the microbiome: sorting the hype from the hope
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The Microbiome Lifeline
Bonnie Feldman, DDS, MBA – Your Autoimmunity Connectionwww.drbonnie360.com | @DrBonnie360
100+ 16% 10diseases US population Top leading
cause of death in women
less than 64 yrs
An Invisible Epidemic
The Gut is Where
It’s AtOrgan of Immunity
The Gut is Where
It’s AtBrain-Gut Axis
Different Microbiome Views: 2 Scientists & 4 Companies
•Andrew Hryckowian PhD – The Sonnenburg Lab •Embriette Hyde PhD - The Knight Lab•Peter DiLaura – CEO of Second Genome•Peter Lee MD – Co-Founder Osel Inc. •Larry Weiss MD – Chief Medical Officer of AOBiome•Colleen Cutcliffe PhD – CEO of Whole Biome
Company Indication What HowSecond Genome Therapeutic - Oral
Crohn’s Disease
Microbiome Modulating Discovery Platform (MMDP)ID key microbial community members/activities/metabolites & assay for modulatory potential against host targets
-Measure & ID changes in the microbial community composition/function/signaling in health or diseased states w/ MMDP-Generation & evaluation of small molecules/peptide biologic/bacterial strains that modulate microbe-microbe & microbe-human interactions
Osel Therapeutic - Topical
Women’s Health
“Live Biotherapeutic Products” (LBP) focusing on women’s health (GU & GI)
-Library of proprietary human bacterial strains-Screening methods to ID strains w/ unique protective properties-Produce stable high quality LBP from selected strains
AOBiome Therapeutic - Topical
Skin
Advance the science of Ammonia Oxidizing Bacteria (AOB) to restore the skin’s microbiome
-Topical therapeutic & consumer product of AOB to reintroduce Nitrosomonas to skin’s bacterial flora & restore Nitric Oxide balance
Whole Biome Diagnostics & Therapeutic
Metabolic Syndrome
Proprietary discovery platform for targeted equilibration of the microbiome. Focus on metabolic syndrome
-Target novel symbiotic functionality inherent in the human-microbial interface with a microbiome diagnostic discovery platform
• Autoimmune Disease: An Invisible Epidemichttp://bit.ly/1m0ttsl
• The Serious Health Concern All 20-somethings Should Know About http://bit.ly/R9cEgp
• Decoding Autoimmunity – a Summary of the State of the Art http://bit.ly/1knzaAQ
• The Lonely Voices of Autoimmune Disease via Youtubehttp://bit.ly/X41mMv
• Believe It or Not – The Real Voices of Autoimmunity http://bit.ly/20xRCXO
Your Autoimmunity Exploration
Exploring The Microbiome Lifeline
• Fasano, Alessio. “Leaky Gut and Autoimmune Diseases.” Clinical Reviews in Allergy & Immunology 42.1 (2012) : 71–8. <http://www.ncbi.nlm.nih.gov/pubmed/22109896>.
• Gomez, Andres, David Luckey, and Veena Taneja. “The Gut Microbiome in Autoimmunity: Sex Matters.”Clinical Immunology 159.2 (2015) : 154–162. <http://www.sciencedirect.com/science/article/pii/S1521661615001576>.
• Kamdar, K et al. “Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.” Cell Host & Microbe 19.1 (2016) : 21-31. <http://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(15)00498-9>.
• McLean, Mairi et al. “Does the Microbiota Play a Role in the Pathogenesis of Autoimmune Diseases?” Gut 64.2 (2014) : gutjnl–2014–308514. <http://gut.bmj.com/content/early/2014/11/28/gutjnl-2014-308514>.
• Waldor, Matthew et al. “Where next for Microbiome Research?” PLoS Biology 13.1 (2015) : e1002050. <http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050>.
• Wu, Hao, Valentina Tremaroli, and Fredrik Bäckhed. “Linking Microbiota to Human Diseases: A Systems Biology Perspective.” Trends in Endocrinology & Metabolism 26.12 (2015) : 758-770. <http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00194-0>.
Autoimmunity and the Microbiome
The Microbiome and Inflammatory Bowel Disease
• De Souza, Heitor, and Claudio Fiocchi. “Immunopathogenesis of IBD: Current State of the Art.” Nature Reviews Gastroenterology & Hepatology (2015) : 13-27 <http://www.ncbi.nlm.nih.gov/pubmed/26627550>.
• Sartor, R. Balfour. “The Intestinal Microbiota in Inflammatory Bowel Disease.” Nestle Nutrition Institute Workshop Series 79 (2014) : 29–39.<https://uncch.pure.elsevier.com/en/publications/the-intestinal-microbiota-in-inflammatory-bowel-diseases>.
• Sartor, RB, and SK Mazmanian. “Intestinal Microbes in Inflammatory Bowel Diseases.” The American Journal of
Gastroenterology … (2012) : 15-21. <http://www.nature.com/ajgsup/journal/v1/n1/abs/ajgsup20124a.html>.
• Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. “An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases.” Cell Host & Microbe 17.5 (2015) : 577-591. <http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00166-3>.
• Costalonga, M, and MC Herzberg. “The Oral Microbiome and the Immunobiology of Periodontal Disease and Caries.” Immunology Letters 162.2 (2014) : 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>.
The Microbiome and Periodontal Disease
Rheumatoid Arthritis
Systemic Lupus Erythematosus
• Scher, JU, and SB Abramson. “The Microbiome and Rheumatoid Arthritis.” Nature Reviews Rheumatology 7 (2011) : 569-578. <http://www.nature.com/nrrheum/journal/v7/n10/abs/nrrheum.2011.121.html>.
• Mu, Q, H Zhang, and XM Luo. “SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?” Frontiers in Immunology (2015) : n. pag. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/>.
Prevention – Diet, Food, & Nutrition• Tilg, H, and AR Moschen. “Food, Immunity, and the Microbiome.” Gastroenterology 148.6 (2015) : 1107-1119. <
http://www.sciencedirect.com/science/article/pii/S0016508515000128>.
• Zeevi et al. “Personalized Nutrition by Prediction of Glycemic Responses.” Cell. 163.5 (2015) : 1079-1094. <http://www.cell.com/abstract/S0092-8674(15)01481-6>.
• Zmora, N et al. “Taking It Personally: Personalized Utilization of the Human Microbiome in Health and Disease.” Cell Host & Microbe 19.1 (2016) : 12-20. <http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)00508-9.pdf>.
Prevention – Prebiotics & Probiotics• Hemarajata, P, and J Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of Intestinal
Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology. (2012) : 39-51. <http://tag.sagepub.com/content/early/2012/09/24/1756283X12459294.abstract>.
• Petschow, B et al. “Probiotics, Prebiotics, and the Host Microbiome: The Science of Translation.” Annals of the New York Academy of Sciences (2013) : 1-17. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.12303/full>.
The Microbiome Lifeline
+1.310.666.5312
www.drbonnie360.com
@DrBonnie360
www.facebook.com/YourAutoimmunityConnection
Bonnie Feldman, DDS, MBADrBonnie360 is helping companies and entrepreneurs counteract the autoimmune epidemic. Through consulting, market research, writing and speaking, she works with teams using data and digital tools to reshape research, diagnosis, treatment and prevention of autoimmune disease.