the human gene map for performance and healt1

The human gene map for performance and health- related fitness phenotypes: the 2001 update TUOMO RANKINEN; LOUIS PÉRUSSE; RAINER RAURAMAA; MIGUEL A. RIVERA; BERND WOLFARTH; CLAUDE BOUCHARD Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA; Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, CANADA; Kuopio Research Institute of Exercise Medicine, Department of Physiology, University of Kuopio and Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, FINLAND; Department of Physiology and Department of Physical Medicine, Rehabilitation and Sports Medicine, University of Puerto Rico School of Medicine, San Juan, PUERTO RICO; and Department of Preventive and Rehabilitative Sports Medicine, University of Freiburg, Freiburg, GERMANY MEDICINE & SCIENCE IN SPORTS & EXERCISE 2002;34:1219-1233 ABSTRACT ABSTRACT ABSTRACT ABSTRACT RANKINEN, T., L. PÉRUSSE, R. RAURAMAA, M. A. RIVERA, B. WOLFARTH, and C. BOUCHARD. The human gene map for performance and health-related fitness phenotypes: the 2001 update. Med. Sci. Sports Exerc., Vol. 34, No. 8, pp. 1219-1233, 2002. This review presents the 2001 update of the human gene map for physical performance and health-related phenotypes. It is based on scientific papers published by the end of 2001. Association studies with candidate genes, genome-wide scans with polymorphic markers, and single gene defects causing exercise intolerance to variable degrees are included. The genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise or for training-induced changes are positioned on the genetic map of all autosomes and the X chromosome. Negative studies are reviewed, but a gene or locus must be supported by at least one positive study before being inserted on the map. By the end of 2000, there were 29 loci depicted on the map. The 2001 map includes 71 loci on the autosomes and two on the X chromosome. Among these genes or

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Human Gene Map

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The human gene map for performance and health-related fitness phenotypes: the 2001 update

TUOMO RANKINEN; LOUIS PÉRUSSE; RAINER RAURAMAA; MIGUEL A. RIVERA; BERND WOLFARTH; CLAUDE BOUCHARD

Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA; Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, CANADA; Kuopio Research Institute of Exercise Medicine, Department of Physiology, University of Kuopio and Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, FINLAND; Department of Physiology and Department of Physical Medicine, Rehabilitation and Sports Medicine, University of Puerto Rico School of Medicine, San Juan, PUERTO RICO; and Department of Preventive and Rehabilitative Sports Medicine, University of Freiburg, Freiburg, GERMANY

MEDICINE & SCIENCE IN SPORTS & EXERCISE 2002;34:1219-1233

ABSTRACTABSTRACTABSTRACTABSTRACT RANKINEN, T., L. PÉRUSSE, R. RAURAMAA, M. A. RIVERA, B. WOLFARTH, and C. BOUCHARD. The human gene map for performance and health-related fitness phenotypes: the 2001 update. Med. Sci. Sports Exerc., Vol. 34, No. 8, pp. 1219-1233, 2002. This review presents the 2001 update of the human gene map for physical performance and health-related phenotypes. It is based on scientific papers published by the end of 2001. Association studies with candidate genes, genome-wide scans with polymorphic markers, and single gene defects causing exercise intolerance to variable degrees are included. The genes and markers with evidence of association or linkage with a performance or fitness phenotype in sedentary or active people, in adaptation to acute exercise or for training-induced changes are positioned on the genetic map of all autosomes and the X chromosome. Negative studies are reviewed, but a gene or locus must be supported by at least one positive study before being inserted on the map. By the end of 2000, there were 29 loci depicted on the map. The 2001 map includes 71 loci on the autosomes and two on the X chromosome. Among these genes or

Page 2: The Human Gene Map for Performance and Healt1

markers, 24 are from prior publications on exercise intolerance and four relate to other pathologies. Finally, 13 sequence variants in mitochondrial DNA have been shown to influence relevant fitness and performance phenotypes.

Med Sci Sports Exerc 2002 August;34(8):1219-1233

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