the krebs cycle occurs in the matrix of the mitochondrion aerobic phase (requires oxygen) 2-carbon...

The Krebs Cycle • Occurs in the matrix of the mitochondrion • Aerobic phase (requires oxygen) • 2-carbon acetyl CoA joins with a 4-carbon compound to form a 6- carbon compound called Citric acid

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The Krebs Cycle

• Occurs in the matrix of the mitochondrion

• Aerobic phase (requires oxygen)

• 2-carbon acetyl CoA joins with a 4-carbon compound to form a 6- carbon compound called Citric acid

• Citric acid (6C) is gradually converted back to the 4-carbon compound -ready to start the cycle once more

• The carbons removed are released as CO2 -enzymes controlling this process called decarboxylases

• The hydrogens, which are removed, join with NAD to form NADH2 -enzymes controlling the release of hydrogen are called dehydrogenases

Page 3: The Krebs Cycle Occurs in the matrix of the mitochondrion Aerobic phase (requires oxygen) 2-carbon acetyl CoA joins with a 4- carbon compound to form a

Page 4: The Krebs Cycle Occurs in the matrix of the mitochondrion Aerobic phase (requires oxygen) 2-carbon acetyl CoA joins with a 4- carbon compound to form a

The Cytochrome System

• 6 points along pathway where hydrogen is released and temporarily bound to NAD

• Reduced coenzyme NADH2 transfers hydrogen to a chain of hydrogen carriers called cytochrome system

• These systems are attached to the cristate of every mitochondrion

Page 5: The Krebs Cycle Occurs in the matrix of the mitochondrion Aerobic phase (requires oxygen) 2-carbon acetyl CoA joins with a 4- carbon compound to form a

• Transfer of hydrogen from each NADH2

along system

-produces 3 ATP

-process called oxidative phosphorylation

• Complete oxidation of glucose yields 38 ATP

-2 during glycolysis

-36 during oxidative phosphorylation

Page 6: The Krebs Cycle Occurs in the matrix of the mitochondrion Aerobic phase (requires oxygen) 2-carbon acetyl CoA joins with a 4- carbon compound to form a

Page 7: The Krebs Cycle Occurs in the matrix of the mitochondrion Aerobic phase (requires oxygen) 2-carbon acetyl CoA joins with a 4- carbon compound to form a

The role of oxygen

• Final hydrogen acceptor

• Combines to form water

• Controlled by enzyme cytochrome oxidase

• Presence of oxygen also essential for hydrogen to pass along the cytochrome system

Page 8: The Krebs Cycle Occurs in the matrix of the mitochondrion Aerobic phase (requires oxygen) 2-carbon acetyl CoA joins with a 4- carbon compound to form a

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