the offices of technology management fiscal 2012 annual...

Fiscal 2012 Annual Report • The Offices of Technology Management • University of Illinois 1

University of Illinois at Urbana-Champaign • University of Illinois at Chicago

The Offices of Technology ManagementFiscal 2012 Annual Report

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Contents


University of Illinois

Message from the Vice

President for Research 04

Five-Year History By Campus 05

Chicago

Director’s Message 23

Updates & Highlights 24

Fiscal 2012 Summary 26

Royalties & Royalty Distribution 27

Start-Ups 28

Patents 30

Contacts 34

Urbana-Champaign

Director’s Message 07

Updates & Highlights 08

Fiscal 2012 Summary 14

Royalties & Royalty Distribution 16

Start-Ups 17

Patents 18

Contacts 35

4 University of Illinois • The Offices of Technology Management • Fiscal 2012 Annual Report

Since I became Vice

President for Research

a little more than a

year ago, many new

opportunities requiring

university leadership

have emerged. Yet at

the same time, our core

mission remains, and we’ve worked hard to grow

the impact of the programs and services for which

the OVPR is responsible.

As you will see in this annual report, we had a

notable fiscal 2012. A few highlights:

• The Research Park was named “Outstanding

Research Park” of 2011 by the Association of

University Research Parks.

• The Chicago Innovation Mentors program,

which the University of Illinois at Chicago

helped to co-found, has been extremely

successful and has expanded to include the

Urbana campus.

• Along with our partners, the University

secured funding for a “University Center”

grant to support entrepreneurship in East

Central Illinois.

• We took occupancy of a new space in the 1871

incubator in Chicago to connect the start-up

community with our faculty and students.

• The Research Park broke ground on a new

development phase.

• The Office of Technology Management at

UIC launched the Proof-of-Concept Gap

Funding Initiative.

• The University became the exclusive

education partner of Chicago Ideas Week

and Think Chicago—giving our students

unprecedented access to the Chicagoland

entrepreneurial community.

Lawrence Schook, Vice President for Research

Chicago Urbana Total

Disclosures 184 223 407

U.s. Patent applications filed 238 194 432

U.s. Patents Issued 30 76 106

licenses & options 44 46 90

start-Ups 7 5 12

royalties Earned $17.05M $6.14M $23.19M

Fiscal 2012 Totals

• “Share the Vision”—a technology showcase

sponsored by the Urbana Office of Technology

Management—brought more than 50 venture

capitalists and industry executives to campus

to spotlight innovation and technology on the

Urbana campus.

I am very proud of the progress my team has

made in such a short time frame and I am

optimistic for the future. Stay tuned to see

where fiscal 2013 leads us!

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U.S

. Pat

ents

Is

sued

FY2008 FY2009 FY2010 FY2011 FY2012

363

120

243

333

130

203

326

146180

346

164 182

407

184223

Five-Year History By Campus: Fiscal 2008 – Fiscal 2012In

vent

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Dis

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U.S

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Num

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of

Star

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ps

FY2008 FY2009 FY2010 FY2011 FY2012

367

184 183

347

202

145

309

166 143

349

183 166

432

238194

FY2008 FY2009 FY2010 FY2011 FY2012

54

16

38

57

15

42

93

24

69

91

23

68

106

30

76

FY2008 FY2009 FY2010 FY2011 FY2012

5.47

1.51

3.96

5.39

1.66

3.72

4.75

1.69

3.06

4.27

1.25

3.02

4.63

1.57

3.05

FY2008 FY2009 FY2010 FY2011 FY2012

61

18

4349

16

33

61

21

40

99

4455

90

44 46

FY2008 FY2009 FY2010 FY2011 FY2012

2

11

56

86

8

35

20

8

12 12

75

FY2008 FY2009 FY2010 FY2011 FY2012

10.558.72

4.48 4.24

15.67

5.12

15.20

9.086.12

19.08

12.71

6.36

23.46

17.05

6.41

CHICAGO COMBInED URBAnA-CHAMPAIGn

6 University of Illinois at Urbana-Champaign • The Offices of Technology Management • Fiscal 2012 Annual Report

Urbana-Champaign

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Fiscal 2012 Annual Report • The Offices of Technology Management • University of Illinois at Urbana-Champaign 7

I am proud to present this

report on the successes

and activities of fiscal

year 2012. As always,

our accomplishments

are a direct result of

engagement with the

University’s stellar

community of researchers and innovators.

This year we used the knowledge we’ve gained

from a decade of achievements and experiences to

spur new ideas that increased both our outreach

and our output.

We put ambitious new programs in place. In April

we hosted a technology showcase that attracted

corporate executives and venture capitalists from

around the country, which led to numerous new

opportunities. We created a mobile applications

program to support the development process, from

enabling access to developer tools to assisting in

design and posting apps in the marketplace.

We’ve been exploring new pathways for

innovation transfer, in particular ways in

which we can provide services to those in

the humanities, arts, education, and social

sciences. We’re getting to know the faculty on

the Springfield campus so we can protect and

commercialize UIS innovations.

We partnered with our campus and our

community. Last winter we collaborated with

the organizers of Champaign-Urbana’s annual

Innovation Celebration to host two awards

celebrating entrepreneurs on campus.

We are proud to have worked with the

Office of Sponsored Programs and Research

Administration (OSPRA) and campus leadership

to help formulate the intellectual property

components in the Abbott-UI Center for

nutrition, Learning and Memory, and in the Dow

Chemical sponsored research agreement.

As new start-ups launched, we worked closely

with our colleagues across campus in units

supporting entrepreneurship. Our strong

relationships with industry representatives

and technology transfer offices in Chicago led

to an invitation to join the Chicago Innovation

Mentors network, which will help our faculty

access a truly world-class group of executives

and venture capitalists.

And we’ve had to be responsive to legislative

changes and court rulings, which have significantly

affected the landscape for protecting and

commercializing university inventions.

To help with all of these efforts, we’ve added

to our elite team of student interns, adding

specialists in mobile development and marketing,

and an intern to help our outreach efforts on the

Springfield campus.

We are an office that promotes innovation; this

year we discovered it in ourselves.

We are an office that promotes innovation; this year we discovered it in ourselves.

Lesley Millar, Director


OTM’s SharetheVision Showcase Helps Advance UI Technologies to MarketThe Office of Technology Management’s first Share the Vision Technology Showcase, on April 5 and 6, 2012, was held to facilitate business relationships between Illinois faculty entrepreneurs and venture capitalists and corporate executives.

As a result of the showcase:

• More than 50 venture capitalists and industry executives from a broad range of sectors attended, including representatives from Ameren, Arch Venture Partners, Astellas Venture Management, Bostik, Elanco Animal Health, Hopewell Ventures, Nidus Partners, Novartis, Raytheon, and Rockwell Collins.

Share the Vision 2012 Directory of Faculty Presenters 1Share the Vision 2012 Technology ShowcaseDirectory of Faculty Presenters

Office of Technology Management

FacultyDirectory-v5.indd 1 3/14/12 1:36 PM

Updates & Highlights• The ChicagoTribune

attended and subsequently wrote about the University’s role in preparing engineering and computer science students for careers in start-up companies.

• 20 different companies have expressed interest in 29 of the presenting faculty and 8 of the presenting start-ups.

The event incorporated presentations from faculty, start-up companies, and keynote speakers.

From left: Lesley Millar, Errol Arkilic, Orlando Saez and Lawrence

Schook. Photo: coUrtEsy of Donna WIlM

• Matthew Wheeler: Customized Implantable Therapeutics for Wound Healing

The 30 faculty and student start-up company presentations included:

• Autonomic Materials Inc: Provides a range of self-healing solutions compatible with most coating chemistries

• Effimax Solar: Specializes in a nanotexturing technique to produce the solar industry’s most powerful silicon cells

• GlucoSentient: Using a personal glucose meter to detect target drug molecules and contaminents

• Nuvixa: Enhancing video presentation suites

The 39 faculty presenters included:

• Rashid Bashir: Microfluidics and nanotechnology for Point-of-Care Diagnostics

• Jennifer Bernhard: Package Integrated Antennas • Stephen Boppart: Disease Detection and Diagnosis via

Optical Coherence Tomography • Donna Cox: The Art of Advanced Scientific Visualization • Brendan Harley: Orthopedic and Soft Tissue Engineering• Jennifer Lewis: Printing Functional Materials • John Rogers: Bio-Integrated Electronics for Consumer and

Clinical Applications • William Sanders: Assured Cloud Computing • Wilfred van der Donk: Discovery and Manipulation

of new Antibiotics


Innovation Celebration 2012

Photo: coUrtEsy of ElIzabEth KEllnEr

Our 3 keynote speakers were:

• Errol Arkilic, Innovation Corps Program Director at the national Science Foundation;

• Orlando Saez, Deputy Director, Entrepreneurship, Innovation & Technology, Department of Commerce & Economic Opportunity, State of Illinois

• Chris Williamson, Executive Director of Information Technologies at Wolfram Research

Partnering with Local Group to Celebrate Inventors and Entrepreneurs In February 2012, the Office of Technology Management was pleased to partner with the organizers of Champaign’s annual Innovation Celebration to host two award categories specific to breakthroughs coming from our campus.

MORE THAn 250 PEOPLE ATTEnDED THE EVEnT,

CELEBRATInG WInnERS In 10 AWARD CATEGORIES.

The two awards hosted by the Office of Technology Management were for Innovation Discovery and Technology Transfer. Eighteen faculty members were nominated.

Innovation Discovery Award Recognizes an individual or group from the University of Illinois’ Urbana campus who has disclosed to the University’s Office of Technology Management a groundbreaking discovery with potential for significant societal impact.

2012 Winner: Dr. Yi Lu Yi Lu has already had commercialization success with his DnAzymes for detecting heavy metals in environmental water supplies, licensed to ANDalyze, a company he co-founded. His new discovery is engineering DnA to test for organic compounds such

as glucose in blood and other organic markers in biological samples. This research is now the basis for the start-up GlucoSentient. Yi Lu has actively engaged with the OTM for more than 15 years; he has disclosed 41 inventions and has 14 issued patents.

Technology Transfer Award Recognizes an individual or group from the University of Illinois’ Urbana campus who has engaged with the University’s Office of Technology Management to successfully commercialize an innovation.

2012 Winner: Dr. David Kranz As co-founder of both Immuven, founded in 2008, and Biodisplay, founded in 1999 and later sold to Abbott Laboratories, David Kranz has consistently demonstrated his entrepreneurial vision and capability. Immuven harnesses a powerful, emerging technology, T-cell

receptors, which are a unique class of immune-targeting therapeutic and diagnostic agents. The company is focused on developing drugs that can be used to treat infectious diseases and cancer. David Kranz has worked with the OTM for more than 22 years; he has disclosed 21 inventions and has more than 20 issued patents.

Mobile Application Services Help OTM Reach Out Across CampusThe OTM has received 15 mobile application disclosures since announcing in early 2011 that the office can help developers of U of I-owned apps get access to developer tools and submit apps to the marketplace. Twelve of the 15 apps were disclosed since January 2012, reflecting increasing momentum for app development on campus.

One of the most striking aspects for OTM has been the sixteen different units across campus represented by our app developers. They are:

• Administrative Information Technology Services (AITS)

• Business• Civil & Environmental

Engineering

• Computer Science• Crop Sciences• Education Administration• Electrical & Computer

Engineering• ACES Extension


• Housing• Information Trust Institute• Journalism• Library• Mechanical Science &

Engineering• nCSA• Office of the Registrar• Public Affairs

In addition to application disclosures, we also received requests for help creating apps. To meet this need, we have hired our first Mobile Development Intern, Robert Cheung, an undergraduate majoring in computer science and finance.

notable Licensing PartnershipsIn addition to licensing 5 start-up companies last year, the office also negotiated several licenses with existing firms. Some are confidential, but those that are public include:

Sigma-Aldrich, headquartered in St. Louis, MO, is a leading life science and high technology company. Sigma-Aldrich has licensed two membrane scaffold proteins used in nanodisc technology, developed by Stephen Sligar, Director of the School of Molecular and Cellular Biology.

AllyChem, a major organoboron chemical manufacturer located in Dalian, China, has obtained license rights enabling them to provide volume quantities of greater than 1kg of MIDA boronates, a class of boronic acid surrogates developed by Martin Burke.

Connect with Us The OTM maintains an active presence on multiple social media sites, including Twitter, Facebook, and LinkedIn. We are especialliy active on Twitter, which provides a platform

for us to publicize campus research breakthroughs and the achievements of our start-ups. We currently reach more than 1,000 entrepreneurially minded people, on campus and off, through our Twitter account.

Connect with us @ILinnovations

Fiscal 2012 Start-Up MilestonesMany of our start-ups logged important achievements and received media attention last year. Here are just a few:

• Citrix Systems acquired U of I start-up Bytemobile, a leading provider of data and video optimization solutions for mobile network operators. Bytemobile’s customers

serve more than 2 billion subscribers and process more than 20 petabytes of data traffic through customer networks daily.

• Catylix, which develops better methods for producing biologically-active compounds with improved pharmacokinetic properties, launched their first product and was featured in Chemical & Engineering News.

• Cazoodle, which builds new search engines by transforming web content into databases, launched Place of Mine, an online service that aggregates apartment listings from thousands of websites. The company also graduated from EnterpriseWorks to the Research Park’s Atkins Building.

• Dioxide Materials, with a focus on reducing carbon dioxide emissions, was a finalist in the Clean Energy

Challenge in Chicago and was featured in Science.

• EdenPark Illumination, which develops microplasma lighting technologies, received a Small Business Innovation Research (SBIR) grant from the Department of Energy.

• Yi Lu’s glucose sensing meter, the basis for the start-up Glucosentient, was one of 21 inaugural projects selected for an nSF Innovation Corps (I-Corps) award. A Chemical & Engineering News article on the glucose meter featured a quote referring to it as “amongst the freshest and most exciting ideas in biosensing.”

• Student start-up IntelliWheels, developing innovative wheelchair technology, was featured on Gizmodo.com.

@ILinnovations now has over 1,000 followers


• Metabolomx, a diagnostic company focused on the identification of lung cancer from breath, announced study results reporting 80% accuracy in lung cancer detection, comparable to a CT scan. The company was also awarded a $1.14 million Small Business Innovation Research (SBIR) contract by the national Cancer Institute and was featured in Businessweek.

• MC10, which develops electronics that can fold, stretch, twist, and conform to three dimensional surfaces, raised $14.85 million in Series B financing, including a $2.25 million investment from Windham Venture Partners. The company formed a Sports Advisory Board to help shape the next generation of athletic performance monitoring devices. Board members include Matt Hasselbeck and Grant Hill. Press coverage included a feature in Scientific American.

• Nuvixa, a developer of gesture-based video communication and presentation solutions, launched the StagePresence enhanced video presentation suite and received funding from AMD Ventures.

• Pattern Insight’s president and founder, Yuanyuan Zhou, won an Association of Computing Machinery (ACM) Distinguished Scientist award. The company also sold its Log Insight product, together with its team and technology, to VMware.

• Semprius, an innovator in high-concentration photovoltaic (HCPV) solar modules, set a world record for photovoltaic module efficiency, reaching 33.9 percent (active area). The company raised $3 million in funding in January and an additional $7.5 million in March. Press coverage included a feature in Forbes.

• SolarBridge, a supplier of electronics for solar panels, received $25 million in Series D financing and will use the funding to expand into Europe. The round was led by Shea Ventures LLC and included Battery Ventures, Rho Ventures, and Osage University Partners. SolarBridge was also featured in MIT’s Technology Review.

• Eastman Renewable Materials acquired TetraVitae Biosciences, a developer of renewable chemicals, including bio-based butanol and acetone.

• Three start-ups were approved to receive funding from the state’s new Invest Illinois Venture Fund, the venture capital arm of the state’s Advantage Illinois program. The companies are ANDalyze, Diagnostic Photonics, and Nuvixa.

AURP Honors Research ParkThe Association of University Research Parks (AURP) named the Research Park at the University of Illinois at Urbana-Champaign the 2011 Outstanding Research Park during its annual Awards of Excellence ceremony in December.

The Outstanding Research/Science Park Achievement Award recognizes parks that excel in bringing technology from the laboratory to economically viable business activities, promoting the growth of businesses, jobs, and public revenue.

I-Start Helps Overcome BarriersEnterpriseWorks launched the I-Start Entrepreneur Assistance Program (I-Start) as a competitive matching award program targeted to University researchers who have strong potential to commercialize technology through new company formation. The program helps new businesses access a suite of first-year startup services, including business development, legal setup, SBIR application, bookkeeping assistance, and marketing assistance, all at discounted cost.

The Illinois Department of Commerce and Economic Opportunity (DCEO) awarded a grant to Enterprise-Works to help fund the program. Combined with funding from the Research Park, it is anticipated that 15 new startup firms can participate in the program over an 18-month launch period.

Chicoine Scholar Raises OTM Profile on Springfield CampusThis past year the OTM began working more closely with faculty at the University of Illinois at Springfield to recognize possible innovations. One of the first steps to closer collaboration was selecting a Chicoine Scholar from the Springfield campus.

The David and Marcia K. Chicoine Science and Technology-Based Economic Development Scholarship was established to provide an award to a student willing to be engaged in the University’s economic development mission. The 2012 Chicoine scholarship was awarded to Stephanie Willig, a communications major from the Springfield campus.

Working with OTM staff, Stephanie surveyed research programs across the UIS campus to determine which innovators could benefit from OTM’s services.

The Chicoine Scholar for 2013 is Rebecca Hoke, a psychology major from the Springfield campus.

12 University of Illinois at Urbana-champaign • the offices of technology Management • fiscal 2012 annual report

OTM Out & About

• advanced Manufacturing Partnership Meeting; ann arbor, MI• association of University technology Managers (aUtM)

annual Meeting; anaheim, ca• aUtM central regional Meeting; oklahoma city, oK• aUtM Meeting; louisville, Ky• battery Power conference; nashville, tn• bIo; boston, Ma• cropWorld north america; charlotte, nc• ibIo Index; chicago, Il• Institute of biological Engineering; Indianapolis, In• licensing Executive society (lEs) annual Meeting;

san Diego, ca• lEs IP 100; Phoenix, az• Materials science & technology conference; columbus, oh• Microscopy society conference; nashville, tn• ncEt2; Washington, Dc• Pittcon; orlando, fl• radiological society of north america annual show;

chicago, Il• Meetings with venture capital firms; boston, Ma

last year, professionals from otM attended and presented at many conferences and tradeshows around the country.


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Mechanical Science and Engineering (MechSE)

Computer Science

Materials Science & Engr

Crop Sciences

Agricultural & Biological Engr

Bioengineering

Food Science & Human nutrition

Institute for Genomic Biology

nuclear, Plasma, & Radiological Engr (nPRE)

Aerospace Engineering

BiochemistryChemical & Biomolecular EngrCivil & Environmental EngPhysicsAdvanced Digital Sciences CenterAnimal SciencesCoordinated Science LaboratoryLibrary

Materials Research LabMicrobiologynCSA

Portfolio Snapshot

1 12# of disclosures

Market Area Strengths


Fiscal 2012 SummaryUrbana Fiscal 2012 - Colleges, Departments & UnitsColleges/Departments/Units in blue submitted their first disclosures in FY2012.

College/Department/Unit DisclosuresU.S. Patent

Applications FiledU.S. Patents

IssuedLicenses &

Options

Campus Total 223 194 76 46

College of Agricultural, Consumer, and Environmental Sciences

39 15 5 10

Agricultural & Biological Engineering 9 2 1 1

Agricultural & Consumer Economics 1

Animal Sciences 4 2 2 3

Cooperative Extension 1 2

Crop Sciences 14 3 1 4

Food Science & Human nutrition 11 7 1 1

Human & Community Development 1

Information Technology & Communications Services

1

national Soybean Research Lab 1

natural Resources & Environmental Sciences

2 1 1 2

College of Applied Health Sciences 2 1

Kinesiology & Community Health 1

Speech & Hearing Science 1 1

College of Business 2

Business Administration 1

College of Business - Admin Offices 1

College of Education 2 1

Education Administration 1

Education Policy 1

Educational Psychology 1

College of Engineering 106 129 55 19

Aerospace Engineering 5 8

Bioengineering 12 10 3

Civil & Environmental Engineering 5 4 4

Computer Science 14 10 3 1

Coordinated Science Lab 4 5 1 2

Electrical & Computer Engineering 35 53 28 8

Industrial & Enterprise Systems Engineering

1 2

Information Trust Institute 1

Materials Research Lab 5 3 1

Materials Science & Engineering 19 38 10 3

Mechanical Science & Engineering 22 29 4 4

Micro & nanotechnology Lab 2 4 1

nuclear, Plasma & Radiological Engineering

9 2 1 2

Physics 4 2 3 2

Theoretical & Applied Mechanics 1

College of Fine & Applied Arts 7 1

Architecture 1

Art & Design 2 1

Landscape Architecture 1

School of Music 2

Urban & Regional Planning 1



IssuedLicenses &

Options


Disclosure Growth Spurts at the UniversityPercent increase in disclosures over FY2011

40%

20%

33%

Departmentof Chemistry

Liberal Arts& Sciences

College of Agricultural, Consumer,and Environmental Sciences

The OTM worked with more than 70

departments and units in FY2012

Prairie Research Institute 2 1 1

Illinois State Geological Survey 1 1

Illinois Sustainable Technology Center

1 1

Non-Academic & Administrative Units

AITS 2

Campus Recreation (Division of) 2

CITES 1

EnterpriseWorks 1

Housing Division 1

Intercollegiate Athletics (Division of) 1

Office of Corporate Relations 1 1

Office of the Registrar 1

Office of the Vice President for Research

1

Public Affairs 1

U of I Online 1

note: Due to the large amount of interdisciplinary research on campus, inventions are often associated with more than one college, department, or unit. As a result, the numbers reported in the table may be counted multiple times, once for each associated college or unit; for the same reason, the totals for each college may be smaller than the sum of their departments.

College of Liberal Arts & Sciences 52 52 22 15

Biochemistry 5 7 4

Biophysics & Computational Biology 1 1

Cell & Developmental Biology 1 2

Chemical & Biomolecular Engineering 6 8 5 2

Chemistry 35 43 16 5

Entomology 1

Geography 1

Linguistics 2 1

Microbiology 4 4

Molecular & Integrative Physiology 2 2 1

Psychology 1

College of Media 1

Journalism 1

College of Medicine 2

Medical Information Science 2

College of Veterinary Medicine 3 2 1 1

Pathobiology 1 1 1 1

Veterinary Clinical Medicine 2 1

Academic & Research Units

Advanced Digital Sciences Center 3 1

Beckman Institute for Advanced Science & Technology

19 24 23 6

Illinois Informatics Institute 1 1

Institute for Genomic Biology 17 7 2 5

International Programs & Studies 1

Labor & Employment Relations (School of)

1 1

Library 4 1

Library & Information Science (Graduate School of)

1

national Center for Supercomputing Applications

3 1 1 3



IssuedLicenses &

Options



IssuedLicenses &

Options

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Top Three Royalty Generating TechnologiesDeuterium Passivation: used in semiconductor devices, the technology provides a solution to hot carrier effects, which are known to cause problems with device reliability.

Native Oxide: a semiconductor technology used in laser printers, fiber optic communications, microelectronic devices, and more.

Transfer Printing: a micro-transfer printing technology that enables small solar cells to create high efficiency solar modules.

Royalties and Royalty DistributionRoyalties Earned: $6,410,386 non-University Share: $138,788 Patent Expense Reimbursement: $1,932,031 Net Available for Distribution: $5,261,527

Actual Distributions Inventors Share: $1,127,176 University Share: Unit/College:$1,721,945 OTMCostRecovery:$1,250,000 OVPR:$40,151 OVCR:$60,228

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Royalties & Royalty Distribution

note: “actual Distributions” do

not match the “net available for

Distribution” in any one year because

of the time lag between the date

many are received and the date actual

distributions are made.


Start-UpsSnapshot EnergySnapshot Energy explores ways to reuse wastewater for biomass production to create crude oil. Founded by Lance Schideman of the College of Engineering and the College of Agricultural, Consumer and Environmental Sciences, the company is located in EnterpriseWorks.

SpectroClickSpectrophotometry (and, eventually, fluorimetry) in the palm of your hand. SpectroClick combines smart software and inexpensive, but ergonomic, hardware to make portable spectro-scopic appliances for just about anyone. Co-founded by Alexander Scheeline from the College of Liberal Arts & Sciences, the company is located in Champaign, IL.

ValkyrieValkyrie Computer Systems is building mobile web browsers and operating systems for mobile devices. The company’s innovative technology is able to increase the efficiency of mobile hard-ware. Valkyrie’s current products include the Adrenaline web browser. Founded by Samuel King from the College of Engineering, the company is currently located in EnterpriseWorks.

Vanquish OncologyVanquish Oncology is a drug development company focused on targeting molecular defects in specific cancer cells to create personalized oncological therapeutics for unmet or under-served cancer markets. The company focuses on small molecular compounds which target cell apoptosis (cell death) across multiple tumor types. The compounds were developed by Paul Hergenrother from the College of Liberal Arts & Sciences, and the company is currently located in San Ramon, CA.

Williamsfield Seed CompanyWilliamsfield Seed Company, located in Illinois, offers the farming industry wholesale vari-eties of conventional soybeans and promotes Illinois non-GMO soybean varieties. They have licensed soybean lines developed by Brian Diers of the College of Agricultural, Consumer and Environmental Sciences.

Alexander Scheeline, Co-founder, SpectroClick Photo: UI nEWs bUrEaU, l. brIan staUffEr

Photo: InstItUtE for gEnoMIc bIology

Paul Hergenrother (second from left) and colleagues

Photo: UI nEWs bUrEaU, l. brIan staUffEr


PatentsPatent ID Patent No. Title Inventor Names Departments

Licensed/Optioned

TF06148-US 7,972,875Optical Systems Fabricated by Printing-Based Assembly

Jong-Hyun Ahn, Alfred Baca, Heung Cho Ko, Matthew Meitl, Etienne Menard, Michael Motala, Ralph nuzzo, Sang II Park, John Rogers, Mark Stoykovich, Jongseung Yoon, Chang-Jae Yu

Beckman Institute, Chemistry, Materials Science & Engr

L

TF04136-COn 7,973,294Methods and Devices for Characterizing Particles in Clear and Turbid Media

Enrico Gratton, Guido Motolese, Abdel Tahari Physics L

TF04140-US 7,976,748 nano-Molding Process Feng Hua, John Rogers, Anne Shim Materials Science & Engr

TF07196-US 7,976,789 Microfluidic Device for Preparing Mixtures Paul Kenis, Sarah Perry, Griffin Roberts, Joshua Tice Beckman Institute, Chemical & Biomolecular Engr

TF07216-US 7,978,343nanoscale Optical Tomography Based on Volume-Scanning near-Field Microscopy

Paul Carney, Rainer Hillenbrand, John Schotland, Jin Sun

Beckman Institute, Electrical & Computer Eng

TF05199-US 7,979,365 Methods and Systems for Interactive Computing David Goldberg, Xavier Llora, Kumara Sastry General Engineering

TF07139-US 7,982,070Ionizable Isotopic Labeling Reagents for Relative Quantification by Mass Spectrometry

neil Kelleher Chemistry

TF04022-DIV 7,982,296Methods and Devices for Fabricating and Assembling Printable Semiconductor Elements

Dahl-Young Khang, Keon Jae Lee, Matthew Meitl, Etienne Menard, Ralph nuzzo, John Rogers, Yugang Sun, Zhengtao Zhu


L

TF06123-CIP 7,985,837Two Component Bacillus Lantibiotic and Methods for Producing and Using the Same

Lisa Cooper, Amanda McClerren, Wilfred (Willem) van der Donk

Chemistry, Institute for Genomic Biology

TF06109-US 7,989,833Silicon nanoparticle White Light Emitting Diode Device

Abdulrahman Almuhanna, Munir nayfeh, Carl Scianna Physics O

TF04048-US 7,994,389 Soybean Gene for Resistance to Aphis GlycinesShawn Carlson, Brian Diers, Glen Hartman, Curtis Hill, Yan Li

Crop Sciences, natural Resources & Env Sci L/O

TF07168-CIP 7,998,330Direct nanoscale Patterning of Metals Using Polymer Electrolytes

nicholas Fang, Placid Ferreira, Keng Hao Hsu, Kyle Jacobs, Anil Kumar, Peter Schultz

Beckman Institute, Electrical & Computer Eng, Mechanical Science and Engineering (MechSE)

TF04020-US 7,998,807 Semiconductor Device and Method Milton Feng, nick HolonyakElectrical & Computer Eng, Micro and nanotechnology Lab

L

TF01082-US 8,000,767Magneto-Optical Apparatus and Method for the Spatially-Resolved Detection of Weak Magnetic Fields

James Eden, Ju Gao Electrical & Computer Eng

TF06156-US 8,003,300Method For Fabricating Complex Micro and nanoscale Electronic Devices and Components Made by the Same

Kanti Jain, Uttam Reddy Electrical & Computer Eng

TF06087-US 8,004,017Buried Circumferential Electrode Wiring, Microcavity Plasma Device Arrays, and Formation Method

James Eden, Kwang Kim, Sung-Jin Park Electrical & Computer Eng L

42% of the OTM’s U.S. patents issued in fiscal 2012 are already licensed or optioned.


TF08187-US 8,005,124Optical Bandwidth Enhancement of Light Emitting and Lasing Transistor Devices and Circuits

Milton Feng, nick Holonyak, Han Wui Then, Gabriel Walter


TF08051-US 8,007,808Composition and Method for Facilitating the Internalization of a Therapeutic Agent into a Cell

Robert Belton, Romana nowak Animal Sciences L

TF06192-US 8,012,949Bisphosphonate Compounds and Methods with Enhanced Potency for Multiple Targets Including FPPS, GGPPS, and DPPS

Eric Oldfield, Yonghui Zhang Chemistry L

TF07094-US 8,013,203 System For Controlling the Reactivity Boronic Acids Martin Burke, Eric Gillis Chemistry L

TF07136-US 8,017,917 Ionizing Radiation Sensor Ling-Jian Meng nuclear, Plasma, & Radiological Engr (nPRE)

TF05028-US 8,022,177 Peptides and Calcium Regulation in Mammalian CellsPhilip Best, PoJu Chu, Jared Hansen, Janice Jones, Zuojun Lin, Karen Weis

Bioengineering, Molecular & Integrative Physiology

TF07082-US 8,025,025Apparatus and Method for Applying a Film on a Substrate

Hyungsoo Choi, Kyekyoon (Kevin) Kim Electrical & Computer Eng

TF07150-US 8,026,860Electrically Small Antenna Devices, Systems, Apparatus, and Methods

Suhail Barot, Paul Klock, Paul Mayes Electrical & Computer Eng

TF06122-US 8,030,833 Metallic nanostructures Hyungsoo Choi, Kyekyoon (Kevin) Kim Electrical & Computer Eng

TF06106-DIV 8,039,847Printable Semiconductor Structures and Related Methods of Making and Assembling

Dahl-Young Khang, Heung Cho Ko, Keon Jae Lee, Shawn Mack, Matthew Meitl, Etienne Menard, Ralph nuzzo, John Rogers, Yugang Sun, Zhengtao Zhu


L

TF02034-COn2 8,043,802 Fluorescence Based Biosensor Juewen Liu, Yi Lu Chemistry L

TF07215-US 8,045,161Robust Determination of the Anisotropic Polarizability of nanoparticles Using Coherent Confocal Microscopy

Paul Carney, Brynmor Davis Beckman Institute

TF06114-US 8,046,218 System and Method for Identifying Perceptual Features Jont Allen, Marion Regnier Beckman Institute, Electrical & Computer Eng

TF08018-US 8,049,502 Tunable Radio-Frequency Coil Boris Odintsov Beckman Institute

TF06128-CIP2 8,056,419 Artificial Lateral Line Sensor Jack Chen, Jonathan Engel, Chang Liu Beckman Institute, Electrical & Computer Eng

TF06190-US 8,058,415Aptamer-and nucleic Acid Enzyme-Based Systems for Simultaneous Detection of Multiple Analytes

Juewen Liu, Yi Lu Beckman Institute, Chemistry

TF06078-US 8,062,408Integrated Vacuum Absorption Steam Cycle Gas Separation

Scott (Shiaoguo) Chen, Yongqi Lu, Massoud Rostam-Abadi

Civil & Environmental Eng, Illinois State Geological Survey

TF08140-US 8,062,893 Fluorescent Sensor for Mercury Jung Lee, Yi Lu, Zidong WangBeckman Institute, Chemistry, Materials Science & Engr

TF06059-US 8,070,679A Method for Accurate Determination of Intraocular Pressure and Characterization of Mechanical Properties of Cornea in Human Eyes

Jamshid Ghaboussi, Youssef Hashash, Tae-Hyun Kwon, David Pecknold

Civil & Environmental Eng, Civil & Environmental Eng, national Center for Supercomputing Applications

TF06012-US 8,070,920 nanometer-Scale Sharpening of Conductor Tips Joseph Lyding, Scott SchmuckerBeckman Institute, Electrical & Computer Eng, Materials Science & Engr

O

Patent ID Patent No. Title Inventor Names DepartmentsLicensed/Optioned


TF04126-COn2 8,071,573Bisphosphonate Compounds and Methods for Bone Resorption Diseases, Cancer, Bond Pain, Immune Disorders, and Infectious Diseases

Julian Chan, Eric Oldfield, John Sanders, Yongcheng Song, Yonghui Zhang

Chemistry L

TF07099-US 8,073,655A Method for Transaction Dependency Graph Construction Using Signal Injection

Shuyi Chen, Kaustubh Joshi, William Sanders Computer Science

TF07146-US 8,076,893Displacement Actuation and Sensing for an Electrostatic Drive

Jingyan Dong, Placid Ferreira Mechanical Science and Engineering (MechSE)

TF05053-US 8,080,095 Steady State Tracking Desorption System and MethodHamidreza Emamipour, Zaher Hashisho, K. James Hay, Byung Kim, Mark Rood

Civil & Environmental Eng, Civil & Environmental Eng

TF07217-US 8,089,630 Spectral near-Field Optical Tomography Paul Carney, Brynmor Davis, John Schotland, Jin Sun Beckman Institute, Electrical & Computer Eng

TF02015-DIV 8,095,344 Methods And Systems For Modeling Material Behavior Jamshid Ghaboussi, Youssef Hashash, David Pecknold Civil & Environmental Eng, Civil & Environmental Eng

TF01092-DIV2 8,101,139 Microcapillary networks Jennifer Lewis, Daniel Therriault, Scott White Materials Science & Engr, Theoretical & Applied Mech

TF05135-US 8,110,404 Luminescent Lanthanide Binding Chelates Pinghua Ge, Paul Selvin Life Sciences O

TF07207-COn 8,110,503Surface Preparation for Thin Film Growth by Enhanced nucleation

John Abelson, Gregory Girolami, navneet Kumar, Angel Yanguas-Gil

Chemistry, Materials Science & Engr

TF07025-DIV 8,114,638 Arabinitol Dehydrogenase from neurospora Crassa Ryan Sullivan, Huimin Zhao Chemical & Biomolecular Engr L/O

TF07114-US 8,115,934Device and Method for Imaging the Ear Using Optical Coherence Tomography

Stephen Boppart, Chuanwu Xi Beckman Institute, Electrical & Computer Eng

TF07088-US 8,117,208A System for Entity Search and a Method for Entity Scoring in a (Linked) Document Database

Kevin Chen-Chuan Chang, Tao Cheng, Xifeng Yan Computer Science L

TF03068-COn 8,121,378 Fast Reconstruction Algorithms for Tomography Yoram Bresler, Ashvin George Coordinated Science Lab, Electrical & Computer Eng L

TF06133-US 8,121,668Functional Imaging Method Using FEnSI: Flow Enhanced Signal Intensity

Bryce Ching, Luisa Ciobanu, Brad Sutton Beckman Institute, Bioengineering

TF05139-US 8,123,834High Gain Selective Metal Organic Framework Preconcentrators

Richard Masel, Zheng ni, Mark ShannonBeckman Institute, Chemical & Biomolecular Engr, Mechanical Science and Engineering (MechSE)

L

TF07153-US 8,123,841 Column Design for Micro Gas Chromatograph Richard Masel, Adarsh Radadia, Mark ShannonBeckman Institute, Chemical & Biomolecular Engr, Mechanical Science and Engineering (MechSE)

L

TF05195-US 8,131,656 Adaptive Optimization MethodsDavid Goldberg, Claudio Lima, Fernando Lobo, Kumara Sastry

General Engineering

TF07154-US 8,152,908Micromachined Gas Chromatograph Columns for Fast Separation of Organophosphonate and Organosulfur Compounds and Methods for Deactivating Same

Richard Masel, Adarsh Radadia Chemical & Biomolecular Engr L

TF07057-US 8,153,065Fluorescent Organic nanofibrils as Sensory Materials for Expolsives Detection

Jeffrey Moore, Tammene naddo, Ling Zang Chemistry L

TF06118-US 8,155,898Methods and Apparatus for Providing an Extremely Fast Response in Switching Power Converters

Philip Krein, Grant Pitel Electrical & Computer Eng



TF06159-US 8,159,134Arrays of Microcavity Plasma Devices and Electrodes with Reduced Mechanical Stress

James Eden, Sung-Jin Park Electrical & Computer Eng L

TF06172-US 8,159,287 Transistor Device and Method Milton Feng, nick Holonyak Electrical & Computer Eng

TF08200-US 8,173,390Method for Facilitating Fermentation of High Solids Compositions

Jameel Shihadeh, Vijay Singh Agricultural & Biological Engr

TF08212-US 8,173,406Deconstructing Lignocellulosic Biomass with a Two-Stage Method

Jose De Frias, Hao Feng, Xiaojuan Wang, Bin Wang, Bin Zhou

Food Science & Human nutrition, Institute for Genomic Biology

TF07176-US 8,179,032Ellipsoidal Microcavity Plasma Devices and Powder Blasting Formation

James Eden, Sung-Jin Park, Seung Hoon Sung Electrical & Computer Eng L

TF09043-US 8,179,937High Speed Light Emitting Transistor Methods and Devices

Milton Feng, nick Holonyak, Han Wui Then, Gabriel Walter, Chao-Hsin Wu

Electrical & Computer Eng L

TF07046-COn 8,179,939Light Emitting and Lasing Semiconductor Devices and Methods

Milton Feng, nick Holonyak, Adam James, Gabriel Walter


TF08051-DIV 8,182,819Composition and Method for Facilitating the Internalization of a Therapeutic Agent into a Cell

Robert Belton, Romana nowak Animal Sciences L

TF06100-US 8,183,046Temperature Resistant pH (TIP) Buffers for Use at Low Temperatures

Dewain Garner, Hee-Jung Hwang, Yi Lu, nathan Sieracki

Beckman Institute, Chemistry L

TF08065-US 8,184,298Spatial Light Interference Microscopy and Fourier Transform Light Scattering for Cell and Tissue Characterization

Gabriel Popescu, Zhuo Wang Beckman Institute, Electrical & Computer Eng

TF06197-US 8,187,500 Biphasic Inks Jennifer Lewis, Qi Li, Ranjeet Rao Materials Science & Engr L

TF08061-US 8,187,795 Patterning Methods for Stretchable Structures Kanti Jain, Kevin Lin Electrical & Computer Eng

TF07166-US 8,188,302 Hydroamination of Alkenes John Hartwig, Zhijian Liu Chemistry L

TF07097-US 8,192,600 Solid State DeviceMaria Gracheva, Jean-Pierre Leburton, Gregory Timp, Julien Vidal

Beckman Institute, Electrical & Computer Eng L

TF06166-US 8,192,947Detection of Specific Binding Reactions Using Magnetic Labels

Mingxing Ouyang, Yingxiao Wang Beckman Institute

TF06060-DIV 8,198,621A Stretchable Form of Single Crystal Silicon for High Performance Electronics on Rubber Substrates

Dahl-Young Khang, Etienne Menard, John Rogers, Yugang Sun

Materials Science & Engr L

TF07182-US 8,199,580 Memory DeviceGil De Aquino Farias, Jeanlex De Sousa, Valder Freire, Jean-Pierre Leburton

Beckman Institute, Electrical & Computer Eng

TF05208-US 8,202,717non-Simian Cells for Growth of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus

Federico Zuckermann Pathobiology

TF00027-COn2 8,206,915 nucleic Acid Enzyme Biosensors for Ions Jing Li, Yi Lu Chemistry L

TF07073-US 8,209,738Analysis of Distributed Policy Rulesets for Compliance with Global Policy

David nicol, William Sanders, Mouna Seri, Sankalp Singh

Computer Science, Electrical & Computer Eng


22 University of Illinois at Chicago • The Offices of Technology Management • Fiscal 2012 Annual Report

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Fiscal 2012 Annual Report • The Offices of Technology Management • University of Illinois at Chicago 23

I am pleased to report on another strong year for the Office of Technology Management. Working with the outstanding faculty, staff, and students at UIC we were able to continue our strong growth and success. The success

of the Office in fiscal year 2012 would not be possible if not for the innovative research being done on campus and the desire by all in the UIC community to see these innovations make an impact on the world.

In FY12 we continued to focus on the importance of partnerships. One of the accomplishments we are most proud of is the launch of our inaugural Proof of Concept (POC) Gap Funding program. Working with campus leadership in the Office of the Vice Chancellor for Research, the College of Engineering, the College of Medicine, and the College of Pharmacy, as well as the Office of the Vice President for Research, we were able to raise $500,000 to support the continued commercialization of UIC inventions and help bridge the gap between basic research funding and commercialization. In the first round in the Spring of 2012, we awarded a total of $250,000 in proof-of-concept gap funds to 4 commercially focused projects. We were truly impressed by the

interest and commitment of UIC innovators to move their inventions forward, evident by the 80 POC pre-proposals we received. The POC Gap Funding program is a critical part of the continued efforts by our Office and the University to help spur commercialization. We will be launching the second round of funding in the Fall of 2012.

Another campus collaboration was the annual recognition ceremony for Inventor of the Year and Researcher of the Year, which we co-host with the Office of the Vice Chancellor for Research. We are honored to recognize the accomplishments of Dr. Alan Feinerman, 2011 UIC Inventor of the Year. You can read more about Dr. Alan Feinerman and his entrepreneurial efforts to commercialize his new vacuum insulation panel technology later in the report. He demonstrates the best of the UIC inventor spirit and we were pleased to recognize him for his efforts with the 2011 UIC Inventor of the Year award.

Our external collaborations have also been an important part of our success. Since it’s establishment in 2010, the Chicago Innovation Mentors program (CIM) has over 100 mentors working with more than 30 early-stage biomedical

and healthcare-related ventures, including 10 ventures from UIC. Co-founded by UIC, the University of Chicago, northwestern, and the iBio Institute, the network has been so well received that in the coming year CIM will expand to include Argonne Laboratory and the University of Illinois’ Urbana campus.

Royalties generated by sales of Prezista, an HIV therapeutic based on a compound discovered at UIC, continue to be a key driver of strong revenue for the office. As satisfying as all of this activity and success has been, it is even more gratifying to look ahead to the new opportunities for productive partnerships in the coming year. We are thrilled to be associated with the new UICentre, which is focused on increasing the potential for successful drug development by harnessing the multidisciplinary expertise available at the University. We will be working closely with UICentre as another important part of the University’s efforts to bring discoveries to market through technology commercialization.Of course, none of our efforts would be possible without the University’s world-class faculty and their willingness to engage in the technology transfer process.

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In FY12 we continued to focus on the importance of partnerships.


Proof-of-Concept Gap Funding AwardsThe inaugural launch of UIC Proof-of-Concept (POC) Gap Funding initiative was a great success and attracted a highly innovative set of 80 pre-proposal applications from

faculty inventors across the UIC campus, as well as from the Rockford and Peoria campuses. A total of 12 faculty members were invited to submit full proposals for funding, and to “pitch” their invention ideas to a panel of venture capitalists and local business leaders. After a comprehensive review, four projects were selected for funding. The projects chosen for funding were:• Samuel C. Dudley and Euy-Myoung Jeong (College

of Medicine – Section of Cardiology): ABloodTesttoDifferentiateSystolicfromDiastolicHeartFailure

• Xavier Llor and Rosa M. Xicola (College of Medicine– Section of Digestive Diseases and Nutrition):DevelopmentofaBlood-BasedTestforColorectalCancerScreeningUsingamiRNAPanel

• Hayat Onyuksel (College of Pharmacy – Department of Biopharmaceutical Sciences): ANovelTargetedsiRNANanomedicineagainstLiverFibrosis

• Katherine Warpeha (College of Liberal Arts and Sciences– Department of Biological Sciences): TransformationofCriticalCropPlantstoEngineerImprovedStressandYieldCharacteristics

Updates & Highlights

Clockwise from top left: Xavier Llor (MD, Phd); David Klick (JD, PhD); nelson Grihalde (PhD); Mark

Krivchenia; Samuel Dudley (MD, PhD); Katherine Warpeha (PhD); Hayat Onyuksel (PhD)

Photo: UIc Photo sErvIcEs

APPLIED HEALTH SCIENCES

DENTISTRY

ENGINEERING

INNOVATION CENTER

LIBERAL ARTS AND SCIENCES

MEDICINE

PHARMACY

Pre-Proposal Applications by College/Unit

“POC WAS CRITICAL TO JUMPSTARTInG OUR TRAnSLATIOnAL EFFORTS. IT PROVIDES A

BRIDGE BETWEEn DISCOVERY AnD IMPLEMEnTATIOn THAT WAS PREVIOUSLY MISSInG

In OUR SYSTEM.” — SAMUEL DUDLEY


The success of the first-ever launch of a POC Gap Fund at UIC was both rewarding and inspiring, given the diversity and breadth of commercially focused projects that were presented to the OTM. A second-round call for proposals is underway, and a long-term goal of the POC Initiative is to continue growing the fund to help sustain and support the wealth of innovative product ideas that exist on the UIC campus. By helping to support and de-risk early-stage university technologies, a critical gap in the commercialization process can be bridged, and university inventions have a greater chance of transitioning from the lab to the marketplace.

The OTM would like to thank all the faculty inventors who submitted proposals for the first round of funding and would especially like to thank the 12 POC finalists for their engagement with the Office during the lead-in to the VC pitch presentations. The OTM would also like to thank the members of the UIC Pre-Proposal Review Committee, as well as the venture capitalists and business leaders who generously took the time to review and score the Full Proposal applications and traveled to the OTM offices to listen to the finalists pitch their product development ideas.

The inaugural 2012 Proof- of- Concept Gap Initiative was jointly funded by the Office of the Vice President for Research (OVPR), the Office of the Vice Chancellor for Research (OVCR), the

Colleges of Engineering, Medicine and Pharmacy, and the Office of Technology Management.

2011 Inventor of the Year Alan FeinermanThe Inventor of the Year Award recognizes and honors an outstanding UIC faculty inventor who has engaged and worked closely with the OTM in the technology transfer process. Awardees must demonstrate a passion for, and commitment to, innovation, which is proudly represented in the development of an invention with the potential to significantly contribute to society.

The OTM was proud to present the 2011 UIC Inventor of the Year Award to Alan Feinerman, Associate Professor of Electrical and Computer Engineering. His groundbreaking research into the development of ultra-low thermal conductivity insulation panels combined with a firm dedication to seeing his discoveries transition from the lab to the marketplace are truly a reflection of the outstanding spirit of innovation and entrepreneurship which exists across the UIC campus.

Dr. Feinerman’s high-performance vacuum insulation panel (VIP) technology (known as Klimate Kontrol™) brings a novel design and strategy to the field of energy conservation and holds the potential to make a significant societal impact.

Use of this technology could in the future result in a drastic reduction in the amount of energy required to heat and cool dwellings, or to refrigerate trucks used in the transport of perishable goods. Feinerman estimates that his VIP can reduce diesel fuel consumption of refrigerated trailers by 75 percent and would save 360 million gallons of diesel fuel each year in the United States — “nearly the volume of the Willis Tower.”

Feinerman is also founder of Thermal Conservation Technologies (TCT), a UIC start-up venture focused on commercializing the Klimate Kontrol™ panel technology. TCT was recently chosen as a finalist in the 2012 Clean Energy Challenge Competition and awarded a SBIR grant to continue Klimate Kontrol™ panel development.

“In ORDER TO DEVELOP CLInICAL RELEVAnT TECHnOLOGIES WE nEED MECHAnISMS

THAT CAn RECOGnIZE THE VALUE AT An EARLY STAGE AnD PROVIDE SUPPORT TO TEST

THESE IDEAS. THE POC MECHAnISM FACILITATES THIS AnD IT LET’S YOU TAKE YOUR

IDEA TO THE TESTInG GROUnD In A MUCH SHORTER TIME FRAME.” — XAVIER LLOR

“THE OTM STAFF REALLY HELPED ME TO FOCUS MY

THInKInG On THE FUTURE MARKET POSSIBILITIES.

THROUGHOUT THE PROPOSAL DEVELOPMEnT

PROCESS I RECEIVED A LOT OF PRACTICAL ADVICE

AnD ASSISTAnCE. I REALLY APPRECIATED THE

COLLABORATIVE nATURE OF PREPARInG THE GRAnT.”

— KATHERInE WARPEHA

Rapid Growth: Fiscal 2012 vs Fiscal 2008

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26 University of Illinois at chicago • the offices of technology Management • fiscal 2012 annual report

Fiscal 2012 Disclosures by College

MEDICINE

ENGINEERING

PHARMACY

LIBERAL ARTS & SCIENCES

DENTISTRY

INNOVATION CENTER

PUBLIC HEALTH

APPLIED HEALTH SCIENCES

MEDICINE (ROCKFORD)

NURSING

BUSINESS

ARCHITECTURE & THE ARTS

MEDICINE (PEORIA)

OTM Out & About

• abbott labs advances in tumor Immunology - catalyzing collaborations between Industry & academia in the life sciences; abbott Park, Il

• association of University technology Managers annual Meeting; anaheim, ca

• bIo-2012; boston, Ma• burrill Digital health;

san francisco, ca

last year, professionals from otM attended, as well as presented at, many conferences and trade-shows around the country.

• chicago Drug Discovery consortium Meeting; chicago, Il

• clean Energy challenge; chicago, Il

• ibio IndEx 2012; chicago, Il

• licensing Executives society annual Meeting; san Diego, ca


Dr. David Carley, Chief Scientific Officer, Pier Pharmaceuticals

Photo: UIc Photo sErvIcEs

Chicago Innovation Mentors Program Continues to GrowChicago Innovation Mentors (CIM) is a multi-institution initiative that cultivates university technology commercialization by matching experienced entrepreneurs, executives, and domain experts with innovating faculty. Started about a year and a half ago by the University of Illinois at Chicago, northwestern University, University of Chicago, and the iBIO® Institute, the program is designed to help start-up ventures thrive by connecting them with experienced mentor teams. CIM has grown to have over 100 mentors engaged with over 50 ventures.

“A superhighway runs into Chicago’s leading universities, carrying innovative scientists, talented students and significant research funds,” says John Flavin, the new executive director. “We need to match that with a superhighway to carry the fruits of this research out into the marketplace. Chicago has many assets and people who are coming together to create an emerging biotech center,” Flavin says. “One of the key gaps, however, is the number and experience of entrepreneurs who can commercialize technologies from Chicago’s universities.”

To help fill that gap, CIM has matched over 70 mentors with more than 10 active ventures at UIC. All ventures are in the biomedical and health care arena, though CIM plans to expand to additional research areas as well.

One of those projects is based on an invention from Dr. Craig niederberger and Dr. Ervin Kocjancic from UIC’s Department of Urology. “Without CIM, we’d have interesting innovations in the lab. With CIM, we have products,” niederberger said.

Although some of CIM’s ventures do not succeed, they all provide lessons learned and useful experience for the participants, Flavin says. “As faculty members float ideas and

work with their mentors, they learn what is and what is not a feasible product or service. Often they come right back with a more carefully honed idea.”

After just a year and a half CIM is also expanding the institutions it serves with the addition of Argonne national Lab and University of Illinois at Urbana-Champaign.

new Incubator Space @ 1871The University of Illinois is leasing space at 1871, the newest tech incubator in Chicago, to further our entrepreneurial mission and improve collaboration with the Chicago entrepreneurial community.

Start-Up Successes• OrthoAccel® Technologies, Inc., developer of the

AcceleDent™ System, an appliance designed to accelerate orthodontic treatment, received FDA approval to begin

marketing and selling its device in the United States. AcceleDent™ is now available to orthodontists in over 15 countries to help accelerate bone remodeling and to effectively complement the orthodontic forces applied by braces. The company also secured a $10 million equity investment led by HealthPoint Capital Partners to support the launch of AcceleDent™ in the US and to provide working capital for the Company.

• Dr. David Carley, co-founder and Chief Scientific Officer at Pier Pharmaceuticals, is the Principal Investigator on a recently awarded $5 million, three-year, National Heart, Lung and Blood Institute (NHLBI) grant to study the potential of the cannabimimetic drug, dronabinol, to treat obstructive sleep apnea (OSA). Pier Pharmaceuticals is currently developing a proprietary drug delivery formulation of dronabinol for use in treating patients with moderate to severe obstructive sleep apnea.

• Tolerogenics, a UIC startup focused on developing novel pharmaceutical approaches to treating autoimmune diseases, was the recipient of an STTR Award from the national Institutes of Allergy and Infectious Diseases (nIAID) to study the use of their patented, bispecific antibody technology for the treatment of non-obese diabetes.

• Senex Biotechnology was awarded a $1.5 million Phase II SBIR grant from the national Cancer Institute (nCI) to further development of the company’s SnX9 program, which is focused on synthesizing novel compounds against a proprietary target present in many tumor cell types, but largely absent in normal cells. The grant will provide funding to the company through the middle of 2013.

• VasSol announced that it has reached agreements with distributors in China, South Korea, and Europe for its NOVA product line. nOVA, or non-invasive Optimal Vessel Analysis, is the first and only product line to non-invasively quantify the volumetric blood flow rate of vessels in the brain. The company looks forward to ramping up growth in these key new markets.

Fiscal 2012 SummaryChicago Fiscal 2012 - Colleges, Departments & Units



IssuedLicenses &

Options

Campus Total 184 238 30 44

Applied Health Sciences 3 4 1

Architecture & the Arts 1 3

Business 2 1

Dentistry 6 10 3 1

Education

Engineering 35 48 7 7

Innovation Center 5

Liberal Arts & Sciences 10 15 1 1

Medicine 93 112 13 27

Medicine - Peoria 1 2

Medicine – Rockford 3 3

nursing 3 3 2

Pharmacy 35 51 7 12

Public Health 4 1

Social Work 1

Note:Asaresultofthelargeamountofinterdisciplinaryresearchoncampus,inventionsareoftenassociatedwithmorethanonecollegeorunit.Asaresult,thenumbersreportedinthetablemaybecountedmultipletimes,onceforeachassociatedcollegeorunit.


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Top Three Royalty Generating TechnologiesMultidrug Resistant Retroviral Protease Inhibitors: protease inhibitor compound known as Prezista used to treat HIV-AIDS.

TICE BCG: for the treatment and prophylaxis of carcinoma insitu (CIS) of the urinary bladder, and for the prophylaxis of Ta and/or T1 papillary tumors following transurethral resection.

Orthodontic Treatment Device: an orthodontic device, used as a complement to braces, that accelerates bone remodeling, and thus tooth movement, through the application of gentle microvibrations.

Royalties & Royalty DistributionRoyalties Earned: $17,050,516 non-University Share: $5,732 Litigation Expense Reimbursement: $286,994 Patent Expense Reimbursement: $763,209 *Previously Undistributed Royalties: $167,840 net Available for Distribution: $16,162,420Actual Distributions Inventors Share: $5,924,654 University Share: Unit:$3,952,691 OTMCostRecovery:$1,250,000 OVPR:$1,957,410 Campus:$2,936,115

Royalties & Royalty Distribution

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Start-UpsOpinionEQopinionEQ is a sentiment analysis company focused on collecting, interpreting, and structuring both Web and real-time communications to determine what people are saying about a company and its products, and how they are saying it. opinionEQ uses advanced semantic and linguistic research methodologies to develop analysis tools that corporations can use to collect and analyze data on consumer sentiment, turning that data into actionable, real-time decision making. opinionEQ was founded by UIc computer science Professor, bing liu, and is based in chicago, Il. www.opinioneq.com

natco Drug Discoverynatco Drug Discovery is a U.S.-based biopharmaceutical start-up company formed as a joint venture with natco Pharma Limited in Hyderabad, India. The company is focused on developing RnA interference therapies to be used in the treatment of currently intractable cancers. They have created a series of bicistronic siRnA constructs that have been tested in multiple cancer models where they have been shown to down regulate gene expression and inhibit cancer growth and metastasis. The company is actively working with the U.S. FDA on an InD submission in advance of human trials for their lead therapeutic agent. natco Drug Discovery was co-founded by Jasti Rao, Head of Cancer Biology and Pharmacology at the University of Illinois College of Medicine at Peoria.

nexHand nexhand is a medical device company developing a highly innovative technology to improve the diagnosis and surgical procedure utilized in the safe and effective treatment of patients suffering from stress urinary incontinence (SUI). nexHand’s proprietary surgical device guides surgeons by providing real-time feedback measurements of their most valuable tool, their hands. The company hopes to validate the market need for its technology in the SUI domain and then adapt it to other surgical fields and forms of surgery. The company also named industry veteran Micah Mackison as President and CEO this past year and received a seed stage investment from IlliniosVEnTURES. nexHand was

co-founded by Craig niederberger, Saelhof Professor and Head of the Department of Urology at UIC, and Ervin Kocjancic, Professor of Urology at UIC. The company is based in Chicago, IL. www.nexhand.com

ActroCell ActroCell is a biotherapeutics company seeking to develop activated mesenchymal stem cells (MSC) into a novel therapeutic modality for the treatment and prevention of graft versus host disease (GVHD). Current treatment options for preventing and treating GVHD are quite limited, and ActroCell is confident that the use of its activated MSC technology can broaden the therapeutic potential of allogeneic stem cell

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Craig niederberger, co-founder of nexHand.


transplantation. ActroCell was formed around technology developed by UIC Professor of Surgery, Amelia Bartholomew, and the company is currently located in Melbourne, Australia.

Cell Habitats Cell Habitats is an IllinoisVEnTURES-backed start-up redefining the field of tissue regeneration by harnessing the body’s own endogenous stem cells to restore normal function to damaged or diseased tissue. Their innovative technologies could provide medical breakthroughs in the treatment of heart muscle injury and may serve as a platform for the regeneration of other tissues such as bone, muscle, and nerve tissues. Cell Habitats was founded by Brenda Russell, UIC Professor of Physiology and Biophysics, and is located in Evanston, IL.

Thermal Conservation Technologies Thermal Conservation Technologies is developing an innovative, vacuum insulated panel (VIP) known as Klimate Kontrol,™ which promises to dramatically reduce heating and cooling costs by providing superior insulation in an environmentally friendly manner. The company’s patented VIP design is a significant improvement over currently marketed VIP technologies and achieves significant R-values (insulation) with improved puncture resistance at competitive manufacturing costs. The company was one of ten finalists in the highly competitive 2012 Clean Energy Challenge hosted by the Clean Energy Trust. The company was also recently awarded a Phase II SBIR grant from the national Science Foundation to accelerate the development of its VIP technology. Thermal Conservation Technologies was founded by Alan Feinerman, UIC Professor of Electrical & Computer Engineering and UIC’s 2011 Inventor of the Year. The company is currently located in Skokie, IL. www.tensilevip.com

TE Bios TE Bios is a Korean bioventure company working to develop an artificial corneal implant utilizing UIC technology. Corneal transplantation is currently the most common form of organ transplant performed in the United States, and successful transplantation depends on the quality and availability of donor corneas as well as the patient’s underlying condition. UIC inventors have engineered a hybrid scaffold of synthetic and natural materials that enhance biointegration of an artificial corneal implant. TE Bios is currently in the process of animal testing the superporous hybrid artificial cornea in collaboration with a premier hospital in Seoul. The company is also in the early stages of developing partnerships with clinical test sites in Korea. TE Bios was formed around technology developed by Michael Cho, UIC Professor of Bioengineering, and the company is based in Daejeon, Korea.

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Brenda Russell, founder of Cell Habitats

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Alan Feinerman, founder of Thermal Conservation Technologies


PatentsPatent ID Patent No. Title Inventor Names Departments

Licensed/Optioned

CZ053/CIP 8,118,752 Apparatus and Method for Mapping Retinal Function John Hetling, Tamas Ban, Safa Rahmani Bioengineering O

CU43/nPA 7,973,064Method and Composition for Potentiating an Opiate Analgesic

Anil Gulati Biopharmaceutical Sciences L

CV94/COn 7,976,835Method and Composition for Preventing and Treating Solid Tumors


DE136/nPA 7,980,856Fall Prevention Training System and Method Using a Dynamic Perturbation Platform

Mark Grabiner, Richard Greenwald, Aaron Buck, Jeff Chu, Robert Palifka

Kinesiology and nutrition L

CY012/nPA-2 8,017,749Compositions and Methods to Treat Cancer with CpG Rich DnA and Cupredoxins

Tapas Das Gupta, Ananda Chakrabarty Surgical Oncology, Microbiology & Immunology L

CX080/PCT/US 8,026,054 Antibodies Against Cells of Fetal Origin Arun Sharma, Sherman Elias Pediatric Hematology/Oncology

CV94/CIP-3 8,026,216Methods and Compositions for Contributing to the Treatment of Cancers

Anil Gulati, Guru Reddy, Luigi Lenaz Biopharmaceutical Sciences L

DA003/nPA 8,029,980Identification and Use of Agents that Modulate Oncogenic Transcription Agent Activity

Andrei Gartel, Senthil Radhakrishnan Hepatology, Microbiology & Immunology

CV94/CIP-2/COn

8,030,278Methods, Compositions and Articles of Manufacture for Contributing to the Treatment of Cancers

Anil Gulati, Guru Reddy, Luigi Lenaz Biopharmaceutical Sciences L

CX016/PCT/US 8,032,209 Localizing neural Sources in a Brain Bin He, Xiaoliang Xu, Bobby Xu Electrical and Computer Engineering, Bioengineering

CW019/PCT/US 8,053,413Methods for Treating Sleep Disorders By Cholecystokinin (CCK) Receptor B Antagonists

David Carley, Miodrag RadulovackiPulmonary, Critical Care, Sleep and Allergy, Pharmacology, Biobehavioral Health Science, Bioengineering

CT66/PCT/US 8,062,874 GFP Fusion Proteins and Their Use Mark Rasenick, Jiang-zhou Yu Physiology and Biophysics, Psychiatry L

DA036/nPA 8,062,898Selection and Rational Development of Solvent Systems in Counter-Current Chromatograph

Guido Pauli, John Brent Friesen Medicinal Chemistry and Pharmacognosy

CW081/PCT/US/COn

8,067,389Silencing of TGF-Beta Type II Receptor Expression by siRnA

nalin Kumar, Beatrice Yue, Shahid Siddiqui, Asrar Malik, Jose Pulido

Ophthalmology and Visual Science, Pharmacology

CY055/PCT/US 8,076,315 Pharmacological Treatments for Sleep Disorders with Prostanoid Receptor Antagonists

David Carley, Miodrag RadulovackiPulmonary, Critical Care, Sleep and Allergy, Pharmacology, Biobehavioral Health Science, Bioengineering

DC042/nPA 8,092,995 Expressed Pseudogene Regulates Gene Expression Primal de Lanerolle, Yoo Jeong Han Physiology and Biophysics

42% of the OTM’s U.S. patents issued in fiscal 2012 are already licensed or optioned.


DB099/nPA 8,094,301 Video and Thermal Imaging System for Monitoring Interiors of High Temperature Reaction Vessels

Alexei Saveliev, Serguei Zelepouga, David Rue Mechanical and Industrial Engineering

DA086/nPA 8,097,728 Iminosugar Compounds with Antiflavivirus ActivityBaohua Gu, Timothy Block, Robert Moriarty, Mahendra Desphande, Rajendra Shah

Chemistry

CX038/PCT/US 8,110,155 Vortex Reactor and Method of Using ItAlexander Fridman, Alexander Gutsol, Young Cho, Lawrence Kennedy, Alexei Saveliev, Andrey Romanets, Igor Matveev, Kenneth Blank

Mechanical and Industrial Engineering

CU43/DIV 8,114,896Method and Composition for Potentiating an Opiate Analgesic


CX017/CIP-2/COn

8,124,055Compositions and Methods to Control Angiogenesis with Cupredoxins

Rajeshwari Mehta, Brad Taylor, Tohru Yamada, Craig Beattie, Tapas Das Gupta, Ananda Chakrabarty

Surgical Oncology, Microbiology & Immunology L

CY067/PCT/US/COn

8,129,141 Fibrous Protein Fusions and Use Thereof in the Formation of Advanced Organic/Inorganic Materials

David Kaplan, Jia Huang, Cheryl Wong Po Foo, Rajesh naik, Anne George

Oral Biology

DB047/nPA 8,153,370 RnA from Cytology Samples to Diagnose Disease Guy Adami, Joel Schwartz Oral Medicine and Diagnostic Sciences

CX037/PCT/US 8,173,595Methods and Compositions for the Inhibition of Thrombus Formation

Kesheng Dai, Xiaoping Du Pharmacology

CY083/PCT/US 8,183,512 Optically Triggered Power System and Devices Sudip Mazumder, Tirthajyoti Sarkar Electrical and Computer Engineering

CZ023/nPA/DIV

8,188,251Transport Agents for Crossing the Blood-Brain Barrier and into Brain Cancer Cells, and Methods of Use Thereof

Chang Soo Hong, Tohru Yamada, Arsenio Fialho, Tapas Das Gupta, Ananda Chakrabarty


CV66/COn 8,192,732Mammalian Multipotent Stem Cells and Compositions, Methods of Preparation and Methods of Administration Thereof

Kiminobu Sugaya, Tingyu Qu, Ankur Vaghani, Christopher Brannen, Hojoong Kim, Jose Pulido, Xianing Dong

Psychiatry L

CY012/COn 8,206,685Cupredoxin Derived Transport Agents and Methods of Use Thereof

Ananda Chakrabarty, Tapas Das Gupta, Arsenio Fialho, Tohru Yamada


CZ061/PCT/CIP/US

8,207,216Benzofuran-3-yl-(indol-3-yl) Maleimides as Potent GSK3 Inhibitors

Alan Kozikowski, Irina Gaysina Medicinal Chemistry and Pharmacognosy

DB062/COn 8,173,598Myeloid Protein Activation of Anti-Inflammatory and Anti-Hypoxic Pathway

Herve Sroussi Oral Medicine and Diagnostic Sciences



ContactOffice of Technology Management, University of Illinois at Chicago 1853 West Polk Street, Suite 446, Chicago, IL 60612 312.996.7018 • [email protected] • www.otm.uic.edu

Director nancy Sullivan • 312.996.7018 • [email protected]

Assistant Director of Business Development Jeremy Hollis • 312.355.1601 • [email protected]

Senior Technology Managers Mark Krivchenia • 312.996.6626 • [email protected] Wade Green • 312.996.0370 • [email protected]

Technology Manager David Klick • 312.996.7779 • [email protected]

Associate Technology Managers Michael Carr • 312.996.5833 • [email protected] Jennifer Andrew • 312.996.1595 • [email protected]

Technology Transfer Coordinator nelson Grihalde • 312.996.4129 • [email protected]

Professional StaffBusiness Development Coordinator Philip BakBusiness Administrative Associate Patrick CooganIT Technical Associate Alex EsparzaLegal Support Michael Hant, Office of University CounselSenior Patent Coordinator Michael MartinPatent Coordinator Ashley RomanoBusiness Administrative Associate Kimberly White

Board of AdvisorsThe Office of Technology Management would like to thank the members of our advisory board for their continued guidance and engagement.

William Beck • Sue Fullman • Didyen MajumdarBellur Prabhakar • Brenda Russell • Larry TobacmanSol Shatz • Christine Wu

ChicagoInternsWe would also like to thank the student interns whose hard work and dedication helps enable so much of our work.

Graduate ScreenersCarson Ingo • Kathleen Broughton • James GocelRayna Saito-Kearney • Tatsos Konstantinidis • Brian Kunzel Jody Lancia • Sameer Malik • niraj Muni • Ashley Pawlitz Adam Sussman • nan Zhang

Undergraduate Screenersnabia Ali • Brian Henry • Christopher RussellJonathan Schelling

Law StudentsGreg Swank • Ashley Pawlisz • Adam SussmanDavid Golub


ContactOffice of Technology Management, University of Illinois at Urbana-Champaign, Ceramics Building, Suite 319, 105 S. Goodwin Avenue, Urbana, IL 61802 217.333.7862 • [email protected] • www.otm.illinois.edu

Director Lesley Millar • 217.333.6807 • [email protected]

Associate Director Delphine Kranz • 217.333.6807 • [email protected]

Assistant Directors/ Senior Technology Managers Lisa Dhar • 217.333.3715 • [email protected] Steven Wille • 217.244.5956 • [email protected]

Senior Technology Managers nathan Hoffmann • 217.244.4747 • [email protected] Jeffrey Wallace • 217-265-0548 • [email protected]

Technology Managers Svetlana Vranic-Sowers • 217.244.7243 [email protected] Jennifer Rice • 217.244.1275 • [email protected]

Interim Technology Manager Brad Edwards • 217.244.6453 • [email protected]

Professional StaffAccount Technician Lori BoltzSenior Patent Coordinator Bill ColburnBusiness Manager Todd CreasonLicense and Agreement Coordinator Karen Higgins Patent Office Manager Tracy HunterOffice Support Specialist Heather JonesSenior Marketing Coordinator nicole nairParalegal-Compliance Coordinator Jane Reid Administrative Aide Billie ScalesChief Clerk Liz SchleefLegal Office Manager Donna WilmLegal Support Karen Etheridge, Office of University Counsel

Board of Advisors The Office of Technology Management would like to thank the members of our advisory board for their continued guidance and engagement.

Bruce Vojak, Chair • Hans Blaschek • Scott CarneySharon Donovan • Albert Feng • Merle GilesGregory Girolami • Gaines Hall • Wen-Mei HwuJozef Kokini • Philip Krein • Steven Leigh • Paul MagelliMichael Philpott • Jennifer Quirk • Molly TracyDavid Weightman • Huimin Zhao Ex Officio: Melanie Loots

Urbana-ChampaignInterns (2012-2013)We would also like to thank the students interns whose hard work and dedication helps enable so much of our work.

Yousuf Ahmed • Karthik Balasendaram • Robert Cheung James Clemons • Chris Collier • Jillian Forkal Mirth Hoyt Rebecca Hoke (Springfield) • Samir Karopady • Jae Hoon Kim • Martin Malone Shannon Peters • Moulik Ranka • Yzzer Roman Paul VanderVelde • Meredith Walker

the offices of technology management fiscal 2012 annual...

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