SCIENTIFIC PROGRAM

08:30 Registration _____________________________________________________________

09:00 Opening Session Auditorium _____________________________________________________________

Opening

Martin Kupiec, President, The Genetics Society of Israel _____________________________________________________________

09:10 – 10:35 Session I Auditorium _____________________________________________________________

Chair: Judy Berman, Tel Aviv University

09:10 THE MECHANISM OF THE SPLICED LEADER SILENCING (SLS) LEADING TO PROGRAMMED CELL DEATH IN TRYPANOSOMA

BRUCEI Shulamit Michaeli, Bar Ilan University, Israel

09:55 ENIGMAS IN VIRAL EVOLUTION Adi Stern, Tel Aviv University, Israel

10:15 IDENTIFICATION AND VISUALISATION OF SPLICING AT THE SINGLE CELL LEVEL Tal Shay, Ben-Gurion University of the Negev, Israel.

10:35 Coffee and Exhibition Viewing _____________________________________________________________

11:05 – 12:25 Session II Auditorium _____________________________________________________________

Chair: Yehuda Tzfati, The Hebrew University of Jerusalem

11:05 READING AND WRITING GENOMES IN 3D Erez Lieberman-Aiden, Baylor University and Rice University, USA

11:25 CYTOPROTECTIVE STRESS RESPONSES REPROGRAM TUMOR STROMA TO SUPPORT MALIGNANCY

Ruth Scherz-Shouval, Weizmann Institute of Science, Israel

11:45 THERAPEUTIC LEVELS OF IN VIVO GENE TARGETING WITHOUT NUCLEASES

Adi Barzel, Tel Aviv University, Israel

SCIENTIFIC PROGRAM (continued)

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11:05 – 12:25 Session II Continued Auditorium

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12:05 SINGLE-CELL CHROMATIN IMMUNOPRECIPITATION REVEALS PRINCIPLES OF CHROMATIN STATE HETEROGENEITY Oren Ram, The Hebrew University of Jerusalem, Israel

12:25 Lunch, Poster Session and Exhibition Viewing _____________________________________________________________

13:45 – 16:00 Session III Auditorium _____________________________________________________________

Chair: Batsheva Kerem, The Hebrew University of Jerusalem 13:45 Genetics Society Assembly Meeting & Elections

14:00 YEAST RESPONSE TO MULTIPLE CARBON SOURCES: A CASE STUDY OF COMBINATORIAL SIGNAL INTEGRATION

Yonatan Savir, Technion – Israel Institute of Technology, Israel

14:20 THE ROLE OF AUXIN IN TOMATO COMPOUND LEAF DEVELOPMENT

Naomi Ori, The Hebrew University of Jerusalem (Rehovot), Israel

14:40 Honorary Member Ceremony Eliezer Lifschitz, Technion – Israel Institute of Technology, Israel

15:00 Coffee Break and Exhibition Viewing

15:20 CHAPERONE-MEDIATED TRANSLATIONAL CONTROL IN PROTEOSTASIS

Reut Shalgi, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Israel

15:40 SPATIAL TRANSCRIPTOMIC ANALYSIS OF THE C. ELEGANS GERMLINE UNCOVERS ENTIRE TRANSCRIPTOME EXPRESSION SWITCH

Yonatan Tzur, The Hebrew University of Jerusalem, Israel

16:00 Closing Remarks and Poster Prizes

POSTER PRESENTATIONS

Board No: 1. THE NEW SYNDROME OF HYPOGONADOROPHIC HYPOGONADISM ARRYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FACIAL DYSMORPHISM AND ABSENCE OF CORPUS CALLOSUM IS ASOCIATED TO TAX1 BINDING PROTEIN GENE MUTATION Maram Arafat The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben Gurion University of the Negev, Beer Sheva, Israel 2. THE EFFECTS OF THE LENGTH HOMOLOGY ON THE SELECTION OF DOUBLE-STRAND BREAKS REPAIR, ECTOPIC OR ALLELIC RECOMBINATION IN SACCHAROMYCES CEREVISIAE Serkalem Ayanaw, Martin Kupiec Department of Molecular Microbiology and Biotechnology, Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel 3. DECIPHERING THE NETWORK OF PPI AMONG HUMAN COMPLEX I

SUBUNITS Gilad Barshad, Maya Schuldiner, Dan Mishmar Department of Life Sciences, Ben Gurion University in the Negev,

Be'er Sheva, Israel, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

4. MITOCHONDRIAL 16S RRNA IS METHYLATED BY TRNA

METHYLTRANSFERASE TRMT61B IN ALL VERTEBRATES Dan Bar-Yaacov, Idan Frumkin, Yuka Yashiro, Takeshi Chujo, Yonatan Chemla, Amit Blumberg, Orr Schlesinger, Philipp Bieri,

Basil Greber, Nenad Ban, Raz Zarivach, Lital Alfonta, Yitzhak Pilpel, Tsutomu Suzuki, Dan Mishmar

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel, Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel

5. EXPRESSION HOMEOSTASIS DURING DNA REPLICATION Yoav Voichek, Raz Bar-Ziv, Naama Barkai Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

POSTER PRESENTATIONS (continued)

6. MILD INHIBITION OF TRANSLATION AS A NOVEL THERAPEUTIC APPROACH FOR RARE CONFORMATIONAL DISEASES: WHICH WAY THE MUTANT AGT WILL GO?

Ruth Belostotsky, Roman Lyakhovetsky, Yaacov Frishberg Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel 7. DYNAMIC REGULATION OF THE HISTONE VARIANT H1.0 GENERATES

INTRATUMOR EPIGENETIC AND FUNCTIONAL HETEROGENEITY Alva Biran, Cristina Morales Torres, Ayelet-Hashacher Shapira Cohen, Paola Scaffidi, Eran Meshorer Department of Genetics, Institute of Life Sciences, the Hebrew University

of Jerusalem, Jerusalem, Israel, The Edmond and Lily Center for Brain Sciences (Elsc), The Hebrew University of Jerusalem, Jerusalem, Israel

8. NOVEL NGS-BASED APPROACH TO ANALYZE MTDNA TRANSCRIPTION

INITIATION: A QUANTITATIVE INSIGHT INTO DIVERSE TISSUES AND ORGANISMS

Amit Blumberg, Charles Danko, Dan Mishmar Department of Life Sciences, Ben Gurion University of the Negev,

Beer Sheva, Israel 9. REGULATION OF COORDINATION BETWEEN DNA REPLICATION AND

TELOMERE ELONGATION MECHANISMS

Shay Bramson, Martin Kupiec

Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel

10. ANCIENT OUT OF AFRICA MITOCHONDRIAL DNA VARIANTS ASSOCIATE

WITH DISTINCT MITOCHONDRIAL GENE EXPRESSION PATTERNS Tal Cohen, Liron Levin, Dan Mishmar Department of Life Sciences, Ben Gurion University of the Negev, Be'er Sheva, Israel

POSTER PRESENTATIONS (continued)

11. MiR181A REGULATORY PATHWAY IN THE INNER EAR Maya Enoch, Kathy Ushakov, Tal Koffler, Yoni Bhonker, Anya Rudnicki,

Karen B. Avraham Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of MedicineTel Aviv University, Tel Aviv, Israel 12. ACCELERATION IN DISCOVERING PATHOGENIC VARIANTS CAUSING

HEARING LOSS BY NEXT GENERATION SEQUENCING Nada Daniel-Farran, Luna Tamer, Zippora Brownstein, Fabio T.A.

Martins, Morad Khayat, Gil Ast, Stavit Allon-Shalev, Karen B. Avraham Human Genetics, Sackler Faculty of Medicine/tel Aviv University, Tel Aviv, Israel, Human Genetics, The Ruth and Bruce Rappaport Faculty

of Medicine, Technion Israel Institute of Technology, Haifa, Israel 13. HISTONE H3 LYSINE K56 HYPER ACETYLATION IS REGULATED BY CTF18

AND DUN1 IN ONE PATHWAY AND ELG1 IN ANOTHER Lihi Gershon, Martin Kupiec Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv,

Israel 14. HUMAN SEX-SPECIFIC GENE EXPRESSION Moran Gershoni, Moran Gershoni, Shmuel Pietrokovski Department of Molecular Genetics, Weizmann Institute of Science,

Rehovot, Israel 15. THE KEY FACTORS OF MRNA LOCALIZATION MECHANISM IN MATING

PROCESS IN YEAST Polina Geva, Stella Aronov Molecular Biology, Ariel University, Ariel, Israel , Mina and Everard

Goodman Faculty of Life Sciences, Bar Ilan, Ramat Gan, Israel 16. GENE ORGANIZER: PHENOTYPIC ANALYSIS OF GENE-ORGAN

ASSOCIATIONS David Gokhman, Guy Kelman, Adir Amartely, Guy Gershon, Shira Tsur,

Liran Carmel Genetics, The Hebrew University of Jerusalem, Israel

POSTER PRESENTATIONS (continued)

17. THE EFFECTS OF DNA DAMAGE RESPONSE PLOIDY AND MATING TYPE ON DNA DAMAGE REPAIR IN SACCHAROMYCES CEREVISIAE

Gilad Grinberg, Martin Kupiec Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv,

Israel 18. TORC2 AND ITS EFFECT ON HETEROCHROMATIC REGIONS Aline Habib, Adiel Cohen, Martin Kupiec, Ronit Weisman Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv,

Israel 19. DATA MINING OF MINIATURE TRANSPOSABLE ELEMENTS IN FOUR

TRITICUM AND AEGILOPS GENOME DRAFTS Danielle Keidar, Khalil Kashkush Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel 20. THE GENOMIC LANDSCAPE OF EVOLUTIONARY CONVERGENCE IN ALL

AMNIOTES Liron Levin, Dan Mishmar Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel 21. RAPID TELOMERE SHORTENINGS IN THE ABSENCE OF RNR1 OCCUR

INDEPENDENTLY OF REDUCED CELLULAR DNTP POOLS AND CANNOT BE RESCUED BY INCREASED TELOMERASE ACTIVITY

Andre Maicher, Inbal Gazy, Andrei Chabes, Martin Kupiec Department of Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 22. LEPTIN AND INSULIN UP-REGULATE MIR-4443 TO SUPPRESS NCOA1 AND

TRAF4, AND DECREASE THE INVASIVENESS OF HUMAN COLON CANCER CELLS

Ari Meerson, Hila Yehuda Molecular Biology of Chronic Diseases, Migal Galilee Research Institute Ltd, Kiryat Shmona, Israel

POSTER PRESENTATIONS (continued)

23. IN HOUSE MRNASEQ PROTOCOL DEMONSTRATED ACCURATE AND REPRODUCIBLE DATA AS COMPARE TO THE ILLUMINA TRUSEQ RNASEQ KIT

Shmulik Motola, Dan Ben-Avraham, Sima Benjamin, Gilgi Friedlander,

Tali Shalit, Shlomit Gilad G Incpm, Weizmann Institute of Science, Rehovot, Israel

24. IDENTIFICATION OF BREAST CANCER SUBTYPES USING MULTI-OMIC

HIGH-THROUGHPUT GENOMIC DATA

Dvir Netanely, Ayelet Avraham, Adit Ben-Baruch, Ella Evron,

Ron Shamir Blavatnik School of Computer Science, Tel Aviv University, Israel

25. C-TO-U RNA EDITING IN C. ELEGANS Yomiran Nissan, Orna Ben-Naim Zgayer, Ayelet T. Lamm Department of Biology, Technion – Israel Institute of Technology, Haifa,

Israel 26. 3-D CHROMOSOMAL DOMAINS AND THEIR RELATION TO GENOMIC

FUNCTION Idan Nurick, Michal Ozery-Flato, Liat Ein-Dor, Ron Shamir Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel 27. A SINGLE POLYCOMB GROUP COMPLEX TARGET GENE TRIGGERS

PARTHENOGENESIS IN PHYSCOMITRELLA PATENS Idan Pereman, Nelly Horst, Aviva Katz, Eva Decker, Ralf Reski, Nir Ohad Department of Molecular Biology and Ecology of Plants, Tel Aviv

University, Tel Aviv, Israel, The Manna Center Program for Food Safety & Security, Tel Aviv University, Tel Aviv, Israel

POSTER PRESENTATIONS (continued)

28. UNC80 MUTATION CAUSES A SYNDROME OF HYPOTONIA, SEVERE

INTELLECTUAL DISABILITY, DYSKINESIA AND DYSMORPHISM, SIMILAR TO THAT CAUSED BY MUTATIONS IN ITS INTERACTING CATION CHANNEL NALCN

Yonatan Perez, Rotem Kadir, Michael Volodarsky, Iris Noyman, Hagit Flusser, Zamir Shorer, Libe Gradstein, Ramon Y. Birnbaum, Ohad S. Birk The Shraga Segal Department of Microbiology, Immunology & Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev,

Beer Sheva, Israel 29. AMINO ACID METABOLISM AND TOR SIGNALING IN FISSION YEAST Sophie Raydman, Martin Kupiec, Ronit Weisman Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel 30. ASSOCIATION BETWEEN COPY-NUMBER VARIATIONS (CNVS) AND SAVANT SKILLS AMONG PEOPLE WITH AUTISM SPECTRUM DISORDER (ASD) Hila Rosenthal, Idan Menashe The Department of Brain and Cognitive Sciences, Ben Gurion University of the Negev, Beersheba, Israel 31. DNA:RNA HYBRIDS AT HUMAN TELOMERES ARE DEPENDENT ON TERRA LEVELS AND ASSOCIATED WITH DYSFUNCTIONAL TELOMERES Shira Sagie, Stella Hartono, Fred Chedin, Sara Selig Molecular Medicine Lab, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and Rambam Health Care Campus, Haifa, Israel 32. A NOVEL-NON CLASSICAL REPLICATION STRESS FOUND IN ONCOGENE EXPRESSING CELLS Dan Sarni, Batsheva Kerem Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

POSTER PRESENTATIONS (continued)

33. MAINTENANCE OF GENOME STABILITY BY YEAST ELG1 GENE Sumitra Sau, Keren Shemesh, Dganit Shkedy, Nishant Singh, Alex Bronstein, Lihi Gershon, Shay Bramson, Batia Liefshitz, Martin Kupiec Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel 34. DESIGNING GENOME-WIDE MUTAGENESIS APPROACHES FOR NON- MODEL ORGANISMS BY LEVERAGING AN ARTIFICIAL TRANSPOSON, DEEP SEQUENCING AND A STABLE HAPLOID ISOLATE Ella Segal, Yael Silberberg, Judith Berman Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences Tel Aviv University, Tel Aviv, Israel 35. UNDERSTANDING THE FORMATION AND REGULATION OF CONTACT SITES BETWEEN PEROXISOMES AND OTHER ORGANELLES Nadav Shai, Maya Schuldiner, Einat Zalckvar Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel 36. STRUCTURE-FUNCTION ANALYSIS OF THE YEAST ELG1 GENE Keren Shemesh, Martin Kupiec Department of Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel 37. T-DNA INTEGRATION: REGULATION, DYNAMICS AND EPIGENETICS Shay Shilo, Cathy Melamed-Bessudo, Pooja Triphati, Theodore Muth, Avraham Levy Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel

38. THE ROLE OF AUXIN AND THE GENE ENTIRE (E) IN LEAF

DEVELOPMENT IN TOMATO

Ido Shwartz, Naomi Ori The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel

POSTER PRESENTATIONS (continued)

39. ANALYSIS OF GxE INTERACTIONS IN BARLEY HEB-25 POPULATION AND ACCELERATION TO GENE ISOLATION BY THE COMSEQ APPROACH Roi Silberman, David Bonfil, Klaus Pillen, Eyal Fridman, Noam Shental Plant Sciences, Aro, the Volcani Center, Bet Dagan, Israel 40. THE RESPIRATION/FERMENTATION SWITCH IN YEAST REQUIRES PROTEIN AGGREGATION Kobi Simpson-Lavy Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Co, United States

41. DETERMINATION OF PATHOGENIC VARIANTS FOR DEAFNESS BY NEXT GENERATION SEQUENCING Christina Srouji, Fabio T.A Martins, Bella Davidov, Lina Basel, Moshe Frydman, Zippora Brownstein, Karen B. Avraham Genetics Institute, Rambam Health Care Campus, Haifa, Israel, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Israel 42. LINEAR PLASMIDS CARRYING BONA FIDE ORIGINS ARE MAINTAINED AS AUTONOMOUS PLASMIDS IN C. ALBICANS Mathuravani Aaditiyaa Thevandavakkam, Hung Ji Tsai, Sophia Hirsch, Judith Berman Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel 43. CHARACTERIZATION OF TELOMERIC ABNORMALITIES IN ICF SYNDROME TYPES II – IV Shir Tubiana, Hagar Katzir, Shiran Yehezkel, Sara Selig

Human Molecular Genetics, Faculty of Medecine, Technion – Israel Institute of Technology, Israel

44. LincRNA GENE EXPRESSION IN THE MOUSE INNER EAR Kathy Ushakov, Tal Koffler, Yoni Bhonker, Shaked Shivatzki, Igor Ulitsky, Karen Avraham Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv, Israel

POSTER PRESENTATIONS (continued)

45. ONE LIBRARY TO MAKE THEM ALL: STREAMLINING YEAST LIBRARY CREATION BY A SWAP-TAG (SWAT) STRATEGY

Uri Weill, Ido Yofe, Maya Schuldiner Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel 46. CMT AND DNMT3 HOMOLOGS PLAY A NOVEL DE NOVO DNA

METHYLATION ROLE IN PHYSCOMITRELLA PATENS Rafael Yaari, Aviva Katz, Nir Ohad Department of Molecular Biology and Ecology of Plants, Tel Aviv

University, Tel Aviv, Israel 47. THE EPIGENETIC BLUEPRINT OF INNER EAR SENSORY EPITHELIUM

FORMATION Ofer Yizhar Barnea, Cristina Valensisi, Kathy Ushakov, Tal Koffler, Kamal Kishore, David R. Hawkins, Mattia Pelizzola, Karen B. Avraham Department of Human Molecular Genetics and Biochemistry, Sackler

Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 48. TETRAPLOID-DERIVED ANEUPLOIDY CONFERS RESISTANCE TO

CANAVANINE Adi Zarenkin, Shay Covo Microbiology and Plant Pathology, The Hebrew University of Jerusalem,

Rehovot, Israel 49. A 612BP DELETION IS ASSOCIATED WITH HIGH TOMATINE LEVEL AND

BITTERNESS IN TOMATO RIPE FRUIT Itay Zemach, Samuel Bocobza, Asaph Aharoni, Dani Zamir The Robert H. Smith Institute of Plant Sciences and Genetics in

Agriculture, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, Israe