the rifle and akin classifications for acute kidney injury

8/9/2019 The RIFLE and AKIN Classifications for Acute Kidney Injury

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The RIFLE and AKIN classifications foracute kidney injury: a critical and

comprehensive revie 1. José António Lopes and2. Sofa Jorge

+Author Afliations1. Department o Nephrology and Renal Transplantation, Hospital de Santa Maria,

Centro Hospitalar de is!oa Norte, "#", is!oa, #ortugal

1. Correspondence and ofprint requests to: $os% Ant&nio opes' "(mail) *alopes+-hotmail.om

• Reei/ed Septem!er 1, 010.

• Aepted 2to!er 13, 010.

Ne4t Setion

Abstract

5n May 06, a ne7 lassi8ation, the R59" :Ris;, 5n*ury, 9ailure, oss o ;idneyuntion, and "nd(stage ;idney disease< lassi8ation, 7as proposed in order tode8ne and stratiy the se/erity o aute ;idney in*ury :A=5or urineoutput, and it has !een largely demonstrated that the R59" riteria allo7s theidenti8ation o a signi8ant proportion o A=5 patients hospitali?ed in numeroussettings, ena!les monitoring o A=5 se/erity, and is a good preditor o patientoutome. Three years later :Marh 0@


2/18

Multiple de8nitions or A=5 ha/e o!/iously led to a great disparity in the reportedinidene o A=5 ma;ing it difult or e/en impossi!le to ompare the /ariouspu!lished studies ousing on A=5 J@E. Thereore, it !eame ruial to esta!lish aonsensual and aurate de8nition o A=5 that ould ideally !e used 7orld7ide.#re/ious SetionNe4t Setion

The RIFLE classification

5n May 00, the Aute Dialysis Kuality 5nitiati/e :ADK5< group or the study o A=5,omposed o nephrologists and intensi/ists, ame together o/er 0 days in aonerene in Lien?a :5taly#monhs

•aP9R, glomerular 8ltration rate' 2, urine output' SCr, serum reatinine.

Table 1.

http://ckj.oxfordjournals.org/content/6/1/8.full#ref-3http://ckj.oxfordjournals.org/content/6/1/8.full#ref-7http://ckj.oxfordjournals.org/content/6/1/8.full#sec-1http://ckj.oxfordjournals.org/content/6/1/8.full#sec-6http://ckj.oxfordjournals.org/content/6/1/8.full#ref-8http://ckj.oxfordjournals.org/content/6/1/8.full#T1http://ckj.oxfordjournals.org/content/6/1/8.full#ref-3http://ckj.oxfordjournals.org/content/6/1/8.full#ref-7http://ckj.oxfordjournals.org/content/6/1/8.full#sec-1http://ckj.oxfordjournals.org/content/6/1/8.full#sec-6http://ckj.oxfordjournals.org/content/6/1/8.full#ref-8http://ckj.oxfordjournals.org/content/6/1/8.full#T1


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Ris;, 5n*ury, 9ailure, oss o ;idney untion and "nd(stage ;idney disease :R59"<lassi8ation 3Ea

The temporal pattern o the SCr and>or 2 /ariation is also rele/ant or de8ning A=5)the deterioration o renal untion must !e sudden :1J@ days< and sustained:persisting Q06 h1.@m0.

!tren"ths and limitations of the RIFLE classification

Strengths of the RIFLE classification

R59" has !een largely /alidated in terms o determining the inidene o A=5 and itsprognosti strati8ation in se/eral settings o hospitali?ed patients 1J0E.

5n these studies, R59" ailitated the identi8ation o a large proportion o A=5patients and there 7as an independent and step7ise inrease in mortality as A=5se/erity inreased' R59" also e4hi!ited a good prognosti auray in terms omortality : Ta!le 0


4/18

Setting N Design CriteriaIncidence(%)

Mortality (%/relativerisk) AUROC

F )2, F )8S,

:uiun"n et al. 41 ;1#@ros"-i"7 sing!"-"nr" Cr7 3

8o 9:I );1,R )11,

I )#,F )5,

0+y mor!iy

8o 9:I )0.,R );.0/8S,

I )21.*/8S,F )#2.5/8S, 0.;2*

Lin et al. 41@ *6

R"ros"-i"7 sing!"

-"nr" Cr7 3

8o 9:I )22,

R )15,I )#,

F )2*,

=osi! mor!iy

8o 9:I )25,

R )5$/5.#,I )$2/10.*,

F )100/Ininiy, 0.;6;

Aortic arch surgery

9rnoukis et al.

413 26$

R"ros"-i"7 sing!"

-"nr" Cr7 GFR

8o 9:I )52,

R )20,I )12,

F )16,

#0+y mor!iy8o 9:I )#,

R )/8S,I )12/8S,

F )#;/8S, 8S

Cirrhosis

B"n et al. 41+ 1#*

@ros"-i"7 sing!"

-"nr" Cr7 3

8o 9:I )*0,

R )12,I )5,

F )*#,

=osi! mor!iy8o 9:I )#2.1,

R )6;.;/*.$,I )$1.*/5.#,

F )*/#;.;, 0.;#$

Liver Transplantation

DRior+n et al. 40 *

R"ros"-i"7 sing!"

-"nr" #5

8o 9:I )8S,

R )8S,

I )11.1,

F )25.$,

#0+y mor!iy8o 9:I )8S,

R )8S,

I );.;/8S,

F )2#.$/2.;, 8S

1y"r mor!iy

8o 9:I )8S,R )8S,

I )2#.5/8S,

F )52.5/2.6, 8S

Sepsis

Lo"s et al. 401 1;2

R"ros"-i"7 sing!"

-"nr" 8S

8o 9:I )62,R )6,

I )12,

F )20,

60+y mor!iy

8o 9:I ).6,R )2$.#/8S,

I )2;.6/8S,

F )55/#.6, 0.$50

Ch"n et al. 400 121

R"ros"-i"7 sing!"

-"nr" Cr

8o 9:I )**,

R )26,I )16,

F )20,

=osi! mor!iy

8o 9:I )#*,

R )*0.0/1.#,I )$#.$/5.*,

F )$6.5/6.#, 0.6$;

Burn

Lo"s et al. 40 126

R"ros"-i"7 sing!"

-"nr" 8S

8o 9:I )6*,

R )1*,I ),

F )1#,

=osi! mor!iy8o 9:I )6,

R )11.1/5.6,I )6#.6/6.2,

F )$5/8S, 0.;#*

HIV

Lo"s et al. 406 $

R"ros"-i"7 sing!"

-"nr" 8S

8o 9:I )5#,

R )12,I ),

F )26,

60+y mor!iy8o 9:I )2#.5,

R )50/8S,I )66.6/5.1,

F )$2/*.6, 0.$#2

Traua

Agsh et al. 40 **

R"ros"-i"7 mu!i

-"nr" Cr7 3

8o 9:I );1.,

R ).*,

I )$.2,

F )1.5,

=osi! mor!iy8o 9:I )$.;,

R )16/1.$,

I )15./1.,

F )2*.$/2.#, 8S


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Setting N Design CriteriaIncidence(%)

Mortality (%/relativerisk) AUROC

HCT

Lo"s et al. 40 ;2

R"ros"-i"7 sing!"

-"nr" Cr7 GFR

8o 9:I )*6,R )1#,

I )2*,

F )1$,

5y"r mor!iy8o 9:I )#2.,

R )**.*/1.62,

I E F )66.$/1.6*, 8S

•aAR2C, area under the reei/er operating harateristi' Cr, reatinine' P9R,

glomerular 8ltration rate' A=5, aute ;idney in*ury' R, ris;' 5, in*ury' 9, ailure' NS,nonspei8ed' 5C, intensi/e are unit' 2, urine output' H5L, humanimmunode8ieny /irus' HCT, haematopoieti ell transplantation.

•!R as the reerene.

Table 2.

5nidene and ategori?ation o A=5 and its assoiation 7ith mortalitya

2riginally, the R59" riteria 7as esta!lished to standardi?e the de8nition andstrati8ation o A=5 se/erity. Se/eral studies, ho7e/er, ha/e determined the a!ility othe R59" in prediting mortality using the area under the reei/er operatingharateristi :AR2C< ur/e, and some o them ha/e inlusi/ely ompared it 7ith

other general or spei8 soring systems 1, 1@, 01, 0, 06, 0@, 03E. Ta;ing intoaount that the R59" relies only on renal untion it 7ould !e onei/a!le that theR59" prognosti apaity 7as inerior to that o other general sores :i.e. Aute#hysiology and Chroni Health "/aluation, Simpli8ed Aute #athophysiology Sore


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i. Sensiti/ity and spei8ity o 2 an !e signi8antly hanged !y the use odiuretis, and this issue is not spei8ally onsidered in the R59"lassi8ation'

ii. the 2 an only !e determined in patients 7ith a !ladder atheter inplae, 7hih, despite !eing ommon in 5C patients, is not reuent in other

hospitali?ed patients'iii. 5t is possi!le that the prediti/e a!ility o 2 ould !e inerior to that o

SCr, 7hih an e4plain the diBerene in terms o mortality !et7een the samelasses de8ned !y eah one o those riteria, o!ser/ed in studies that utili?ed!oth riteria to de8ne and lassiy A=5 11, 1, 6E. The apaity o the R59":using !oth riteria< to predit mortality an !e more sta!le than the a!ility othis lassi8ation employing only SCr 1E, 7hih orro!orates the linialutility o using simultaneously !oth riteria as proposed !y the ADK5 7or;group 3E.

9ith, the aetiology o A=5 and the reuirement or RRT are not onsidered in the R59"lassi8ation. 5n t7o studies that e/aluated 5C patients 7ith A=5 reuiringontinuous RRT, the R59" lassi8ation sho7ed less auity in prediting mortality

, E. 2ne possi!le e4planation or this phenomenon is that in !oth the studies,the linial se/erity o patients 7as so high that it ould not allo7 R59" todisriminate mortality aording to A=5 se/erity :i.e. !et7een the three lasses


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!aseline /alue;g>h ormore than hstaging system o aute ;idney in*ury 6Ea

Stage SCr UO

1↑ SCr '26.5 (mo!/L )'0.# mg/+L, or ↑SCr '150 200%

)1.5 2×, 6 h,

2 ↑ SCr >200 #00% )>2 #×, 12 h,

#!↑ SCr >#00% )>#×, or i &s"!in" SCr '#5#.6 (mo!/L )'*

mg/+L, ↑SCr '**.2 (mo!/L )'0.5 mg/+L,


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Setting

Incidence andcategoriation o!

A"I (%)

Mortality (%/relative

risk) AUROC

N Design RIF#$ A"I RIF#$ A"I RIF#$ A"I

F )1;.1,

Sg" 2

)10.1,Sg" #

)1.2,

)*1.#/2.;,

R )#0./2.$,I )#2.;/2.0,

F )55/#.6,

)#.;/#.6,

Sg" 1

)#0.$/#.5,Sg" 2

)#2.;/2.$,Sg" #

)5#.5/#.6,

Lssnigg et al.41 $.2*1 @ros"-i"7mu!i-"nr"

9:I )ny

-!ss,

)#.0,

R )2.2,

I )0.6,F )0.2,

9:I )nysg",

);.2,Sg" 1

)6.*,

Sg" 2

)0.0*,

Sg" #)1.;,

#0+ymor!iy

8o 9:I )#.6,9:I )ny

-!ss,

)2$.5/8S,

R )2/8S,

I )1/8S,F )##/8S,

#0+y

mor!iy

8o 9:I )2.;,

9:I )nysg",

)2#.1/8S,Sg" 1

)16.*/8S,

Sg" 2

)66.$/8S,

Sg" #)#;.2/8S, 8S 8S

Bonni+is et al.

40 16.$;*

R"ros"-i"7mu!i

-"nr"

9:I )ny

-!ss,

)#5.5,

R )$.6,I )11.1,

F )16.;,

9:I )ny

sg",

)2;.5,

Sg" 1

)$.5,

Sg" 2

)$.2,Sg" #

)1#.;,

=osi!

mor!iy

8o 9:I )1#.6,

9:I )ny

-!ss,)#6.5/

8S,

R )2.2/1.*,I )#2.#/1.,

F )*2.6/#.0,

=osi!

mor!iy8o 9:I )15.,

9:I )ny

sg",

)#6.*/8S,

Sg" )1

#*.5/2.0,

Sg" )2

2/1.,Sg" )#

*1.2/#.0, 8S 8S

s"rmmnn e

t al. 4 *1.1$2

R"ros"-i"7mu!i

-"nr"

9:I )ny

-!ss,)#5.,

R )1$.2,

I )11,

F )$.6,

9:I )ny

sg",

)#5.*,Sg" 1

)1.1,Sg" 2

)#.;,

Sg" #

)12.5,

=osi!

mor!iy

8o 9:I )8S,9:I )ny

-!ss,)#6.1/8S,

R )20./1.*,

I )*5.6/1.,

F )56.;/1.6,

=osi!

mor!iy8o 9:I )8S,

9:I )ny

sg",

)*0.*/8S,Sg" 1

)2./0.;,Sg" 2

)#5.;/1.1,

Sg" #

)5$./2.01, 0.;$ 0.;*0

Cardiac surgery

=s" et al.

46 2;2@ros"-i"7sing!"-"nr"

9:I )ny-!ss,

)*5.;0R )#0.1,

I )12.1,F )#.5,

9:I )ny

sg",

)**.$,

Sg" 1)##.$,

Sg" 2)6.$,

Sg" #)*.#,

=osi!

mor!iy

8o 9:I )0,

9:I )ny-!ss,

)*.$/8S,R )1.2/8S,

I );.;/8S,F )20/8S,

=osi!

mor!iy

8o 9:I )0,

9:I )ny

sg",

)*.;/8S,

Sg" 1)1.1/8S,

Sg" 2)0/8S,

Sg" #)*1.$/8S, 0.10 0.*0

ng!&"rg"r et

al. 4

*.;#6 R"ros"-i"7sing!"

-"nr"

9:I )ny

-!ss,

)1;.,R )1*.;,

I )#.5,F )0.6*,

9:I )ny

sg",

)26.#,Sg" 1

)2#.6,Sg" 2

)1.2,

Sg" #

=osi!

mor!iy

8o 9:I )0.6*,9:I )ny

-!ss, )$/*.5,R )#.;/8S,

I )1;.#/8S,

F )1.*/8S,

=osi!

mor!iy

8o 9:I )0.5#,9:I )ny

sg",)$.$/5.#,

Sg" 1

)2.6/8S,

0.;00 0.;20


9/18

Setting

Incidence andcategoriation o!

A"I (%)

Mortality (%/relative

risk) AUROC

N Design RIF#$ A"I RIF#$ A"I RIF#$ A"I

)1.5,

Sg" 2

)12.#/8S,

Sg" #)**.6/8S,

Ro&"r et al.

4 2*.$*$

@ros"-i"7sing!"

-"nr"

9:I )ny-!ss,

)#1.2,R )21.$,

I )5.,

F )#.6,

9:I )ny

sg",

)2.,

Sg" 1)22.,

Sg" 2)#.*,

Sg" #

)#.6,

=osi!

mor!iy

8o 9:I )1.*,

9:I )ny-!ss,

).;/8S,R )#.#/2.*0,

I )11.1/;.,

F )#6.*/*0.,

=osi!

mor!iy

8o 9:I )1.#,

9:I )ny

sg",

).1/8S,

Sg" 1)*.1/#.2,

Sg" 2)1*.2/12.*,

Sg" #

)#6.;/*#.;, 0.$;0 0.$0

•aA=5, aute ;idney in*ury' AR2C, area under the reei/er operating

harateristi' 5C, intensi/e are unit' R59", Ris; 5n*ury 9ailure oss o ;idneyuntion "nd(stage ;idney disease' A=5N' Aute =idney 5n*ury Net7or;' R, ris;' 5,in*ury' 9, ailure' NS, non(spei8ed.Table 4.

Comparison !et7een R59" and A=5N lassi8ations in terms o inidene andategori?ation o A=5 and its assoiation 7ith mortalitya

!tren"ths and limitations of the AKIN classification

The A=5N lassi8ation is a modi8ed /ersion o the R59" lassi8ation' thereore,their strengths and limitations are /ery similar to those aorementioned or the R59". The A=5N lassi8ation has, ho7e/er, some additional !ene8ts and limitations relatedto the modi8ations introdued to the R59" lassi8ation.

Strengths of the AKIN classification

9irst, the A=5 de8nition is only onsidered ater an adeuate status o hydration isahie/ed. Thereore, the A=5N lassi8ation, unli;e R59", adds important aetiologialinormation. Seond, the A=5N lassi8ation is !ased on SCr and not on P9R hanges. Third, the A=5N lassi8ation does not need !aseline SCr to de8ne A=5, although itreuires at least t7o SCr determinations 7ithin 63 h.

Limitations of the AKIN classification

9irst, the A=5N lassi8ation does not allo7 the identi8ation o A=5 7hen SCr

ele/ation ours in a time rame higher than 63 h. Seond, Stage o the A=5Nlassi8ation inludes three diagnosti riteria :Cr, 2 and RRT reuirement


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lassiying A=5, suh as the use :or non(use< o 2 and !aseline SCr, and o theestimated P9R instead o the /ariation in SCr.

The =idney Disease 5mpro/ing Plo!al 2utomes 7or; group reently om!ined theR59" and A=5N lassi8ations in order to esta!lish one lassi8ation o A=5 orpratie, researh and pu!li health. Thereore, A=5 has !een de8ned as an inrease

in SCr U. mg>d :U0. Fmol>< 7ithin 63 h' or an inrease in SCr to U1. times!aseline, 7hih is ;no7n or presumed to ha/e ourred 7ithin the prior @ days or aurine /olume o . m>;g>h or h. 9urthermore, A=5 has !een staged in se/erityaording to the A=5N riteria :Ta!le d :Q6 Wmol>d :U66Wmol>< o/er an unspei8ed time period, it instead reuire that the patient 8rstahie/e the reatinine(!ased hange spei8ed in the de8nition either U. mg>d:U0. Wmol>< 7ithin a 63(h time 7indo7 or an inrease o U1. times !aselineE. This hange !rings the de8nition and staging riteria to greater parity and simpli8esthe riteria @E. The integration o the ne7 !iomar;ers o A=5 into the liniallassi8ation ould inrease the sensiti/ity and spei8ity o A=5 diagnosis,

o/er7helming some o the limitations o the traditional mar;ers o ;idney untion,suh as Cr and 2 3E.#re/ious SetionNe4t Setion

#onflict of interest state$ent

None delared.

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6. et al. 2utome predition o aute renal ailure in medial intensi/e are. 5ntensi/e CareMed 1++1'1@)1+(06.CrossReMedlineIe! o SienePoogle Sholar

6.

1. Ori/et 9P,0. =lein;neht D$,. oriat #,6. et al

. Aute renal ailure in intensi/e are unitsYauses, outome, and prognosti ators ohospital mortality) a prospeti/e, multienter study. Crit Care Med 1++'06)1+0(1+3.CrossReMedlineIe! o SienePoogle Sholar

.

1. iano 9,0. #asual $

. Madrid Aute Renal 9ailure Study Cluster. "pidemiology o aute renal ailure) a prospeti/e,multienter, ommunity(!ased study. =idney 5nt 1++')311(313.CrossReMedlineIe! o SienePoogle Sholar

.

1. Sil/ester I,0. Oellomo R,. Cole

. "pidemiology, management, and outome o se/ere aute renal ailure o ritial illness inAustralia. Crit Care Med01'0+)1+1(1+1. doi)1.11>*[email protected]+66 .CrossReMedlineIe! o Siene

@. ↵

1. Cherto7 PM,0. Ourdi; ",. Honour M,

6. et al. Aute ;idney in*ury, mortality, length o stay, and osts in hospitali?ed patients. $ Am SoNephrol 0'1)(@. doi)1.11>S16@(06:39R"" 9ull Te4t

3. ↵

1. Oellomo R,0. Rono C,. =ellum $A,6. et al

. #ale/s;y # and the ADK5 7or;group. Aute renal ailureY de8nition, outome measures,animal models, uid therapy and inormation tehnology needs) the Seond 5nternationalConsensus Conerene o the Aute Dialysis Kuality 5nitiati/e :ADK5< Proup. CritCare06'3)R06. doi)1.11>S16@(06:@


12/18

. An assessment o the R59" riteria or aute renal ailure in hospitali?ed patients. Crit CareMed 0'6)1+1([email protected]! o SienePoogle Sholar

11. ↵

1. Hoste "A,0. Clermont P,. =ersten A,6. et al

. R59" riteria or aute ;idney in*ury are assoiated 7ith hospital mortality in ritially illpatients) a ohort analysis.Crit Care 0'1)[email protected] Sholar

10. ↵

1. 2stermann M,0. Chang RI

. Aute ;idney in*ury in the intensi/e are unit aording to R59". Crit CareMed 0@')13@(136.CrossReMedlineIe! o SienePoogle Sholar

1. ↵

1. Cru? DN,0. Oolgan 5,. #era?ella MA,6. et al

. North "ast 5talian #rospeti/e Hospital Renal 2utome Sur/ey on aute ;idney in*ury:N"i#HR2S(A=5*ni>d*p6+.MedlineIe! o Siene

1. ↵

1. =uitunen A,0. Lento A,. Suo*aranta(Zlinen R,6. et al

. Aute renal ailure ater ardia surgery) e/aluation o the R59" lassi8ation. Ann ThoraSurg0'31)60(6. doi)1.11>*ama.1++6.16@3 .CrossReMedlineIe! o Siene

1@. ↵

1. in CZ,0. Chen ZC,. Tsai 9C,6. et al

http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/01.CCM.0000224227.70642.4F&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16715038&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000238639300007&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=S%20Uchino&author=R%20Bellomo&author=D%20Goldsmith&publication_year=2006&journal=Crit%20Care%20Med&volume=34&pages=1913-1917http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-11-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc4915&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16696865&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=EA%20Hoste&author=G%20Clermont&author=A%20Kersten&publication_year=2006&journal=Crit%20Care&volume=10&pages=R73http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-12-2http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/01.CCM.0000277041.13090.0A&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17581483&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000248251600004&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=M%20Ostermann&author=RW%20Chang&publication_year=2007&journal=Crit%20Care%20Med&volume=35&pages=1837-1843http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-13-2http://dx.doi.org/10.1046/j.1525-1497.2003.20220.xhttp://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=clinjasn&resid=2/3/418http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=clinjasn&resid=2/3/418http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=clinjasn&resid=2/3/418http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-14-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=23/4/1203http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=23/4/1203http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=23/4/1203http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-15-2http://dx.doi.org/10.1093/jnci/djp409http://ckj.oxfordjournals.org/external-ref?access_num=16865083&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000241918800004&link_type=ISIhttp://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-16-2http://dx.doi.org/10.1001/jama.1994.03510400075038http://dx.doi.org/10.1001/jama.1994.03510400075038http://ckj.oxfordjournals.org/external-ref?access_num=10.1016/j.athoracsur.2005.07.047&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16427848&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000235142400022&link_type=ISIhttp://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-17-2http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/01.CCM.0000224227.70642.4F&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16715038&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000238639300007&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=S%20Uchino&author=R%20Bellomo&author=D%20Goldsmith&publication_year=2006&journal=Crit%20Care%20Med&volume=34&pages=1913-1917http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-11-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc4915&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16696865&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=EA%20Hoste&author=G%20Clermont&author=A%20Kersten&publication_year=2006&journal=Crit%20Care&volume=10&pages=R73http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-12-2http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/01.CCM.0000277041.13090.0A&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17581483&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000248251600004&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=M%20Ostermann&author=RW%20Chang&publication_year=2007&journal=Crit%20Care%20Med&volume=35&pages=1837-1843http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-13-2http://dx.doi.org/10.1046/j.1525-1497.2003.20220.xhttp://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=clinjasn&resid=2/3/418http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-14-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=23/4/1203http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-15-2http://dx.doi.org/10.1093/jnci/djp409http://ckj.oxfordjournals.org/external-ref?access_num=16865083&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000241918800004&link_type=ISIhttp://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-16-2http://dx.doi.org/10.1001/jama.1994.03510400075038http://ckj.oxfordjournals.org/external-ref?access_num=10.1016/j.athoracsur.2005.07.047&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16427848&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000235142400022&link_type=ISIhttp://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-17-2


13/18

. R59" lassi8ation is prediti/e o short(term prognosis in ritially ill patients 7ith auterenal ailure supported !y e4traorporeal mem!rane o4ygenation. Nephrol Dial

Transplant 0'01)03@([email protected]!strat>9R"" 9ull Te4t

13.

1. Arnaouta;is P$,0. Oihora A,. Martin TD,6. et al

. R59" riteria or aute ;idney in*ury in aorti arh surgery. $ Thora Cardio/asSurg 0@'16)16(1.CrossReMedlineIe! o SienePoogle Sholar

1+.

1. $en CC,0. Tsai MH,. Tian ZC,6. et al

. R59" lassi8ation an predit short(term prognosis in ritially ill irrhoti

patients. 5ntensi/e Care Med 0@')1+01(1+.CrossReMedlineIe! o SienePoogle Sholar

0. ↵

1. 2[Riordan A,0. Iong L,. MKuillan R,6. et al

. Aute renal disease, as de8ned !y the R59" riteria, post(li/er transplantation. Am $ Transplant 0@'@)13([email protected]! o SienePoogle Sholar

01. ↵

1. opes $A,0. $orge S,. Resina C,6. et al

. #rognosti utility o R59" or aute renal ailure in patients 7ith sepsis. CritCare 0@'11)63.CrossReMedlinePoogle Sholar

00.

1. Chen ZC,0. $en CC,. Tian ZC,6. et al

. Rie lassi8ation or prediting in(hospital mortality in ritially ill sepsis

patients. Sho; 0+'1)1+(16.CrossReMedlineIe! o SienePoogle Sholar

0. ↵

1. opes $A,0. $orge S,. Ne/es 9C,6. et al

. An assessment o the R59" riteria or aute renal ailure in se/erely !urnedpatients. Nephrol Dial Transplant0@'00)03.9R"" 9ull Te4t

06. ↵

1. opes $A,0. 9ernandes $,. $orge S,

http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=21/10/2867http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=21/10/2867http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=21/10/2867http://ckj.oxfordjournals.org/external-ref?access_num=10.1016/j.jtcvs.2007.08.039&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18023682&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000251244200025&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=GJ%20Arnaoutakis&author=A%20Bihorac&author=TD%20Martin&publication_year=2007&journal=J%20Thorac%20Cardiovasc%20Surg&volume=134&pages=1554-1560http://ckj.oxfordjournals.org/external-ref?access_num=10.1007/s00134-007-0760-6&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17605129&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000250407600010&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=CC%20Jenq&author=MH%20Tsai&author=YC%20Tian&publication_year=2007&journal=Intensive%20Care%20Med&volume=33&pages=1921-1930http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-20-2http://ckj.oxfordjournals.org/external-ref?access_num=10.1111/j.1600-6143.2006.01602.x&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17109735&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000242779400024&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=A%20O%27Riordan&author=V%20Wong&author=R%20McQuillan&publication_year=2007&journal=Am%20J%20Transplant&volume=7&pages=168-176http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-21-2http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc5722&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17430577&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=JA%20Lopes&author=S%20Jorge&author=C%20Resina&publication_year=2007&journal=Crit%20Care&volume=11&pages=408http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/SHK.0b013e31817d419e&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18520698&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000262573300006&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=YC%20Chen&author=CC%20Jenq&author=YC%20Tian&publication_year=2009&journal=Shock&volume=31&pages=139-145http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-23-2http://ckj.oxfordjournals.org/cgi/ijlink?linkType=FULL&journalCode=ndt&resid=22/1/285http://ckj.oxfordjournals.org/cgi/ijlink?linkType=FULL&journalCode=ndt&resid=22/1/285http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-24-2http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=21/10/2867http://ckj.oxfordjournals.org/external-ref?access_num=10.1016/j.jtcvs.2007.08.039&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18023682&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000251244200025&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=GJ%20Arnaoutakis&author=A%20Bihorac&author=TD%20Martin&publication_year=2007&journal=J%20Thorac%20Cardiovasc%20Surg&volume=134&pages=1554-1560http://ckj.oxfordjournals.org/external-ref?access_num=10.1007/s00134-007-0760-6&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17605129&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000250407600010&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=CC%20Jenq&author=MH%20Tsai&author=YC%20Tian&publication_year=2007&journal=Intensive%20Care%20Med&volume=33&pages=1921-1930http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-20-2http://ckj.oxfordjournals.org/external-ref?access_num=10.1111/j.1600-6143.2006.01602.x&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17109735&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000242779400024&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=A%20O%27Riordan&author=V%20Wong&author=R%20McQuillan&publication_year=2007&journal=Am%20J%20Transplant&volume=7&pages=168-176http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-21-2http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc5722&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17430577&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=JA%20Lopes&author=S%20Jorge&author=C%20Resina&publication_year=2007&journal=Crit%20Care&volume=11&pages=408http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/SHK.0b013e31817d419e&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18520698&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000262573300006&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=YC%20Chen&author=CC%20Jenq&author=YC%20Tian&publication_year=2009&journal=Shock&volume=31&pages=139-145http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-23-2http://ckj.oxfordjournals.org/cgi/ijlink?linkType=FULL&journalCode=ndt&resid=22/1/285http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-24-2


14/18

6. et al. An assessment o the R59" riteria or aute renal ailure in ritially ill H5L(inetedpatients. Crit Care 0@'11)61.CrossReMedlinePoogle Sholar

0.

1. Oagsha7 SM,0. Peorge C,. Pi!ney RT,6. et al

. A multi(enter e/aluation o early aute ;idney in*ury in ritially ill trauma patients. Ren9ail 03')31(3+.CrossReMedlineIe! o SienePoogle Sholar

0. ↵

1. opes $A,0. Pon\al/es S,. $orge S,6. et al

. Contemporary analysis o the inuene o the aute ;idney in*ury ater redued intensity

onditioning haematopoieti ell transplantation on long(term sur/i/al. Oone Marro7 Transplant03'60)1+(0.CrossReMedlineIe! o SienePoogle Sholar

0@. ↵

1. A!osai NZ,0. Tol!a ZA,. Heap M,6. et al

. The outome o aute renal ailure in the intensi/e are unit aording to R59") modelappliation, sensiti/ity, and predita!ility. Am $ =idney Dis 0'6)13(163.CrossReMedlineIe! o SienePoogle Sholar

03. ↵

1. Ahlstr]m A,0. =uitunen A,. #eltonen S,6. et al

. Comparison o 0 aute renal ailure se/erity sores to general soring systems in theritially ill. Am $ =idney Dis0'63)00(03.CrossReMedlineIe! o SienePoogle Sholar

0+. ↵

1. Oagsha7 SM,0. hino S,. Cru? D,6. et al

. A omparison o o!ser/ed /ersus estimated !aseline reatinine or determination o R59"lass in patients 7ith aute ;idney in*ury. Nephrol Dial Transplant 0+'06)0@+([email protected]!strat>9R"" 9ull Te4t

. ↵

1. Iai;ar SS,0. Oon/entre $L

. Creatinine ;inetis and the de8nition o aute ;idney in*ury. $ Am So Nephrol 0+'0)@0(@+.A!strat>9R"" 9ull Te4t

1. ↵

1. Shemesh 2,0. Pol!et? H,. =riss $#,6. et al

http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc5561&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17227575&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=JA%20Lopes&author=J%20Fernandes&author=S%20Jorge&publication_year=2007&journal=Crit%20Care&volume=11&pages=401http://ckj.oxfordjournals.org/external-ref?access_num=10.1080/08860220802134649&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18661407&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000258002700001&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=SM%20Bagshaw&author=C%20George&author=RT%20Gibney&publication_year=2008&journal=Ren%20Fail&volume=30&pages=581-589http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-26-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1038/bmt.2008.207&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18622411&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000260866100007&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=JA%20Lopes&author=S%20Gon%C3%A7alves&author=S%20Jorge&publication_year=2008&journal=Bone%20Marrow%20Transplant&volume=42&pages=619-626http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-27-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1053/j.ajkd.2005.08.033&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16310569&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000233933600005&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=NY%20Abosaif&author=YA%20Tolba&author=M%20Heap&publication_year=2005&journal=Am%20J%20Kidney%20Dis&volume=46&pages=1038-1048http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-28-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1053/j.ajkd.2006.04.086&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16860192&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000239629700010&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=A%20Ahlstr%C3%B6m&author=A%20Kuitunen&author=S%20Peltonen&publication_year=2006&journal=Am%20J%20Kidney%20Dis&volume=48&pages=262-268http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-29-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=24/9/2739http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=24/9/2739http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=24/9/2739http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-30-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=20/3/672http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=20/3/672http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=20/3/672http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-31-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc5561&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17227575&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=JA%20Lopes&author=J%20Fernandes&author=S%20Jorge&publication_year=2007&journal=Crit%20Care&volume=11&pages=401http://ckj.oxfordjournals.org/external-ref?access_num=10.1080/08860220802134649&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18661407&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000258002700001&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=SM%20Bagshaw&author=C%20George&author=RT%20Gibney&publication_year=2008&journal=Ren%20Fail&volume=30&pages=581-589http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-26-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1038/bmt.2008.207&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18622411&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000260866100007&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=JA%20Lopes&author=S%20Gon%C3%A7alves&author=S%20Jorge&publication_year=2008&journal=Bone%20Marrow%20Transplant&volume=42&pages=619-626http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-27-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1053/j.ajkd.2005.08.033&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16310569&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000233933600005&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=NY%20Abosaif&author=YA%20Tolba&author=M%20Heap&publication_year=2005&journal=Am%20J%20Kidney%20Dis&volume=46&pages=1038-1048http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-28-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1053/j.ajkd.2006.04.086&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16860192&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000239629700010&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=A%20Ahlstr%C3%B6m&author=A%20Kuitunen&author=S%20Peltonen&publication_year=2006&journal=Am%20J%20Kidney%20Dis&volume=48&pages=262-268http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-29-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=24/9/2739http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-30-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=20/3/672http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-31-1


15/18

. imitations o reatinine as a 8ltration mar;er in glomerulopathi patients. =idney5nt 1+3'03)3(33.CrossReMedlineIe! o SienePoogle Sholar

0. ↵

1. Molith M",0. Rodman ",. Hirsh CA,6. et al

. Spurious serum reatinine ele/ations in ;etoaidosis. Ann 5ntern Med 1+3'+)03(031.CrossReMedlineIe! o SienePoogle Sholar

. ↵

1. Hoste "A,0. =ellum $A

. Aute ;idney in*ury) epidemiology and diagnosti riteria. Curr 2pin Crit Care 0'10)1(@.CrossReMedlineIe! o SienePoogle Sholar

6. ↵

1. opes $A,0. 9ernandes #,. $orge S,6. et al

. Aute ;idney in*ury in intensi/e are unit patients) a omparison !et7een the R59" and theAute =idney 5n*ury Net7or; lassi8ations. Crit Care 03'10)R11.CrossReMedlinePoogle Sholar

. ↵

1. Oell M,0. il*estam ",. Pranath 9,6. et al

. 2ptimal ollo7(up time ater ontinuous renal replaement therapy in atual renal ailurepatients strati8ed 7ith the R59" riteria. Nephrol Dial Transplant 0'0)6(.A!strat>9R"" 9ull Te4t

. ↵

1. Maariello ",0. Soares M,. Lalente C,6. et al

. R59" lassi8ation in patients 7ith aute ;idney in*ury in need o renal replaementtherapy. 5ntensi/e Care Med0@')+@(.CrossReMedlineIe! o SienePoogle Sholar

@. ↵

1. Len;ataraman R,0. =ellum $A

. De8ning aute renal ailure) the R59" riteria. $ 5ntensi/e Care Med 0@'00)13@(1+.A!strat>9R"" 9ull Te4t

3. ↵

1. Mishra $,0. Dent C,. Tara!ishi R,6. et al

. Neutrophil gelatinase assoiated lipoalin :NPA< as a !iomar;er or aute renal in*ury aterardia surgery. anet0')101(103.CrossReMedlineIe! o SienePoogle Sholar

+. ↵

1. #ari;h CR,

http://ckj.oxfordjournals.org/external-ref?access_num=10.1038/ki.1985.205&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=2418254&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=A1985AXC0400017&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=O%20Shemesh&author=H%20Golbetz&author=JP%20Kriss&publication_year=1985&journal=Kidney%20Int&volume=28&pages=830-838http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-32-1http://ckj.oxfordjournals.org/external-ref?access_num=10.7326/0003-4819-93-2-280&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=6773457&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=A1980KD07200014&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=ME%20Molitch&author=E%20Rodman&author=CA%20Hirsch&publication_year=1980&journal=Ann%20Intern%20Med&volume=93&pages=280-281http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-33-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/MCC.0b013e3280102af7&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17077682&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000242480000002&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=EA%20Hoste&author=JA%20Kellum&publication_year=2006&journal=Curr%20Opin%20Crit%20Care&volume=12&pages=531-537http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-34-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc6997&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18755026&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=JA%20Lopes&author=P%20Fernandes&author=S%20Jorge&publication_year=2008&journal=Crit%20Care&volume=12&pages=R110http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-35-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=20/2/354http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=20/2/354http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=20/2/354http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-36-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1007/s00134-007-0535-0&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17310365&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000245170300005&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=E%20Maccariello&author=M%20Soares&author=C%20Valente&publication_year=2007&journal=Intensive%20Care%20Med&volume=33&pages=597-605http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-37-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=spjic&resid=22/4/187http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=spjic&resid=22/4/187http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=spjic&resid=22/4/187http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-38-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1016/S0140-6736(05)74811-X&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=15811456&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000228107600026&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=J%20Mishra&author=C%20Dent&author=R%20Tarabishi&publication_year=2005&journal=Lancet&volume=365&pages=1231-1238http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-39-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1038/ki.1985.205&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=2418254&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=A1985AXC0400017&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=O%20Shemesh&author=H%20Golbetz&author=JP%20Kriss&publication_year=1985&journal=Kidney%20Int&volume=28&pages=830-838http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-32-1http://ckj.oxfordjournals.org/external-ref?access_num=10.7326/0003-4819-93-2-280&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=6773457&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=A1980KD07200014&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=ME%20Molitch&author=E%20Rodman&author=CA%20Hirsch&publication_year=1980&journal=Ann%20Intern%20Med&volume=93&pages=280-281http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-33-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/MCC.0b013e3280102af7&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17077682&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000242480000002&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=EA%20Hoste&author=JA%20Kellum&publication_year=2006&journal=Curr%20Opin%20Crit%20Care&volume=12&pages=531-537http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-34-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc6997&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18755026&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=JA%20Lopes&author=P%20Fernandes&author=S%20Jorge&publication_year=2008&journal=Crit%20Care&volume=12&pages=R110http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-35-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=20/2/354http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-36-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1007/s00134-007-0535-0&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17310365&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000245170300005&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=E%20Maccariello&author=M%20Soares&author=C%20Valente&publication_year=2007&journal=Intensive%20Care%20Med&volume=33&pages=597-605http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-37-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=spjic&resid=22/4/187http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-38-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1016/S0140-6736(05)74811-X&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=15811456&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000228107600026&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=J%20Mishra&author=C%20Dent&author=R%20Tarabishi&publication_year=2005&journal=Lancet&volume=365&pages=1231-1238http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-39-1


16/18

0. Mishra $,. Thiessen(#hil!roo; H,6. et al

. rinary 5(13 is an early prediti/e !iomar;er o aute ;idney in*ury ater ardiasurgery. =idney 5nt0'@)1++(0.CrossReMedlineIe! o SienePoogle Sholar

6. ↵

1. #ari;h CR,0. A!raham ",. Anu;ie7i? M,6. et al

. rine 5(13 is an early diagnosti mar;er or aute ;idney in*ury and predits mortality inthe intensi/e are unit. $ Am So Nephrol 0'1)6(0.A!strat>9R"" 9ull Te4t

61. ↵

1. Hirsh R,0. Dent C,. #riem H,

6. et al. NPA is an early prediti/e !iomar;er o ontrast indued nephropathy in hildren. #ediatrNephrol 0@'00)03+(0+.CrossReMedlineIe! o SienePoogle Sholar

60. ↵

1. #ari;h CR,0. $ani A,. Melni;o/ LZ,6. et al

. rinary interleu;in(13 is a mar;er o human aute tu!ular nerosis. Am $ =idneyDis 06'6)6(616.CrossReMedlineIe! o SienePoogle Sholar

6. ↵

1. #ari;h CR,0. $ani A,. Mishra $,6. et al

. rine NPA and 5(13 are prediti/e !iomar;ers or delayed grat untion ollo7ing ;idneytransplantation. Am $ Transplant 0')1+(16.CrossReMedlineIe! o SienePoogle Sholar

66. ↵

1. ^hang #,0. Roth!lum ,. Han I=,

6. et al. =idney in*ury moleule(1 e4pression in transplant !iopsies is a sensiti/e measure o ellin*ury. =idney 5nt 03'@)3(16.CrossReMedlineIe! o SienePoogle Sholar

6. ↵

1. Mehta R,0. =ellum $A,. Shah SL,6. et al

. Aute =idney 5n*ury Net7or;) report o an initiati/e to impro/e outomes in aute ;idneyin*ury. Crit Care 0@'11)R1.CrossReMedlinePoogle Sholar

6. ↵

1. e/y "M,

http://ckj.oxfordjournals.org/external-ref?access_num=10.1038/sj.ki.5001527&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16710348&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000238969300035&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=CR%20Parikh&author=J%20Mishra&author=H%20Thiessen-Philbrook&publication_year=2006&journal=Kidney%20Int&volume=70&pages=199-203http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-40-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=16/10/3046http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=16/10/3046http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=16/10/3046http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-41-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1007/s00467-007-0601-4&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17874137&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000250755700013&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=R%20Hirsch&author=C%20Dent&author=H%20Pfriem&publication_year=2007&journal=Pediatr%20Nephrol&volume=22&pages=2089-2095http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-42-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1053/j.ajkd.2003.10.040&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=14981598&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000220538800002&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=CR%20Parikh&author=A%20Jani&author=VY%20Melnikov&publication_year=2004&journal=Am%20J%20Kidney%20Dis&volume=43&pages=405-414http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-43-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1111/j.1600-6143.2006.01352.x&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16827865&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000238465400021&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=CR%20Parikh&author=A%20Jani&author=J%20Mishra&publication_year=2006&journal=Am%20J%20Transplant&volume=6&pages=1639-1645http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-44-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1038/sj.ki.5002697&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18160964&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000253193100014&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=P%20Zhang&author=L%20Rothblum&author=WK%20Han&publication_year=2008&journal=Kidney%20Int&volume=73&pages=608-614http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-45-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc5713&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17331245&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=RL%20Mehta&author=JA%20Kellum&author=SV%20Shah&publication_year=2007&journal=Crit%20Care&volume=11&pages=R31http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-46-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1038/sj.ki.5001527&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16710348&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000238969300035&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=CR%20Parikh&author=J%20Mishra&author=H%20Thiessen-Philbrook&publication_year=2006&journal=Kidney%20Int&volume=70&pages=199-203http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-40-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=16/10/3046http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-41-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1007/s00467-007-0601-4&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17874137&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000250755700013&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=R%20Hirsch&author=C%20Dent&author=H%20Pfriem&publication_year=2007&journal=Pediatr%20Nephrol&volume=22&pages=2089-2095http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-42-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1053/j.ajkd.2003.10.040&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=14981598&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000220538800002&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=CR%20Parikh&author=A%20Jani&author=VY%20Melnikov&publication_year=2004&journal=Am%20J%20Kidney%20Dis&volume=43&pages=405-414http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-43-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1111/j.1600-6143.2006.01352.x&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=16827865&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000238465400021&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=CR%20Parikh&author=A%20Jani&author=J%20Mishra&publication_year=2006&journal=Am%20J%20Transplant&volume=6&pages=1639-1645http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-44-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1038/sj.ki.5002697&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18160964&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000253193100014&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=P%20Zhang&author=L%20Rothblum&author=WK%20Han&publication_year=2008&journal=Kidney%20Int&volume=73&pages=608-614http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-45-1http://ckj.oxfordjournals.org/external-ref?access_num=10.1186/cc5713&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=17331245&link_type=MEDhttp://scholar.google.com/scholar_lookup?author=RL%20Mehta&author=JA%20Kellum&author=SV%20Shah&publication_year=2007&journal=Crit%20Care&volume=11&pages=R31http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-46-1


17/18

0. Lisoli CM,. Hor7it? R5

. The eBet o aute renal ailure on mortality. A ohort analysis. $AMA 1++'0@)163+(16+6.CrossReMedlineIe! o SienePoogle Sholar

6@. ↵

1. assnigg A,0. Shmidlin D,. Mouhieddine M,6. et al

. Minimal hanges o serum reatinine predit prognosis in patients ater ardiothoraisurgery) a prospeti/e ohort study. $ Am So Nephrol 06'1)1+@(1.A!strat>9R"" 9ull Te4t

63. ↵

1. Oarrantes 9,0. 9eng Z,. 5/ano/ 2,6. et al

. Aute ;idney in*ury predits outomes o non(ritially ill patients. Mayo Clin

#ro 0+'36)61(61.CrossReMedlineIe! o SienePoogle Sholar

6+.

1. Oarrantes 9,0. Tian $,. La?ue? R,6. et al

. Aute ;idney in*ury riteria predit outomes o ritially ill patients. Crit CareMed 03')1+@(16.CrossReMedlineIe! o SienePoogle Sholar

. ↵

1. Oagsha7 SM,0. Peorge C,. Oellomo R

. or the AN^5CS Data!ase Management Committee. A omparison o the R59" and A=5Nriteria or aute ;idney in*ury in ritially ill patients. Nephrol Dial Transplant 03'0)1+([email protected]!strat>9R"" 9ull Te4t

1.

1. assnigg A,0. Shmid "R,. Hiesmayr M,6. et al

. 5mpat o minimal inreases in serum reatinine on outome in patients ater ardiothorai

surgery) do 7e ha/e to re/ise urrent de8nitions o aute renal ailure_ Crit CareMed 03')110+([email protected]! o SienePoogle Sholar

0.

1. $oannidis M,0. Metnit? O,. Oauer #,6. et al

. Aute ;idney in*ury in ritially ill patients lassi8ed !y A=5N /ersus R59" using the SA#S data!ase. 5ntensi/e Care Med0+')1+0([email protected]! o SienePoogle Sholar

.

1. 2stermann M,0. Chang RI

http://ckj.oxfordjournals.org/external-ref?access_num=10.1001/jama.1996.03530430033035&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=8622223&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=A1996UJ93700032&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=EM%20Levy&author=CM%20Viscoli&author=RI%20Horwitz&publication_year=1996&journal=JAMA&volume=275&pages=1489-1494http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-47-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=15/6/1597http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=15/6/1597http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=15/6/1597http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-48-1http://ckj.oxfordjournals.org/external-ref?access_num=10.4065/84.5.410&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=19411437&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000265618000005&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=F%20Barrantes&author=Y%20Feng&author=O%20Ivanov&publication_year=2009&journal=Mayo%20Clin%20Proc&volume=84&pages=410-416http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/CCM.0b013e318168fbe0&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18434915&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000255623100001&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=F%20Barrantes&author=J%20Tian&author=R%20Vazquez&publication_year=2008&journal=Crit%20Care%20Med&volume=36&pages=1397-1403http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-50-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=23/5/1569http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=23/5/1569http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=23/5/1569http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/CCM.0b013e318169181a&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18379238&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000254679900014&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=A%20Lassnigg&author=ER%20Schmid&author=M%20Hiesmayr&publication_year=2008&journal=Crit%20Care%20Med&volume=36&pages=1129-1137http://ckj.oxfordjournals.org/external-ref?access_num=10.1007/s00134-009-1530-4&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=19547955&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000270171900009&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=M%20Joannidis&author=B%20Metnitz&author=P%20Bauer&publication_year=2009&journal=Intensive%20Care%20Med&volume=35&pages=1692-1702http://ckj.oxfordjournals.org/external-ref?access_num=10.1001/jama.1996.03530430033035&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=8622223&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=A1996UJ93700032&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=EM%20Levy&author=CM%20Viscoli&author=RI%20Horwitz&publication_year=1996&journal=JAMA&volume=275&pages=1489-1494http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-47-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=jnephrol&resid=15/6/1597http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-48-1http://ckj.oxfordjournals.org/external-ref?access_num=10.4065/84.5.410&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=19411437&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000265618000005&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=F%20Barrantes&author=Y%20Feng&author=O%20Ivanov&publication_year=2009&journal=Mayo%20Clin%20Proc&volume=84&pages=410-416http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/CCM.0b013e318168fbe0&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18434915&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000255623100001&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=F%20Barrantes&author=J%20Tian&author=R%20Vazquez&publication_year=2008&journal=Crit%20Care%20Med&volume=36&pages=1397-1403http://ckj.oxfordjournals.org/content/6/1/8.full#xref-ref-50-1http://ckj.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ndt&resid=23/5/1569http://ckj.oxfordjournals.org/external-ref?access_num=10.1097/CCM.0b013e318169181a&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=18379238&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000254679900014&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=A%20Lassnigg&author=ER%20Schmid&author=M%20Hiesmayr&publication_year=2008&journal=Crit%20Care%20Med&volume=36&pages=1129-1137http://ckj.oxfordjournals.org/external-ref?access_num=10.1007/s00134-009-1530-4&link_type=DOIhttp://ckj.oxfordjournals.org/external-ref?access_num=19547955&link_type=MEDhttp://ckj.oxfordjournals.org/external-ref?access_num=000270171900009&link_type=ISIhttp://scholar.google.com/scholar_lookup?author=M%20Joannidis&author=B%20Metnitz&author=P%20Bauer&publication_year=2009&journal=Intensive%20Care%20Med&volume=35&pages=1692-1702


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