the urinary system michael hall university of california los angeles mannekin pis
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The Urinary SystemThe Urinary System
Michael HallMichael Hall
University of CaliforniaUniversity of CaliforniaLos AngelesLos Angeles
Mannekin PisMannekin Pis
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Nephron CollectingDuct
Uriniferous tubuleUriniferous tubule
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THE RENAL CORPUSCLE THE RENAL CORPUSCLE HAS:HAS:THE RENAL CORPUSCLE THE RENAL CORPUSCLE HAS:HAS:
UPUP VPVP USUS
PEPE VEVE
A simple squamous parietal epithelium (PE) A simple squamous parietal epithelium (PE) which lines Bowmans capsule (BC).which lines Bowmans capsule (BC).A tuft of capillaries called the glomerulus (G)A tuft of capillaries called the glomerulus (G)A modified epithelium lining the capillaries (VE)A modified epithelium lining the capillaries (VE)A vascular pole (VP) A vascular pole (VP) A urinary pole (UP)A urinary pole (UP)A urinary space (US) A urinary space (US)
G BC
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Renal CorpuscleRenal Corpuscle
Efferent arterioleEfferent arteriole
Afferent arterioleAfferent arteriole
FiltrateFiltrate
Bowman’sBowman’s capsulecapsule
GlomerulusGlomerulus
Urinary spaceUrinary space
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Filtration apparatus of renal corpuscleFiltration apparatus of renal corpuscle
Basal laminaBasal lamina
Filtration slit membraneFiltration slit membrane
Fenestrated endotheliumFenestrated endotheliumof capillaryof capillary
PodocytePodocyte
PedicelPedicel
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FenestrationsFenestrations
Basal la
mina
Basal la
mina
PedicelsPedicels
Filtration slit membraneFiltration slit membrane
RBCRBCcapillary
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The glomerular basement membrane is a size and charge-selective barrier
• SIZE: Only proteins below 60,000 mw can get through the fenestrae and slits
• CHARGE: It is anionic (sialoproteins and proteoglycans)
Most macromolecules are anionic at neutral pH, so they are repelled
The glomerular basement membrane is a size and charge-selective barrier
• SIZE: Only proteins below 60,000 mw can get through the fenestrae and slits
• CHARGE: It is anionic (sialoproteins and proteoglycans)
Most macromolecules are anionic at neutral pH, so they are repelled
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Thin loop of Thin loop of HenleHenle
Ascending Ascending straight straight segmentsegment
Distal Distal convolutedconvolutedtubuletubule
Collecting ductCollecting ductProximal Proximal convoluted convoluted tubuletubule
Descending Descending straight straight segmentsegment
Vasa rectaVasa recta
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Collecting ductCollecting duct
PCTPCT DCTDCT
microvillimicrovilli
Tubules in cortex of kidneyTubules in cortex of kidney
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CDCD
Thin loops of HenleThin loops of Henle
Tubules in medulla of kidneyTubules in medulla of kidney
PCTPCT
DCTDCT
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Distal convoluted tubuleDistal convoluted tubule
Macula densaMacula densa
PCTPCT
DCTDCT
Macula densaMacula densa
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Macula densaMacula densa
Distal tubuleDistal tubuleJG cellsJG cells
The JuxtaglomerularThe JuxtaglomerularApparatusApparatus
GlomerularGlomerularcapillariescapillaries
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ACE
The role of the The role of the JG cells on the JG cells on the permeability of permeability of the collecting the collecting ducts to waterducts to water
Cells of macula Cells of macula densa sense densa sense decreased blood decreased blood volume/flowvolume/flow
from posterior pituitary
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Changes in Changes in osmolarity in blood osmolarity in blood and urine during and urine during urine formationurine formation
vasa recta
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Manneken Pis has Manneken Pis has over 500 outfits that over 500 outfits that are used for special are used for special occasionsoccasions
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Blood vessels of the kidneyBlood vessels of the kidney
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Renal Blood SupplyRenal Blood Supply
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Arcuate artery and veinArcuate artery and vein
CortexCortex
MedullaMedulla
Renal Renal corpusclescorpuscles
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Interlobulararteries
Lobule
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Interlobular arteriesInterlobular arteries
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Juxtamedullary nephrons and vasa rectaJuxtamedullary nephrons and vasa recta
Cortical nephronCortical nephron
JuxtamedullaryJuxtamedullarynephronnephron
Loop of HenleLoop of Henle
Vasa rectaVasa recta
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Renal papilla
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PapillaPapilla
Minor calyxMinor calyx
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transitionaltransitionalepitheliumepithelium
UreterUreter
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BladderBladder
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Bladder (relaxed)Bladder (relaxed)
Bladder (stretched)Bladder (stretched)
Transitional epithelium
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UrethraUrethra
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Ahhhh!Ahhhh! :):)
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Blood circulation Blood circulation in kidneyin kidney
ILIL
AfferentAfferent
EfferentEfferent
juxtamedullary nephronsjuxtamedullary nephrons