single allelic disparity caused observ-able differences in the sibling data;quantitative disparity increased whentwo allelic differences were comparedwith one. Kinetic measurements indi-cated a minimal "responding unit" of1 per 300 cells, a "dividing unit" of Iper 200 cells, and a cell generationtime of 18 hours. Reasons for highfrequency of 'responding units" in cel-lular immune reactions and the mech-anism for recognition were discussed.

The second speaker, Eli Sercarz(University of California, Los Angeles)elaborated on in vitro experiments thatwere directed toward substantiating hispreviously formulated X-Y-Z sch me ofmaturation of immunocompetUnt cells.Briefly, this schemiie involves an X cellor antigen-sensitive lymphocytic cellwhich, upon cantigen stimulation, isconverted to a Y or "memory" c211;the latter, triggered by antigen, dividesaind matuLres irreversibly to a Z orterminial cell that is a mature, antibody-producing plasma cell. Using a con-stant in vivo dose of 10 mg of bovineserum albumin per rabbit and exposingspleen tissue in vitro to varying levelsof antigen, different levels of unresponi-siveness wvere obtained. While the data

established the existence of a reversiblestate of in vitro paralysis, the cell stageat which paralysis occurs remains un-known. The time for establishment ofmemory in the primary response was

less than 1 day. During this time, nocell division was required, but duringthe first day of the secondary responseprogenitor cells divided. It was con-cluded that it may be possible to stuLdydirectly the antigen-binding activity ofmemory cells by sensitive techniquesof micromanipulation, specific enzyme-binding antibody, and tluorimetry.

Robert Good (University of Minne-sota, Minneapolis) chaired the sessionotn "Cell l'opulation Qualities and Ki-netics in the Immune Response." Ed-ward Boyse (Sloan-Kettering Institutefor Cancer Research) spoke on "Anti-genic Differentiation of LymphoidCells" and primarily about his owninvestigations. This work deals withnormally occurring surface antigens,involving genAtic differences amongcells of the same type (for example,thymocytes) from different individuals,or phenotypic differences among thecells of a single individual. Whereasthe genetic differences are of practicalsignificance in homotransplantation, the

phenotypic differences are of specialinterest because they are presumablyrelevant to the organization of inter-dependent cell populations within anindividual. Six antigen systems havebeen defined for mouse thymocytes,using cytotoxic antisera in an in vitrotest. The cell surfaces have b-en miappedon the principle that when antibodyis absorbed by one of two cell antigensof different specificity, both situLated inclose proximity on the cell surface,the subsequenit absorption of antibodyby the other antigen is impeded. Allthe antigens stuLdi-d OCCUIr on boththymocytes and lymphocytes with theexception of one set, TL, that is pros-ent only on thymocytes. Normally theantigens are stroniger on thymocytesthan on lymphocytes except H-2 whichhaIs four times as muLch on lymphocytesas on thymocytes. The genes for H-2and Tl are linked: the others are inde-pendent in inheritance. The TL genes(Tlti) are unexpressed in TL- mice,but may be activated during leukzmo-genesis. Leukemia cells taken fromimmunized animals do not express TLantigkn but the cells regain the antigenupon passage in nonimmuLnized syn-geneic hosts, a phenomenon termed

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lti'eeniC oilulationl. 1 h1 features ofantigcllic modulation wxere amplified.It iS ~iSSLimlled, but niot established, thatthe cluster patter-1n of the antigens iS' abasic r epetitix CeIuit onl the ccll ImlemlI-brane1z.

-lakashi Nlakinodan (Oak Ridee Na-tionarl Laboraitories)ISpoke about ''Ki-netics Of CCll Populations" an1d dIC-scribcd various iodels of cell imltli-plicatioll thalt m1ight atccounlt for theexploncntial inlCreaseliS inl nuime sO fantibod -for ming cclls. The expeil-

mental systcm of this ins est igator inl-Vo VCS Spl)eenC1 tiSSuIe from m1ice Stimu-111lated wxith sheep iect blood cells. Al-thOLugh thec rItC Of cell inicrealse isatulClyllN dCepCendiCeIt ti)on llantiedtCo1 SC

a1111d falCtOrIS SuIChl tS CCel lligr aItiol.dleath. and possibly dlediflercntiation. themiiodels wsere simple and dlidl not inl-volve the latter plarameters. I hIeimodelsdifle'rlCe NxithI IrCeSipCCt to nuIlmlber ofc-CCI LtitmllClltS ( SinleC or multiple)mI n-nler of recruitmiienlt (ranldom 01o 1non-rmndom )- and proliferatix e capacity ofthle ICci tlitCCd cCllS ( 11o di ision: sxn-cliroIoLtis or- assrnchl01onLIS diision1t).1 he atallt fr-omii Per-kinis and otht}er col-kaborators at Oak Ridr-e xxcrc miostc]olmp,aIt-)Ib xith the miodel characte-liZCCIaS ic0trandcrir, IrlLtiptl.lIrICruit-mIcnlt, -rI-olitfI;ctinig SVlnhronlousIvl. Rze-CI uitmicnlt of cells capable of dixidingw ould caral;Ictcri/e 1a hihly ctfficienltdiffer nCll ttion pr ocess in xw hich onula liit.zed iurinber of pr orammilled cellsnced be)C storedl It ans onle tille.

The conclirdirie sessionl on1 "Reeulla-tdion of thC IImmun1liie Response" waschaJircd bv IEdwin L cinox (Saldk In-Istitute, San Diego I. C(oinlestigaltorsDonald Rolevx and Fr nk Fitclh (Ui-\eCrsitv oft Chicaigo) spiokc oni "Fccl-hack Rcla ionl."'Mtode.l s histemcshere-ctr-dlation llhls Ib)Cee achiex ed \xrc pre-seitCdc aInd falctors irixnolvcl x crc dis-cussed1 fr-olim the findillns. Onie modelmIakel.ws LusC Of -enal aIllogrf(-A'ts ill rats.rid x\ as studied for- the etl'ect of atdl-

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inhibition of response had been pri-marily in the delayed hypersensitivitysystem. When the established kidneywas removed, without further treatmentof the host, a successful second renalallograft could be achieved. Thus, itappeared that treatment with antigenand antibody had modified host ratherthan effecting a change in graft. Froma second in vivo model involvingSprague-Dawley rats sensitized withsheep red blood cells and Freund'sadjuvant specific antibody reduced thedelayed hypersensitivity response whenantigen was given 9 days later. It waspostulated that delayed hypersensitivityinvolves two interactions between cellsof limited number and that one ofthese (non-macrophage) had been sup-pressed by antibody. It had been shownpreviously by an in vitro model (plaqueassay) that Sprague-Dawley rats,treated with specific antibody prior tosensitization with 108 sheep red bloodcells, had a greatly reduced numberof plaques in the spleen. The numberrepresented a negligible response com-pared to well characterized responsesto sheep red blood cells over a widedosage range. It was suggested that,because of the importance of givingantibody before antigen, antibody actsby combining with antigen (at the levelof specific antigenic determinants) andits effect is independent of adjuvanteffect. Cell interaction appears to beimportant in both in vivo and in vitroreactions, as evidenced by the fact thatthe "rocking" of dispersed cells in cul-tures produced an increased numberof plaques. The mechanism for feed-back regulation by antibody was sug-gested as prevention of cell interactionthrough combination with antigen.

Eugene Lance (Cornell University)gave the concluding speech on "Im-munosuppression." Nonspecific immu-nosuppressive agents (those whose ac-tion is not unique to the immunesystem or to particular antibody re-sponses) include x-irradiation, radio-mimetric drugs, steroids, and antimet-abolites (all acting on processes of celldivision, cell viability, and componentsof the DNA-RNA-protein sequence).Some uncertain miscellaneous phenom-ena such as hypnotism, reticuloendo-thelial blockade and treatment of graftswith RNA were also noted. Specificsuppression by antigen and by anti-lymphocyte serum (ALS) were takenup in some detail. ALS, serum obtainedby injecting lymphocytes of one animalinto another species (or the antibodyfraction eluted after absorption of such11 JULY 1969

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serum to lymphocytes), alters immunereactions profoundly. Some points indescribing the scope of the effect ofALS on humoral response were: im-portance of giving ALS before antigen(optimal effect when given intravenous-ly 3 days before antigen), effectivenesson primary response which is sup-pressed but not abolished, and non-effectiveness against the secondary re-sponse. In order to prolong skin graftsurvival indefinitely, ALS must begiven continuously. The seruLm causedno change in the thymus but producedselective damage in the paracorticalarea of thymus-dependent lymphoidtissue (spleen and bone marrow). Thefate of labeled ALS-eluted antibodywas studied. Because of rapid bloodclearance it was assuLmed to exert arapid effect. Radioautography of vari-ous tissues indicated only a small per-centage uptake into lymphoid tissues.Because of large uptake in liver, amodel was presented that indicated in-teraction of recirculating lymphocyteswith circulating ALS and clearance ofthese cells by the liver. Lance expressedconcern about the tendency of immuno-suppressive drugs and ALS to increasethe background of neoplastic cells thatmight give rise to lymphomas. How-ever, he was optimistic about derivingexperimental models using skin graftsand limited amounts of ALS plus otherimmunosuppressive agents that wouldlead to avoiding untoward clinical reac-tions to grafts.The conference was supported in part

by Ames Laboratories, Elkhart, Indiana;the Office of Naval Research, Biochem-istry Branch, Washington, D.C.; andHyland Laboratories, Los Angeles,California. This is contribution No.3828.

Division ofEngineering,Techlnlology,

JUSTINE S. GARVEYChemiiistry and ChlemizicalCalifornia Instititte ofPasadena 91109

National Meetings

August

3-6. National Heat Transfer Conf.,I1th, Minneapolis. Minn. (D. C. Kelly.American Inst. of Chemical Engineers,345 E. 47 St., New York 10017)

3-7. Society for Cryobiology, 6th an-nual, BuLffalo, N.Y. (R. E. Greco, 3175Staley Rd., Grand Island. N.Y. 14072)

4-5. Aerospace Structures Design Conf.,Sealttle, Wash. (J. R. Fuller, Boeing Co.,P.O. Box 707, Orgn. 6-8650, M/S 77-89,Renton, Wash. 98055)

4-5. American Soc. of Safety Engineers,College Park, Md. (W. C. Christensen,11 JULY 1969 Circl

ASSE, 850 Busse Highway, Park Ridge,Ill. 60068)

4-6. Deterioration and Preservation ofLibrary Materials, 34th annual conf.,Chicago, Ill. (H. W. Winger, GraduateLibrary School, Univ. of Chicago, 1116E. 59 St., Chicago 60637)

4-8. Molecular Biology and Pathology,2nd conf., Saratoga Springs, N.Y. (K. T.Lee, Dept. of Pathology, Albany MedicalCollege, Albany, N.Y. 12208)

5-8. World Conf. on Records, Salt LakeCity, Utah. (S. E. Beesley, 1030 S. Or-chalrd Dr., Bountiful, Utah 84010)

6-8. Applications of X-Ray AnalysisConf., Denver, Colo. (B. L. Henke, Div.of Metallurgy, Denver Research Inst.,Denver 802 10)

10-13. Soil Conservation Soc. of Amer-ica. Fort Collins, Colo. (H. W. Pritichard,7515 NE Ankeny Rd., Ankeny, Iowa50021)

11-13. Symposium on Crystal Growth,Washington, D.C. (H. S. Peiser, RoomB316, Bldg. 223, National Bureau of Stan-dards, Washington, D.C. 20234)

11-14. Society of Photo-Optical Instru-mentation Engineers, 14th annual tech-nical symp., San Francisco, Calif. (H. L.Kasnitz, SPIE Symposium. P.O. Box 288,Redondo Beach, Calif. 90277)

12. American Astronomical Soc., Al-bany, N.Y. (G C. McVittie, Univ. ofIllinois Observatory, Urbana 61801)

13-24. Frontier Topics in Crystallog-raphy, Stony Brook, L.I., N.Y. (E. H.Kone, American Inst. of Physics, 335 E.45 St., New York 10017)

17-22. Animal Behavior Soc., Burling-ton, Vt. (B. Dane, Tufts Univ., Medford,Mass.)

17-22. American Inst. of BiologicalScience, Burlington, Vt. (J. R. Olive, 3900Wisconsin Ave., NW, Washington, D.C.20016)

17-22. American Soc. of Zoologists,Burlington, Vt. (J. R. Shaver, Dept. ofZoology, Michigan State Univ., East Lans-ing 48823)

18-20. Genetics Soc. of America, Mad-ison, Wis. (B. Wallace, Dept. of Genetics,Cornell Univ., Ithaca, N.Y. 14850)

18-21. American Hospital Assoc., Chi-cago, Ill. (E. L. Crosby, 840 N. LakeShore Dr., Chicago 60611)

18-22. New England Assoc. of Chem-istry Teachers, 31st summer conf., Plym-outh, N.H. (M. P. Olmsted, PublicityChairman, NEACT, 9 Brookmont Dr.,Wilbraham, Mass. 01095)

18-22. American Soc. of Pharmacog-nosy, 10th annual, Corvallis, Ore., withMarine Biomed cinals Symp. (P. Catal-fomo, School of Pharmacy, Oregon StateUniv., Corvallis 97331)

18-22. American PhytopathologicalSoc., Spokane, Wash. (J. P. Fulton, Dept.of Plant Pathology, Univ. of Arkansas,Fayetteville 72701 )

18-22. National Goals in Water Pollu-tion Control, Santa Barbara, Calif. (F. A.Butrico, Coordinator of EnvironmentalSciences Programs, Battelle MemorialInst., Columbus Laboratories, Washing-ton, D.C.)

19. Biometric Soc., western NorthAmerican regional, Pullman, Wash. (J. S.Williams, Statistical Lab., Colorado StateUniv., For-t Collins)

19-21. Birch Symp., Durham, N.H.le No. 86 on Readers' Service Card on page 11OA

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(R. R. Weyrick, Dept. of Forest Re-sources, Univ. of New Hampshire, Dur-ham 03824)

19-22. Biometric Soc., eastern NorthAmerican regional, New York, N.Y. (D.G. Gosslee, P.O. Box 713, Oak Ridge,Tenn. 37830)

19-22. American Assoc. of ClinicalChemists, 21st natl. mtg., Denver, Colo.(J. Preston, P.O. Box 18323, Capitol HillStation, Denver 80218)

19-22. Western Electronic Show andConvention, San Francisco, Calif. (D. W.Martin, WESCON, 3600 Wilshire Blvd.,Los Angeles, Calif. 90005)

19-22. American Soc. for HorticulturalScience, 44th annual, Pullman, Wash. (C.Blackwell, The Society, 615 Elm St., St.Joseph, Mich. 49085)

19-22. Phytochemical Soc. of NorthAmerica, Banff, Alberta, Canada. (J. W.Watkin, Prairie Regional Lab., Saskatoon,Sask., Canada)

19-22. American Statistical Assoc.,129th, New York, N.Y. (D. C. Riley, TheAssociation, 810 18th St., NW, Washing-ton, D.C. 20006)

19-23. American Fern Soc., Seattle,Wash. (A. M. Evans, Dept. of Botany,Univ. of Tennessee, Knoxville 37916)

20-22. American Soc. of Civil Engi-neers, Hydraulics Conf., Logan, Utah.(ASCE Hydraulics Conf., % Utah WaterResearch I ab., Utah State Univ., Logan84321)

21-23. American Nature Study Soc.,PuLllman, Wash. (J. Geisler, MilewoodRd., Verbank, N.Y. 12585)

24-25. Programming Languages Defi-nition, San Francisco, Calif. (J. A. Paint-er, IBM Corp., Research Lab., Dept. 978,Bldg. 025, Monterey and Cottle Rds., SanJose, Calif. 95114)

24-27. Alaska Div., AAAS, College.(V. Fisher, Inst. of Social, Economic andGovernment Research, Univ. of Alaska,College 99701)

24-27. Defects in Electronic Materialsfor Devices, Boston, Mass. (D. P. Sera-phim, IBM Components Div., Bldg. 300,Hopewell Junction, N.Y. 12533)

24-27. Conference on Food-Drugs fromthe Sea, Kingston, R.I. (G. F. Greene,Jr., % Professional Services, Abbott Labs.,North Chicago, 111. 60064)

24-29. Gerontological Soc., Washing-ton, D.C. (E. Kaskowitz, The Society, 660S. Euclid St., St. Louis, Mo. 63110)

24-2. Botanical Soc. of America, Seat-tle, Wash. (R. C. Starr, Dept. of Botany,Indiana Univ.. Bloomington 47401)

25-27. Applied Mechanics WesternConf., Albuquerque, N.M. (A. B. Conlin,Jr., Technical Depts., 345 E. 47 St., NewYork 10017)

25-27. Mathematical Assoc. of Amer-ica, Eugene, Ore. (A. B. Willcox, TheAssociation, 1225 Connecticut Ave., NW,Washington, D.C. 20036)

25-28. Chromosphere-Corona Transi-tion. Boulder, Colo. (J. W. Evans, Sacra-mento Peak Observatory, Sunspot, N.M.88349)

25-29. American Physiological Soc.,Davis, Calif. (G. Hamilton, APS, 9650Rockville Pike, Bethesda, Md. 20014)

26-28. Engineering Applications ofElectronic Phenomena Conf., Ithaca,

SCIENCE, VOL. 165

N.Y. (H. J. Carlin, School of ElectricalEngineering, Cornell Univ., Ithaca 14850)

26-29. Electron Microscope Soc. ofAmerica, St. Paul, Minn. (G. G. Cocks,Olin Hall, Cornell Univ., Ithaca, N.Y.14850)

28-1. Society of Petroleum Engineers,Denver, Colo. (J. B. Alford, 6200 N.Central Expressway, Dallas, Tex. 75206)

31-4. American Psychological Assoc.,Washington, D.C. (K. Goodall, The So-ciety, 1200 17th St., NW, Washington,D.C. 20036)

31-4. Psychometric Soc., Washington,D.C. (W. B. Schrader, Educational Test-ing Service, Princeton, N.J. 08540)

31-6. Quantum Solids: Hydrogen andHelium, Aspen, Colo. (J. C. Raich, Colo-rado State Univ., Fort Collins 80521)

September

2-4. Comparative Virology, intern.conf., Montreal, Canada. (K. Maramo-rosch, Boyce Thompson Inst. for PlantResearch, Yonkers, N.Y. 10701)

2-6. Molecular Structure and Spectros-copy, 24th annual symp., Columbus,Ohio. (K. N. Rao, Physics Dept., OhioState Univ., Columbus 43210)

2-6. Tuberculosis, intern. conf., NewYork, N.Y. (J. E. Perkins, Natl. Tuber-culosis Assoc., 1790 Broadway, New York10019)3-5. Weather Forecasting and Analysis,

3rd, Virginia Beach, Va. (E. C. Kindle,Navy Weather Research Facility, Bldg.R 48, Naval Air Station, Norfolk, Va.23511)

3-6. Conference on Biogenic Aminesas Physiological Regulators, Woods Hole,Mass. (B. A. Curtis, Tufts Univ. Schoolof Medicine, 136 Harrison Ave., Boston,Mass. 02111)

3-6. American Political Science Assoc.,New York, N.Y. (E. M. Kirkpatrick,APSA, 1527 New Hampshire Ave., NW,Washington, D.C. 20036)

4-6. American Assoc. of Obstetriciansand Gynecologists, Hot Springs, Va. (R.B. Wilson, 200 First St., SW, Rochester,Minn. 55901)

4-6. Parapsychological Assoc., 12thintern. conv., New York, N.Y. (J. G.Pratt, Box 152, Univ. of Virginia MedicalSchool, Charlottesville 22901)

5-7. Society for the Study of Am-phibians and Reptiles, 12th annual, Car-bondale, Ill. (J. T. Collins, Museum ofNatural History, Univ. of Kansas, Law-rence 66044)

7-12. American Chemical Soc., 158thnatl., New York, N.Y. (Manager, Natl.Meeting and Divisional Activities, 115516th St., NW, Washington, D.C. 20036)

7-12. Experimental Medicine and Sur-gery in Primates, 2nd conf., New York,N.Y. (J. Moor-Jankowski, New York Univ.Medical Center, 550 First Ave., NewYork 100 16)

8-9. Symposium on Turbulence Mea-surements in Liquids, Rolla, Mo. (G. K.Patterson, Dept. of Chemical Engineering,Univ. of Missouri, Rolla 65401)

8-10. Agriculture Meteorology Conf.,9th, Seattle, Wash. (R. J. Hanks, Dept.of Soils and Meteorology, Utah StateUniv., Logan 84321)

8-10. Metallurgy and Materials Science,

11 JULY 1969

Pick the handiest spot to do your paper and thin-layer chromatograms.Put the CC-20 Chromato-Vue portable darkroom there; it takes up only10" x 14"; Specifically designed for TLC work, the CC-20 is perfect for8" square plates.

Naturally the CC-20 Chromato-Vue unit costs much less than acumbersome walk-in darkroom. The bonus is that it actually gives youbrighter UV contrast and better definition. Top-mounted pushbuttonslet you flick on short-wave, ultraviolet, or white light.

Here is the ideal instrument for analyzing steroids, porphyrins, lipids,vitamins, chlorinated hydrocarbons, many more. Excellent for scienceclasses too.The price: only $149.50. Write for descriptive literature, or see your

lab equipment dealer.

C-5 CHROMATO-VUE UNIT-theultimate for analyzing paper orTLC chromatograms. Provides fourtimes the power of ordinary UVlamps. Camera can be mounted oncabinet. Can accommodate largesheets, or two plates for com.parison.

TRANSILLUMINATORS amplify dimor marginal fluorescence into bril-liant, well-defined spots. Availablewith either long- or short-wavelamps. Can be used alone or witheither Chromato-Vue cabinet.

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intern. conf., Philadelphia, Pa. (G. R.Belton, School of Metallurgy and Ma-terials Sciences, Univ. of Pennsylvania,Philadelphia 19104)

8-10. Standards Engineers Soc., 18thannual, Washington, D.C. (J. M. Ward,11208 Long Pine Trail, Potomac, Md.20857)

8-11. Electrical Insulation Conf., 9th,Boston, Mass. (H. P. Walker, Code61 58D, Naval Ship Engineering Center,Washington, D.C. 20360)

8-12. Dietetics, 5th intern. congr.(American Dietetic Assoc., 52nd annual),Washington, D.C. (Public Relations, TheAssociation, 620 N. Michigan Ave., Chi-cago, Ill. 60611)

8-12. American Soc. of Limnologyand Oceanography, La Jolla, Calif. (G.H. Lauff, W. K. Kellogg Biological Sta-tion, Michigan State Univ., HickoryCorners, 49060).

8-13. High Energy Physics and NuclearStructure, intern. conf., New York, N.Y.(S. Devons, Dept. of Physics, ColumbiaUniv., New York 10027)

9-10. Society of Logistics Engineers,4th annual, Cape Canaveral, Fla. (G.Dill, Aerospace Services Div., Pan Amer-ican World Airways, Inc., Patrick AFB,Fla. 32925)

11-12. Symposium on Sulphur in Nu-trition, Corvallis, Ore. (J. E. Oldfield,Dept. of Animal Science, Oregon StateUniv., Corvallis 77331)

14-17. Association of Medical Illus-trators, Washington, D.C. (B. J. Melloni,AMI, Georgetown Univ., Washington,D.C. 20007)

14-20. College of American Pathol-ogists and American Soc. of ClinicalPathologists, joint annual mtg., Chicago,Ill. (O. Neibel, CAP, 230 N. MichiganAve., Chicago 60601)

15-17. Woodhandling, 2nd symp., Otta-wa, Ont., Canada. (Technical Section,Canadian Pulp and Paper Assoc., 2280Sun Life Bldg., Montreal 110, P.Q.)

17-19. American Science Film Assoc.,Washington, D.C. (B. J. Melloni, ASFA,Georgetown Univ., Washington, D.C.20007)

17-19. Blood and Tissue Antigens,intern. symp., Ann Arbor, Mich. (D.Aminoff, Simpson Memorial Inst., Univ.of Michigan, Ann Arbor 48104)

17-19. Industrial Research, 5th natl.conf., Chicago, Ill. (V. J. Danilov, In-dustrial Research Bldg., Beverly Shores,Ind. 46301)

18-20. Chemical Marketing ResearchAssoc., Lake Placid, N.Y. (P. E. Levesque,FMC Corp., 633 Third Ave., New York10017)

18-20. Symposium on Coniferous For-ests of the Northern Rocky Mountains,Missoula, Mont. (Center for Natural Re-sources, Univ. of Montana, Missoula59801)

21-24. American Assoc. of MedicalClinics, New York, N.Y. (E. M. Wurzel,Executive Director, The Association, 421King St., Alexandria, Va. 22314)

21-24. Petroleum Mechanical Engineer-ing Conf., Tulsa, Okla. (H. E. Broadbent,Atlantic Richfield Co., P.O. Box 8138,Philadelphia, Pa. 19101)

21-25. Comparative Leukemia Re-search, 4th intern. symp., Cherry Hill,N.J. (R. M. Dutcher, School of Veteri-

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Circle No. 76 on Readers' Service Card on page 1 IOA

nary Medicine, Univ. of Pennsylvania,New Bolton Center, Kennett Square19348)

22-24. National Conf. on PackagingWastes, San Francisco, Calif. (M. Li,Food Protection and Toxicology Center,Univ. of California. Davis 95616)

22-26. International Simulation andTraining Conf.. Montreal, Canada. (W.1. Marble. SAE Hq., Meetings Manager,2 Pennsylvani'a Plaza, New York 10001)

23-25. Physics and Nondestructive Test-ing, 9th annual, Chicago, Ill. (W. J. Mc-Gonnagle, Symp. Coordinator, P.O. Box554, Flmhuirst, Ill. 60126)

24-26. IEEE Ultrasonics Symp., St.Louis, MIo. (D. r. Bolef, Inst. of Electricaland Electronics Engineers, UltrasonicsSymp.. Dept. of Physics, WashingtonUniv., St. Louis 63130)

26-3. American Acad. of General Prac-tice, Philadelphia, Pa. (M. F. Cahal,The Ac,ademy. Volker Blvd. at Brookside,Kansas City. Mo. 64112)

28-1. Society of Petroleum Engineersof AIME, 44th annLual, Denver, Colo. (J.R. Dempsey. Northern Natural Gas Co.,P.O. Box 308. Omaha, Neb. 68102)

29-1. Internaitional Conf. on Bioelec-trical Impedance, New York, N.Y. (S. E.MLarovich. The Conference. 1150 NW 14thSt., NliaImi Fla. 33136)

29-3. Anmer-ican Soc. of Photogram-metry. Portland, Ore. (L. P. Jacobs, 105N. Virginia Ave., Falls Chur-ch, Va. 22046)

Foreign Meetings

September

1-4. International Soc. of GeographicalPathology Conf.. Jerusalem. Israel. (I. S.I ei;. Dept. of Pathology, Hebrew Univ.,Hadassah Medical School. P.O. Box 1172,JerLsallemn)

1-5. British Pharmaceuitical Conf., Bel-fast. Norther-n Ireland. (Secretary, TheConference. 17 Bloomsbtury Sq., London,W.C. 1, England)

1-5. International Soc. of Neurochem-istry, 2nd. Milan, Italy. (R. Paoletti. Sci-entific Secretalry, Inst. of Pharmacology,Univ. of Milan. via Andrea del Sarto 21,20129 Milan)

1-5. Phenomena in Ionized Gases,9th intein. conf., Bucharest, Rumania. (E.BadarenL, Inst. of Physics. Acad. of Sci-ence, BuLcharest, Rumania)

11-. Non-Linear Coiatiiauum Theoriesin Nlechaiaics and Physics and Their Ap-plications, Padua, Italy. (D. H. Rivlin,Scientific Director, Center of AppliedMathematics, Lehigh Univ., Bethlehem,Pa. 18015)

1 -2. International Assoc. of Geomag-lnetism and Aeronomy, Madrid, Spain.( P. A. Romatna, Observatoire del Ebro,Apdo 9, Tariatosa, Spain)

7119. Geophysical Fluid Dynamics,Bangor, N. Wales. (G. E. R. Deacon,Natl. Inst. of Oceanography, Wormley,Godalmning Surrey, United Kingdomu)

2-4. Hyperbaric Medicine, 4th intern.congr., Sapporo, Japan. (T. Iwa, Dept. ofThoracic and Cardiovascular Sturgery,Sapporo Medical College and Hospital,So. 1. West 16. Sapporo 060)

3- 1. International Assoc. of Statisticsin Physical Sciences, London, England.

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(J. Neyman, Dept. of Statistics, Univ. ofCalifornia, Berkeley 94720)

4-9. Ferroelectricity, 2nd intern. conf.,Tokyo, Japan. (H. Takahashi, Faculty ofScience, Univ. of Tokyo, 7 Hongo,Bunkyo-ku Tokyo, Japan)

5-10. International Clay Conf., Tokyo,Japan. (S. Iwao, Secretary General, Or-ganizing Committee, The Conference,Science Council of Japan, Ueno Park,Tokyo 110)

7-12. Conference on Atomic CollisionPhenomena in Solids, Brighton, England.(Meetings Office, Inst. of Physics and thePhysical Soc., 47 Belgrave Sq., London,S.W. 1, England)

7-12. Pharmaceutical Sciences, 29thintern. congr., London, England. (J. C.Bloomfield, Pharmaceutical Soc. of GreatBritain, 17 Bloomsbury Sq., London,W.C.1)

7-14. International Symp. on UnprovenMethods of Cancer Diagnosis and Treat-ment, Sao Paulo, Brazil. (A. C. C.Junqueira, % Hospital A.C. Camargo,P.O. Box 5217, Sao Paulo)

8-12. Congenital Malformations, 3rdintern. conf., The Hague, Netherlands.(Local Secretary, % Holland OrganizingCentre, 16, Lange Voorhout, The Hague)

8-12. Fiscal Assoc., 23rd intern. congr.,Rotterdam, Netherlands. (Local Secretary,Holland Organizing Centre, 16, LangeVoorhout, The Hague, Netherlands)

8-12. Symposium on In Vitro Proce-dures with Radioisotopes in Clinical Med-icine and Research, Vienna, Austria. (J.H. Kane, Div. of Technical Information,U.S. Atomic Energy Commission, Wash-ington, D.C. 20545)

8-12. International Symp. on Man-Machine Systems, Cambridge, England.(L. R. Young, Room 37-155, Massachu-setts Inst. of Technology, Cambridge02139)

8-12. International Assoc. of Seismol-ogy and Physics of the Earth's Interior,Madrid, Spain. (J. P. Rothe, GeneralSecretary, The Association, 38 Boulevardd'Anvers, 67 Strasbourg, France)

8-13. Electrosleep and Electroanaesthe-sia, 2nd intern. symp., Graz, Austria.(F. M. Wageneder, Secretary, ISEE,Chirurgisch Universitatsklinik Graz, 8036Graz)

9-12. International Symp. on Confor-mational Analysis, Brussels, Belgium. (R.C. Smekens, Executive Secretary, ISCA,49, Square Marie-Louise, Brussels 4)

11-12. Symposium on Earthquake Me-chanics, Madrid, Spain. (L. R. Alldredge,Inst. for Earth Science, ESSA, Boulder,Colo. 80302)

11-13. History of Science, intern.congr., Cordoba, Argentina. (A. Marsal,Casilla Postal 130, Cordoba, Argentina)

14-19. International Soc. for Rehabili-tation of the Disabled, 11th world congr.,Dublin, Ireland. (C. J. Sweeney, NationalRehabilitation Board, 18, Merrion Rd.,Dublin 4)

15-18. Internal Medicine, 10th intern.congr., Warszawa, Poland. (M. Tulczyn-ski, ul. Lekarska 11, Warszawa 22)

15-20. International Symp. on Designand Application of Logical Systems, Brus-sels, Belgium. (J. Florine, Laboratoired'Electronique Industrielle, UniversiteLibre de Bruxelles, 50, Avenue F. D.Roosevelt, Bruxelles, 5, Belgium)

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2nd Edition

THE EYE, Volume 1Y1I7edited by HUGH DAVSON, PhysiologyDepartment, University College, London,EnglandIn this completely revised edition of Vol-ume 1 there have been some essentialchanges in scope. The great advances inour knowledge of the biochemistry of theretina have made a separate chapter nec-essary to cover this aspect adequately;similar advances in the biochemistry ofthe lens have made it advisable to splitthe subject into two chapters.Contents: Peter C. Kronfeld, THE GROSSANATOMY AND EMBRYOLOGY OFTHE EYE; H. Davson, THE INTRA-OCULAR FLUIDS; H. Davson, THE IN-TRAOCULAR PRESSURE; AntoinettePirie, THE VITREOUS BODY; S. G.Waley, THE LENS: FUNCTION ANDMACROMOLECULAR COMPOSITION;Ruth van Heyningen, THE LENS: ME-TABOLISM AND CATARACT; D. M.Maurice, THE CORNEA AND SCLERA;C. N. Graymore, GENERAL ASPECTSOF THE METABOLISM OF THE RET-INA. 1969, 679 pp., $26.00

FLUORESCENCE ASSAYIN BIOLOGY ANDMEDICINE, Volume 2by SIDNEY UDENFRIEND,Roche Insti-tute of Molecuilar Biology, Nutley, NewJerseyA Volume of Molecular BiologyAn International Series of Monographs andTextbooks

Provides a working knowledge of fluo-rescence theory and practice, and con-veys to the biologist the potentialities offluorescence assay, seeking to make himaware that applications to structuralstudies on proteins and other macro-molecules, enzyme-coenzyme-substrate in-teraction, and immunochemistry will opennew vistas and that the development ofnewer instrumentation and chemicalmethodology will make more metabolitesamenable to microfluorometric assay. Anattempt has been made to instill the feel-ing that this is a versatile and powerfultool and that present applications do notbegin to realize its full potential.

September 1969, about 618 pp.

Circle No. 85 on Readers' 5ervice Card on page 11OA

218

BOOKS RECEIVED

(Continued from page 168)

Collier-Macmillan, London, 1969. xii +252 pp., illus. Paper, $4.95.Mathematical Papers. William Kingdon

Clifford. Robert Tucker, Ed. Chelsea, NewYork, 1968. lxxii + 658 pp., illus. $15.Reprint of the 1882 edition.

Mechanical Engineering for Profession-al Engineers' Examinations. IncludingQuestions and Answers for Engineer-in-Training Review. John D. Constance.McGraw-Hill, New York, ed. 2, 1969. xx+ 492 pp., illus. $11.50.Mechanisms of Molecular Migrations.

Vol. 2. B. S. Thyagarajan, Ed. Intersci-ence (Wiley), New York, 1969. x + 470pp., illus. $22.50.

Medical Thermography. Proceedings ofa Boerhaave Course for PostgraduateMedical Education Given in Collaborationwith the Netherlands' Society of Radiol-ogy, Leiden, 1968. S. F. C. Heerma vanVoss and P. Thomas, Eds. Karger, Basel,1969 (U.S. distributor, Phiebig, WhitePlains, N.Y.). viii + 224 pp., illus. Paper,$15.60. Bibliotheca Radiologica, No. 5.Methoden der Organischen Chemie.

Vol. 7, Part 4. Sauerstoffverbindungen II,Part 4. Eugen Muller, 0. Bayer, H. Meer-wein, and K. Ziegler, Eds. Thieme Verlag,Stuttgart, ed. 4, 1968 (U.S. distributor,Intercontinental Medical Books, NewYork). xxx + 508 pp., illus. DM 178.The Mutants of Maize. A pictorial sur-

vey in color of the usable mutant genesin maize with gene symbols and linkagemap positions. Arranged by chromosomelocation. M. G. Neuffer, Loring Jones,and Marcus S. Zuber. Crop Science So-ciety of America, Madison, Wis., 1968.vi + 74 pp., illus. Cloth, $6; paper, $5.

Orbitals and Chemical Bonding. P. F.Lynch. Mifflin, Boston, 1968. viii + 56pp., illus. Paper, $1.75. Concepts inChemistry.The Organic Compounds of Lead. Hy-

min Shapiro and F. W. Frey. Interscience(Wiley), New York, 1969. xiv + 498 pp.,illus. $18. Chemistry of OrganometallicCompounds.

Origin and Distribution of the Ele-ments. An international symposium, Paris,1967. L. H. Ahrens, Ed. Pergamon, NewYork, 1968. xviii + 1178 pp., illus. + 2plates. $48. International Series of Mono-graphs in Earth Sciences, vol. 30.The Origins of Intellect: Piaget's The-

ory. John L. Phillips, Jr. Freeman, SanFrancisco, 1969. xviii + 150 pp., illus.Paper, $2.75. Psychology Series.

Palladium Alloys. E. M. Savitskii, V.P. Polyakova, and M. A. Tylkina. Trans-lated from the Russian edition (Moscow,1967) by R. E. Hammond. PrimarySources, New York, 1969. x + 214 pp.,illus. $24.50.

Plant Cell Organelles. Proceedings ofthe Phytochemical Group Symposium,London, 1967. J. B. Pridham, Ed. Aca-demic Press, New York, 1968. xiv + 264pp., illus. $9.50.The Prairie World. David F. Costello.

Crowell, New York, 1969. xiv + 242 pp.,illus. $7.95.

Principles of Zoophysiology. In twovolumes. B. Rybak. Vol. 1. Translatedfrom the French edition (Paris, 1962).

Pergamon, New York, 1968. viii + 600pp., illus. $25. International Series ofMonographs in Pure and Applied Biol-ogy: Zoology, vol. 39.

Psycholinguistics. Experiments in Spon-taneous Speech. F. Goldman Eisler. Aca-demic Press, New York, 1968. viii + 172pp., illus. $8.50.The Radio Amateur's Handbook. Head-

quarters Staff, American Radio RelayLeague. Doug DeMaw, Ed. AmericanRadio Relay League, Newington, Conn.,ed. 46, 1969. 702 pp., illus. Cloth, $6.50;paper, $4. Radio Amateur's Library, Pub-lication No. 6.

Reality and Dream. Psychotherapy of aPlains Indian. George Devereux. Psycho-logical tests edited and interpreted byRobert R. Holt. Anchor (Doubleday),Garden City, N.Y., 1969. 1 + 622 pp. +8 plates. Paper, $3.95. Revised version ofthe 1951 edition.

Reforming American Education. TheInnovative Approach to Improving OurSchools and Colleges. Alvin C. Eurich.Harper and Row, New York, 1969. xviii+ 270 pp. $6.50.Rock and Mineral Analysis. John A.

Maxwell. Interscience (Wiley), NewYork, 1968. xviii + 590 pp., illus. $24.50.Chemical Analysis, vol. 27.

Spectral Properties of Disordered Chainsand Lattices. J. Hori. Pergamon, NewYork, 1968. xii + 232 pp., illus. $10.International Series of Monographs inNatural Philosophy, vol. 16.

Spiders, Scorpions, Centipedes andMites. J. L. Cloudsley-Thompson. Per-gamon, New York, 1968. xvi + 280 pp.,illus. + 18 plates. Cloth, $6.50; paper,$4.50. Commonwealth and InternationalLibrary: Biology Division. Reprint, withadditions, of the 1958 edition.The Starch Industry. J. W. Knight. Per-

gamon, New York, 1969. xiv + 190 pp.,illus. + 16 plates. Cloth, $5.50; paper, $4.Commonwealth and International Library:Chemical Industry.

Statistical Mechanics of Chain Mole-cules. Paul J. Flory. Interscience (Wiley),New York, 1969. xx + 432 pp., illus.$17.50.

Stochastic Integrals. H. P. McKean, Jr.Academic Press, New York, 1969. xvi +144 pp. $9. Probability and MathematicalStatistics, vol. 5.

Theory of Finite Groups. A symposium,Cambridge, Mass., 1968. Richard Brauerand Chih-Han Sah, Eds. Benjamin, NewYork, 1969. xiv + 270 pp. $12.50.Theory of Matrices. Peter Lancaster.

Academic Press, New York, 1969. xii +316 pp. $11.Tobacco and Your Health: The Smok-

ing Controversy. Harold S. Diehl. Mc-Graw-Hill, New York, 1969. xvi + 272pp., illus. $4.95.The Transmission of Schizophrenia.

Proceedings of the Second Research Con-ference of the Foundations' Fund for Re-search in Psychiatry, Dorado, PuertoRico, 1967. David Rosenthal and Sey-mour S. Kety, Eds. Pergamon, New York,1968. xii + 436 pp., illus. $15.The Transport of Plant Hormones.

Proceedings of the NATO/EGE Univer-sity Summer Institute, Izmir, Turkey,1967. Y. Vardar, Ed. North-Holland,Amsterdam, 1968. viii + 460 pp., illus.$20.

SCIENCE, VOL. 165

METHODS INENZYMOLOGYVolume 13; CITRIC ACID CYCLEedited by JOHN M. LOWENSTEIN,Graduate Department of Biochemistry,Brandeis University, Waltham, MassachusettsJune 1969, 728 pp., $29.50Volume 14; LIPIDSedited by JOHN M. LOWENSTEIN,Graduate Department of Biochemistry,Brandeis University, Waltham, MassachusettsThird quarter, 1969, 704 pp., $29.50Volume 15; STEROIDS AND TERPENOIDSedited by RAYMOND B. CLAYTON,Stanford University School of Medicine,Palo Alto, CaliforniaAugust 1969, 796 pp., $32.50Volume 16; FAST REACTIONSedited by KENNETH KUSTIN,Department of Chemistry, Brandeis Univer-sity, Waltham, MassachusettsFourth quarter, 1969, about 438 pp.