Basdekis Georgios MD, PhDORTHOPAEDIC SURGEON

LARISSA, GREECE

Hadjimoissis Sofoklis MD,PhD GP, LARISSA, GREECE

The used of double or triple dose of COLLAGEN MD in the same visit, is it safe and does it improve the outcomes?

Regenerative medicineand

orthopedic

• The regeneration of orthopedic tissues requires 4 key components:

• cells,

• morphogenetic signals,

• scaffolds, and

• an appropriate mechanical environment

rotator cuff calcific tendinopathy and tendinitis THERAPY OPTIONS

• NSAID

• INJECTION (CORTIZONE , PRPs, ozon, etc)

• COLLAGEN MD

• SHOCK WAVE THERAPY

• SURGERY

hypothesis

• could we use more dose of collagen MD

• With fewer sessions and with the same results

• and with safety

MD collagen

Control Study

• 2 Groups

• 20 patients each

• same disease rotator cuff calcific tendinopathy and tendinitis

1 groupMD COLLAGEN subcutaneous 2-3 dose (MD knee, MD shoulder and MD tissue)

2 groupMD collagen subcutaneous1 dose mixed MD knee and MD tissue

1 groupCOLLAGEN MD subcutaneous 2-3 dose (MD knee-MD shoulder and MD tissue)

• ultrasound-guided tendinopathy or calcification mark the point and

• (MD Knee or MD shoulder and MD tissue)

• 3 successive sessions

• once every 15 days

• (27g needle )

2 group collagen MD subcutaneous 1 dose mixed MD knee and MD tissue

• ultra-sound guided, mark the lesion and

• 27 g needle

• 5-7 small skin needling

• 3 times every 7 days

• MD Knee and MD tissue

METHOD

• VAS score

• use of drugs

• safety of methods

results VAS score

• 1 group / 2 group

• before 9/ 9

• 2 day 6/4

• 4 day 5/3

• 10 day 2/3

• 12 day 2/4

results use of drugs

• 1 group /2 group

• 3 drugs/5-7 drugs

• 3-5 days/ 10-15 days more after 2 WEEKS USED

• not allergic reaction in both groups

conclusions

• both method are safe

• excellent results with more dose (1 group)

• double dose longer results

• BOTH showed pain relief and less NSAID

• more studies with control groups randomized trials

• in vivo with different collagen sources to treat different types of pain conditions

• Regenerative medicine turn back the clock and regenerate worn-out tissue???

Regenerative medicineAND COLLAGEN

Conclusions

thank you