tpe sms
TRANSCRIPT
THERAPEUTIC PLASMA
EXCHANGE: BOON FOR
NEUROLOGICAL
DISORDER
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Apheresis – Donor Or Therapeutic
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Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• Therapeutic plasma exchange (TPE) is a procedure that reduces circulating autoantibodies in patients. TPE is commonly done in neurological disorders where autoimmunity plays major role.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
5
Fundamental Assumption of Therapeutic
Plasma Exchange
Reduce a pathologic substance, antigen: antibody alteration; decrease in
antibody titre; clearance of immune complexes , supply an essential
substance.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Apheresis – Centrifuge (C>>>>M)
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The Technology
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
ASFA categories for TPECategory Description
I Disorders for which apheresis is accepted as first-line
therapy, either as a primary standalone treatment or in
conjunction with other modes of treatment.
II Disorders for which apheresis is accepted as second-
line therapy, either as a standalone treatment or in
conjunction with other modes of treatment.
III Optimum role of apheresis therapy is not established.
Decision making should be individualized.
IV Disorders in which published evidence demonstrates or
suggests apheresis to be ineffective or harmful. IRB
approval is desirable if apheresis treatment is undertaken
in these circumstances.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Indications• Neurological disorders
– Acute inflammatory demyelinating polyneuropathy/ Guillain–Barre syndrome
– Myasthenia gravis
– Chronic inflammatory demyelinating polyneuropathy
– Multiple sclerosis
– Neuromyelitis optica
– Acute transverse myelitis
– Acute disseminated encephalomyelitis
• Hematological disorders
– Symptomatic leukocytosis
– Symptomatic thrombocytosis
– Atypical hemolytic uremic syndrome
– Thrombotic thrombocytopenic purpura
– AIHA
• Renal disorders
– ANCA-associated rapidly progressive glomerulonephritis
– Good Pasture’s syndrome
– Post renal transplant rejection (AMR)
– Rapidly progressive glomerulo-nephritis
• Rheumatic disorders
– Systemic lupus erythematosus
• Others
– Wilson’s disease
– ABO incompatible solid organ transplants
– Graft Versus Host disease (GVHD)
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Cell Separator
Continuous Vs Intermittent
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Vascular Access
• -Peripheral :Anticubital vein using one or two large bore needles (16-18
gauge).
• -Central Venous Access : Catheterize the patient with 12/11.5 no. French dialysis catheter in Internal Jugular, Subclavian, femoral vein
• 60 and 150 mL/minute
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Dosage
• Estimated plasma volume(in liters)-0.07 x wt (kg) x(1-Hct)
• 40ml/kg
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Replacement Fluids• 0.9% normal saline
• 5% Human albumin (albumin /saline 70%/30%)
• FFP (Group compatible, cross matched)
• The primary function of the replacement fluid is to maintain intravascular volume
- Restoration of important plasma protein
- Maintenance of colloid osmotic pressure
- Maintenance of electrolyte balance
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• We report our experience with regard to indications, adverse events and outcomes of plasma exchange in neurological disorders
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Material &
Methods
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• 78 procedure were done in ICU settings with HAEMONETICS MCS+ cell separator
• This retrospective study over a period of 1 year from 1st June 2016 to 31st May 2017.
• Detailed Analysis of all the procedures was done by Department of Immunohaematology & Transfusion Medicine,SMS Hospital Jaipur
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Age Analysis
• Median age-38 years
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
0
5
10
15
20
25
30
35
18-27 28-37 38-47 48-57 58-67
Gender Analysis
• Male : Female
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
0 20 40 60
Male
Female
59
19
Neurological indications
1. Guillain-Barrè syndrome (n = 42)
2. Myasthenia gravis (n = 24)
3. Chronic inflammatory demyelinatingpolyneuropathy (n = 5)
4. Neuromyelitis optica (n = 4)
5. Multifocal motor neuropathy (n = 1)
6. Multiple sclerosis (n = 1)
7. Transverse myelitis (n = 1)
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Neurological Indications
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
0
5
10
15
20
25
30
35
40
45
GBS MG CIDP NMO MMN MS TM
Line Of access
• Central venous access-97 %
• Peripheral venous access-3 %
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Central Venous
Peripheral
Replacement Fluid
• Human albumin was used as replacement fluid in 63 %, fresh frozen plasma & normal saline in 100% cases.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
0%
20%
40%
60%
80%
100%
Normal SalineFresh Frozen
Plasma Human albumin
Percentage
• Adverse event were recorded in 11 % of the procedures
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Advere Event
Uneventful
Adverse event
Adverse Events
• These were mild and manageable such as allergic reactions, hypotension and hypocalcaemia
Hypocalcemia
Allergic reaction
Hypotension6
2 1
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
Hypocalcemia
Diagnosis SessionsGBS 3
NMO 2
NMO 1
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• The major indication for the procedure was GBS.
• In GBS, the recommended treatment options are TPE or Intravenous immunoglobulin (IVIG) and both have been found to be equally effective and significantly better than the conservative treatment for recovery from the disability.[1,2,3]
• But in IVIG resistant cases TPE in GBS has shown better outcomes.
1. Hartung HP, Willison HJ, Keiseier BC. Acute immunoinflammatory neuropathy: Update on Guillain-Barresyndrome. Curr Opin Neurol. 2002;15:571–7.
2. van der Meche FG, Schmitz PI. A randomised trial comparing intravenous immunoglobulin and plasma exchange in Guillain-Barre Syndrome. Dutch Guillain Barre Study Group. N Engl J Med. 1992;326:1123–9
3. Randomised Trial of Plasma exchange, Intravenous Immunoglobulin and Combined treatments in GuillainBarre Syndrome. Plasma exchange/Sandoglobulin Guillain-Barre Syndrome Trial Group. Lancet. 1997;349:225–30.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• Because of the ease of administration and less chance of complications, IVIG is preferred by most physicians.
• According to the report of the therapeutics and technology assessment subcommittee of the American Academy of Neurology on plasmapheresis in 2011, it was found that TPE is extremely safe in experienced hands.[4]
4. Cortese I, Chaudhry V, So YT, Cantor F, Cornblath DR, Rae-Grant A. Evidence-based guideline update: Plasmapheresis in neurologic disorders: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2011;76:294–300.]
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• Major age group 37-48 with more of male patients.
• Majority of patients were adults and middle aged persons.
• We did not employ TPE in patients in the pediatric age group. The procedures are often performed using evidence or experience extrapolated from adult clinical practice, which may not be evidence based. In addition to the clinical challenges, relevant psychological issues technical hardware are often necessary for safe and effective treatment in children.[5]
5.Wong EC, Balogun RA. Therapeutic apheresis in pediatrics: Technique adjustments, indications and nonindications, a plasma exchange focus. J Clin Apher. 2012;27:132–7.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• Although complication can occur, most of these are rapidly recognized and reversed, and are rarely serious
.• Hypotension, allergic reactions, nausea-vomiting,
paresthesia and arrhythmias are the most common complications of TPE which may be seen in 3-20% of the procedures. These events are usually mild and resolves without treatment.[6]
• Because of problems related to vascular access, 4-5% of PE may have to be terminated.[6]
6. Basic-Jukic N, Brunetta B, Kes P. Plasma exchange in elderly patients. TherApher Dial. 2010;14:161–5.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• We used FFP as the replacement fluid which has been associated with higher incidence of hypotension and other adverse events.
• The French Cooperative Group on plasma exchange in GBS has recommended albumin in place of FFP, as replacement fluid,[7] but we preferred FFP over albumin owing to the higher cost of the latter.
7. Korach JM, Berger P, Giraud C, Le Perff-Desman C, Chillet P. Role of replacement fluids in the immediate complications of plasma exchange. French Registry Cooperative Group. Intensive Care Med. 1998;24:452–8.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• Neurological disorders constitute the leading indication for TPE, followed by hematological, renal and rheumatologic disorders.
• The complication and mortality rates do not vary significantly among different clinical indications.
• The overall mortality rate in TPE, neurological and non-neurological indications combined together, is estimated to be 1-3 per 10,000 procedures.[8]
8. Ward DM. Conventional apheresis therapies: A review. J Clin Apher. 2011;26:230–
8.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• TPE is an effective treatment in neurologic diseases with minimum adverse reaction.
• TPE is not only a safe and effective treatment but also cost effective alternative to IVIG, for various immune mediated neurological disorders
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR
• Always should be done in ICU setting in presence of Transfusion medicine consultant.
• Centrifuge Cell Separator should always be preferred rather than membrane filtration as it is superior in every aspect of quality as well as yield.
Department of Immunohaematology & Transfusion Medicine
BLOOD BANK,SMS HOSPITAL, JAIPUR