TheStateofEvolu.onaryBiology

150yearssinceDarwin’sOriginofSpecies

50yearssincetheModernSynthesis(Neo‐Darwinism)

FromtheModernEvolu.onarySynthesis

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•  Dobzhansky,1990‐1975

•  “Nothinginbiologymakessenseexceptinthelightofevolu.on”

•  JulianHuxley=grandsonofThomasHenryHuxley(Darwin’sbulldog)

ArchitectsoftheModernSynthesis

R.A.Fisher,TheodosiusDobzhansky,J.B.S.Haldane,SewallWright,E.B.Ford,ErnstMayr,BernhardRensch,SergeiChetverikov,GeorgeGaylordSimpson,andG.LedyardStebbins.

JianzhiZhang

•  h[p://www.umich.edu/~zhanglab/people.htm

Rule#7:Changesinproteinfunc.onandgeneexpressionarebothimportantinphenotypicevolu.on

•  GeneexpressionplaysacentralroleinEvo‐Devo(chapter9)

•  h[p://www.pbs.org/wgbh/nova/evolu.on/darwin‐never‐knew.html

•  1:44:00‐1:48:00

Focus

•  Evo‐devo(gene.cbasisofcomplexstructures)•  Selec.onistvs.neutralistdebate•  Whatformsofselec.onareimportant?– Standardnaturalselec.onvs.kinselec.on– Purifyingselec.onvs.posi.veselec.on

•  Whatcausesspecia.on?

•  Treeoflifevs.weboflife