activities and has also produced more traditional materials aimed at engaging adults in an educational-preventative context. The multi-lingual website can be viewed at www.helllobrain.eu Awareness in AD; IRC / ASI PhD study examining Awareness issues in people with a diagnoses of Alzheimer’s disease BiomarkAPD; HRB /JPND This study is in its sendond year of a 3yr progarmme and after establishing the Irish Network for Biomarkers in Neurodegeneration (INBIND) will develop normal and disease ranges for the ELISA assay that will be established at the Central Pathology Laboratory, St. James's Hospital, the group will becollecting blood and CSF samples for collaborative studies in Ireland and with investigators in Europe. Cognitive Performance, BDNF and Fitness; IRCSET – Post Doctoral Research Funding Data collection for this study examining the relationship between fitness, baseline circulating BDNF, noreadrenaline, dopamine and cognitive performance has been ongoing using volunteers from the NEIL Memory Research Unit.


Cognitive Reserve; Irish Research Council – PhD Scholarship This study of over 400 people from the MRU followed up over 2 years will be completed within 12 months, and will test the hypothesis that cognitive reserve is mediated by noradrenergic function, using pupillometry as a proxy measure of NA function. DeStress: Medical Research Charities Group –Health Research Board Referred to as Cognitive Function Caregiver Stress and Cortisol Mechanisms and implications for prevention of adverse health consequences in spouse dementia caregivers in our previous report. This study commenced in June 2013, assessment protocols have been developed and is currently in the data collection phase. Early Intervention Coordinator; Alzheimer’s Society of Ireland / NEIL joint collaboration Dr Michelle Kelly was appointed as Early Intervention Coordinator in December 2011 for a 30 month period – out puts from this post have been considerable and include; outreach activities, cognitive stimulation training, cognitive rehabilitation research and literature reviews. The Ageing Brain Training and Plasticity Work continues on this project examining the potential for positive transfer from coordination training regimes to the cognitive domain. In conjunction with colleagues at the University of Tasmania, there will be related exploration of how brain plasticity mechanisms influence individual differences in cognitive and motor function and training responsiveness. Memory Research Unit; FAS JobBridge Scheme, Volunteers, Charity Donations, TCIN. To date the unit has recruited 1527 volunteers and are about to embark on follow up assessments of the first volunteers. The MRU assessments are completed by trained interns and volunteers. We have two testing rooms operating at full capacity. Web-based working memory This WMT training is one of two training programmes (the other is also our programme - self–alert training – see above) which have been adopted for a proposed EU–funded multi centre rehabilitation trial with older people with and without amyloid protein in their brains. (Pub: McAvinue et al 2013) Ruth Byrne Group Prof Ruth Byrnes group were awarded a prestigious grant from the Templeton foundation and presented at 4 international conferences as well as being active in outreach activities in the Science gallery. PhD Studentship A PhD Studentship in Moral Reasoning was funded from a grant awarded by the John Templeton Foundation in 2013. This PhD studentship will carry out research on cognitive processes in moral judgments. Visitors to Laboratory Professor Sergio Moreno-Rios from Granada University in Spain visited on May 23rd and lab members presented talks on a variety of topics.


Professor Phil Johnson-Laird (New York University) visited the lab 22nd-25th August 2013, and attended talks: Eoin Gubbins: Inconsistency in reasoning about morally good and bad actions. Mary Parkinson: Moral responsibility judgments about causal and enabling agents. Science gallery Mary Parkinson and Ruth Byrne contributed an experiment to the Science Gallery’s latest exhibition ‘RISKLAB’. The Science Gallery described RISK LAB as examining “the psychology and mathematics underpinning the risks that surround every aspect of our lives, and our ability to assess and understand those risks”. The Byrne group experiment examined how people make risky moral decisions.” RISKLAB ran from 2nd May to 23rd June 2013. *Trinity’s Science Gallery – ‘a place where science and art collide’ - is one of the top ten free cultural attractions in Ireland. CNS Inflammation and Neurodegeneration group (Colm Cunningham & colleagues). We have advanced on a number of research fronts: in our animal models of delirium during dementia and in CNS inflammation in a general sense, publishing in the Journal of Neuroscience on the former and publishing 2 studies in PLoS One in the latter domain. In collaboration with clinical colleagues in the University of Edinburgh we have recently had parallel clinical findings on similar inflammatory pathways accepted for publication. Collectively these studies implicate the pro-inflammatory cytokine IL-1 and cyclooxygenase-1-mediated prostaglandins in acute cognitive dysfunction and/or delirium occurring during dementia. The work continues to have impact in the clinical delirium field with invitations to speak at the annual meetings of both the American and European Delirium research societies in 2013 (Indianapolis and Leuven respectively) and the invitation to speak at the US National Institutes of Aging (NIA/NIH)-organised meeting on delirium in older adults in Bethesda. Maryland. Other invited talks in 2013 include invitations to John’s Hopkins School of Medicine, Vanderbilt University, the Roslin Institute, the University of Edinburgh as well as participation in symposia at international meetings such as EUROGLIA (Berlin) and Society for Neuroscience annual conference (San Diego). Furthermore, CC was invited to write a number of reviews on microglia and delirium and these are already well cited. Prof. Aiden Corvin heads the Psychosis Research Group at TCD. Our goal was to identify and investigate genetic mechanisms of psychosis, to define molecular etiology and to use this information to serve patients by improving future care delivery. We published 34 peer reviewed publications in 2013 in work funded by Science Foundation Ireland and the National Institute of Mental Health, US. Prof Corvin was on the organizing committee for the Inaugural Molecular Psychiatry Meeting (San Francisco, US) and became Associate Editor for Genetics for the leading journal in the field, Schizophrenia Bulletin. He gave four international talks as an Invited Speaker (e.g. European Molecular Biology Laboratory, Heidelberg (EMBL); Cold Spring Harbor Laboratories (CSHL) Lecture series) and was an invited participant to one expert group (Banbury Meeting on Psychiatric Genomics (CSHL)). Research highlights for the year (reviewed in 1) included: • Discovery of a novel, chromosomal risk duplication that increases psychosis risk more than

ten-fold (2). • Discovery of rare, loss-of-function mutations in synaptic genes in schizophrenia (3)


• Contribution to discovery of novel schizophrenia common risk variants of much smaller individual effect (4,5)

• Collaborative discovery of that many of these small effects increase risk across adult and childhood onset psychiatric disorders (6,7).

• Studies showing how individual risk variants can impact cognitive performance and brain structure in carriers (8,9)

• Development of novel methods of genome sequence analysis (10). Recent Publications list here

PAK7 Pedigrees (a risk factor for Psychosis from Reference 2 above)

PAK 7 genetic study


https://www.tcd.ie/Neuroscience/partners/PI%20Profiles/Aiden_Corvin.php

Professor Michael Gills’s group has continued to look for biomarkers for the development of Alzheimer’s Disease. The genome-wide association study has already identified variants at CLU and PICALM associated with Alzheimer's disease and a number of other candidates have emerged over the last year. His recent publications are available here. In addition to leading Psychiatry in TCD, he also leads the new 1,300sqm Wellcome Trust/HRB Clinical Research Facility (CRF) at St. James’s Hospital which was opened by An Taoiseach on the 30th May 2013. The €7 million facility is a joint initiative between Trinity College Dublin and St James’s Hospital, and is funded by a partnership between the Wellcome Trust and the Health Research Board. Prof Andrew Harkin Professor Andrew Harkin leads the Neuropsychopharmacology and Neuroimmunology research groups. Research Highlights for 2013 included: 1. The role of hepatic tryptophan 2,3 dioxygenase (TDO) was assessed in the provocation of stress-induced depression-related behaviour in the rat. TDO drives tryptophan metabolism via the kynurenine pathway (KP) and led to the production of neuroactive metabolites including kynurenine. Our recent findings indicated that stress-induced release of the stress hormone corticosterone and consequent activation of hepatic TDO, tryptophan metabolism and production of kynurenine provoke a depression-related behavioural phenotype. Inhibition of stress-related hepatic TDO activity promotes antidepressant activity. TDO may therefore represent a promising target for the treatment of depression associated with stress-related disorders in which there is evidence for KP activation. See - Gibney SM, Fagan EM, Waldron AM, O'Byrne J, Connor TJ, Harkin A. (2014) Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour. Int J Neuropsychopharmacol. 17(6):917-28. 2. Nitric oxide synthase inhibitors display antidepressant-like properties in an animal model of depression. Magnetic resonance imaging (MRI) was employed to assess regional brain volumes, blood perfusion and T1 and T2 relaxometry times both with and without drug treatment. Behavioural observations are consistent with an antidepressant action of NOS inhibitors where associated changes in perfusion and T2 relaxation times may be related to the antidepressant action of NO synthase inhibition in the model. See- Gigliucci V, Gormley S, Gibney S, Rouine J, Kerskens C, Connor TJ, Harkin A. (2014) Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulbectomised rat model of depression. Eur Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2014.05.003. [Epub ahead of print] 3. The neurotransmitter noradrenaline (NA) had anti-inflammatory properties and promoted expression of neurotrophic factors in the central nervous system (CNS) via activation of glial adrenoceptors. Here the ability of conditioned media (CM) from NA-treated glial cells was examined to impact upon neuronal complexity of primary rat cortical neurons. The results indicated a novel role for NA acting at glial β₂-adrenoceptors to induce neuritic growth through the expression of soluble factors that elicit a neurotrophic action and increase neuronal complexity.


https://www.tcd.ie/Neuroscience/partners/PI%20Profiles/Michael_Gill2.php

http://www.sjhcrf.ie/default.aspx

See - Day JS, O'Neill E, Cawley C, Aretz NK, Kilroy D, Gibney SM, Harkin A, Connor TJ. (2014) Noradrenaline acting on astrocytic β₂-adrenoceptors induced neurite outgrowth in primary cortical neurons. Neuropharmacology. 77:234-48. 4. The impact of systemic treatment with the brain penetrant β2-adrenoceptor agonists clenbuterol and formoterol on NFκB activity and IκB expression were determined in rat brain. Our findings that clenbuterol and formoterol inhibit NFκB activity in the CNS supported the idea that β2-adrenoceptors may be an attractive target for treating neuroinflammation and combating inflammation-related neurodegeneration. See - Ryan KJ, Griffin É, Yssel JD, Ryan KM, McNamee EN, Harkin A, Connor TJ. (2013) Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB. Neurochem Int. 63(5):368-78. Prof Mani Ramaswami Prof Ramaswami published 4 papers in 2013, including a major review in Cell, based in part on his laboratory's work on neuronal RNA regulation. The review was entitled- Altered ribostasis: RNA-protein granules in degenerative disorders proposes and justifies a thesis to explain a central pathway altered in ALS and related neurodegenerative disorders. He was a Symposium speaker in the Annual Society for Neuroscience meeting in San Diego (2013) In addition, in 2013 he: 1. Received an SFI Investigator grant award of €1.4 million 2. Was Lead PI and Academic Director of an SFI International Collaborative Award to a

consortium of 6 Irish Universities to build collaborations in Science and Technology with India. Award €700,000 for 2013.

3. Served as Champion for the Genes and Society Reseach Theme in Trinity College Dublin. 4. Was appointed to the Board of Reviewing Editors of eLife, a flagship open access journal

jointly funded by the Wellcome Trust, Howard Hughes Medical Institute and the Max Planck Society.

Prof Richard Reilly The Reilly group has been active in a consortium of colleagues from St Vincent's University Hospital, University College London and Albert Einstein School of Medicine (New York) and Trinity College Dublin (Professor Richard Reilly) was awarded a large HRB grant to investigate temporal discrimination as an endophenotype in Adult Onset Primary Torsion Dystonia (TCD allocation: Eur480,306). In October 2013 Professor Richard Reilly commenced a 3-year collaborative project with Cochlear Research and Development Ltd to develop neurophysiological based objective measures of speech perception in Cochlear Implant users (adults and children). This project also involves the National Cochlear Implant program at Beaumont Hospital. (TCD allocation: €120,000) Professor Reilly gave the Haughton Keynote Lecture at the 19th Annual Conference of the Bioengineering Section of the Royal Academy of Medicine in Ireland, 2013. The title of the lecture was "All a question of timing: how EEG and MRI can inform the pathophysiology of movement disorders"


Professor Reilly also gave the keynote lecture at the 6th International Joint Conference on Biomedical Engineering Systems and Technology, BIOSTEC 2013, Barcelona, February 2013. Prof Des O’Neill’s stroke and medical humanities group in Tallaght are researched the impact of neurological illness in aesthetic, cultural and leisure activities, a neglected field of research (1). They found that popular activities included mainstream cinema, listening to music, dancing, attending plays or musicals, and being outdoors. Many patients ceased these activities after their stroke, mostly because of health issues and inaccessibility. Most of the patients valued the importance of the arts in the health-care setting. A further area of interest for the Tallaght group is work on narratives of neurological illness. In 2013, there was the world premiere of music relating to Parkinson’s disease in the atrium of Tallaght Hospital composed by the composer-in-residence, Ian Wilson to poems by Leontia Flynn. This completes a triptych of works, the others relating to stroke and Alzheimer’s disease. The genesis and performance of the work, Matter, by members of the Irish Chamber Orchestra and actress Ingrid Craigie, was the subject of a documentary due to be screened on TV3 http://www.johnkellehermedia.com/upcoming/ Prof Marina Lynch The overall objective of the research in Prof Marina Lynch’s laboratory is to evaluate the impact of neuroinflammatory changes on loss of synaptic function and amyloid pathology in a transgenic mice animal model of Alzheimer’s disease, which over express amyloid precursor protein (APP) and presenilin 1 (PS1; APP/PS1 mice). In the past 12 months, we have reported that blood brain barrier permeability increases with age and, particularly in aged APP/PS1 mice and that this contributes to the infiltration of inflammatory cells including macrophages. The evidence suggests that infiltrating macrophages contribute to the ongoing pathology and the ongoing neuroinflammation. Analysis of the effect of peripheral infection in control and APP/PS1 mice (with Professor Kingston Mills), revealed that infiltration of circulating cells, including T cells, macrophages and natural killer cells, was more profound in APP/PS1 mice. This was associated with significantly more amyloid pathology and neuroinflammation in APP/PS1 mice compared with wildtype controls. This increased susceptibility to infection is consistent with that observed in the clinic. Ongoing analysis is focussing on developing strategies which limit infiltration of cells. An additional collaboration with Professor Kingston Mills was designed to identify the factors that contribute to the pathology associated with an animal model of multiple sclerosis. Recent data that has just been published established that infiltration of natural killer cells and the subsequent release of interferon- (IFN) was a key factor in driving the early inflammatory changes in the disease. However IFN is protec effect of natural killer cells, which also infiltrate the brain in APP/PS1 mice, on microglia is ongoing. Current Grants: 1. IRC Postgraduate grant for Hannah Wolfe (Sept 2013-Aug 2017) 2. Enterprise Ireland Innovation Partnership Programme grant (with Opsona; March 2014-June 2015).


http://www.johnkellehermedia.com/upcoming/

3. PI coordinator of an interdisciplinary and inter-institutional PRTLI-funded structured PhD programme: (Sept 2011-Sept 2015). Title: Molecular and cellular mechanisms underlying inflammatory processes Total budget €2,968,000 4. SFI Principal Investigator grant (Sept 2012-Sept 2016) Title: Modulating microglial function and its impact on neuronal function Amount: €1,141,448 Dr Connail McCrory’s group continued to make progress in research on the response of the human nervous system to pain. In particular his group has been researching: (i) Human neuronal cytokine biosynthesis response to chronic pain (ii) Mechanisms of human neuronal response to neuromodulation in vivo In addition to his clinical commitments, he was organiser for a number of conferences on the topic of Pain management and published a paper in the journal Neuromodulation. ‘Cerebrospinal Fluid levels of VEGF correlate with reported pain and are reduced by spinal cord stimulation in patients with failed back surgery syndrome. McCarthy KF, Connor TJ, McCrory C. Neuromodulation 2012 Nov8 [epub ahead of print] He also delivered an invited lecture to the Faculty of Pain Medicine Annual Scientific Meeting February 2013. ‘Neuroimmune response to chronic pain in vivo in man. McCarthy KF, McCrory C’ Redmond O'Connell published 3 peer-reviewed papers in 2013 in journals such as Neuropsychologia, Journal of Neuroscience and Neurobiology of Aging. A key research highlight was the Internal and External Influences on the Rate of Sensory Evidence Accumulation in the Human Brain. The focus on this was the need to make timely decisions based on sensory evidence that is weak, ambiguous, or noisy resulting from conditions in the external environment. One discovery was how errors on our continuous version arise far more often from missing the temporarily unpredictable seamless transition to coherent motion interval than from incorrect choices on detected charges. His publications in 2013 included: Newman DP, O'Connell RG, Bellgrove MA. (2013). Linking time-on-task, spatial bias and hemispheric activation asymmetry: a neural correlate of rightward attention drift. Neuropsychologia. 51(7):1215-23 Balsters, J.H., O’Connell, R.G., Galli, A., Nolan, H., Greco, E., Kilcullen, S.M., Bokde, A.L.W., Upton, N, Lai, R.K., & Robertson, I.H. (2013). Changes in resting connectivity with age: A simultaneous EEG/fMRI investigation. Neurobiology of Aging. 34(9): 2194-207. Kelly, S. P., & O'Connell, R.G. (2013). Internal and External Influences on the Rate of Sensory Evidence Accumulation in the Human Brain. Journal of Neuroscience, 33(50), 19434-19441. Harty, S., O’Connell, R.G., Hester, R. & Robertson, I.H. (2013). Older Adults Have Diminished Awareness of Errors in the Laboratory and Daily Life. Psychology and Aging. 8(4):1032-41 Grants Received: National Science Foundation, Cognitive Neuroscience project grant. $500k Invited Talks: June 2013 Colloquium, School of Psychology, Bangor University, Wales


March 2013 Colloquium, Department of Economics, University of Zurich, Switzerland. The O'Connell lab currently has 5 PhD candidates and was awarded funding from the Irish Research Council and the Welcome Trust. EU FP7 International Resarch Staff Exchange Scheme award for collaboration with researchers at Cambridge university, Monash university and University of Queensland. Prof. Shane O’Mara published 4 papers in 2013 in journals such as Journal of Comparative Neurology, Central European Journal of Public Health American Journal of Health behavior and American Journal of Preventive Medicine Frontier Psychology, European Journal of Neuroscience. His main research had focused on the relations between synaptic plasticity, cognition and behavior, in the context of brain aging and depression. In his research on depression when compared to age-sex-and-education matched controls, patients with depression showed impaired learning, delayed cued-recall, and delayed free-recall. However, they also showed preserved recognition of the verbal and nonverbal components of this task. Results indicate that the face-name pair’s task is sensitive to neurocognitive deficits in major depression. When examining Respiratory cycle entrainment of septal neurons findings provided experimental evidence that MS/DB does not merely generate theta rhythm, but actively integrates sensorimotor stimuli that reflect sniffing rate. Such integration may provide temporal oscillatory synchronisation of MS/DB-innervated limbic structures with the sniffing cycle. He has been working on a book called Interrogating the Brain a Journey without Light Cambridge, Mass: Harvard University Press which was completed in 2014. Research Support and Research Funding: Research work has been or currently is supported by the Welcome Trust; Science Foundation Ireland; the Health Research Board; the European Commission; GlaxoSmithKline; Alkermes. His Research Group Management consisted of 5 Postdoctoral Fellows; 5 PhD students and I Research Assistant on average. Kevin Mitchell published 5 articles in 2013 in journals such Public Library of Science and Schizophrenia: Evolution and Synthesisas. In his article on A Framework for Advancing the Use of Models in Schizophrenia discusses how animal, cellular, and computational models can be used to explore convergence at the intervening level of pathophysiology. It considers such models as experimental platforms to investigate specific neurobiological hypotheses, in particular to elucidate causal chains of pathogenic events. Professor Pete Humphries has established that targeting a protein integral to the blood brain barrier mediates reversal opening of the blood brain barrier; this paper which employed a multidisciplinary team and included findings from the MRI team led by Dr Kerskens, was recently published in J Gene Med. Professor Brian Lawlor’s group is continuing their study on determining whether neurocardiovascular instability contributes to the transition from Mild Cognitive Impairment (MCI) to dementia. Prof Lawlor’s group have also recently been awarded funding under EU FP7 health call. The new grant NILVAD is a large investigator initiated multicentre European trial in patients with mild to moderate Alzheimer’s Disease (AD) with a total value of €6 million across 10 European countries. This will be the largest investigator led clinical trial in Alzheimer’s Disease ever conducted in Europe. Professor Rose-Anne Kenny


Research output using TILDA data continued to increase. Since the publication of the first summary report ‘Fifty Plus in Ireland’ in May 2011, six topic reports have been released. In 2013, topic reports on healthcare utilisation and pharmacy costs, and on the ‘sandwich generation’ were released. TILDA-based papers are now also being accepted for publication in major international journals in health, economics and demography. In May 2013, the Journal of the American Geriatrics Society published a special supplement on the TILDA study with a view to assisting researchers in the interpretation of the TILDA data, and to encourage widespread use of the TILDA data, both nationally and internationally. Research grants totaling over €3m have been awarded to TILDA to date and in October 2013, Dr Aisling O’Halloran, TILDA Research Fellow, was awarded a three-year CARDI Fellowship to study frailty in Ireland, North and South. In terms of policy impacts, two important government publications have used data from TILDA to inform their work; the cross-departmental strategy on the nation’s health, ‘Healthy Ireland – A Framework for Improved Health and Well-Being’ (published in March 2013), and the ‘National Positive Ageing Strategy’ (published in April 2013). Data from TILDA will support implementation of these strategies. TILDA also hosted a conference on the 13th March 2013 on ‘Meeting the challenge of an ageing Ireland’ for policy makers and researchers in ageing which was very well received by policymakers and researchers alike. In June 2013, the Centre for Longitudinal Studies in Ireland (CLSI) hosted a conference on ‘The Long Shadow of Childhood Adversity on Health: Evidence from Ireland and Policy Implications’, in which TILDA research was presented to academics and policymakers. At an international level, TILDA was invited by Emer Costello, MEP to present to the European Parliament in October 2013. The seminar, entitled ‘Living happier and healthier in the age of longevity: how longitudinal studies on ageing informed policy for Healthy Life Years. Insights from TILDA’, focussed on how TILDA is characterising the older citizen and exploring the ageing process and the determinants of successful ageing in order to plan appropriate health, social and economic policies. Collaboration with other international ageing studies continues to increase. In addition to a visit to TILDA by a delegation from the Korean Longitudinal Study on Ageing (KLoSA) in November 2013, the inaugural meeting of the British and Irish Longitudinal Studies on Ageing was hosted by TILDA on October 31st and November 1st 2013. Researchers and PIs from TILDA, ELSA (the English Longitudinal Study of Ageing), NICOLA (the Northern Ireland Cohort for Longitudinal Study of Ageing) and the planned Scottish Longitudinal Study of Ageing, as well as guest speakers, presented research and discussed methodological issues arising from the longitudinal studies. The Irish Longitudinal Study on Ageing (TILDA), led by Principal Investigator Professor Rose Anne Kenny, now employs 40 research and clinical staff. The primary objective of TILDA is to generate a longitudinal dataset of people aged 50 and over and living in Ireland, with data covering topics such as economic and social circumstances, health status, health and social care utilisation and early life circumstances. Additional objectives include the generation of research findings through the use of the data and the influencing of policy through the application of research findings. In 2013, wave 2 of data collection was completed successfully and preparations began for wave 3 began. For the first time in Ireland, longitudinal data on the over 50s in Ireland are now available to researchers.


Professor Declan McLoughlin’s groups in St Patrick’s University Hospital and TCD had started a 7-year research programme called the EFFECT-Dep Study. This programme was supported by a HRB Translational Research Award and its purpose is to improve electroconvulsive therapy (ECT) practice and use it to interrogate the molecular neurobiology of depression. The group have recently completed a definitive randomised controlled trial comparing bilateral and high-dose unilateral ECT, recruiting 140 patients with severe depression. The study also employed an animal model of ECT treatment to characterize changes in global protein expression in brain and plasma and is performing parallel studies using plasma from depressed patients recruited into the clinical trial. The research aimed to identify candidate peripheral biomarkers for depression, treatment response and depression relapse. Current grants include: Science Foundation Ireland International Strategic Cooperation Award (SFI/ISCA) India Collaboration Award Declan McLoughlin, BN Gangadhar, Jagadisha Thirthalli Title: NIMHANS/TCD Depression Collaboration Duration: 1 year, 2013 Value: €10,000 Health Research Board Research Enhancement Awards 2012 Declan McLoughlin, Karen Ryan Title: Telomere length, depression and ECT – an enhancement award to The EFFECT-Dep Study: enhancing the effectiveness of electroconvulsive therapy in severe depression and understanding its molecular mechanism of action Duration: 1 year, Nov 2012 – Oct 2013 Value: €99,920 Health Research Board /MRCG Joint Funding Scheme (MRCG/2008/9) Paul Fearon, Declan McLoughlin, Craig Morgan Title: Measuring Quality of Care in an Irish Mental Health Service Context’. Duration: 3 years, 2010-2014 Value: €300,000 Health Research Board Translational Research Award (TRA/2007/5) Declan McLoughlin, Michael Dunn, Harald Hampel, Shane O’Mara Title: The EFFECT-Dep Study: enhancing the effectiveness of electroconvulsive therapy in severe depression and understanding its molecular mechanism of action Duration: 5 years, Oct 2007 – July 2014 Value: €1,481,484 (€1,395,537) Recent Publications Recent publications are listed here. Professor Ian Robertson’s group had a successful year and a number of notable achievements. Main achievements in last year: Siobhan Harty, PhD student jointly supervised by Ian Robertson and Redmond O’Connell discovered that elderly people on average are less aware of their mistakes both in the laboratory and in everyday life. This finding may be an important


https://www.tcd.ie/Neuroscience/partners/PI%20Profiles/Declan_Mcloughlin2.php

factor in some elderly people not learning to compensate for age-related memory changes. Harty et al, (2013), Psychology and Aging In another paper Siobhan Harty, PhD student jointly supervised by Ian Robertson and Redmond O’Connell, showed that you could improve awareness of mistakes in older people by applying tiny voltage stimulation to the right frontal lobe of their brains. Harty et al (2014) The Journal of Neuroscience, 5 March 2014, 34(10): 3646-3652 The Robertson laboratory demonstrated that it is possible to produce lasting changes in short-term memory in older people using a 5 week web-based cognitive training programme. McAvinue, L. P., et al. (2013), Frontiers in Aging Neuroscience 5. In collaboration with Prof Marina Lynch’s lab, the Robertson lab also discovered that a particular memory profile in older people is associated with distinct cellular inflammatory patterns in them: Downer et al (2013). PLOS ONE DOI: 10.1371/journal.pone.0063194 Ian Robertson was the keynote speaker at the Danish Neuropsychological Society annual meeting in September 2013 and one of the keynote speakers at the International Neuropsychological Society meeting in Amsterdam in June 2013. Grants obtained in the last year include:

• Partner in FP7 ITN INDIREA, led by Oxford: 2 PhD students • Funded investigator in SFI Insight Programme (1 Postdoc) • Irish Research Council postgraduate award (Eric Lacey) • Industry funding from VSL, Rome for nutritional trial.

Dr Marian Tzanov’s research group provided experimental evidence that medial septum did not merely generate theta rhythm, but actively integrates sensorimotor stimuli that reflect sniffing rate. Such integration may provide temporal oscillatory synchronization of septal-innervated limbic structures with the sniffing cycle. Our findings suggest that the septo-hippocampal axis integrates respiratory rate and limbic theta rhythm. This temporal coupling incorporated the integration of intrinsic theta and extrinsic sensorimotor signals on each theta cycle. The functional significance of our data addresses the assembly organization of hippocampal neurons, which was crucially dependent on the relationship between global theta frequency, the oscillation frequency of single neurons and the sensorimotor theta timescale. Using novel electrophysiological techniques, I aimed to understand how the hippocampal formation, which supports episodic memory, is dynamically modulated by dopaminergic and cholinergic signals. Our recent findings established causal links between the patterns of spatial neural activity across hippocampal areas. Our research demonstrated major advances in multi-site electrode technology and optogenetic techniques to test fundamental theories of neuroaminergic modulatory control on memory networks and navigation behaviour. Due to successful collaboration with Prof Boyden (MIT, Boston) I had applied optogenetic tools in parallel with electrophysiological recordings in the context of rodent spatial behaviour Optogenetic tools allow us to investigate the roles of differing neuronal subtypes in behavioural contexts. The stimulation protocols mimic the spiking activity of septal neurons, the spiking of which we have recently investigated. The latest advances in optogenetic tools allowed us to investigate the functional role of neuronal subtypes in behavioural contexts. Neurons of a


specific type could be identified among the numerous recorded neurons from their response to light, and subsequently, their firing pattern can be analysed in relation to the firing of other neurons, local field potential patterns and the animal's behaviour. Optical stimulation of genetically targeted neurons expressing light sensitive channelrhodopsin could be used as a rapid activator of neuronal firing with potential cell type selectivity. To distinguish the particular effect of septal cholinergic neurons we applied septal stimulation of choline acetyltransferase (Chat)::Cre rat line with optogenetic laser stimulation after the injection of ChR2-YFP adeno-associated virus in the septal cholinergic neurons. Our data showed that the modulatory role of septal cholinergic control over the hippcampal place field representation was mediated by the rhythmic entrainment of hippocampal neurons and the ability of septo-hippocampal circuits to resonate in theta frequency.

Figure 1. Selective activation of cholinergic neurons in medial septum of transgenic rats. I have successfully implanted injected channelrhodopsin-AVV and implanted animal with optogenetic fiber in medial septum (left). I Have applied septal stimulation of choline acetyltransferase (Chat)::Cre rat line with optogenetic laser stimulation after the injection of ChR2-YFP adeno-associated virus in the septal cholinergic neurons (right). Invited talks: The bursting properties of thalamic head direction cells mediate turn-specific modulation of the directional tuning curve. Stresa, 2013: Neurobiology of Action, ESF-FENS Conference. Grants: Research Career Development Fellowship for five years (2013 – 2018) funded by Wellcome Trust (WT) / Science Foundation Ireland (SFI)/Health Research Board (HRB)/ Biomedical Partnership. People: He has hired 1 post-doctoral fellow (Dr Omar Mamad) MRI Technical Group


We were successful in December 2012 in winning major funding of €1.34 million to upgrade both of our MRI systems under the SFI Infrastructure Grant 2012. The awards will double resolution and speed on both systems and should enhance our international competiveness for grant applications. The 3T system was fully upgraded in June 2013 and has been running well for many new studies. We expect the 7T system which is a major and state of the art system upgrade should be completed by June 2014. In addition under the SFI opportunistic funding we were able to acquire MRI compatible physiological monitoring equipment, a crash trolley and additional MRI coils for Aging studies.


GRANT FUNDING IN TCIN 1. NEIL, NeuroEnhancement for Independent Lives The NEIL program funded initially by Atlantic Philanthropies and run by Dr Sabina Brennan, Assistant Director NEIL, Prof. Brian Lawlor, Clinical Director NEIL and Prof. Ian Robertson as Director of NEIL has leveraged a significant amount of external funding (€12m in value to date) from the EU, NGOs and Industry and is a model for the types of programmes we intend to develop in TCIN in the future. 2. SFI Infrastructure award 2012 & OpportunisticFunding award 2013 TCIN successfully won infrastructure funding of 1.34 Million Euro from Science Foundation Ireland to upgrade both MRI systems. This funding will double the resolution and scan speed of both systems as well as enabling additional functionality to enable specialised blood flow studies on the Clinical system and Cardiac studies on the Pre-Clinical system. TCIN also won infrastructure funding of €95k from Science Foundation Ireland to purchase highly discounted accessories for the MRI systems including a patient monitoring system. 3. Industry Partners Several new industrial programs commenced in 2013 with a number of partners including Alkermes, Opsona and Transpharmation UK. 4. The TRIL programme This program which concluded in CY-2012 was one of the biggest industry-academic partnerships ever funded in Ireland. This €10 million programme - a partnership between TCD/TCIN, UCD, NUIG, Intel and GE designed and delivered technology solutions to support independent living in the ageing population. 5. PRTLI 5-PhD Programme TCD investigators led by the Programme Director Professor Marina Lynch were awarded funding in July 2010 under the PRTLI Cycle 5, to introduce a PhD programme in Molecular and Cellular mechanisms underlying inflammatory processes. The programme commenced in Oct 2011, and a total of 11 students have been recruited. The program runs in parallel with other Institutions including UCD, UCC, NUIG and Queen’s University Belfast. 6. TILDA Professor Rose-Anne Kenny leads The Irish Longitudinal StuDy on Ageing (TILDA), a multi-disciplinary study which conceptualises ageing along three main dimensions: health, wealth and social connectivity. Its first pilot study, which provides baseline data that allows for the longitudinal assessment and evaluation of biomeasures in particular areas of disease that are prevalent with age, has been successfully completed. The next phase of the study will include several nested studies complementing and extending ongoing research activity in TCIN and St James’s Hospital. 7. Science Foundation Ireland Several TCIN investigators hold a prestigious SFI Principal Investigator award. The latest recipient of one of these awards is Prof. Louise Gallagher.


Funding Breakdown TCIN’s research funding comes from a variety of sources and resulted in a research spend of €4.3 million in 2013 broken down as follows. Although 22% of our funding came from industrial grants in 2012 (made up of large consortium grants with Intel, GSK and GE); this declined to 11% in 2013 as the grants conclude. The revenue spend on other industry projects has increased 5-fold from 1% of total in 2012 to nearly 5% in 2013 and government funding is stable at 63% in 2013.

2012 Expenditure HRB €1,371,693 Science Foundation Ireland €959,286 Intel TRIL €652,924 HEA/PRTLI cycle 5 €630,589 Trinity Foundation/Atlantic Philanthropies €408,573 GlaxoSmithKline €379,548 Wellcome Trust €200,077 IRCSET Post Doctoral Fellowship €144,636 EU FP7 Research €128,646 Other Industrial €50,447 Interreg 4A IV €38,110 Enterprise Ireland €20,994 Irish Motor Neuron Disease Research Foundation €12,902 Irish Research Council €12,398 Grand Total € 5,010,823

27%

19%

13%

13%

8%

8%

4% 3%

3% 1% 1%

2012 grant expenditure for TCIN HRB

Science Foundation Ireland

Intel TRIL

HEA/PRTLI cylce 5

Trinity Foundation/Atlantic Philanthropies GlaxoSmithKline

Wellcome Trust

IRCSET Post Doctoral Fellowship

EU FP7 Research


2013 Sum of Expenditure

Science Foundation Ireland € 1,450,148 HEA/PRTLI cycle 5 € 730,089 HRB € 468,272 Trinity Foundation/Atlantic Philantropies € 456,342 Wellcome Trust € 298,015 Other Industry € 201,793 EU FP7 Research € 156,716 INTEL TRIL € 135,850 GlaxoSmithKline € 132,569 Interreg 4A IV € 132,518 Charity sponsors € 90,212 Irish Research Council or IRCSET € 78,184 Other € 23,647 Enterprise Ireland € 9,436 Grand Total € 4,363,792

33%

17% 11%

10%

7%

5%

4%

3% 3%

3%

2% 2%

0% 0%

2013 grant expenditure for TCIN

Science Foundation Ireland

HEA/PRTLI cycle 5

HRB

Trinity Foundation/Atlantic Philantropies Wellcome Trust

Other Industry

EU FP7 Research

INTEL TRIL

GlaxoSmithKline

Interreg 4A IV

Charity sponsors

Irish Research Council or IRCSET


PROMOTIONS AND AWARDS PROMOTIONS TCIN is delighted to welcome four new research PIs in 2013: Dr Marian Tsanov Dr Sabina Brennan Dr Matt Campbell Dr Mary Cannon (RCSI) AWARDS Samuel Haughton Silver Medal Professor Reilly was awarded the Samuel Haughton Silver Medal by the Royal Academy of Medicine in Ireland (2013). Get Started Technology Venture Programme Claire McDonald a Postdoctoral researcher with TCIN won the pitching competition which came at the end of the Get Started Technology Venture Programme at the DCU Ryan Academy. For the prize, SFI will pay for the winning participant to spend a week in Silicon Valley hosted by the ITLG (Irish Technology Leadership Group). Government of Ireland Postgraduate Scholarship, Irish Research Council, 2012/13: Sabina Brennan/Ian Robertson, TCIN- PhD Student: Caoimhe Hannigan (TCD) ‘Cognitive Reserve: Developing a Model of the Social Processes that Mediate Age-Related Cognitive Decline.’ Government of Ireland Postgraduate Scholarship, Irish Research Council, 2012/13: Ruth Byrne, TCIN- PhD Student: Mary Parkinson ‘Situating Moral Responsibility in a Framework of Moral Judgement.’ Government of Ireland Postgraduate Scholarship, Irish Research Council, 2012/13: Richard Carson, TCIN- PhD Student: Emmet McNickle (TCD) ‘Transcranial alternating current stimulation: optimisation of parameters and investigation of mechanisms of action.’


EDUCATION & OUTREACH AT TCIN TCIN has multiple activities in education and outreach. In 2013, we had almost 50 students graduate with PhD, MSc or BSc Neuroscience degrees. In addition TCIN invited over 50 national and international speakers who gave lectures in associated teaching courses, seminars, workshops and conferences. The Extramural Course: 21st Century Brain specifically designed for public engagement has 41 registrants this year. PhD Programmes TCIN is committed to attracting the best PhD candidates from around the world, international students currently comprise 36% of our PhD student register, 18% of whom are from outside the EU; similarly over 20% of our MSc enrollment are from outside the EU. Structured PhD Programmes TCIN introduced Ireland’s first 4-year integrated PhD programme in October 2004 funded by the Health Research Board, which over 4 intakes, graduated a total of 20 PhD students. Due to the success of this programme, we made strong efforts to replace it. After a very competitive selection process, we enrolled 7 Neuroscience PhD students in October 2011, on a new HEA PRTLI 5 (funded) Structured PhD program ‘Molecular and Cellular Mechanisms underlying inflammatory processes’, this multi-institution program is led by Professor Marina Lynch of TCIN. http://www.tcd.ie/Graduate_Studies/PRTLI/cellular.php Traditional PhD’s In addition to the structured PhD programmes, we also have many fine students enrolled in traditional individual PhD research in our PI group laboratories. These opportunities arise from time to time as research funding becomes available and are advertised on our website and partner websites. We had 8 PhD submissions in 2013. PhD submissions 2012/2013 Luke Healy Gillian Muirhead Martina Hughes Marika Doucet Jack Prenderville James Barrett Barry McGuiness Adam Pritchard

MSc Programs MSc Neuroscience The MSc in Neuroscience was launched in 2006 and has been recently awarded the Best Science Course in Ireland by PostGrad Ireland in 2012. Starting with just 11 students, we have expanded the intake due to increased demand. We currently have a 26-strong cohort of students in the 2013/2014 class. In 2013, there were 22 graduates and we wish them well in their future careers.


http://www.tcd.ie/Graduate_Studies/PRTLI/cellular.php

The MSc in Neuroscience is a 1 year (full time) or 2 year (part time) taught course. This MSc in Neuroscience is the only integrative postgraduate course of its kind in the country. It draws together students from a variety of backgrounds including Life Sciences and Medical Sciences. Students accepted onto the course have a background in neuroscience, pharmacology, immunology, biochemistry, biotechnology, pharmacy and medicine. This course builds on these strengths of individual students’ knowledge base and develops their skills in a range of specialties. Students leave this course skilled in both academic and clinical aspects of Neuroscience research, prepared to embrace the challenges of Neuroscience in academia, industry, in clinical settings and beyond. Under the course director, Prof. Kumlesh K. Dev, we are committed to attracting a diverse cohort of excellent students. Governance & Management-MSc Neuroscience Course Committee The MSc Neuroscience course committee comprises: Prof. Kumlesh Dev (KD), Prof. Arun Bokde (AB); Dr. Daniel Ulrich (DU); Prof. Aine Kelly (AK); Prof. Andrew Harkin (AH); Prof. Richard Reilly (RR) MSc Neuroscience Graduations 2012 Andrew Lockhart (Novartis Prize winner) BA Mod Degree Neuroscience An undergraduate speciality (BA. Mod) in Neuroscience was introduced in Trinity College Dublin in 2002 with a quota of 10 students per annum. This quota increased to 22 in October 2010. Twenty students graduated in June 2012 of these 4 were awarded first class honours. There are currently 22 Junior Sophister and 22 Senior Sophister students. The course directors are Prof. Tom Connor and Dr. Daniel Ulrich. Governance & Management-Neuroscience Moderatorship Course Committee The Neuroscience moderatorship is an interfaculty degree programme comprised of modules from six Schools across three Faculties, consequently, a course committee is required in order to ensure effective running of this degree programme. The committee is comprised of the three academic members of staff that were employed specifically to teach on this degree programme- Dr. Gavin Davey (Biochemistry), Dr. Daniel Ulrich (Physiology), Ass. Prof. Neuroscience (Physiology), the Director of Undergraduate Teaching and Learning in the School of Biochemistry and Immunology (as the Neuroscience degree is nominally affiliated to this School for administrative purposes), representatives from all other academic units that contribute to the degree programme, and the Executive Officer in TCIN who provides administrative support to the degree programme. Terms of reference: This committee will govern the effective running of the Neuroscience degree programme from both an academic and administrative perspective, and will report to the Course Director of TR071 (Science) via the TR071 course management committee. The membership of the Neuroscience degree course committee is to be included in the “Committees” section of the University Calendar. Meetings: The committee will meet on the first and penultimate Thursday of each Semester. The Neuroscience degree course committee comprises:


Associate Professor in Neuroscience, Senior Sophister coordinator and Director, Neuroscience degree programme (Chair) Dr. Gavin Davey, Associate Professor in Neuroscience, Head of School of Biochemistry & Immunology Dr. Daniel Ulrich, Assistant Professor in Neuroscience & Junior Sophister coordinator Dr. Clair Gardiner – Director of Undergraduate Teaching and Learning, School of Biochemistry and Immunology Dr. Paul Tierney – Anatomy Dr. Aine Kelly – Physiology Dr. Kevin Mitchell – Genetics Dr. Andrew Harkin – Pharmacy Dr. Paula Murphy – Zoology Prof. Shane O’Mara – Psychology

Societies and Outreach Activities University of Dublin Neuroscience Society (Neurosoc) The University of Dublin Neuroscience Society was set up in 2008 and is Ireland's first university society for neuroscience. It was founded by a group of TCIN-based postgraduate students funded on the 4 year PhD programme. The aims of the society are to organise academic and social events for students and staff with an interest in neuroscience. Academic events includes hosting talks by prestigious national and international speakers, in association with TCIN, and holding public events on issues such as Alzheimer’s Disease, Autism and Multiple Sclerosis. The society also caters for the social needs of its members; events include table quizzes, pub nights and fund-raising events. The society’s e-mail address is: [email protected]. More information is available at Website: http://neurosoc.csc.tcdlife.ie/ Neuroscience Seminar Series The Neuroscience seminar series, set up in 2006, aims to provide a forum to facilitate transfer of knowledge and trigger discussion among researchers in different disciplines associated with TCIN. The purpose of the series is to foster the integrative approach to neuroscience research that TCIN was established to develop, as well as promote TCIN as an internationally competitive institute. The seminar topics cover all aspects of molecular, cellular, developmental and cognitive neuroscience as well as neuroscience-related topics in disease, psychiatry, and genetics. Participants include researchers at all levels within TCIN and internationally-regarded external speakers. This series is coordinated and organised by ‘Neurosoc’ in collaboration with Dr Colm Cunningham. Extramural Course: TCIN’s Extramural Course in Neuroscience- ‘21st Century Brain’ is now in its 5th year. The course is an 18 week series of lectures (9 weeks per term) that is open to all members of the general public. The course lectures cover a variety of topics including Alzheimer’s Disease and MRI, Stem Cells, therapeutic neuro-modulation and neuroimmunology (among others) with each weeks’ lecture being delivered by a TCIN PI.


http://neurosoc.csc.tcdlife.ie/

Neuroscience Prizes 2013 Barbara Ryan Memorial Prize 2013 The Barbara Ryan Memorial Prize in Neuroscience is awarded for outstanding academic performance in the Junior Sophister year of the BA-Mod Neuroscience (JS Class). The prize is for €400 and was presented by Dr Dan Ulrich the Course Co-ordinator for the BA-Mod Neuroscience (JS). The 2013 award was made to Sean O’Malley. Novartis Prize in Neuroscience 2013 The Novartis Prize is awarded for outstanding academic performance in the MSc Neuroscience class. The prize is for €350 and was awarded by Novartis Ireland Medical Director, Greg Hays. The 2013 award was made to Andrew Lockhart. Lundbeck Prize 2013 The Lundbeck Prize in Neuroscience is awarded for outstanding academic performance in the Senior Sophister year of the BA-Mod Neuroscience (SS Class). The prize is for €500 and was awarded by Mr Tom Campion of Lundbeck Ireland. The 2013 award was made to Robert Walsh.


MEETINGS Meetings Held: TCIN have become regular contributors to the Science Gallery program of outreach and education with at least 1 event per year. The 3rd Annual meeting of Frontiers in Neurology was held on 15th November, 2013 at the Science Gallery, Trinity College Dublin. This was organized by three TCIN PIs: Prof Orla Hardiman, Prof Kumlesh K. Dev and Prof Marina Lynch. An international conference on WIRING THE BRAIN moves to the US for the first time in 2013. Organised by TCIN PI Kevin Mitchell and other colleagues it was held from July 18 – 22, 2013 in Cold Spring Harbor. A Science Gallery event called Risk lab was held in June 2013 and TCIN PI Prof Ruth Byrne and her group presented a number of exhibits and talks. A TCIN Symposium was held on November 6, 2013 in the Lloyd building, Trinity College. A number of international keynote speakers attended including Prof. Elizabeth Gould of Princeton University; Prof. Kia Nobre of Oxford University and Prof. Maria Sánchez Vives of University of Barcelona. Our local speakers also contributed very strongly with a range of very interesting and diverse talks. The event was very successful once again with over 100 attendees. Planned Meetings: The TCIN Annual Symposium will be held on November 4, 2014 in the Lloyd building, Trinity College. A number of international and local guest speakers will be invited to speak on a broad range of neuroscience topics. Lecture Series: The TCIN-Neurosoc lecture series continues to draw excellent speakers and good attendances. The meetings are primarily held on Mondays at lunchtime, though occasionally may be held in the evening depending on the demand. The program for 2013/2014 is below and future talks are available on the Neurosoc website.


Date

Speaker (confirmed)

Affiliation Title Neurosoc Liaison

30/09/13 (Mo)

Dr. Kevin Murphy

University of Cardiff

FMRI measures of cerebrovascular physiology'.

Deirdre

07/10/13 (Mo)

Dr. Colm Cunningham

TCIN "Bad Synergy: The interaction of systemic inflammation and prior neurodegenerative pathology in the pathophysiology of delirium"

Isabell

14/10/13 (Mo)

Dr. Marian Tsanov

TCIN Turn-specific encoding of head directional information

Isabell

21/10/13 (Mo)

Prof. Mani Ramaswami

TCIN "From yeast to the brain (not Guinness, but the 2013 Nobel Prize in Medicine)."

Isabell

28/10/13 (Mo)

Bank holiday

05/11/13 (Tu)

TCIN annual symposium

11/11/13 (Mo)

Dr. Erik O’Hanlon

RCSI & TCIN "Can high angular resolution diffusion imaging (HARDI), capture the pathway to psychosis? A study of adolescents with psychotic symptoms in the ‘pre-prodomal’ phase."

Deirdre

02/12/13 (Mo)

Dr. Matthew Campbell

Genetics & TCIN "Alzheimer's Disease and the amyloid conspiracy"

Isabell

09/12/13 (Mo)

Dr. Daniele Volpe

Music and Irish dance in Parkinson's disease

James

2014

17/01/14 (Fri)

Prof Gary Donohue

NUI Galway Schizophrenia, connectomics and the social brain

Roisin

20/01/14 (Mo)

Prof Charan Ranganath

UC Davis Re-contextualizing the hippocampus

Isabell

24/01/14 (Fr)

Frederic Marion-Poll

CNRS, France Why do we avoid bitter molecules?

Jointly hosted -Neuroscience & Functional Biology


Program

27/01/14 (Mo)

Dr. Joshua Balsters

ETH Zurich “In Praise of Tedious Anatomy: The importance of anatomy and physiology to human neuroimaging”.

Deirdre

30/01/14 (Th)

Prof David Nutt

Imperial College London

Why neuroscience should direct 21st century drug and alcohol policy

James

03/02/14 (Mo)

Dr. Heleen Slagter

University of Amsterdam

Sustaining attention for a prolonged period of time decreases attentional control and stability: neural and behavioral evidence

Deirdre

10/02/14 (Mo)

Dr Yvonne Nolan

UCC Inflammation: a negative modulator of the hippocampal neurogenesis in the developing and adult brain

Roisin

17/02/14 (Mo)

Dr. Paul Sauseng

University of Surrey

Brain oscillatory signatures of short-term memory control functions in humans

Deirdre

19/02/14 Dr. Jacinta O’ Shea

University of Oxford

Driving adaptive neural plasticity with non-invasive brain stimulation

John

03/03/14 (Mo)

Dr. Aine Kelly TCD BDNF: a prolific promoter of plasticity

Colin

07/03/14 (Fr)

Dr. John Hardy

UCL "Genetic dissection of neurodegenerative disease"

James

20/03/14 (Thurs)

Axel Cleeremans

Brussels ‘Consciousness: the Radical Plasticity Thesis’

Deirdre

24/03/14 (Mo)

Dr. Chris Summerfield

Oxford Attention & Decision-Making Deirdre

03/04/14 (Thurs)

Prof. Upinder Bhalla

NCBS,Bangalore Memory traces and event sequences.

John

07/04/14 (Mo)

Prof. Wynand Van Der Goes

Cardiff University Interaction among sensory neurons in Drosophila

John


Van Naters

14/04/14 (Mo)

Dr. Justin McCarthy

UCC A role for presenilins and γ-secretase-regulated signalling in the immune system.

Colin. Co-hosted with PRTLI Training Program

21/04/14 (Mo)

Easter Monday

25/04/14 (Friday)

Dr. Eric Downer

UCC “Cannabinoids and TLRs: Clearing the smoke on Multiple Sclerosis”

Roisin

28/04/14 (Mo)

05/05/14 (Mo)

Bank holiday

12/05/14 (Mo)

16/5/14 (Fri)

Dr. Jessica Teeling

University of Southampton

''Immune adaptations to the CNS following systemic infection''

Roisin

19/05/14 (Mo)

Prof. Howard Eichenbaum

Boston University

The hippocampus in space and time

John

26/05/14 Dr. Cora O’Neill

UCC Insulin signalling resistance: converging mechanisms and treatments for the chronic diseases of ageing, Alzheimer’s and diabetes

Colin

02/06/14 Bank holiday

13/06/2014

Michael Shadlen

Columbia University

"Predicting the accuracy of a decision: A neural mechanism for confidence."

Deirdre

09/07/14 (We)

Garret Stuber University of North Carolina

"Dissecting the neural circuits that mediate motivated behaviours"

Isabell


INNOVATION

Industrial Collaborations Professors Ian Robertson Shane O’Mara and Sabina Brennan have signed 3 separate industrial research partnership agreements with individual SME’s. Prof. Peter Humphries continues to have industry collaborations with Wyeth Pharmaceuticals. Professor Marina Lynch has industry collaborations with Opsona, Vasogen Ireland and Amarin: Commercialisation Activities Patents/Inventions TCIN have been active in 2013 with 7 Invention disclosures and 1 patent submitted. (In 2012, we had 4 invention disclosures, 5 patents submitted and 1 granted.)

Number of Invention Disclosures 7 Christian Kerskens X 1

Daniela Tropea X 1

Ian Robertson X 1

Kingston Mills X 1

Richard Reilly X 3

Number of Patent Applications submitted 1 Richard Reilly

Number of Patents Granted 0

Activities ‘07 ‘08 ‘09 ‘10 ‘11 ‘12 ‘13

Number of Patent Applications submitted

10 8 6 1 1 5 1

Number of Patents Granted 2 0 0 0 0 1 0

Number of Invention Disclosures 3 4 6 3 0 4 7 Smart Arm Prof Richard Carson continue to work on technology to assist in rehabilitation from stroke, he was involved in developing the Smart ArmTM. A start-up company was formed in 2012 to commercialise this product.


Spinout Companies TCIN has generated 2 new spinouts in the last 12 months: (i) Trinity Brain Health Ltd is an educational services company formed by Dr Sabina Brennan arising out of work from her EU funded research, (ii) Transpharmation Ireland offers translational medicine services to Pharma and was developed by Prof Shane O’Mara and colleagues formerly from GSK. Innovation Education/Training In association with the Innovation Academy up to 20 PhD students registered in TCIN have been trained so far in Innovation and entrepreneurship. Innovation Academy Ambassador Niamh McGuinness – PhD Candidate, Neuroscience was appointed as an Innovation Academy Ambassador for 2013/14. “As a scientist who was very much committed to a logical and quite black-and-white way of thinking, the Innovation Academy taught me how to be creative (no mean feat!) and it changed the way I view my work.” Niamh’s research concerns the roles of microglia (which are the immune or defense cells of the central nervous system) and natural killer cells (immune cells in the periphery, i.e. everywhere else) in multiple sclerosis or MS.


Commercialisation Committee There were 2 meetings of the commercialisation committee in 2013 and a number of new activities have been started to drive innovative outputs. Innovation Notice Board We have set up an innovation notice board advertising innovation related events, new devices and products and awards for external (non-exchequer) funding. Science Coffee mornings We continue to run these events on Friday mornings to foster engagement with external groups and hospital based staff. It is planned to develop these further to enhance an interdisciplinary problem solving approach. Short courses/CPD We held 3 more CPD courses in 2013 on a variety of topics including Depression and Alzheimers disease. There have been modest benefits initially in TCIN’s income diversification and it reached a level of 9k+ euro net income in 2013. We plan that the course material will be integrated into a new certificate programme in the next few years. The benefit of these courses lie in informing medical professionals of recent research developments in the neuroscience space, fostering communication with a range of stakeholders in the health area generally and building a reputation for professional education. We will also seek feedback from attendees to reflect and address current issues in professional practice.


MEASURING RESEARCH OUTCOMES

Research, Innovation, Education & Outreach TCIN is committed to achieving maximum impact for the resources invested in us by all our stakeholders. We measure a broad suite of parameters aligned to the College strategic plan and as detailed in the TCIN strategic plan 2010-2016. a) Summary as per HEA Submission Template

Activities ‘00 ‘06 ‘07 ‘08 ‘09 ‘10 ‘11 ‘12 ‘13 Research Activities Number of Publications (*5yr Avg)

N/A 175 200 228 248 278 315 386 410

Number of Citations N/A 2229 1839 2234 2332 2661 2898 4279 5455 Number of Conference Presentations (est.)

43 60 52 38 43 37 33 23

Conferences Hosted 1 1 1 1 1 1 1 Number of PhDs graduated (*GSO)

15 14 11 17 8 12 13 8

Number of Patent Applications submitted

2 19 10 8 6 1 1 5 1

Number of Patent Registrations secured

0 0 2 0 0 0 0 1 0

Number of Invention Disclosures

1 3 4 6 3 0 4 7

b) Industry/Innovation Company Visits PI Spinouts New Activities

2013 6 2 4 2012 8 4 2011 7 2 2010 12 1 2009 13

c) Outreach Science Gallery Conferences

2013 1 1 2012 1 2 2011 1 2 2010 2 2 2009 2

d) Education Graduations/Year PhD MSc UG ExtraMural Short course

2013 6 17 20 38 5 2012 13 17 20 35 1 2011 12 17 20 30 0 2010 8 23 20 15 0 2009 17 20 20 20 0


TCIN Publications Analysis As a relatively new interdisciplinary subject, there are no readily available datasets that can capture both benchmarking and accurate publication counts for Neuroscience together so we measure (i) benchmark publication data from ISI Thompson and (ii) publication counts generated from the PubMed database. Furthermore some journals are not classified in the Neuroscience category but may often contain important Neuroscience publications. This is particularly true for older publications & their citations.

Publications Benchmarking Analysis, as indexed by (i) ISI Thompson The ISI data below is a limited subset of the total publication s of TCIN but represent a repeatable measure across institutions and over time. INSTITUTION RANKINGS IN NEUROSCIENCE & BEHAVIOR

Rank 2013

Rank 2012 Institution Papers Citations Citations Per Paper

18 18 CALTECH 729 32,010 44 21 13 MIT 1439 61691 43 32 29 STANFORD UNIV 3039 119,774 39 62 48 UNIV CAMBRIDGE 2576 87,256 34 83 69 UCL 6671 210,830 32 115 178 UNIV COLL DUBLIN 269 7,845 29 203 221 TRINITY COLL DUBLIN 621 15,182 24 214 205 UNIV EDINBURGH 1251 29,833 24 259 237 KAROLINSKA INST 2988 66,453 22 280 286 UNIV MUNICH 2320 50,016 22 289 250 UNIV BRISTOL 1120 23,806 21 293 247 UNIV LONDON 552 11,657 21 Trinity College's ranking in Neuroscience & Behaviour improved from 221 to 203 out of 450.

TCIN Publications & Citation Data

5-year Intervals: 2005-2009 2006-2010 2007-2011 2008-2012 2009-2013

# of Papers 248 278 315 386 410

Times Cited 2,332 2,661 2,898 4,279 5,455 Citations per Paper 9.4 9.57 9.2 11.08 13.29


TCIN Publication & Citation data from (i) are shown below in graphic form-

TCIN Publications Analysis 2011-2013, as indexed by (ii) PubMed. TCIN publishes in over 200 international journals in the broad field of Neuroscience and Behaviour. We have over 600 publications in the last 3 years (2011-2013) with an average impact factor of 6.6; breaking this down further we find that over 10% of our publications have an impact factor greater than 10 and over 25% have an impact factor greater than 7. The following Tables show TCINs publication breakdown by Impact factor and by Frequency.

0 50

100 150 200 250 300 350 400 450 TCIN papers in 5yr intervals

Series1

0 1000 2000 3000 4000 5000 6000 TCIN citations in 5yr intervals

Series2

0 2 4 6 8

10 12 14 TCIN citations/paper in 5yr intervals

Series3


TCIN’s Journal Publication Ranking by Impact Factor (Impact Factor from JCR dataset)

Abbr J Title No of Pubs in last 3 yrs

5 year Impact

Cum Sum Pubs

Cumulative % of Pubs

NEW ENGL J MED 1 50.807 1 0.20 NATURE 1 38.159 2 0.40 LANCET 4 36.427 6 1.21 NAT GENET 9 34.52 15 3.04 CELL 1 34.366 16 3.24 JAMA-J AM MED ASSOC 1 29.273 17 3.44 NAT MED 2 26.441 19 3.85 NAT IMMUNOL 1 25.005 20 4.05 LANCET NEUROL 3 22.959 23 4.66 J CLIN ONCOL 1 17.255 24 4.86 TRENDS COGN SCI 1 16.845 25 5.06 NAT NEUROSCI 4 16.412 29 5.87 NEURON 6 16.403 35 7.09 NAT CHEM BIOL 1 15.6 36 7.29 AM J PSYCHIAT 4 14.396 40 8.10 J EXP MED 1 14.102 41 8.30 DEV CELL 1 14.091 42 8.50 NAT REV NEUROL 2 13.994 44 8.91 ANN NEUROL 1 11.047 45 9.11 BRAIN 2 10.87 47 9.51 P NATL ACAD SCI USA 4 10.583 51 10.32 PROG NEUROBIOL 2 10.322 53 10.73 TRENDS PHARMACOL SCI 1 10.158 54 10.93 NAT COMMUN 3 10.02 57 11.54 BIOL PSYCHIAT 9 9.773 66 13.36 TRENDS IMMUNOL 1 9.715 67 13.56 EMBO MOL MED 1 9.39 68 13.77 TRENDS GENET 2 9.325 70 14.17 SCHIZOPHRENIA BULL 3 8.934 73 14.78 PHARMACOL THERAPEUT 1 8.736 74 14.98 CANCER RES 1 8.576 75 15.18 NEUROLOGY 4 8.397 79 15.99 CURR OPIN GENET DEV 1 8.209 80 16.19 CURR OPIN NEUROBIOL 2 8.165 82 16.60 J NEUROSCI 23 7.869 105 21.26 HUM MOL GENET 2 7.541 107 21.66 CEREB CORTEX 7 7.463 114 23.08 PHILOS T R SOC B 2 7.298 116 23.48 AM J CLIN NUTR 1 7.196 117 23.68 J AM ACAD CHILD PSY 1 7.148 118 23.89 BRIT J PSYCHIAT 2 7.112 120 24.29 NEUROIMAGE 5 7.063 125 25.30 HUM BRAIN MAPP 4 7.032 129 26.11

A detailed list of our publications is available on our website at the following URL: http://www.tcd.ie/Neuroscience/about


http://www.tcd.ie/Neuroscience/about

TCIN’s Journal Publication Ranking by Frequency

Rank Abbr J Title No of Pubs in last 3 yrs

1 PLOS ONE 24 2 J NEUROSCI 23 3 NEUROBIOL AGING 18 4 AGE AGEING 10 5 AM J MED GENET B 10 6 NAT GENET 9 7 BIOL PSYCHIAT 9 8 J AM GERIATR SOC 9 9 INT J GERIATR PSYCH 9 10 BRAIN BEHAV IMMUN 8 11 J NEUROL NEUROSUR PS 8 12 FRONT HUM NEUROSCI 8 13 CEREB CORTEX 7 14 EUR J HUM GENET 7 15 J AFFECT DISORDERS 7 16 AGING MENT HEALTH 7 17 NEURON 6 18 HIPPOCAMPUS 6 19 NEUROIMAGE 5 20 NEUROPSYCHOLOGIA 5 21 WORLD J BIOL PSYCHIA 5 22 EXP BRAIN RES 5 23 ADV EXP MED BIOL 5 24 LANCET 4 25 NAT NEUROSCI 4 26 AM J PSYCHIAT 4 27 P NATL ACAD SCI USA 4 28 NEUROLOGY 4 29 HUM BRAIN MAPP 4 30 J NEUROINFLAMM 4 31 J ALZHEIMERS DIS 4 32 NEUROPHARMACOLOGY 4 33 PSYCHOPHYSIOLOGY 4 34 EUR J NEUROSCI 4 35 BMC PSYCHIATRY 4 36 PSYCHIAT RES 4 37 LANCET NEUROL 3 38 NAT COMMUN 3 39 SCHIZOPHRENIA BULL 3 40 J MED CHEM 3


PERSONNEL IN TCIN 2013 (APPENDIX 1) Current Principal Investigators, Postdoctoral Fellows, Postgraduate Students Principal Investigator Affiliation Postdoctoral Fellows PhD Students & RAs

Dr Arun Bokde School of Medicine Elizabeth Kehoe Ciara Molloy (Psychiatry) Dearbhile Farrell Sinead Nugent

Prof. Ruth Byrne School of Psychology Mary Parkinson Prof. Veronica Campbell School of Medicine

(Physiology) Stephen Fagan

Michael McDonald Dr. Colm Cunningham School of Biochemistry Eadaoin Griffin Carol Murray

Edel Hennessy Conor O'Boyle Niamh McGarry Michael Rooney

Dr. Gavin Davey School of Biochemistry and Immunology

Dr. Gary Donohoe School of Medicine

Dr. Jane Farrar Genetics Prof Thomas Frodl School of Medicine

(Psychiatry) Friedrich Wetterling Leonardo Tozzi

Hazel McCarthy

Prof Louise Gallagher School of Medicine (Psychiatry)

Jacqueline Fitzgerald Dimitris Bolis

Prof. Michael Gill School of Medicine (Psychiatry)

Dr. Andrew Harkin School of Pharmacy Allison McIntosh Eileen O'Toole Eimear O'Neill Eoin Sherwin Jusin Yssel Shane Gormley Jennifer David

Prof. Orla Hardiman School of Medicine Peter Bede Prof. Peter Humphries Genetics Dr. Aine Kelly School of Medicine Bibiana Mota

(Physiology) Ruth Hennessy Noreen Boyle (temp) Katherine O'Farrell

Dr. Julie Kelly/ Dr. Jane Farrar Dr. Christian Kerskens School of Medicine David Lopez Prof. Rose Anne Kenny School of Medicine

(Gerontology) Dr. Ali Sheikhi Ms. Lorna Greene Dr. Orna Donoghue Ms. Laura Dunne Dr. Joanne Feeney Ms. Margaret Foley Dr. Siobhan Leahy Ms. Sanna Nivakoski Dr. Hilary Cronin Ms. Deirdre Robertson


Principal Investigator Affiliation Postdoctoral Fellows PhD Students & RAs Dr. Anne Nolan Dr. Claire O’Regan Dr. Cara Dooley

Prof. Brian Lawlor School of Medicine (Psychiatry)

Maria Pertl David Loughrey Jennifer Rogers (RA)

Prof. Marina Lynch School of Medicine Aedin Minogue Hannah Wolfe (Physiology) Claire McDonald Robert Holland Raasay Jones Colin Dempsey Derek Costello Roisin McManus Niamh McGuinness Kate Flanagan Aidan Falvey (UG)

Prof. Kingston Mills/ School of Biochemistry and Immunology

N. McGuinness Prof. Marina Lynch Prof. Kingston Mills School of Biochemistry

and Immunology

Dr. Kevin Mitchell Genetics Prof. Declan McLoughlin School of Medicine Karen Ryan Dr Thekiso Thekiso

(Psychiatry) Victoria Dalton Dr Martha Finnegan Conor Mythen

Dr. Fiona Newell School of Psychology David Mc Govern Maeve Barrett Eugenie Roudaia Corrina Maguinness Hanni Kiiski Brendan Cullen Niamh Merriman John Stapleton Sarah Louise Clavin (UG) Natalia Duda (UG) Alicia Rybicki (RA)

Redmond O’Connell School of Psychology Siobhan Harty Aoife Hayes Deirdre Twomey Ger Loughnane Daniel Newman

Prof Desmond O’Neill School of Medicine

(Gerontology) Mairead Bartley

Hilary Moss Tadhg Stapleton

Prof. Shane O’Mara School of Psychology Jennifer Rouine Paul Wynne Charlotte Callaghan Nurul Islam (RA) Pawel Matulewicz Rosalind Hussey Jack Prenderville


Principal Investigator Affiliation Postdoctoral Fellows PhD Students & RAs Prof. Mani Ramaswami Genetics Adrian Dervan John Lee

Joern Huelsmeier Eimear Holohan Jens Hillebrand Isabell Twick Sahar Osman

Prof. Richard Reilly

School of Medicine (Gerontology) and School of Engineering

Dr Myles McLoughlin Dr Shona D’Arcy Dr Sonja Hermann Dr John Butler

Conor Fearon Hanni Kiiski Hugh Nolan Isabelle Killane Viliam Rapcan Alejandro Lopez Martin Holmes Terrence Taylor Brendan Quinlivan Niamh McDevittt

Prof. Ian Robertson School of Psychology Mahnaz Arvaneh Caoimhe Hannigan Grainne Fleming Eric Lacey Deirdre Twomey Ann Marie Connely Aoife Hayes Siobhan Harty (RA)

Prof. Michael Rowan School of Medicine (Pharmacology & Therapeutics)

Igor Klyubin Neng Wei Hu Tomas Ondrejcak

Dr. Daniel Ulrich School of Medicine (Physiology)

Sabina Brennan School of Psychology Joanna McHugh Chloe Teevan Niamh Aspell (RA) Michelle Loftus (RA) Olga Lee (RA) Alan Galvin (RA) Iseult Cremin (RA) Emma McCormak (RA) Cathy Newell (part time) (RA) John Weir (Intern)

Marian Tsanov Omar Mamad Conor McDonald Paul Dockree Meadhbh Brosnan

Lisa Fitzgearld Adrien Martel (RA)

Veronica O’Keane Chloe Farrell Chiatrz Gaiaj Kelly Doolin

Richard Carson School of Psychology Emmet McNickle

Connail McCrory School of Medicine Hari Gopal


trinity college institute of neuroscience

Documents