the

RecordU. S. DEPARTMENT OF

HEALTH. EDUCATION, AND WELFAREDecember 5, 1973Vol. XXV, No. 25 NATIONAL INSTITUTES OF HEALTH

Dr. Robert Levy NamedDirector, Div. of HeartVascular Diseases, NHLI

Dr. Robert I. Levy has been ap-pointed director of the Divisionof Heart and Vascular Diseases,National Heart and Lung Institute.

Dr. Levy replaces Dr. TheodoreCooper, NHLI Director, who hasserved as acting director of theDivision since its creation in July1972.

Dr. Levy has been with the In-stitute since 1963 when he joinedthe staff as a clinical associate inthe Molecular Disease Branch.

He has served since 1966 ashead of the branch's Section onLipoprotein Metabolism and Inter-vention, and since 1971 as chief ofthe Lipid Metabolism Branch. Hewill continue to hold both of thesepositions.

Dr. Levy will plan and directthe Institute's research and train-ing programs in heart and bloodvessel diseases.

This area encompasses the ma-jor killer diseases: hardening ofthe arteries (arteriosclerosis) andits complications (heart attack,stroke, and kidney failure); highblood pressure and hypertensiveheart disease; congestive heartfailure; congenital heart defects;rheumatic heart disease; variousabnormalities of heart rhythm,

NIAID Researchers May Have VisualizedVirus That Causes Infectious Hepatitis

•

Dr. Levy has published numerous pa-pers in the areas of lipid and lipopro-tein metabolism, atherosclerosis, nu-trition, and clinical disorders of bloodfats.

and other disorders of the circu-latory system.

Dr. Levy received his A.B. (withhighest honors and distinctions)

(See DR. LEVY, Page 7)

The investigators (I to r), Drs. Purcell, Kapikian, and Feinstone, sit at the elec-tron microscope that was used to observe the one millionth of an inch, spherical,virus-like particle. Its identification should aid in attempts to isolate thevirus in cell culture. (See story on hepatitis B discovery, page 8.)

By Madeleine Jacobs

Scientists at the National Institute of Allergy and Infectious Diseasesbelieve they have visualized, for the first time, the virus that causesinfectious heptatitis. v

This debilitating disease—which is accompanied by inflammation of theliver, fever, nausea, fatigue, andjaundice—afflicted a reported 54,-000 Americans last year. The truefigure may be ten times that be-cause of unreported cases.

The organism, which Drs. Ste-phen M. Feinstone, Albert Z. Ka-pikian, and Robert H. Purcell havecaptured on film, was found in thestools of patients experimentallyinfected with infectious hepatitis.

These stool specimens and serawere collected several years agoby other investigators who con-ducted volunteer studies of infec-tious hepatitis in Illinois.

The agent visualized by theNIAID scientists is a very small—27 nanometers or one millionth ofan inch—spherical, virus-like par-ticle. In appearance and size, itresembles the picornaviruses andparvo viruses.

Infectious hepatitis, or hepatitisA—as opposed to serum hepatitis,or hepatitis B—is usually spreadby direct contact or by contam-inated drinking water or food.

It frequently is the culprit inlarge community-wide outbreaks.Scientists have long suspected thatthe disease is caused by a virus

and have shown that it can betransmitted to volunteers.

However, efforts by many inves-tigators to isolate causative agentsin cell cultures have failed, andsuccess in transmitting the a^entto laboratory animals has beenlimited to a South American mon-key, a marmoset.

Attempts to find a virus or anantigen—a protein which coujdserve as a marker for the virus—in the serum of hepatitis A pa-tients have also been unsuccessful,possibly because the virus is pres-ent in the bloodstream for only ashort time.

Scientists know, however, thatstools of patients with hepatitis Aare infectious from approximately2 weeks before until 2 weeks afteronset of clinical symptoms.

The NIAID researchers decidedto examine stool specimens fromhepatitis A patients using immuneelectron microscopy (IEM).

Dr. Kapikian had previouslyused this method in detecting, ina stool filtrate, t h e "Norwalk"agent, which is morphologically

(Continued on Page S)

New $30 MillionTraining ProgramPlans Announced

Approximately $30 million willbe available this fiscal year in anew HEW research manpower pro-gram to support training at thedoctoral level in the bioniedicalsciences.

HEW Sec. Caspar W. Wein-berger recently announced detailsof the program and said that ap-plications for fellowship awardswill be accepted immediately.

The awards will be made foradvanced training in research inspecified shortage areas in biomed-ical and health-related sciencesonly. Study leading to the doctoralor other professional degree willnot be supported under this pro-gram.

Awards—which will be admini-stered by NIH and the Alcohol,Drug Abuse, and Mental HealthAdministration—are of two types:

Postdoctoral Research Fellow-ships are to be awarded in nation-al competition to individuals whohave already received the doctoralor equivalent degree.Details Explained

All applicants must be U.S. citi-zens or have been admitted to theUnited States for permanent resi-dence.

The basic stipend is $10,000 perannum. No dependency allowanceswill be provided. The institution atwhich each Fellow trains will re-ceive up to $3,000 per annum tohelp defray the necessary research

(See TRAINING PROGRAM, Page h)

Greetings to All Readers;Next Issue Will Be Jan. 3The NIH Record staff extends

greetings for the holiday sea-son to all of its readers.

Only one issue of the NIHRecord — now approaching its25th year of publication—ispublished in December.

Because of bindery sched-ules, the next Record will notbe off the press until Thurs-day, Jan. 3. Subsequent issueswill come out—as usual—onpaydays unless a holiday de-lays publication.

Page 2 December 5, 1973 THE NIH RECORD

RecordPublished biweekly at Bethesda, Md., by the Publications and ReportsBranch, Office of Information, for the information of employees of theNational Institutes of Health, Department of Health, Education, andWelfare, and circulated by request to interested writers and to investi-gators in the field of biomedical and related research. The content isreprintable without permission. Pictures are available on request.The NIH Record reserves the right to make corrections, changes or dele-tions in submitted copy in conformity with the policies of the paper andthe Department of Health, Education, and Welfare.

NIH Record Office Bldg. 3 1 , Rm. 2B-03. Phone 49-62125

Editor Frances W. DavisAssistant Editor Fay LevieroStaff Writer Ed Driscoll

Staff CorrespondentsADA, Melissa Howard; OC, Thalia Roland; DCRT, Joan Chase; DRG,§ue Meadows; DRR, Jerry Gordon; DRS, Cora M. Suit; FIC, Lois P.Meng; NCI, Carolann Hooton; NEI, Bonnie Friedman; NHLI, BillSanders; NIAID, Krin Larson; NIAMDD, Pat Gorman; NICHD, KathyKowalczyk; NIDR, Sue Hannon; NIEHS, Elizabeth Y. James; NIGMS,Wanda Warddell; NINDS, Carolyn Holstein; NLM, Ruth E. Armstrong.

Final Depot Location T r i o d i M i | a n° to Play Selectionsn fc.uu kiHUtA/* From Haydn, Ravel, Beethoven

B e t w e e n NIH, NNMC The ^ di Milano ^ performApproved by Metro *n the third concert of the 1973-

r r 74 Chamber Music Series of theThe Metro Board has given ap- Foundation for Advanced Educa-

proval for the final location of the tion in the Sciences, on Sunday,Medical Center Metro station on Dec. 9, at 4 p.m. in the MasurRockville Pike between NIH and Auditorium.the National Naval Medical Cen- This is the group's second Amer-ter. ican tour; they appeared at NIH

The depot entrance will be on during the 1971-72 FAEiS concertthe south side of South Drive, series. Their program will includeabout 200 feet west of Rockville selections from Haydn, Ravel, andPike. Beethoven. Admission is by ticket

No parking will be allowed at only.the terminal; however, the stationwill have 30 passenger drop-off location as well, and will provide(kiss 'n' ride) facilities for auto- public transportation to NIH em-mobiles and six Metrobus bays. ployees in areas to be served by_ - , _. . the feeder buses.Bus System Planned M e t r o e s t i m a t e s t h a t 1 6 3 0 0

A feeder bus system will serve passengers will use t h e stationcommunities to the east and west daily, and it is expected that aboutof the station, with_ a portion of one-third will be NIH and NNMCthese buses traversing the NIH employees, visitors, and patients.grounds. At a later date, the NIH Record

It is intended that the buses will provide a more complete de-serve as a shuttle for NIH em- scription of the approved stationployees to and from their work at NIH.

V ^ * * * ^ ^ L i i i I

RQCKVI .ET PIKE

WILSON. .DRJVE

\V NNMC

Dr. Waggoner is the author of severalpapers in the field of medical statis-tics.

'After-Hours' ProgramOffers College Courses

Over 60 college-level courses arebeing offered in 23 downtown Fed-eral buildings in the District ofColumbia this spring through theFederal After^Hours EducationProgram.

The College of General Studies,George Washington University,has undergraduate and graduatecourses leading to bachelor of sci-ence and master of science de-grees.

Registration will be held Jan. 9and 10 for the spring semesterbeginning the week of Jan. 21.

Tuition is $63Tuition is $63 per semester hour,

and all courses are 3 semesterhours.

Federal agencies are authorizedto pay tuition costs and other feesif courses are related to job re-quirements.

For further information, contactRobert W. Stewart, field represen-tative, GWU, 676-7018.

2nd Annual Davis Plan Bake SaleTo be Held Tomorrow, Dec. 6

Come one, come all to the secondannual Davis Bake Sale to be heldtomorrow (Dec. 6) from noon to1:30 p.m. in Bldg. 31, Room 11A-10,

Items for sale include cookies,cakes, cheese balls, and lots more.

Proceeds will toe donated to thePatient Emergency Fund throughthe Davis Plan.

"X" MARKS the approximate location of the recently-approved Metro station,

NIH Stage Band Will PresentConcert on Thursday, Dec. 13

The NIH Stage Band will pre-sent a concert on Thursday, Dec.13, at 8 p.m. in the Jack MasurAuditorium.

The free concert will featuretunes from the '40s and '50s, pro-gressive jazz, and current jazz-rock.

NIH employees, relatives, andfriends are invited to attend.

Dr. Deward E, WaggonerOf NCI Retires After20 Years with Gov't

Dr. Deward E. Waggoner, chiefof the Office of Program Analysisand Communication, Viral Oncolo-gy, Division of Cancer Cause andPrevention, NCI, retired recentlyafter 20 years of Federal service.

During his career as an ana-lytical statistician, Dr. Waggonerheld several overseas posts. In1953 he was sent on a 2-year mis-sion to Egypt as an advisor onhealth statistics.

From 1955 to 1958 he was chief,Natality Branch, National Office ofVital Statistics. In 1958 he wasagain stationed in the Ne>ar Eastas an advisor to the Governmentof Iran on a national system ofvital statistics.

From 1959 until his retirement,Dr. Waggoner held several postsat NIH in the program analysisarea.

A camping enthusiast, Dr. Wag-goner was presented with severalpieces of camping equipment at aluncheon held in his honor.

John Sharkey Dies;Top Finance Officer

John E. Sharkey, 52, Director of .the Office of Financial Manage- \ment, Office of the Director, diedunexpectedly on Nov. 29 in Holy >Cross Hospital, Silver Spiling, Md. 'He had been ill only a few days.

Mr. Sharkey came to NIH aschief of the Financial ManagementBranch in 1968, and was named

John E. SharkeyDirector of OFM a year later.

Before coming to NIH, he hadserved as a financial managementand budget officer in the NationalAeronautics and Space Adminis- i,tration and the Atomic EnergyCommission.

Mr. Sharkey was born in Cin-cinnati, Ohio, and was a graduateof Xavier University. He is sur-vived by his wife and 12 childrenat the family home in Gaithers-burg, Md.

The family requests that, in lieuof flowers, contributions be sent tothe NIH Patient Emergency Fund,

THE NIH RECORD December 5, 1973

\

Page 3

The Rise of the Energy Crisis at NIHResults in the Fall of the Thermostat

During these last balmy days ofIndian summer it sometimes seemshard to believe that the energycrunch is on. But the Office of En-gineering Services has been busydevising new ways of reducingenergy consumption at NIH.

The first and most obvious stepwas the resetting of heating ther-mostats in office and laboratoryareas to 68 degrees. As Dr. CharlesEdwards, HEW Assistant Secre-tary for Health, remarked:

"The President's recommenda-tion to reduce room temperatureto 68 degrees is quite consistentwith good health practices. So faras maintenance of good health isconcerned, mid-70's temperatures,to which many of us have becomeaccustomed, are just not neces-sary."Temperatures Adjusted

Settings in animal and otherspecial-purpose areas will also beadjusted. Temperatures in animalrooms may be lowered in gradualsteps, giving the animals time tobecome conditioned to their coolerenvironment.

In all cases, settings will be low-ered only after consultation withlab personnel indicates t h a t itwould be a feasible move.

Chilled water supply to manybuildings is shut off at this timeof the year to prevent coils fromfreezing and to conserve energy.

The unseasonably warm weatherin recent weeks has caused manyspaces to get uncomfortably warmbecause outside air cannot be usedeffectively to offset heat generatedby lighting, people, and equipment.Other Plans Explained

The overhead lighting systemcontributes many degrees of heatto the office temperature, andturning off all non-essential lightsis a sure way to lower room tem-perature and save energy as well.

Another plan set in motion byEngineering Services has been thereduction of ventillation (outsideair supply) in office buildings dur-ing nights and weekends. Air isre-circulated throughout the build-ings rather than pumped in fromthe outside.

Certain systems have been mod-ified to lower nightime tempera-tures in non-laboratory buildingsto 60 degrees.

Already the outside lighting sys-tem on the campus has been cutback. Lights illuminating the Na-tional Library of Medicine are nowturned off at 9-10 p.m.

Reductions in parking lot light-ing in selected areas are now lim-ited by existing equipment, but

1 design work is in progress toachieve more savings in this area.

The motor pool has been directlyaffected by the energy crisis. Itsgas allotment was reduced by 8

per cent, and a maximum speed forall Government vehicles has beenset at 50 miles an hour.

The motor pool further advisesall drivers to take the shortest,least congested route, and to avoid"jack rabbit" starts and stops.

The jitney service between thePoolesville farm and the NIH res-ervation has been discontinued.

Other energy-savers are beingconsidered but require considerablestudy to determine energy reduc-tion and cost benefits.

A re-examination of productsdesigned to reduce solar heat gainis in progress, a matter of particu-lar concern to buildings with largeglass exposures. Bldg. 31, for in-stance, has a number of heating-cooling problems because of itsmany-windowed facade.

Even such prosaic items as toil-ets and sinks have come under thescrutiny of Engineering Services.A spring-valve device that elim-inates leaks is being studied as analternate faucet model. Water con-servation becomes energy conser-vation, since electricity is used torun the pumps.

Dr. H. G. Fletcher, Jr.,Dies; Was With NIAMDD

Dr. Hewitt G. Fletcher, Jr., ofthe National Institute of Arth-ritis, Metabolism, and DigestiveDiseases, died recently at the ageof 56 after a long illness.

At the time of his death, hewas chief of the (Section on Carbo-hydrates in t h e Laboratory ofChemistry.

Dr. Fletcher received a Ph.D. de-gree in organic chemistry in 1942from the Massachusetts Instituteof Technology.

He was a chemist with AtlanticResearch Associates in 1940 and1941, and in the following 6 yearsserved as instructor in chemistryat M.I.T.

From 1945 to 1948, Dr. Fletcherwas a research associate and Chem-ical Foundation Fellow at NIH. In1951, he was named chief of theSection on Carbohydrates, NIAM-DD.

Dr. Fletcher authored over 170publications on the synthesis,structure elucidation, and biochem-istry of carbohydrates.

He also supervised a number ofpostdoctoral fellows through theNIH Visiting Scientists program.

Modern, Redesigned Car Pool LocatorsSoon to Be Installed in Buildings 10, 31

The new car pool locator, shown un-der construction, will be installed inthe middle of December.

Clothing for Kids DriveIs Now Underway at NIH

The large marked boxes thathave suddenly appeared in thehalls of NIH are part of this year'sClothing for Kids Campaign.

Any donation of clean, service-able clothing for pre-school andschool-age children would be ap-preciated. Hangers are also need-ed.

The drive will continue throughDec. 15.

Clothing deposit boxes have beenplaced in Bldgs. 1, 10, 12-A, 13,31, 35, and 38, as well as the West-wood, Landow, and Federal Build-ings.

Has the energy crisis put asqueeze on your gas tank? Do youwant to increase your gas mile-age? If you answer yes to both ofthese questions, then a oar pool isyour solution.

To ease the problem of findingemployees willing to join or forma car pool, the Travel and Admin-istrative Services Branch, OAS,will install two new modern carpool locators around the middle ofDecember.

One will be placed in the samelocation as the locator in Bldg. 31near the cafeteria. The other willbe situated in Bldg. 10 on the Bllevel near the cafeteria, R & Wstore, and bank.

Pockets are provided on the lo-cator for 3 x 5 cards in coordina-tion with areas on the map.

The new units consist of anorientation map of the WashingtonMetropolitan area and a locator.The map is divided into 20 num-bered grids which are broken downinto 12 additional sections and let-tered to key them to the locator.

The TASB will also provide cov-erage f o r Damascus, Frederick,and other areas not included onthe Metropolitan Washington map.

Because of proposed regulations,possible parking fees, increases ingasoline prices, and fuel shortages,employees are encouraged to ar-range for and use car pools.

Car pooling offers many advan-tages—saving gas and money; re-

Dr. Harley Sheffield (r), head. CellBiology and Immunology Section,NIAID, and NIH Credit Union presi-dent, presents Dr. John F. Sherman,NIH Deputy Director, with a cup com-memorating International Credit UnionDay. The NIH Federal Credit Union,one of the largest in the U.S. withassets totalling over $34 million, cele-brated its 33rd birthday by servingNIH employees an estimated 5,000cups of coffee and 4,800 doughnuts.

Ruth M. Bell, FormerNIMH Secretary, Dies

Ruth M. Bell, secretary to theNIMH chief of Clinical Care be-fore her retirement this past June,died Nov. 16 in Holy Cross Hos-pital following a long illness.

Mrs. Bell served as a medicalsecretary with the NIMH Labora-tory of Psychology as well as withNCI and NIAID. Her career atNIH covered more than 20 years;

A native of Rockport, Ind., Mrs.Bell attended public school thereand graduated from the LockyearBusiness College before coming toWashington, D.C. in 1945.

Mrs. Bell leaves her husband,Vance, of Adelphi, Md., her moth-er, Mrs. Minnie Mackey, of Rock-port; and three sisters, MaryHowes of Rockville, and NaomiEbley and Lucille Harris, of Rock-port.

Protect Personal Property;Special Precautions Urged

Happiness and joy go handin hand with the holiday sea-son. However, at this time ofyear, personal property lossesand theft also tend to increase.

The Office of Protection andSafety Management, OAS,urges employees to take spe-cial precautions to protecttheir property.

Lock car doors, keep attrac-tive items in a safe place outof sight, and do not leave of-fices unattended. The burdenof protecting personal prop-erty is on each employee.

ducing air pollution, and easingfrustration with traffic. Join a carpool now.

Page 4 December 5, 1973

Poinsettias, Plum Pudding, Parties, PlusCarols Mark Holidays for CC Patients

Each year Santa and his helpers preside at a Christmas party sponsored bythe Clifton Park Citizens Association. Patients and staff are invited.

Carols and roast turkey, poinsettias and plum pudding will mark theholidays this year for Clinical Center patients.

A full schedule of activities has been planned by the Patient ActivitiesSection and the Spiritual Ministryand Nutrition Departments.

Patients will make special tripsto see Santa, buy Christmas gifts,view the poinsettia show at theBotanical Gardens, and see the na-tional Christmas tree on the elipse.

They will trim trees and makeChristmas crafts and gifts. Enter-tainment will be provided by theScottish Rite Masons and the D.C.Annunciation Church choir.

Christmas Eve, carolers willvisit the nursing units and a Pro-testant carol service will be heldearlier in the week. Chanukkahcandle lighting ceremonies are alsoscheduled.

Parties will include the annualchildren's party presented by theClifton Park Citizens Association,a Holly Hop, and an open housefor patients and staff from 2 to 4p.m., Wednesday, Dec. 19.

The season's festivities will cul-minate in a New Year's Eve galawith games, music, favors, andprizes for patients of all ages.

TRAINING PROGRAM(Continued from Page 1)

costs to the institution.In addition, a limited number of

Institutional Research Fellowshipawards will be made to institutionsfor the support of individuals atthe postdoctoral level in fieldswhere there are critical manpowershortages and demonstrated na-tional need.

Application material for bothprograms — and information re-garding the specified fields—maybe obtained from the Office of Re-search Manpower, Division of Re-search Grants, NIH, Bethesda, Md.20014.

Capt. Jeanne M. ReidOf NI AM DD Receives1973 McLester Award

Capt. Jeanne M. Reid, USPHS,research dietician at the NationalInstitute of Arthritis, Metabolism,and Digestive Diseases, receivedthe 1973 MeLester Award at the80th annual meeting of the Asso-ciation of Military Surgeons of theUnited States held in Washing-ton last week.Plaque Presented

The bronze plaque and honorar-ium, provided by the Lederle Lab-oratories Division of AmericanCyanamid Company, were pre-sented to Capt. Reid "for outstand-ing contributions in metabolic min-eral balance studies for GeminiVII and Skylab programs."

Capt. Reid's work with the Na-tional Aeronautics and Space Ad-ministration began in 1965 withmetabolic studies as part of theGemini VII program. Since 1969she has been involved in the plan-ning and implementation of foodsused in metabolic balance studiesof the Skylab program. (See theOct. 9 issue of the Record.)

The Association of Military Sur-geons selects award winners foroutstanding work in the field ofnutrition and dietetics. The Led-erle-sponsored award honors Col-onel James Somerville MeLesterwho was a consultant to the Sur-geon of the American Expedition-ary Forces in World War I.

Applicants who submit materialby Jan. 1 will be notified by letterin May-June 1974 of the final ac-tion on their application.

Postmaster RequestsReduced Bulk MailingsOver Holiday Season

Due to the increased burden im-posed upon the U.S. Postal Serviceduring t h e holiday season, thePostmaster, Washington, D.C., re-quests that from Dec. 1 throughDec. 26, all bulk mailings of pam-phlets, books, forms, and otherprinted matter or supplies be with-held.

The NIH Mail Room will coop-erate with the Postal Service's re-quest. Bulk mailings during thi.sp e r i o d will be restricted tothose which are absolutely neces-sary.

A problem frequently encounter-ed in the Mail Room involvesthe handling of personal packagesand greeting cards which inter-fere with the delivery and dis-patch of official mail.

NIH personnel can help alleviatethe situation by mailing all per-sonal mail through regular USPSfacilities.

In addition, personal mail forNIH employees should be address-ed to the persons' home ratherthan their offices.

L. D. Weiford, Jr., R&W manager,congratulates Helene Thomas on herT4 years of service as R & W post-mistress. Mrs. Thomas will now workat the R&W activity desk since afully-automated facility was recentlyinstalled in the Clinical Center.

U.S. PHS Profile PublishedA. Profile of the United States

Public Health Service, 1798-1948,has been published by the NationalLibrary of Medicine.

The book was written under aPHS contract by Bess FurmanArmstrong, well-known newspaperwriter and author, who died short-ly after completing t h e manu-script.

Most of the original documentsused in the preparation of the bookcan be found in NLM, the Libraryof Congress, or the National Ar-chives.

A Profile may be purchased for$4.35 from the Superintendent ofDocuments, U.S. GovernmentPrinting Office, Washington, D.C.20402.

Marjorie Guthrie NamedNIGMS Council Member

Marjorie M. Guthrie, nationallyprominent lay health leader andwidow of folk singer Woody Guth- Krie, has been named to a 4-yearterm on the Advisory Council ofthe National Institute of GeneralMedical Sciences.

A former creative dancer and in-structor with the Martha Grahamtroupe, Mrs. Guthrie undertook tofoster medical research and serv-ices 6 years ago by founding theCommittee to Combat Hunting-ton's Disease.

Her change in careers followedthe death of her husband in 1967from Huntington's disease, an in-herited disorder of the nervoussystem which affects men and wo-men alike, occurs most often inmiddle life, and usually is fatalwithin 5 to 15 years of onset.

The OCHD, which works closelywith health, research, and socialworkers to assist Huntington'sdisease patients and their families,now has 48 chapters in the UnitedStates and affiliates in Canada,England, Scotland, and Australia.

THE NIH RECORD December 5, 1973 Page 5

When You Commute to Work by BicycleYou Might Follow These Suggestions

Dr. Harold Wooster, chief, Research and Development Branch,Lister Hill National Center for Blomedical Communications, NLM,is Safely Chairman of the Potomac Pedalers Touring Club. Heoffers some suggestions that future NIH Mice commuters mightfollow when riding to work.

Had you thought about riding a bicycle to work to conserve gas ? Doyou live 5 miles or less from campus ? Do you think you would like toexperiment with commuting by bicycle ?

Let me offer some hints about bicycle safety.1. For commuting, a good three-speed is better than a cheap 10-speed.

It's more reliable and less likelyto get ripped off.

2. Make sure that your bike isin top mechanical condition. OldGeorgetown Road during rush houris no place for a brake failure. Geta safety check-up from a bike shopif necessary.

3. It gets dark around 5 p.m.now. Montgomery County law saysthat all bicycles must show a whitelight in front and a red light inthe rear. Do not ride after darkwithout these lights.

Leg lights (two-headed flash-lights strapped on the legs) arecute and sexy but don't show youwhere you are going.

I like generator lights in front;some of my friends swear by bat-teries. There is no substitute for agood two-cell battery light in therear.

4. Be visible. Slather reflectivetape liberally on your bike. Weara bright colored jacket, yellow ororange—not red, which is loud inthe daytime but looks black by

y -

Dr. Wooster waits at a stop sign fortraffic to subside. He is wearing abright yellow nylon jacket and anorange crash helmet. From behind, aluminescent triangle, reflector, reflect-ing tape, and tail light make his bikeeasy to see at night.

headlight.Put reflective tape on your

jacket. Be drab and inconspicuousduring duty hours, but be a peacockon your bike.

5. Be a rodent on the road. Amouse sticks close to the walluntil he dashes for the open spaces.

Ride close to the right-hand sideof the road, or even on sidewalks.

NIH has fantastic sewer grat-ings which you can ride over; thestandard Montgomery County grat-ings are bike traps and should beavoided.

Do not cut in and out of traffic.At traffic lights take advantage ofyour dual status and turn pedes-trian when safe to do so.

6. Plan your route. The way youdrive to work isn't necessarily thebest way to travel by bicycle. Stayoff main roads (Rockville Pike, OldGeorgetown Road) until close tocampus.

NIH is bounded by a network ofsuburban residential streets. Usethem. A good rule of thumb is tostay off roads that don't allowparking.Keep Head on Shoulders

7. Wear a crash helmet. You puta lot of time and money into yourhead—try to keep it together.

8. Remember, with few excep-tions, bicycles are subject to thesame laws that govern automo-biles.

For technical advice on bicycles,call Dr. Wooster on Ext. 64441.

Med. Professor TalksOn DMSO Research

Dr. Jack C. de la Torre, a spe-cialist in neuropharmacology, Uni-versity of Chicago, will talk on theexperimental use of DMSO— di-methyl sulfoxide—in trauma re-search at the second symposium onDMSO at the N.Y. Academy ofScience, Jan. 9-11. The research onthis drug was supported by agrant from the National Instituteof Neurological Diseases andStroke.

Dr. de la Torre, who is assistantprofessor in the departments ofsurgery (neurology) and psychia-try, will describe results from us-ing DMSO in experimental studiesof spinal cord injuries, stroke, andgunshot wounds, compared to re-sults from other drugs now inclinical use.

He will also discuss an experi-mental technique to predict motorfunction recovery utilizing evokednerve and brain potentials, beforeand after the use of DMSO andother drugs.

Soviet U.S. ResearchersMeet to Assess ResultsOf Joint Cancer Studies

At the end of the meetings, Dr. Rau-scher (I) and Dr. Trapeznikov held afinal discussion on the collaborativeprogram. The Russian scientist agreedwith the NCI Director, who said," . . . we accomplish much more forthe cancer patient than we could byworking independently."

The U.S.-U.S.S.R. Joint Subcom-mittee on Oncology held its firstmeeting, Nov. 12-14, at the Nation-al Cancer Institute. The sub-committee's coordinators are Dr.Frank J. Rauscher, Jr., Director,National Cancer Institute, for theUnited States, and Prof. N. N.Blokhin, Director, Institute of Ex-perimental and Clinical Oncology,for the Soviet Union.

The meeting assessed the resultsof collaborative projects undertak-en since the initial agreement wassigned by the two countries onMay 23, 1972.

Participants discussed projectsand programs and formulated plansfor future cooperation in majorareas of cancer research. Theseareas are cancer chemotherapy,leukemia and tumor viruses of ani-mals and man, mammalian somaticcell genetics related to neoplasia,and immunotherapy of tumors.

The subcommittee reported onseveral important results of the co-operative program. They are:

Protocols have been establishedfor mutual cooperation on the fouroriginal oncologic problems; jointinvestigations have been initiated;an effective program for the ex-change of scientists has beenachieved; both sides have also ex-changed drugs and strains of vi-ruses which are under study, andseven meetings have been plannedfor 1974.

These programs were approvedby Dr. Rauscher and Dr. N. N.Trapeznikov, the Soviet DeputyCoordinator for the U.S.-U.S.S.R.cooperative program on malignantneoplasms. Dr. Trapeznikov is theDirector for Science, Institute ofExperimental and Clinical Oncol-ogy.

Dr. Rauscher expressed appreci-

'People's Forum' HeldOn Contracting Issue

Dr. Robert S. Stone, NIH Direc-tor, met with employees in a "peo-ple's forum" held last Tuesday,Nov. 27, in Masur Auditorium.

The meeting brought togetherNIH-EEO Officer Raymond Jack-son, Dr. Stone, and many lowergrade service workers concernedabout t h e issue of "contractingout."

A number of service areas, in-cluding laundry and housekeeping,are being examined to evaluatewhether an outside contractorcould do the work more econom-ically.

Dr. Stone emphasized the factthat management was studying thesituation to determine what futurecourse would most benefit the en-tire NIH community.

Questions came fast and furious-ly from the floor. Workers, feelingtheir jobs were in jeopardy, re-peatedly voiced concern that if lowgrade, entry level positions arecontracted out, an important ave-nue for upward mobility at NIHwould be eliminated.

Both Dr. Stone and Mr. Jacksonstressed that the meeting was heldto promote free dialogue and ex-change of information.

The "people's forum" made onepoint crystal clear: any decisionwhich may be reached on "con-tracting out" will have to weigh"costs" in human as well as eco-nomic terms.

Dr. James R. Ganaway (r), veterinaryofficer, receives the PHS Commenda-tion Medal from Dr. Joe R. Held,DRS Director, for advancing knowledgeof laboratory animal diseases—"par-ticularly for designing methods tomaintain animal health."

ation to the Soviets for their ef-forts in making the sessions pro-ductive.

He stated that "In getting thevery best of Soviet science togeth-er with the very best of Americanscience we accomplish much morefor the cancer patient than wecould by working independently."

Dr. Trapeznikov said he agreedwith Dr. Rauscher, and consideredthe results so far as ". . . indica-tive of the success that will beachieved in this joint program."

Page 6 December 5, 1973 THE NIH RECORD

Safety Tips for NIH HEPATITIS A VIRUS MAY HAVE BEEN VISUALIZED

ACCIDENTAL

PUNCTURE

A puncture wound from a con-taminated needle poses a hazardfor all laboratory personnel. Pol-lowing these tips could reduce theincidence of puncture wounds:

1. Use extreme care in handlingall needles.

2. Never discard a contaminatedneedle in a waste basket.

3. Never place unsheathed need-les into plastic bags.

4. Always recap the needle be-fore placing in a clean-up tray.

5. In case of puncture, cleansewound immediately.

6. Report punctures to thenearest employee health unit atonce.

For more information on safedisposal of needles and syringes,contact the Environmental ServicesBranch, Ext. 66034.

NIAMDD Forms SectionOn Chemical Immunology

A section on Chemical Immunol-ogy has been established in theArthritis and Rheumatism Branchof the National Institute of Arth-ritis, Metabolism, and DigestiveDiseases.

Under the direction of Dr.Henry Metzger, the section staffwill conduct research on problemsrelated to the structure of immu-noglobulins and their interactionwith antigens and cell surfaces.

Dr. Metzger, a PHS medicalofficer, is a former staff memberof the Section on Connective Tis-sue Diseases, ARB.

A graduate of Columbia Univer-sity School of Medicine, his chiefinterests lie in both clinical andbasic research in autoimmunediseases.

In a parallel action, Dr. RobertT. Simpson has been named chiefof the Section on DevelopmentalBiochemistry in the NIAMDD'sLaboratory of Nutrition and En-docrinology.

(Continued from Page l)

similar to the hepatitis A agent.The Norwalk agent was found tobe associated with a form of acuteinfectious nonbaeterial gastroente-ritis—intestinal flu—in humans.

The IEM method involves theuse of serum from convalescentpatients which usually contains an-tibody specific for a causative or-ganism. This antibody, when mix-ed with infective material, coatsthe infecting particles and makesthem appear in aggregates orgroups or as readily recognizableindividual units.

The procedure enables the recog-nition—not possible by convention-al electron microscopic examina-tion—of a very small virus whichmay be present in small numbers.

In their initial experiment, theNIAID team examined stool fil-trates which had been obtainedfrom four adult volunteers, beforeand after they were infected withhepatitis A in the Illinois study.

The scientists found the small,virus-like particles in two of thefour acute illness specimens afterincubation with serum from a con-valescent hepatitis A patient. Incontrast, they could not detect par-ticles in any of the four pre-infec-tion specimens.

Using the stool filtrates derivedfrom one of the acute phase speci-mens that had detectable particles,the scientists examined severalgroups of sera for antibody to thisvirus-like antigen.Antibody in Volunteers

They found antibody to the anti-gen in all sera from six volunteerstudy patients—four from Illinoisand two from an investigation car-ried out in 1967 in New York.

None of these volunteers showedevidence of antibody prior to infec-tion. In addition, the NIAID groupfound serologic evidence of infec-tion with the virus-like particle insix patients who had naturally ac-quired infectious hepatitis.

Three of these were students

at the College of the Holy Crossin Massachusetts during the 1969hepatitis outbreak there and threewere scientists who acquired thedisease in American Samoa.

In other experiments, the inves-tigators were unable to detect anyrelationship between the hepatitisA antigen and the "Australia" orhepatitis B antigen which is asso-ciated with hepatitis B disease.

In addition, they were unable todetect a serologic relationship be-tween the hepatitis A antigen andthe Norwalk agent.

The scientists also tested twosamples of commercially preparedimmune serum globulin, which pro-tects against or modifies hepatitisA illness.

They found that one of the lotscontained a substantial quantity ofantibody, whereas the other con-tained only a moderate quantity ofantibody to the newly-found hepa-titis A antigen.Further Testing Suggested

The investigators suggest thattesting for antibody to hepatitis Aantigen may prove useful in stan-dardizing the potency of immuneserum globulin.

The NIAID investigators, whoreported their work in the currentissue (December 7) of Science, con-clude that their data strongly sug-gest that the observed small virus-like particle is the causative agentof hepatitis A.

Electron microscopic identifica-tion of the virus should aid in at-tempts to isolate the virus in cellculture. Growing a supply of virusis a necessary prerequisite to vac-cine manufacture.

More immediately, the discoveryof this virus-like antigen and thedevelopment of a technique able todetect antibody to it provide, forthe first time, •& means of diagnos-ing and studying hepatitis A.

These findings may provide aspur to research on hepatitis Aanalogous to that provided to hep-atitis B research by the discoveryof the hepatitis B antigen.

Drs. Kouwenhoven, ZollReceive Lasker Award

Dr. William B. Kouwenhovenand Dr. Paul M. Zoll have beennamed recipients of the 1973 Al-bert Lasker Award for ClinicalMedical Research.

Much of the work for whichthey were honored was supportedby grants from the National Heartand Lung Institute.Heart Massage Pioneer

Dr. Kouwenhoven, department ofsurgery, Johns Hopkins UniversitySchool of Medicine, was cited fororiginating closed chest cardiacmassage and for his contributionsto techniques for the control ofpotentially fatal heart-rhythm dis-turbances, including the develop-ment of devices for both open andclosed chest defibrillation.

Closed chest cardiac massage re-quires only the hands for the rhy-thmic application of pressure tothe breastbone.

In victims of cardiac arrest, therhythmic compression of the heartbetween breastbone and spinal col-umn maintains its output of bloodand, combined with mouth-to-mouth resuscitation, can sustainlife until definitive therapy be-comes available.

The technique has been taughtto firemen, rescue workers, andpolicemen and its application hassaved thousands of lives.

Dr. Paul M. Zoll, Department ofMedicine, Harvard Medical Schooland Beth Israel Hospital, was citedfor his contributions in developingelectrical techniques for restartingarrested hearts, correcting heart-rhythm disturbances, and sustain-ing a regular heartbeat with arti-ficial pacemakers in patients withchronic heart-rhythm abnormali-ties.Pacemakers Not Uncommon

Today, an estimated 60,000Americans have received artificialpacemakers for the control of dis- (abling, chronic arrhythmias, and an ',estimated 12,000 to 15,000 new [pacemaker implants are done an- jnually.

Dr. Zoll also developed the '-theory and technique for the con-tinuous monitoring of heart rhy- Ithm now widely practiced in hos- fpital coronary care units.

Immune electron microscopy reveals these virus-like particles in a concentratedfiltrate prepared from a stool specimen of a patient with hepatitis A. Mag-nification is 225,000 times.

Symphony Orchestra to PresentConcert, Sunday, December 16

The NIH Symphony Orchestra, Iconducted by Robert Webb, willpresent a concert at 3 p.m., Sun-day, Dec. 16, in the Masur Audi- Jtorium.

The program will include theFugue in G Minor by Bach, Sym-phony No. 31 by Hadyn, and Sym-phony No. 5 by Schubert.

There is no charge for admis-sion.

THE NIH RECORD December 5, 1973 Page 7

PEOPLE'S REPUBLIC OF CHINA SCIENTISTS spent 3 days at NIH, Nov. 5-7.The nine-member group—for whom briefings were held—visited a numberof laboratories. Part of the group was interested in the physiology of pain,the other, in biomedical engineering. Their tour included (top, left to right)visits to Dr. Ronald Dubner, chief of NIDR'S Neurophysiology and Anesthesi-ology Branch; Dr. Ante L. Padjen, visiting scientist from Yugoslavia, NIMH, atSt. Elizabeths, and Dr. Arnold W. Pratt, DCRT Director, who is explaining howthe remote terminal in his office works. Later (r) the Chinese visitors met withDr. Robert S. Stone, NIH Director.

NIEHS-EPA ConferenceCovers Possible EffectsOf Ingested Asbestos

The National Institute of En-vironmental Health Sciences andt h e Environmental ProtectionAgency recently co-sponsored aconference in Durham, N.C, todiscuss what is known and sus-pected about the possible effects ofingested asbestos.

The conference brought togetherapproximately 140 scientists fromvarious parts of the world to out-line research needed to assess thethreat of swallowed asbestos.

Particles of asbestos breathedin with air can sometimes affectthe lining of the abdomen or chestto produce a form of cancer calledmesothelioma.Frequency Unexpected

Also, gastro-intestinal cancers,such as cancer of the esophagus,stomach, colon and rectum, tend tooccur more frequently than ex-pected in persons exposed to as-bestos dust.

One explanation suggests thatasbestos fibers coughed up fromthe lung are swallowed, and thushave a chance to enter the gut wallto induce cancer.

However, at present too littleis known to draw any conclusionsabout the poissible adverse effectsof asbestos taken in with food andWater.

Over the next 5 years, NIEHSwill invest approximately $2.9 mil-lion to support an EnvironmentalHealth Sciences Center to concen-trate on asbestos research.

The center has been establishedat the Mount Sinai School of Med-icine in N.Y.C. under the directionof Dr. Irving J. Selikoff, a pioneerin asbestos epidemiology.

DR. LEVY(Continued from Page 1)

from Cornell in 1957. He attendedYale University Medical School,where he received his M.D. degree,cum laude, in 1961 and also wonthe Keese Prize for his researchthesis.

As chief of the Institute's LipidMetabolism Branch for the past2 years, Dr. Levy has been respon-sible for the establishment of acontinent-wide network of LipidResearch Clinics.

These Clinics are engaged in re-search and demonstration projectsdesigned to improve the diagnosisand management of blood fat dis-orders and determine the preva-lence of these disorders in the pop-ulation and their association withcoronary artery disease.

Investigators at the Clinics willalso determine whether loweringblood cholesterol in high risk pa-tients will prevent or retard thedevelopment of atherosclerosis—the most common form of arterio-sclerosis and the Nation's numberone killer.

Applications Now Available forPHS Art Exhibit Next Spring

An art exhibit will be held inconjunction with the PHS Profes-sional Association's meeting nextApril in Washington, D.C.

Those who register for the con-ference and their immediate familymembers (over age 16) are eligibleto submit applications for entriesin six categories: oils and acrylics;water colors; sculptures; graphicsincluding pen and ink, etchings,lithographs, colages, etc.; photo-graphs, black and white, and pho-tographs, color.

The entry fee is $2 and applica-

HEW Makes CFC Goal; NIH, Campaigners CitedEight NIH employees were sin-

gled out for special honors at theCombined Federal Campaign vic-tory celebration held last Thurs-day, Nov. 29, at the HEW NorthAuditorium to mark the first timethe Department reached its CFC

The overall Government groupalso surpassed its goal.

HEW Sec. Caspar W. Weinber-ger, CFC chairman for the Metro-politan area, praised the partici-pants' efforts in making the cam-paign such a success.

Dr. Robert S. Stone, NIH Direc-tor, accepted the 1974 CFC Awardpresented to NIH for outstandingachievement.

According to the latest NIH tabu-lation — with contributions stilltrickling in — $207,334 has beencollected here.

Secretary Weinberger also pre-sented a Special Recognition Awardto Dr. Stone.

The Secretary's Certificates forOutstanding Performance werepresented to Kent A. Smith, ofNLM, CFC Coordinator for NIH;James J. Bozek, FIC; Jerome N.Kerkhof, NLM; Leland W. Mose-dale, OD, and John A. Wassell,DRG.

A Special Secretary's Recogni-tions may be obtained by callingDr. John M. Lynch, chief of theEmployee Health Service, Ext.64411.

tion Award for creativity in con-ducting fthe campaign went to twoNHLI employees, Mildred F. Get-tings and Marceline H. Lee.

Special recognition was also giv-en to Tony d'Angelo, ODA—NIHStage Dance Band. The band play-ed at numerous CFC rallies and atthe victory celebration.

After the presentations, theaward winners and special guestsattended a reception in the SnowRoom.

EHS Changes ArrangementsFor Care of NIH Personnel

The Employee Health Serv-ice has announced that it ischanging its emergency healthcare arrangements during non-regular work hours. However,there will be no change inservices between 8:30 a.m. and5 p.m. on working week days.

EHS will no longer be openon weekends and holidays.This ruling became effectivelast Sunday (Dec. 1).

Employee emergency medi-cal care during non-regularworking hours will now beavailable under an expandedarrangement with SuburbanHospital.

A detailed! account of thenew proceedings is given in amemorandum that has hada desk-to-desk distributionthroughout NIH.

Page 8 December 5, 1973 THE NIH RECORD

Discovery of Elusive Virus That CausesHepatitis B Gives Clue for Prevention

Dane particles and filamentous forms of hepatitis B antigen found in hepatitisB disease. Magnification, 1 50,000 times.

NIH-supported scientists may havehuman serum hepatitis.

The disease causes 6,000 deaths areceived infected blood productsduring transfusions.

Scientists have long suspectedthat serum hepatitis is caused by avirus which can be transmittedfrom person to person by infectedblood materials.Nucleic Acid Found

Now, investigators have foundevidence t h a t the agent whichcauses serum hepatitis containsnucleic acid, the genetic materialfor many viruses and other organ-isms, including man.

This is the first clue that theagent has one of the most im-portant attributes of a conven-tional virus. Until this time, thevirus itself had never been isolatedand cultivated in living cells, norhad scientists shown conclusivelythat it contained nucleic acid.Findings Are Important

These findings are important ifa vaccine is to fee developed toprevent the disease, and could alsolead to a better test for detectinginfectious blood and blood prod-ucts.

For several years, scientists haveknown that a foreign substance,or antigen, is associated withserum hepatitis (also called hepa-titis B).

In the sera of hepatitis patientsor carriers this antigen exists inthree physical forms: a smallsphere; a filamentous form, and alarger, more complex particle hav-ing an outer coat and a smallerinner core.

The complex form is called theDane particle after the British in-vestigator who first described it in1970.

Since the Dane particle's appear -

found the elusive virus that causes

year, mostly in people who have

ance is similar to that of a virus,scientists have been trying to de-tect associated nucleic acid or someother marker of viral activitywhich could confirm that the par-ticle is the long-sought-after hepa-titis B virus.

The team of scientists found justsuch a marker—an enzyme calledDNA polymerase which directs thesynthesis of deoxyribonucleie acid(DNA), one type of nucleic acid.NIAID-AEC Sponsored

Molecular Anatomy Laboratoryscientists—sponsored by the Na-tional Institute of Allergy and In-fectious Diseases and the AtomicEnergy Commission—first examin-ed plasma samples from chroniccarriers of hepatitis B antigen us-ing electron microscopy.

Dr. John L. Gerin of MAN Lab-oratory selected eight patientswhose sera had relatively highconcentrations of Dane particles.The sera from these individualswere then concentrated and puri-fied by Dr. Gerin.Results Noted

Working with these preparations,a t e a m of Stanford UniversityMedical School scientists detectedDNA polymerase activity in eachof the eight sera. In contrast, theStanford researchers were unableto detect any DNA polymerase ac-tivity in seven samples of serafrom people who did not have hep-atitis B antigen.

From other experiments, the in-vestigators determined that thecore of the Dane particle mostlikely contains a DNA "template"which directs t h e synthesis ofDNA.

These findings, although indirect,

Dr. Stephen G. WaxmanDelivers First LectureIn Tuve Memorial Series

Dr. Stephen G. Waxman, clinicalfellow in neurology at HarvardMedical School and a resident inthat specialty at Boston City Hos-ton City Hospital, was the firstguest lecturer in the new TrygveW. Tuve Memorial Seminar Seriesheld recently at NIH.

The series—named in memoryof the late associate director formanpower, National Institute ofGeneral Medical Sciences—honorsoutstanding young scientists sup-ported through NIH intramuraland extramural programs.Was NIGMS Trainee

Its objective is to foster the ex-change of ideas and informationbetween these two programs.

Dr. Waxman is one of 50 gradu-ates of the NIGMS Medical Scien-tist Training Program, which pro-vides support for combined medi-cal and scientific training to high-ly-motivated persons of superiorresearch potential.

In his lecture on structural dif-ferentiation of axons, Dr. Waxmanobserved that these axons—fibers

suggest that the Dane particle isthe human hepatitis B virus thatscientists have been seeking for solong and that the virus itself is aDNA virus.

A better test for infectious bloodand blood products could be onein which polymerase activity wouldbe a marker of infectivity. Cur-rently, screening tests for hepa-titis B rely upon detection of hepa-titis B antigen.Researchers Listed

In addition, identification of theDane particle as the virus of hepa-titis B would be an important stepin development of a vaccine, since,traditionally, isolation and growthof a virus in tissue culture is avital prerequisite.

This research was carried outby Drs. Paul M. Kaplan, WilliamS. Robinson, and Richard L. Green-man of the Stanford UniversitySchool of Medicine; Dr. John L.Gerin of the MAN Laboratory,Rockville, and Dr. Robert H. Pur-cell of NIAMDD's Laboratory ofInfectious Diseases. (Dr. Kaplan isnow at the MAN Laboratory.)Other Support Given

In addition to NIAID and ABCsupport, the scientists receivedfunds from the National CancerInstitute; the National Institute ofArthritis, Metabolism, and Diges-tive Diseases, and the Damon Run-yon Memorial Fund.

A report of the research is pub-lished in the November issue ofthe Journal of Virology.

Dr. Michael Sela to GiveNIH Lecture on Dec. 12

Fogarty Scholar Dr. MichaelSela will present the next NIHLecture, Probing into Immun-ological Phenomena: F r o mMolecule to Cell, on Wednes-day, Dec. 12, in the MasurAuditorium.

Dr. Sela is dean of the fac-ulty of biology and head ofthe department of chemicalimmunology at the WeizmannInstitute of Science, Rehovot,Israel.

that carry impulses from nervecells to other areas of the centraland peripheral nervous systems—are not simple "transmissionlines" but far more complex struc-tures requiring intensive study.

New information on the struc-ture and function of axons is need-ed, Dr. Waxman said, to determinewhat happens in nerve cells whenprotective coatings around nervetissues are damaged by diseaseor injury.Myelin Destroyed

Such damage may result aftersevere injury to the spinal cordor in diseases such as multiplesclerosis. In either ease, the mye-lin sheath which protects the fi-bers is often destroyed or severelydamaged.

The Tuve Memorial SeminarSeries was established by friendsof Dr. Tuve shortly after his deathin 1972 at the age of 38.Funds Contributed

They contributed funds to theFoundation for Advanced Educa- ,tion in the Sciences to support anappropriate activity in his mem-ory.

During much of his 14-year ca-reer at NIH, Dr. Tuve played akey role in the administration ofthe MSTP and other NIGMS train-ing activities for young scientists.

Dr. Waxman holds both the'M.D. andPh.D. degrees from Albert EinsteinCollege of Medicine in New York.

U.S. GOVERNMENT PRINTING OFFICE! 1973 544-802/7