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111010

our 41ST year

Covering Homewood, East Baltimore, Peabody,

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September 26, 2011 The newspaper of The Johns Hopkins university Volume 41 No. 5

Job Opportunities

Notices

Classifieds

CoNVerGeNCe

Homewood students, residents

of nearby neighborhoods come

together at block party, page 8

SaFeTy uPDaTe

University, city work together

to improve conditions for

pedestrians, bike riders, page 4

I N B r I e F

Friedman, Mandelbaum book discussion; local

authors read; Work and Family Fair

C a L e N D a r

Amitav Ghosh; ‘A Taste of Africa’ at

SPH; Rosh Hashana services; blood drive2 12

NIH Director’s Awards go to three JHU scientists for work that challenges status quo, speeds translation of research

K U D O S

Celebrating innovation at JHUB y G r e G r i e n z i

The Gazette

From the proximity fuse that helped the Allies win World War II to the first “blue baby” operation that

opened the way to modern heart sur-gery, Johns Hopkins University boasts a history and culture of innovation and

discovery. Since its inception, the university and its personnel have pushed the bound-aries of human understanding in a number of fields, at times making the seemingly impos-sible a reality.

To celebrate and help support this culture, the Office of the Provost has launched the Provost’s Project on Inno-vation to spotlight current Johns Hop-kins faculty and staff who are on discov-ery’s frontline. The Provost’s Lecture Series, begun in 2010 to spread the wealth of academic excellence at Johns Hopkins among its campuses, will kick off the initiative. The theme of this year’s lecture series will be innovation, highlighting the unique role of research universities in fostering innovative thinking and cre-ative solutions to some of the world’s greatest challenges. The stellar fall lineup will feature patient safety cham-pion Peter Pronovost, tissue engineering expert Jennifer Elisseeff and award-win-ning astrophysicist Adam Riess. “From pioneering the use of the check-list in health care, to inventing bioma-terials, to discovering the accelerating universe, the fall lineup demonstrates the breadth of innovative and creative thinking at Johns Hopkins,” said Lloyd B. Minor, provost and senior vice presi-dent for academic affairs. “Innovation is at the heart of our mission. We have the tools, we have the minds, the exper-tise, the skills and experience needed to discover innovative solutions to age-old and emerging problems. Research uni -

Continued on page 7

F O C U S

Provost’s

initiative will

kick off with

lecture series,

interviews B y M a r y a l i c e y a k u t c h i k

Johns Hopkins Medicine

A pioneer in the field of epigenetics who has been spearheading the use of genomewide technology for epigenetics research, a

researcher who has revealed a weakness in the tuberculosis bacterium that makes it more susceptible to antibiotics and a scientist who seeks to revolutionize new methods for toxicological testing to Continued on page 3

Thomas Hartung

Envisioning a community-changing school E A S T B A L T I M O R E

Continued on page 7

President Daniels talks with business leaders about Johns Hopkins’ plans

B y a n d r e w B l u M B e r G

Carey Business School

A fledgling K-8 East Baltimore charter school represents a “poignant, vivid, and galvanizing place” for Johns

Hopkins University to reaffirm its commit-ment to the present and future fortunes of

the community, said Johns Hopkins Presi-dent Ronald J. Daniels in his remarks Sept. 20 as inaugural speaker for the 2011–2012 Carey Business School’s Leaders + Legends lecture series. Daniels delivered his remarks, titled “Enduring Institutions, Evolving Cities: Johns Hopkins and Baltimore,” to a collec-tion of regional business and community leaders and policymakers, as well as members of the Carey School community, many of whom live, work, study or conduct business in East Baltimore. His talk examined the symbiotic 130-year relationship between city and university by citing the East Baltimore

Community School, a small start-up public institution with fewer than 220 students, as an illustration “to help concretize the ways in which Johns Hopkins has committed to, and will continue to commit to, the better-ment of our community here in Baltimore.” Declaring it a “core priority” in the sweeping $1.8 billion East Baltimore Devel-opment Inc. initiative, Daniels outlined the ways in which the school has already started to change the lives of individuals, families and, by increments, a community long beset by poverty, crime and drug abuse.

improve human health and reduce animal testing have received Director’s Awards from the National Institutes of Health. Andrew P. Feinberg, the King Fahd Pro-fessor of Molecular Medicine; a professor in the departments of Molecular Biology and Genetics and of Oncology; and direc-tor of the Center for Epigenetics in the Institute for Basic Biomedical Sciences, all at the Johns Hopkins University School of Medicine, is one of 13 winners this year of the Director’s Pioneer Award, which confers $2.5 million in direct funding over five years. Microbial geneticist Gyanu Lamichhane

of the Johns Hopkins Center for Tuber-culosis Research is one of 49 recipients of the New Innovator Award, which is given to promising scientists in the early stages of their careers and is supported directly with $1.5 million in research funding over five years. Thomas Hartung, director of the Cen-ter for Alternatives to Animal Testing at the Johns Hopkins Bloomberg School of Public Health, where he is the inaugu-ral holder of the Doerenkamp-Zbinden

Gyanu Lamichhane andrew Feinberg

2 THE GAZETTE • August 15, 20112 THE GAZETTE • September 26, 2011

I N B R I E F

Friedman and Mandelbaum to discuss new book at SAIS

On Tuesday, Sept. 27, SAIS will host a discussion of That Used to Be Us: How America Fell Behind in the

World It Invented and How We Can Come Back, a recently published book co-authored by New York Times columnist Thomas L. Friedman and Michael Mandelbaum, direc-tor of the SAIS American Foreign Policy Program. A live webcast of the 5:30 p.m. event, for which attendance is by invitation only, will be accessible at www.sais-jhu.edu. In That Used to Be Us (Farrar, Straus and Giroux), Friedman and Mandelbaum ana-lyze the four challenges the United States faces—globalization, the revolution in infor-mation technology, the nation’s chronic def-icits and the country’s pattern of excessive energy consumption—and spell out what needs to be done to sustain the American dream and preserve American power in the world. The authors say that the end of the Cold War blinded the nation to the need to address these issues seriously, and that China’s educational successes, industrial might and technological prowess remind Americans of the ways in which “that used to be us.” They explain how the paralysis of the political sys-tem and the erosion of key American values have made it impossible to carry out the poli-cies the country urgently needs. Friedman and Mandelbaum say they believe that the recovery of American great-ness is within reach. America’s history, when properly understood, they say, offers a five-part formula for prosperity that will enable the country to cope successfully with the challenges it faces.

Work and Family Fair for employees planned for Oct. 5

All employees are invited to attend the 2011 Johns Hopkins Work and Family Fair. More than 30 experts

will provide information and resources relat-ed to work-life balance from 11:30 a.m. to 1:30 p.m. on Wednesday, Oct. 5, in the Turn-er Concourse on the East Baltimore campus. The Work and Family Fair provides resources to help employees better integrate their work and personal lives, maintain a healthy lifestyle and create a quality work environment. Representatives from local agencies and organizations will be available to discuss child care and parenting, aging parents/older adults, finances, legal issues, disability services, and health and wellness. One lucky attendee will win a family mem-bership to The Maryland Zoo. During the fair, the Johns Hopkins Top 10 Strategies for Achieving Work-Life Bal-ance will be announced. Employees may contribute their work-life balance strategies

Applied Physics Laboratory Michael Buckley, Paulette CampbellBloomberg School of Public Health Tim Parsons, Natalie Wood-WrightCarey Business School Andrew Blumberg, Patrick ErcolanoHomewoodLisa De Nike, Amy Lunday, Dennis O’Shea,Tracey A. Reeves, Phil SneidermanJohns Hopkins MedicineChristen Brownlee, Stephanie Desmon, Neil A. Grauer, Audrey Huang, John Lazarou, David March, Vanessa McMains, Ekaterina Pesheva, Vanessa Wasta,Maryalice YakutchikPeabody Institute Richard SeldenSAIS Felisa Neuringer KlubesSchool of Education James Campbell, Theresa NortonSchool of Nursing Kelly Brooks-StaubUniversity Libraries and Museums Brian Shields, Heather Egan Stalfort

e d i t o r Lois Perschetz

w r i t e r Greg Rienzi

Pr o d u c t i o n Lynna Bright

co P y ed i t o r Ann Stiller

Ph o t o G r a P h y Homewood Photography

ad v e rt i s i n G The Gazelle Group

Bu s i n e s s Dianne MacLeod

ci r c u l at i o n Lynette Floyd

we B M a s t e r Lauren Custer

c o n t r i B u t i n G w r i t e r s

The Gazette is published weekly Sept-ember through May and biweekly June through August for the Johns Hopkins University community by the Office of Communications and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscriptions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publica-tion date.

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to the list by Wednesday, Sept. 28, at www.hopkinsworklife.org.

Short story writer and poet to read at Barnes & Noble

Two local authors will read from their latest works this week at Barnes & Noble Johns Hopkins.

Rae Bryant, a JHU Writing Seminars alumna who lives in the Washington, D.C., area, will read at 7 p.m. on Tuesday, Sept. 27, from her story collection, The Indefinite State of Imaginary Morals, which has been nominated for the Hemingway Foundation/PEN Award. It was published in June. At 7 p.m. on Thursday, Sept. 29, Michael Fallon, a Charles Village–based poet and a senior lecturer at UMBC, will read from The Great Before and After, a collection of poetry published this month.

Clifton Taulbert kicks off intro of new high school curriculum

More than 200 students and teachers from the Baltimore Talent Devel-opment High School, along with

40 students from March Middle School and Baltimore Civitas School, will visit the Johns Hopkins Homewood campus on Tuesday, Sept. 27, for an inspirational talk, “Making the Impossible Possible,” by Clif-ton Taulbert, an international best-selling author and entrepreneur. The event marks the kick-off at BTDHS of a new interactive curriculum developed by Taulbert, the Eli Company and the Kauff-man Foundation of Kansas City. The course work is based on Taulbert’s book Once Upon A Time When We Were Colored, the story of his childhood in the Jim Crow–segregated Mississippi Delta. BTDHS students will be among the first to use the new elective course, which is designed to help young people, despite chal-lenging circumstances, think like entrepre-neurs. The high school is an “innovation school” run in partnership by the Baltimore City Public Schools and Johns Hopkins’ Center for Social Organization of Schools. CSOS operates both March Middle School and Baltimore Civitas School.

Frederick Starr of SAIS receives New Orleans Spark Plug Award

On Sept. 15, the Greater News Orleans Foundation presented Fred-erick Starr, chair of the SAIS Cen-

tral Asia–Caucasus Institute, with its first Spark Plug Award. The award recognizes the instrumental role that Starr played in 1983, when he was vice president of Tulane Uni-versity, in creating the foundation to serve the community of New Orleans. Starr also is a professional jazz musician and an expert in the architecture of New Orleans.

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September 26, 2011 • THE GAZETTE 3

Continued from page 1

NIH

Endowed Chair in Evidence-based Toxicol-ogy in the Department of Environmental Health Sciences, is one of 17 recipients of a $5 million Transformative Research Projects Award. “The NIH Director’s Award programs reinvigorate the biomedical workforce by providing unique opportunities to conduct research that is neither incremental nor conventional,” said James M. Anderson, director of the NIH’s Division of Program Coordination, Planning and Strategic Ini-tiatives, who guides the NIH Common Fund’s High-Risk Research program. “The awards, this year totaling $143.8 million, are intended to catalyze giant leaps forward for any area of biomedical research, allowing investigators to go in entirely new direc-tions.” Andrew Feinberg’s groundbreaking research involving non-DNA sequence-related heredity spans three decades; his early studies of epigenetic alterations of genes in human cancer were controversial. Because epigenetics involves the relation-ship between an individual’s genetic back-ground, the environment, aging and diseases such as cancer, it is today at the epicenter of modern medicine. “I feel incredibly lucky to receive this award,” Feinberg said. “It gives me the chance to test a unified theory I’ve been developing for understanding the relation-ship between normal development, epi-genetics and evolutionary selection in a changing environment. I plan to test the model in ways I never could with regu-lar grant funding; for example, by genetic and epigenetic analysis of honeybees, which show remarkable epigenetic plasticity that is environmentally sensitive, and a relatively

small genome compared to other model organisms.” Based on the results of recently published research using the latest gene-sequencing tools to examine epigenetic influences on the DNA makeup of colon cancer, Feinberg suggests that cancer treatment might even-tually be more tolerable and successful if therapies could focus on helping cancer cells get back to normal, in addition to strate-gies for killing them. His team focused on a particular epigenetic biochemical signature known as methylation, which silences genes. Although not part of a gene’s central DNA sequence, it is copied when a cell divides, perpetuating its activ-ity. “The most excit-ing medical idea in epigenetics is that it might be possible to intervene at the junc-tion between the genome and the environ-ment to modify the effects of deleterious genes, and to influence the effects of the environment on us, perhaps influencing aging or mastering tissue reprogramming in regenerative medicine,” Feinberg said. “We’re only just now really seeing how large its impact might be, and so it’s surprising to be recognized for the work done in my labo-ratory.” Gyanu Lamichhane has discovered the key role of enzyme L,D-transpeptidase in forming chemical linkages inside the pro-tective cell wall in Mycobacterium tuber-culosis, the bacterium responsible for TB diseases. The same enzyme and chemical linkages help hold together the cell walls of other disease-causing bacteria, including salmonella, Enterococcus and Escherichia coli. Lamichhane’s recent research shows that when L,D-transpeptidase is unable to func-tion, especially in chronic infections when

the enzyme is more active, the TB bacte-rium loses its virulence, as chemical linkage formation stalls and the bacterial cell wall weakens. This, in turn, exposes other chemi-cal linkages holding the cell wall together, linkages that are known targets of widely prescribed beta-lactam drugs, such as amoxi-cillin. As part of the new project, Lamichhane plans to investigate chemicals that inter-fere with L,D-transpeptidase activity and whether these compounds, when used in combination with antibiotics, hasten treat-ment of chronic TB or other kinds of bacterial infection. He will also study the enzyme’s fundamental role in the physiology of the bacterial cell wall. “Our research shows the potential for relatively simple genetic observations about bacterial enzymes to have a broad and pow-erful impact on possible treatments for a host of infectious diseases,” said Lamichhane, an assistant professor in the Johns Hopkins School of Medicine. “As a whole new class of drugs, L,D-transpeptidase inhibitors, plus antibiotics, could potentially shorten TB treatment, which now takes a minimum of six months, and it could offer new treatment options to people who have developed drug resistance,” he said. Experts estimate that 2 billion people worldwide are infected with tuberculosis, 10 million of whom fall ill each year. Tuber-culosis is the leading cause of death among people co-infected with HIV, the virus that causes AIDS, leading to some half-million deaths annually among those co-infected. As the director of CAAT, Transformative Research Projects Award recipient Thomas Hartung received the funding for a con-sortium to develop a new technological methodology for mapping the molecular pathways of toxicity within cells. CAAT’s ambitious goal is a comprehensive under-standing of molecular “pathways of toxicity” that lead to adverse health effects when

perturbed. “Mapping the entirety of these pathways—which I’ve termed the ‘Human Toxome’—will be a large-scale effort, per-haps on the order of the Human Genome Project,” Hartung said. As a first step to mapping the Human Toxome, Hartung and his collaborators have proposed tackling the pathways of endocrine disruption, a perturbation of the hormonal system that can cause tumors, birth defects and developmental disorders. Since its inception, the NIH Director’s Award Program has funded a total of 406 High-Risk Research Awards: 111 Pioneer Awards since 2004, 216 New Innovator Awards since 2007 and 79 Transformative Research Projects Awards since 2009.

David March of Johns Hopkins Medicine and Tim Parsons of the Bloomberg School of Public Health contributed to this article.

Related websitesandrew Feinberg: www.hopkinsmedicine.org/ geneticmedicine/People/Faculty/ Feinberg.html

Center for epigenetics at Johns Hopkins: epigenetics.jhu.edu

Gyanu Lamichhane: www.hopkinsmedicine.org/DOM/ TB_Lab/faculty/lamichhane.html

Thomas Hartung: www.jhsph.edu/faculty/directory/ profile/5038/Hartung/Thomas

JHu Center for alternatives to animal Testing: caat.jhsph.edu

altweb.jhsph.edu

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B y i a n M a t h i a s

Krieger School of Arts and Sciences

Physics and Astronomy professors Charles Bennett, Adam Riess and Joseph Silk were honored together last week in recogni-tion of their recently received

endowed professorships and the remarkable work they have contributed to the fields of astronomy and astrophysics. The event took place Sept. 19 in the Bloomberg Center for Physics and Astronomy on the Homewood campus. “Appointment to an endowed chair has been a coveted honor for distinguished fac-ulty ever since the first professorships were created five centuries ago at the universities of Oxford and Cambridge,” noted Katherine

Newman, the James B. Knapp Dean of the Krieger School of Arts and Sciences, at the event celebrating the three faculty mem-bers. “Those who hold endowed chairs are leaders in their fields. They are the pioneers who will chart new courses of discovery and attract the brightest and most promising stu-dents. These faculty members bring added luster to the name of Johns Hopkins.” Charles Bennett, the Alumni Centen-nial Professor in Physics and Astronomy, is one of the world’s leaders in the study of the cosmic microwave background radia-tion that fills the universe. A professor at Johns Hopkins since 2005, he has brought numerous accolades to the department in his short time here, including his being elected to the National Academy of Sci-ences in 2005 and receiving the National Academy of Sciences’ Henry Draper Medal

Three named professorships awarded in Physics and Astronomyin 2005, the Harvey Prize in 2006, the Comstock Prize in Physics in 2009 and the 2010 Shaw Prize in Astronomy (co-winner). His named professorship com-memorates a century of achievement at Johns Hopkins, which celebrated its 100th birthday in 1976 with a year of events and a symposium that brought scholars from all over the world to Johns Hopkins. Adam Riess, the Krieger-Eisenhower Pro-fessor in Physics and Astronomy, joined the department in 2006. He has played a critical role in discovering the nature of dark energy, which has offered a profound contribution to the human understanding of our uni-verse. Among the honors he has garnered are the 2004 Sackler Prize, the 2006 Shaw Prize in Astronomy (co-winner), the 2007 Gruber Prize in Cosmology (co-winner), a 2008 MacArthur Fellowship and the 2011

Einstein Medal (co-winner). The Krieger-Eisenhower Professorship is a tribute to one of the university’s greatest benefactors, Zan-vyl Krieger, and his close friendship with for-mer JHU President Milton S. Eisenhower. Joseph Silk, the Homewood Professor in Physics and Astronomy, is a widely respected veteran of his field who joined Johns Hop-kins in 2010. Over his 40-year career, Silk has established himself as one of the world’s leading theoretical astrophysicists, having published more than 500 scholarly papers with more than 23,000 citations. Of his many awards and honors, he most recently received the 2011 Balzan Prize for his inspired work on the early universe. His professorship is named in honor of Arts and Sciences’ North Baltimore home and was established by the school’s Academic Coun-cil.

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The Gazette

In concert with Baltimore City agencies, Johns Hopkins has been working hard to further enhance pedestrian and bicycle

safety around the Homewood campus. The measures developed and being stud-ied will require a combination of traf-fic enforcement, engineering solutions and safety education to create behavioral changes and awareness among students, faculty and staff. Several serious accidents over the past several years involved undergraduates being struck by cars. Nathan Krasnopoler, a 20-year-old student in the Whiting School of Engineering, died this summer from the severe injuries he received in February, when he was struck by a car while bicycling on University Parkway near the campus. Sarah B. Steinberg, vice provost for stu-dent affairs, and Daniel Ennis, senior vice president for finance and administration, said that Krasnopoler’s traffic death under-scored the urgent need to address this issue. “We want to help create a walkable and safer community for everyone,” Steinberg said. The university worked in the spring with the Baltimore Police Department to arrange

for traffic checkpoints and enhanced traffic law enforcement in the area. Those efforts focused on late-night and early-morning weekend hours. Patrols and monitoring will continue in Charles Village on weekend nights this fall, with the aim of keeping speeds down, citing drivers who commit moving violations and removing intoxicated drivers from the roads. At the university’s behest, Baltimore Police are also instituting regular daytime traffic enforcement efforts at hours when many students and other pedestrians are crossing busy streets. Additionally, Johns Hopkins has been a major player in the ongoing renovation of Charles Street, specifically the stretch of Charles Street that runs roughly the full length of the Homewood campus. The three-year $25 million endeavor will serve many goals, primarily to enhance pedes-trian safety. Johns Hopkins is contributing significantly to the city’s budget for the project. At the request of university administra-tion, the Center for Injury Research and Policy at the Bloomberg School of Public Health conducted a comprehensive study of other intersections and major roads around Homewood. The center recommends addi-tional crosswalks, more speed limit signs, better-synchronized traffic lights and walk signs, and other measures. The center’s study noted that San Martin Drive, the winding roadway on the west side of campus, has poor sightlines and is too narrow to accommodate two lanes of traffic plus bicycles, runners and pedestrians. The university is pursuing traffic-calming approaches, traffic-flow design elements and pedestrian-oriented improvements, but must do so in concert with the community and subject to municipal requirements. Andrea Gielen, director of the Center for Injury Research and Policy, said that the center conducted a series of interviews this summer with a Homewood faculty and stu-dent focus group. She said the results were somewhat eye-opening. “It might seem obvious, but the people

Pedestrian, bike safety issues are focus of effortshere at Johns Hopkins come from all parts of the country and all different environments, so we’re dealing with a group of people with different pedestrian behaviors,” she said. “That has to be taken into account.” Gielen said that the center’s work will contribute to safety efforts at Johns Hop-kins and elsewhere. “Somewhat surprisingly, there is not much information out there about pedestrian and bike safety around college campuses. The issue hasn’t received the level of attention it deserves. It’s worth looking at, and we hope to share our findings with other urban universities.” The university also hired traffic engineers to study the intersection of St. Paul and 33rd streets. The engineers’ report detailed a number of options for improving safety at that sometimes dangerous and confus-ing intersection, reinforcing the Center for Injury Research and Policy’s findings. The university and the community have advo-cated action by the city and state. Nighttime lighting and visibility on and around campus have been significantly improved. Over the past several months, Johns Hopkins and Baltimore City have trimmed more than 200 trees. The uni-versity has spent more than $300,000 to upgrade on-campus lighting, and the city has installed new street lamps along Charles Street from 29th Street to Art Museum Drive, the first phase of an effort that even-tually will continue up to University Park-way. Steinberg said that students, faculty and staff are encouraged to walk to and from campus but should use “basic street smarts.” Homewood Security and the Office of Stu-dent Affairs, she said, have made a point to educate students on safety issues. “There is a lot of traffic in this area, and we want drivers, pedestrians and cyclists to be educated and aware,” she said. “The solu-tions will result from engineering, enforce-ment and education.” Steinberg and Ennis said that the Johns Hopkins community will continue to be updated with the university’s efforts to improve pedestrian and bike safety.

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Innovation

versities have long pushed the boundaries of what is known. As chief academic offi-cer, I see every day how these pieces come together, allowing us to approach old prob-lems with new ideas.” Minor said that the Project on Innova-tion, which also will manifest itself in his public speeches and a yearlong series of faculty innovation stories on the Provost’s Office website, will also help illustrate how the world’s most pressing problems, such as the global water crisis and health care deliv-ery, demand a tapestry of expertise. “Finding these solutions will require bring-ing people and ideas together in new and creative ways,” he said. “Universities bring multiple experts and disciplines together to take up the profoundly complex issues that can be solved no other way. Assumptions are routinely questioned, ideas are debated, and new knowledge is created and shared. Research universities are havens of ideas and laboratories of innovation.” The fall series opens on the Homewood campus with a talk by Peter Pronovost, director of the new Armstrong Institute for Patient Safety and Quality and Johns Hopkins Medicine senior vice president for patient safety and quality. Pronovost will discuss the importance of health-delivery research from 4:30 to 6:30 p.m. on Oct. 13 in Gilman Hall, room 50. While patients have benefited signifi-cantly from the investment in biomedical research, “preventable harm” is the third-leading cause of death in the United States, according to Pronovost, a professor of anes-thesiology and critical care medicine in the School of Medicine. His talk will focus on how research universities can help address the U.S. health care crisis. Pronovost, who also holds appointments in the schools of Public Health and Nurs-ing, has dedicated his career to finding ways to make hospitals and health care safer for patients. He developed a scientifically proven method for reducing the deadly infections associated with central line cath-eters. His checklist protocol, piloted in Michigan, virtually eliminated these infec-tions at participating hospitals, saving 1,500 lives and $100 million annually for the state. The checklist protocol is now being imple-mented in other states and in several other countries. Pronovost chronicled his efforts in his new book, Safe Patients, Smart Hospitals: How One Doctor’s Checklist Can Help Us Change Health Care from the Inside Out. He has published more than 400 articles related to patient safety. He serves in an advisory capacity to the World Health Organization’s World Alliance for Patient Safety and regu-

larly addresses Congress on related medical issues. He has won several national awards, includ-ing the 2004 John Eisenberg Patient Safety Research Award and a coveted MacArthur Fellowship in 2008. He was named by Time magazine as one of the world’s “100 most influential people” in 2008. Jennifer Elisseeff’s talk, to take place on Nov. 21 at the Bloomberg School of Public Health, will be titled “Materials in Medi-cine: From Tools to Translational Tissue Engineering.” The event is scheduled for 5 to 7 p.m. in the Feinstone Room, E2030. Elisseeff said that recent advances in syn-thesis and design allow researchers to create and manipulate synthetic structures that mimic many aspects of native tissue. The understanding of cell response to biomateri-als and structure-function correlations, she said, is being leveraged to design composite biomaterials that can direct tissue repair and regeneration for translational tissue engi-neering in the musculoskeletal, craniofacial and ocular systems. Elisseeff, an associate professor at the School of Medicine and the Jules Stein Pro-fessor in Ophthalmology at its Wilmer Eye Institute, joined Johns Hopkins in 2001 as an assistant professor in the Department of Biomedical Engineering. In 2004, she co-founded Cartilix Inc., a company that combined adhesive and biomaterial technologies for treating ortho-pedic disease. In 2009, she founded Aegeria Soft Tissue and Tissue Repair, two startups that both focused on soft-tissue regeneration and wound healing. Elisseeff also directs the recently estab-lished Translational Tissue Engineering Center at Johns Hopkins in collaboration with the university’s Biomedical Engineer-ing Department. She serves on several advi-sory boards and in 2008 was elected a fellow in the American Institute for Medical and Biological Engineering.

In the final talk of the fall series, Adam Riess will discuss “Dark Energy and the Cosmic Expansion History” at the Applied Physics Laboratory. The event will take place from noon to 2 p.m. on Jan. 27, 2012, in Parsons Auditorium. An overflow room will be created as last year’s Provost’s Lecture at APL with Charles Bennett was so popular that space ran out. Riess, a professor of physics and astron-omy at Johns Hopkins and a staff member at the Space Telescope Science Institute, leads the High-z SN Search Program, which uses the Hubble Space Telescope to discover distant supernovae. The program has studied the expansion of the universe more than 10 billion years ago. This work has detected an early phase of decelerating expansion, causing the most distant supernovae to look relatively brighter. In his talk, Riess will explain how the universe’s expansion rate and its evolution must be empirically determined to reveal its composition, scale, age and fate. He will review a number of recent Hubble Space Telescope experiments, including improve-ments in the determination of the Hubble constant using a new infrared array, and a three-year search for the most distant exploding stars. In 1998, as a Miller Fellow at the Uni-versity of California at Berkeley, he led the study for the High-z Supernova Search Team that first reported evidence that the universe’s expansion rate is accelerating. Science magazine named the discovery the “Breakthrough of the Year” in 1998. In 2006, he shared the Shaw Prize in Astronomy for the discovery of cosmic acceleration and the 2007 Gruber Prize with members of the High-z team and the Super-nova Cosmology Project. Riess was awarded a MacArthur Fellowship in 2008, elected to the National Academy of Sciences in 2009 and was a co-recipient of the Einstein Medal in 2011.

Each lecture will be followed by a Q&A session and reception. The fall series will also include an external speaker, Newark, N.J., Mayor Cory Booker, at 5:30 p.m. on Saturday, Oct. 15, in Shriver Hall on the Homewood campus. Booker’s lecture is in partnership with the Milton S. Eisenhower Symposium, whose theme this year is “America’s Boundless Possibilities: Innovate, Advance, Transform.” Mayor of Newark since 2006, Booker has earned a reputation as one of the coun-try’s most innovative leaders. Under his leadership, the city has reduced crime and brought a sense of renewal to streets. He was named one of the “100 Most Influential People” in 2011 by Time magazine and is often called the “innovative mayor.” The spring 2012 Provost’s Lecture Series lineup features clinical psychologist and bipolar disorder expert Kay Jamison from the School of Medicine, child psychologist Lisa Feigenson from the School of Arts and Sciences, and Provost Minor, a scientist and surgeon and University Distinguished Ser-vice Professor of Otolaryngology–Head and Neck Surgery. The list of past speakers in the series includes Nobel Prize winner Carol Greider from the School of Medicine, China expert and noted author David Lampton from SAIS, and embryologist and science enthusiast Steve Farber from the School of Arts and Sciences. The online Project on Innovation series of faculty profiles, scheduled to premier Oct. 3 at www.jhu.edu/provost, will feature wide-ranging conversations with innovative thinkers from every division, beginning with Krieger-Eisenhower Professor of Anthropol-ogy Veena Das, whose work has expanded anthropologists’ understanding of complex societies. For more information on the upcoming lec-tures, go to www.jhu.edu/provost/lectures. Those planning to attend are asked to email [email protected].

Peter Pronovostadam riess Jennifer elisseeff

“We believe the school has the potential to change a child’s trajectory, a family’s trajectory and, indeed, the trajectory of an entire neighborhood,” Daniels said. The EBCS opened in 2009 in a tem-porary location, a former city elementary school. In August of this year, Johns Hop-kins and Morgan State University assumed operating responsibilities, with Johns Hop-kins’ School of Education taking over day-to-day operations as part of the partnership. In August 2013, the school is scheduled to relocate to a new 90,000-square-foot facil-ity, part of a seven-acre campus within the EBDI redevelopment area, directly north of the Johns Hopkins Medical Institutions. The first new school built in East Baltimore in a quarter-century, it will be comple-mented by a $10 million 28,000-square-foot early childhood center, the two facili-ties providing a “connected continuum of care” for children through grade 8, accord-ing to Daniels. The school itself will have


School the capacity to accommodate almost 550 students. When completed, the EBDI area will feature affordable and market-rate housing, a grocery store and other retail offerings, and a fitness center, as well as lab space for bio-science startup firms and a signature urban park, presenting the potential for sustain-able business development and partnership opportunities of special interest to many in attendance at the lecture. Daniels stressed the challenges—and opportunities—inherent in the daily run-ning of a startup school. “That includes everything from recruiting teachers and designing curricula to deciding the color of the hallway bulletin boards,” he said. “Even our smallest decisions … are deeply rooted in the best evidence-based research avail-able.” Citing the “depth and breadth of the community’s problems and privations,” Dan-iels also acknowledged the “significant chal-lenges” facing the EBCS. Noting research that links lower socioeconomic status with language development and long-term mem-ory problems, Daniels emphasized that the school “must respond” to these findings. One long-term strategy is in promoting the

EBDI as a mixed-income, socioeconomically diverse community. “We know that [all] children thrive in socioeconomically diverse settings,” said Daniels, citing the benefits to both children from higher-income families as well as those from more modest back-grounds. Another key component to the school’s success, Daniels added, is to “focus holisti-cally on each child’s behavioral, cognitive and physical health. Simply put, we can design the most dynamic and engaging edu-cational program in the world, but if the kids are too hungry to pay attention or sit still long enough to listen, they can’t and won’t take advantage of the pedagogical experi-ence,” he said. That experience is predicated in large part on an extensively tested comprehensive education model, Success for All, designed by two Johns Hopkins professors and cur-rently in use in more than 1,500 schools nationwide. “We’re thrilled to be bringing this marquee program home again,” Daniels said. To meet the myriad challenges repre-sented by the undertaking, Daniels pointed to the many areas of the university, in addi-tion to the School of Education, that are

contributing their time, passion and exper-tise, ranging from mental health counseling from the schools of Medicine, Public Health and Nursing, to a Preparatory branch open-ing by the Peabody Conservatory to after-school programs and sports clinics hosted by the Athletic Department. Daniels also acknowledged the numerous commitments made by the Carey School to the overall well-being of Baltimore, includ-ing Innovation for Humanity’s marketing plans for urban farms to combat city “food deserts”; Stocks in the Future, a financial literacy program for middle school students; and CareyServes, a student-formed club engaged in volunteer services throughout the city. In closing, Daniels reiterated the high hopes that Johns Hopkins has for EBCS’s becoming an educational and institutional anchor for the EBDI development. “Over time, we expect the centripetal pull of this school, and all it has to offer, will draw the nascent community together, helping to forge a new, shared sense of place,” he pre-dicted. “It’s not hard to imagine the radical effect a stable, safe and sought-after neigh-borhood could have on East Baltimore and the entire city.”

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The Johns Hopkins University and the Charles Village Business Associa-tion hosted the seventh annual JHU

Convergence block party on Sunday, Sept. 18. Johns Hopkins students and adminis-trators, including President Ron Daniels; residents from the neighborhoods surround-ing the Homewood campus; and locally ori-ented exhibitors came together to celebrate the community and enjoy the free food, a

Neighborhood get-togethermoon bounce, face painting, carnival games and $1,000 in prizes from local businesses. McGruff the crime dog and the JHU Blue Jay mascot also made appearances. New this year was a dunk tank, with “dunkees”—JHU students, community members and Salem Reiner, JHU’s director for community affairs—raising $250 for the Village Learn-ing Place. More photos are posted online at gazette.jhu.edu. —Melissa Thompson

Students and residents gather at the annual JHu Convergence block party.

B y c h r i s t e n B r o wn l e e


A team of researchers says it has dis-covered why so many people under-going magnetic resonance imaging,

especially in newer high-strength machines, get vertigo, or the dizzy sensation of free-

falling, while inside or when coming out of the tunnel-like machine. In a new study published in Current Biol-ogy online Sept. 22, a team led by Johns Hopkins scientists suggests that MRI’s strong magnet pushes on fluid that circulates in the inner ear’s balance center, leading to a feel-ing of unexpected or unsteady movement. The finding could also call into question

Johns Hopkins researchers pinpoint the cause of MRI vertigoresults of so-called functional MRI studies designed to detect what the brain and mind are doing under various circumstances. To determine the mechanism behind MRI-induced vertigo, Dale C. Roberts, senior research systems engineer in the laboratory of David Zee within the Depart-ment of Neurology at the Johns Hopkins University School of Medicine, and his colleagues placed into MRI scanners 10 volunteers with healthy labyrinths (inner tube–like structures in the ears that control balance) and two volunteers who lacked labyrinthine function. They tracked vertigo not only by the volunteers’ reports but also by looking for nystagmus, a type of involun-tary eye movement that reflects the brain’s detection of motion—the kind of jerky eye tracking that a person on a merry-go-round might experience. Because visual clues can help suppress nystagmus, the researchers conducted their experiments in the dark. Footage from night vision cameras showed that all the healthy volunteers had nystagmus in the MRI, but those without labyrinthine function didn’t, a sure sign that the labyrinth plays a key role in MRI-related vertigo. To figure out how MRI’s magnetic field acts on the labyrinth, the researchers tested the healthy volunteers in MRIs of differ-ent strengths for various periods of time. They also tracked the volunteers’ nystag-mus as they were moved in and out of the machines’ tunnels, called bores, both from the usual entryway and from behind—experiments designed to test the impact of motion or direction of magnetic field on the volunteers’ balance centers. Roberts’ team found that higher magnetic field strengths caused significantly faster nystagmus. These eye movements persisted throughout the time volunteers spent in the machine, no matter how long the experi-ments lasted. In addition, the direction of the eye movements changed depending on which way the volunteers entered the bores,

suggesting that the effect on the labyrinth was directionally sensitive. Combining their results with what’s known about the inner ear, the researchers surmised that MRI-related vertigo most likely relates to interplay between electrical currents flow-ing through the salty fluid in the canals of the labyrinth and MRI’s magnetic field. Through an effect well known to physi-cists called the Lorentz force, the magnetic field apparently pushes on the current of charged particles in the inner ear’s fluid. This exerts a force on cells that use the fluid’s flow as a way to sense motion. Roberts notes that the finding not only solves a decades-long scientific question but also has implications for research that uses MRI. In one technique, known as functional MRI, researchers measure brain activity by tracking blood flow in the brain as subjects perform tasks. The new findings suggest that the scanner itself could be causing previously unnoticed brain activity related to movement and balance, potentially affecting results. “We’ve shown that even when you think there’s nothing happening in the brain while volunteers are in the scanner, there’s actu-ally a lot happening because MRI itself is causing some effect,” Roberts said. “These effects must be taken into account in the way we interpret functional imaging.” The researchers add that doctors already use methods that stimulate the labyrinth to diagnose and treat inner ear and bal-ance disorders, but these methods can be uncomfortable. They note that MRI’s strong magnetic field could eventually be used for the same purpose, providing a novel method that’s more comfortable and noninvasive. Other researchers who participated in this study are Joseph S. Gillen, John P. Carey, Charles C. Della Santina and Zee, all of Johns Hopkins; and Vincenzo Marcelli, of Federico II University of Naples. The study was supported by a grant from the Johns Hopkins Brain Science Institute and gifts from grateful patients.


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McDonogh

McDonogh School in Owings Mills offers a challenging curriculum and the support of the entire McDonogh family—innovative teachers, caring advisors, involved parents, and truly remarkable peers.

For information about our K-12 college preparatory program or to register for an open house, please call us at 410-581-4719 or visit us online at www.mcdonogh.org.

Open House Dates:

Grades K-4 9:00 a.m. Thursday, October 13Wednesday, November 9Wednesday, November 30

Grades 5-8 1:00 p.m. Sunday, October 16

Grades 9-12 3:30 p.m. Sunday, October 16

Visiting Day for Kindergarten–First Grade:Saturday, November 12 9:30 a.m.

JHU Gazette 9-19.indd 1 9/20/11 3:25 PM

CalendarContinued from page 12

S E P T . 2 6 – O C T . 3

of Maryland, College Park. Sponsored by Geography and Environmental Engineer-ing. 234 Ames. HW

Tues., Sept. 27, 4:30 p.m. “Multilin-gual Guidance for Unsupervised Linguis-tic Structure Prediction,” a Center for Language and Speech Processing seminar with Dipanjan Das, Carnegie Mellon University. B17 Hackerman. HW

Tues., Sept. 27, 4:30 p.m. “Twin Cities,” an Algebraic Geometry/Number Theory seminar with Walter Freyn, Uni-versity of Munster, Germany. Sponsored by Mathematics. 302 Krieger. HW

Wed., Sept. 28, 12:15 p.m. Mental Health Noon Seminar—“Sleep Distur-bance and Functional Decline in Older Adults” with Adam Spira, SPH. B14B Hampton House. eB

Wed., Sept. 28, 4 p.m. “Personalized Medicine and Statistical Learning,” a Biostatistics seminar with Michael Koso-rok, University of North Carolina, Cha-pel Hill. W2030 SPH. eB

Thurs., Sept. 29, 10:45 a.m. “Pro-grammed Assembly and Manipulation of Complex Particles by Electric Fields,” a Chemical and Biomolecular Engineering seminar with Orlin Velev, North Caro-lina State University. 110 Maryland. HW

Thurs., Sept. 29, noon. Advocacy and Action: Local, State, Regional and National Perspectives, the Health Policy and Man-agement Fall Policy Seminar Series—This week’s guest is Jeffrey Levi, George Washington University. The seminar includes a Q&A session and discussion. B14B Hampton House. eB

Thurs., Sept. 29, noon. The Bromery Seminar—“Scaling Laws in Modeling Ocean Ecosystems” with Ananad Gnana-desikan, KSAS. Sponsored by Earth and Planetary Sciences. Olin Auditorium. HW

Thurs., Sept. 29, noon. “Home Reno-vating: How Malaria Exports Effector Proteins Into Erythrocytes,” a Molecular Microbiology and Immunology/Infec-tious Diseases seminar with Justin Bod-dey, The Walter and Eliza Hall Institute for Medical Research, Australia. W1020 SPH. eB

Thurs., Sept. 29, noon. “Controlling Brain Assembly,” a Cell Biology seminar with Ronald McKay, Lieber Institute for Brain Development. Suite 2-200, 1830 Bldg. eB

Thurs., Sept. 29, 1 p.m. “Respond-ing and Adjusting to Stress: A Synaptic Perspective,” a Neuroscience research seminar with Jaideep Bains, University of Calgary. West Lecture Hall (ground floor), WBSB. eB

Thurs., Sept. 29, 1:30 p.m. “Matrix Splitting Methods for Bound-Con-strained Quadratic Programming and Linear Complementarity Problems,” an Applied Mathematics and Statistics sem-inar with Daniel Robinson, WSE. 304 Whitehead. HW

Thurs., Sept. 29, 3 p.m. “Recent Developments in Understanding Small-Scale Mechanical Behavior,” a Mechani-cal Engineering seminar with Easo George, Oak Ridge National Laboratory. 210 Hodson. HW

Thurs., Sept. 29, 4 p.m. “Alternative Splicing in Drosophila,” a Biology seminar

with Brent Graveley, University of Con-necticut Health Center. 100 Mudd. HW

Thurs., Sept. 29, 4 p.m. “The Demo-graphic Transformation of Cities and Their Neighborhoods,” an Institute for Policy Studies Social Policy seminar with Paul Jargowsky, Rutgers-Camden. Co-sponsored by Economics and Health Pol-icy and Management. 50 Gilman. HW

Fri., Sept. 30, 9:30 a.m. “Population-Based Surveillance: Strategic Data for Monitoring HIV Care and Treatment Needs in Kenya,” an Epidemiology thesis defense seminar with Sufia Dadabhai. W2033 SPH. eB

Fri., Sept. 30, 11 a.m. “The Tohoku Tsunami of 2011,” a CEAFM seminar with Robert Dalrymple, WSE. 50 Gilman. HW

Fri., Sept. 30, noon. “Cause-Specific Mortality After 35 Among HIV-Infect-ed Individuals in the Area of Effective Therapy Compared to HIV-Negative Individuals From the Same Long-Term Cohort Studies,” an Epidemiology the-sis defense seminar with Nikolas Wada. W2030 SPH. eB

Fri., Sept. 30, 1 p.m. “Drug Abuse Liability Assessment in Non-Human Pri-mates and the Quest for a Non-Addicting Anxiolytic,” a Molecular and Compara-tive Pathobiology seminar with Nancy Ator, SoM. West Lecture Hall, PCTB. eB

Mon., oct. 3, 4 p.m. “Entangled Bodi-ly Discourses: Black Consciousness and Biomedical Opposition to Skin Light-eners in Apartheid South Africa and Beyond,” a Humanities seminar with Lynn Thomas, University of Washing-ton. 308 Gilman. HW

S P e C I a L e V e N T S

Mon., Sept. 26, 4:30 to 6:30 p.m. “A Taste of Africa,” a chance to experi-ence African culture through food, music and networking. Co-sponsored by the African Public Health Network and the JHSPH Student Assembly. Cafe, 9th floor, SPH. eB

W o r K S H o P S

Tues., Sept. 27, 1:30 p.m. “Prepar-ing for the First Day of Class,” an Eyes on Teaching workshop open to all grad students, postdoctoral fellows, lecturers and faculty in KSAS or WSE. To regis-ter, go to www.cer.jhu.edu/events.html. Sponsored by the Center for Educational Resources. Garrett Room, MSE Library. HW

MSe Library workshops, open to all Hopkins affiliates. To register, go to www .library.jhu.edu/researchhelp/workshops .html. Electronic Resource Center, M-Level, MSE Library. HW

• Wed., Sept. 28

2 p.m. “Citation and Organization Tools.”

4:30 p.m. “Scopus and Web of Sci-ence.”

Thurs., Sept. 29, 1 p.m. “Tools for Digital Humanities Research,” a Bits & Bytes workshop. The training is open to full-time Homewood faculty, lecturers and TAs; staff are also welcome to attend. Registration is strongly encouraged; go to www.cer.jhu.edu/events.html. Sponsored by the Center for Educational Resources. Garrett Room, MSE Library. HW


This is a partial listing of jobscurrently available. A complete

list with descriptions can be found on the Web at jobs.jhu.edu.

B U L L E T I N B O A R D

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NoticesKSaS Dean’s undergraduate research awards — Applications are now being accepted from KSAS undergraduates and faculty mentors for the newly created Dean’s Undergraduate Research Awards. The awards are designed to promote inde-pendent research projects among undergrad-uate students in the Krieger School of Arts

Job OpportunitiesThe Johns Hopkins University does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or other legally protected characteristic in any student program or activity administered by the university or with regard to admission or employment.

S c h o o l s o f P u b l i c H e a l t h a n d N u r s i n g

H o m e w o o d49496 Research Service Analyst49267 Executive Specialist49276 Employee Assistance Clinician49279 Employee Assistance Clinician49316 Sr. Financial Analyst49317 Sr. Programmer Analyst49436 Software Engineer48853 Software Engineer48873 Network Security Engineer48989 Software Engineer49104 Sr. Internal Auditor49151 HR Specialist49217 ERP Business Analyst,

HR/Payroll49218 Sr. ERP Business Analyst,

HR/Payroll49223 Sr. ERP Business Analyst, Supply

Chain/SRM49348 Sr. Financial Analyst49471 Gift Processing Supervisor49474 Programmer Analyst

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48788 Program Manager, CTY49246 Student Payroll Specialist49237 Multimedia Systems Specialist49238 Research Technologist49287 Systems Network Administrator49426 LAN Administrator49431 IRC Technical Assistant49439 Associate Director, Research

Administration49440 Research Technologist49447 School Based Transformation

Facilitator 49450 Youth Development Facilitator49467 Foundation Relations Officer49487 Instructional Technologist

Office of Human Resources:2021 East Monument St., 410-955-3006JoB# PoSITIoN

44976 Food Service Worker44290 LAN Administrator III44672 Administrative Secretary41388 Program Officer44067 Research Program Assistant II44737 Sr. Administrative Coordinator44939 Student Affairs Officer44555 Instructional Technologist44848 Sr. Financial Analyst

44648 Assay Technician44488 Research Technologist43425 Research Nurse43361 Research Scientist44554 Administrative Specialist44684 Biostatistician42973 Clinical Outcomes Coordinator43847 Sr. Programmer Analyst45106 Employment Assistant/Receptionist45024 Payroll and HR Services Coordinator42939 Research Data Coordinator42669 Data Assistant44802 Budget Specialist44242 Academic Program Administrator44661 Sr. Research Program Coordinator45002 Research Observer

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S c h o o l o f M e d i c i n e

Office of Human Resources: 98 N. Broadway, 3rd floor, 410-955-2990JoB# PoSITIoN

47679 Laboratory Assistant47740 Nurse Practitioner 48165 Research Assistant48194 Research Data Analyst 48238 MRI Technologist48250 Research Data Analyst 48312 Sr. Medical Office Coordinator48639 Research Program Assistant II 48699 Patient Access Manager

48702 Immunogenetics Technologist Trainee

48705 Clinic Manager48824 Occupational Therapist 49059 Research Navigator Nurse49090 Physician Assistant 49094 IT Specialist49119 Technical Facility Manager49125 Research Program Assistant II49150 Research Program Assistant49167 Sr. Financial Manager49186 Research Technologist49242 Data Assistant49249 Disclosure Specialist49325 Revenue Cycle Coordinator

and Sciences. Funding, which ranges from $500 to $3,000, will enable undergraduates in KSAS to pursue original research, work closely with a faculty mentor and advance knowledge for the world. Two types of awards are available, Faculty Research Assistant-ships and Senior Capstone Project Awards. For additional information and application instructions go to http://krieger.jhu.edu/dura. The application deadline for both awards is Oct. 14. Questions should be directed to Ami Cox at [email protected].

B y e l l e n B e t h l e v i t t


Heart specialists at Johns Hopkins have figured out how a widely used pacemaker for heart failure, which

makes both sides of the heart beat together to pump effectively, works at the biological level. Their findings, published in the Sept. 14 issue of Science Translational Medicine, may open the door to drugs or genetic thera-pies that mimic the effect of the pacemaker and to new ways to use pacemakers for a wider range of heart failure patients. All sides of the heart’s left ventricle, the main pumping chamber, need to beat in concert in order for the heart to pump blood effectively to the rest of the body. In many people who suffer from heart failure, the right and left sides of the ventricle are out of sync, with one side contracting while the other is relaxed. Several years ago, Johns Hopkins research-ers helped develop a modified pacemaker that synchronizes the heartbeats and restores normal contractions. That treatment, called cardiac resynchronization therapy, or CRT, was approved by the Food and Drug Admin-istration in 2001 and is widely used today to improve symptoms and enable people to live longer. However, the reasons why it worked at the biological level were unknown until now. David Kass, a professor of medicine and biomedical engineering at the Johns Hop-kins University School of Medicine, who led the development of CRT, is senior author of the new study. “We have revealed a key and important underlying biological mechanism that helps us understand how CRT works. With this information, we can work to develop completely new treatments, such as a drug or gene therapy, to essentially have a kind of ‘pacemaker in a bottle’ to help a wide variety of patients with a failing heart,” said Kass, who is also a cardiologist at the Johns Hopkins Heart and Vascular Institute. When investigating the changes that were occurring with CRT at the basic sci-ence level, Kass and his colleagues found that resynchronizing the heart makes the heart muscle more responsive to adrenaline, which stimulates pumping ability. “What we learned,” Kass said, “is that the modified pacemaker used in CRT raises the levels of regulator of G-protein-signaling proteins in the heart. The RGS proteins direct the activity of G proteins, which are messengers that tell the heart and other organs what to do.” In heart failure, levels of a particular G protein, known as Gi, go up. Gi inhibits heart muscle pumping, getting in the way of another protein, Gs, that stimulates the heart muscle, thereby preventing Gs from doing its job. CRT restores the normal bal-ance of Gi and Gs. Kass uses a car analogy to explain the pro-cess: The Gs proteins represent the accel-erator; the Gi proteins represent the brake. Heart failure, he says, is like driving with one foot on the gas and the other on the brake. CRT takes the foot off the brake, inhibiting the Gi proteins, so that not only does the entire left ventricle pump in a coor-dinated fashion but the heart muscle now

responds to hormones, such as adrenaline, more like a healthy heart. While the typical pacemaker has only one wire, which goes to the right side of the heart, the modified CRT pacemaker that Kass and his colleagues first helped develop has two wires. The second lead goes to the surface of the left ventricle so that both sides of the heart are stimulated at the same time. Usually, translational research begins at the laboratory bench, in cellular, molecular or animal models, and then discoveries are tested in people. However, with CRT, the modified pacemakers were developed first and offered to patients suffering from severe heart failure. The results were significant, helping hearts become stronger and health-ier. In published studies, the majority of patients receiving CRT had less fatigue and shortness of breath, and better long-term survival. “This was remarkable,” Kass noted, “since CRT also made the heart do more work, and we had never had a heart failure treatment that made the heart work more while also decreasing mortality.” The next step for Kass and his colleagues was to go into the basic science lab to try to understand why and how CRT worked. The majority of people with heart failure are not offered CRT because the two sides of their heart are beating in sync. Out of 6 million heart failure patients in the United States, an estimated 1 million have the type of disease that CRT was designed to treat. However, in another part of the study, the researchers discovered in animal models that if a heart that beats in sync was tem-porarily forced to beat out of sync, then was resynchronized, the heart muscle improved, Gi declined, and the response to adrenaline was better. “That finding gives us yet another avenue to explore,” Kass said. “By temporarily put-ting a heart out of sync and then letting it go back, we may be able to trigger the type of biological effect that CRT produced. This theoretically could be applied to patients sooner than developing a drug or gene therapy.” Kass and his colleagues are actively pursuing both gene therapy and modified pacing approaches. According to co-author Gordon Toma-selli, a professor and director of the Division of Cardiology at the Johns Hopkins Univer-sity School of Medicine, “Understanding the molecular basis for the beneficial effects of CRT may have implications for the development of new types of treatment for a wider range of heart failure patients, not only those whose heart contractions are out of sync.” Tomaselli is also president of the American Heart Association. In addition to Kass and Tomaselli, Johns Hopkins researchers involved in this study were lead author Khalid Chakir, Char-lene Depry, Veronica Dimaano, Theodore Abraham, Manling Zhang, Eiki Takimoto and Jin Zhang. Other authors were We-Zhong Zhu and Rui Ping Xiao, both of the Gerontology Research Center of the National Institute on Aging; Mark Van-derheyden and Jozef Bartunek, both from Belgium; Shu-bai Liu and Yang Xiang, both of the University of Illinois at Urbana-Champaign; and Nickolai Dulin, of the University of Chicago.

Scientists uncover how pacemakerworks at the biological level


Classifieds M A R K E T P L A C E

aParTMeNTS/HouSeS For reNT

Bayview, 1BR, 1BA apt, 1 min to campus, dining rm, kitchen, AC, hdwd flrs, lg deck, Internet. $380-$480/mo + utils. 443-386-8471 or [email protected].

Bolton Hill, 4BR, 2BA house, hdwd flrs, spacious kitchen and BRs, walk to Hopkins shuttle. $2,100/mo + utils. 443-540-0713 or [email protected].

Charles Village North, 1BR apt in owner-occupied bldg nr Homewood campus, avail Dec. $825/mo. 410-917-2443.

Cross Keys Village, 3BR, 2.5BA TH, access to swimming pools and tennis courts, avail Nov 1. [email protected].

Deep Creek Lake/Wisp, cozy 2BR cabin w/full kitchen, call for wkly/wknd rentals, pics avail at [email protected]. 410-638-9417.

Ferndale, cozy efficiency in priv home, lg kitchen and BA, nr BWI. $900/mo incl utils, Internet, cable. Marsha, 410-766-8385.

Manhattan, 1BR apt, walking distance to Central Park, excel when in town for conference. $2,000/wk. NYC1BR@yahoo .com.

Mt Washington, stunning short-term rent-al, 2BRs, 2 studies, baby grand piano, par-quet flrs, patios. 718-915-3180. $2,600/mo. [email protected].

Mt Washington, 3BR, 2.5BA condo, W/D in unit, CAC, hdwd flrs (1st flr), crpt (2nd flr), lg balcony, garage prkng, swimming pool and tennis court in community, nr I-83/lt rail, avail Nov 1. $1,500/mo + utils. 443-220-2138 or [email protected].

Old Homeland, 3BR, 2BA house w/many updates, lg fenced backyd; option to buy. $1,100/mo. 443-286-1233 or [email protected].

Owings Mills, gorgeous 3BR, 2.5BA TH, short-term rental (1 night up to 3 mos), 5-min drive to metro, save gas and prkng, live in stress-free environment, pics emailed on request. Georgia, 240-246-5665.

Perry Hall, condo in elevator bldg, 3 lg BRs, 2 full BAs, new W/D, balcony, no pets/no smokers, refs req’d, great location, easy access to I-95/restaurants. $1,300/mo + sec dep (1 mo) + utils. 410-256-8563.

Rodgers Forge/Towson, 3BR EOG TH w/new kitchen, no pets/no smoking, avail Oct 1. $1,800/mo. totalnsolutions@yahoo .com.

Upper Waverly, charming 2BR, 1BA apt nr the 33rd Street Y. $750/mo. Andrea, 410-905-4036.

3BR, 2BA charmer in diverse, historic neighborhood nr JHU, inlaid wood flrs, new appls, sunrm, no smokers/no pets. $1,600/mo. [email protected].

HouSeS For SaLe

Cockeysville, 5BR, 3.5BA house on 1.24 acres. 443-846-2950.

Fells Point (300 S Durham), 3-story RH, long yd, 4 blks to JHH. $175,000/best offer. Dorothy, 410-889-5334.

Gardenville, 3BR, 1.25BA RH in quiet neighborhood, new kitchen and BA, CAC, hdwd flrs, club bsmt w/cedar closet, fenced maintenance-free yd and carport, 15 mins to JHH. $130,000. 443-610-0236 or [email protected].

Owings Mills New Town, 2BR condo, nr metro, ready for immediate sale. www .4409-silverbrook.info.

Rosedale, 4BR house, 2 full BAs, all appls, lovely kitchen, mins to Hopkins campus, move-in cond, affordable price. 410-499-2139.

3BR, 2.5BA TH, 10 mins south of Balti-more, just off I-95, fin’d bsmt, fp, bar. ktbsn@ mac.com.

rooMMaTeS WaNTeD

Lg 1BR apt in single-family home, eat-in kitchen, priv entrance, lg front porch, on bus line, freshly painted/cleaned, no smok-ing/no pets. $675/mo + sec dep ($675) + utils. 410-592-5780.

Share new 3BR, 3.5BA TH, 2 blks to JHMI. $550/mo + utils. 410-979-0721 or [email protected].

Furn’d bsmt apt and priv BA in 2BR TH in Edgewood, nr 95/Rt40/Aberdeen Prov-ing Grounds. $700/mo incl water, electric, cable, WiFi. 443-655-4901.

Share Owings Mills TH in quiet neigh-borhood, W/D, dw, Internet, 10 mins to metro. $500/mo (each). 443-841-2098 or [email protected].

Share 3BR house 10 mins to E Baltimore campus in the Belair-Edison community. Darrick, 443-226-6497.

CarS For SaLe

’08 Saturn Vue XE, 4-dr sport utility, auto-matic, 4-cyl, silver exterior/gray cloth inte-rior, ABS, alloy wheels, AC, CD, cruise con-trol, power everything, AM/FM stereo, rear defroster, overhead/side airbags, ext’d service plan, 45K mi. $14,500. 410-908-9632.

Classified listings are a free ser-vice for current, full-time Hop-kins faculty, staff and students only. Ads should adhere to these general guidelines:

• Oneadperpersonperweek.A new request must be submitted for each issue. • Adsarelimitedto20words, including phone, fax and e-mail.

• WecannotuseJohnsHopkins business phone numbers or e-mail addresses.• Submissionswillbecondensedat the editor’s discretion. • DeadlineisatnoonMonday, one week prior to the edition in which the ad is to be run.• Realestatelistingsmaybeoffered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.)Classified ads may be faxed to 443-287-9920;e-mailedinthebody of a message (no attach-ments)[email protected];ormailed to Gazette Classifieds, Suite540,901S.BondSt.,Bal-timore, MD 21231. To purchase a boxed display ad, contact the GazelleGroupat410-343-3362.

PLaCING aDS

Mobile auto detailing and power wash ser-vice. Jason, 443-421-3659.

Want to lose weight, look great? You won’t be disappointed: Go Ardyss. 443-453-4152 or www.ardysslife.com/healthymanoffaith.

Two prof’l movers w/30-ft box truck avail-able for your next move, free estimate, 15% discount for all Hopkins. 410-419-3902.

Computer data recovery, website and administrative services provided by Jolene Patey. 410-746-8345 or jpatey@jolenepatey .com.

Tutor wanted: F AP statistics tutor w/prior experience, once a wk on Saturday. [email protected].

Chinese zither (GuZheng) lessons offered at low price, instrument provided. 573-529-4358 or [email protected].

Tai chi: Beginner’s classes starting in Charles Village and Towson. 410-296-4944 or www .baltimoretaichi.com.

Letters written by experienced writer, all types, first-come free in exchange for your references for start-up company. [email protected].

Piano lessons by Peabody graduate, 50% off this month for private lessons. 425-890-1327 or [email protected].

Affordable and professional landscaper and certified horticulturist available to maintain existing gardens, also designing, planting or masonry; free consultations. David, 410-683-7373 or [email protected].

Licensed landscaper avail for spring or sum-mer lawn maintenance, yd cleanup; other services incl trash hauling, fall/winter snow removal. Taylor Landscaping LLC. 410-812-6090 or [email protected].

Masterpiece Landscaping: knowledgeable, experienced individual, on-site consulta-tion, transplanting, bed preparation, instal-lation, sm tree and shrub shaping; licensed. Terry, 410-652-3446.

Friday Night Swing Dance Club, open to public, great bands, no partners needed. 410-663-0010 or www.fridaynightswing .com.

Horses for lease or half-lease for trail rid-ing, showing, eventing, must stay on farm in Glyndon in Baltimore County, your expense. $150-$275/mo (including farrier). 410-812-6716.

Cheap, reliable DJ, $30 for 1st hour, $20 for each subsequent hour. Weston Butler, 908-418-8689 or [email protected].

Blanka will clean houses, apts, do laundry and more; free estimates, reasonable prices, great refs, text or leave message (Eng-lish OK, Spanish better). 443-621-1890 or [email protected].

Horse boarding and horses for lease, beauti-ful trails from farm. $500/mo (stall board) and $250/mo (field board). 410-812-6716 or [email protected].

Personal shopper/stylist, will shop for you or with you, gift buying or accompany your teen. 404-200-5009 or tr@fashionrehabbersinc .com.

WYMANCOURTJustRenovated!

HICKORYHEIGHTSA lovely hilltop setting

on Hickory Avenue in Hampden!

2 BD units from $760 w/Balcony - $790!

Shown by appointment 410.764.7776www.BrooksManagementCompany.com

Beech Ave. adj. to JHU!Studios - $595 - $630 1 BD Apts. - $710-740

2 BD from $795

Live NearYour Work

The Live Near Your Work program provides Johns Hopkins employees with the opportunity to receive combined cash grants from the university, Baltimore City and the state of Maryland to be used for the purchase of homes within selected local neighborhoods. Grants are available to full-time, benefits-eligible employees of Johns Hopkins University, Johns Hopkins Hospital, Johns Hopkins Health Care, Johns Hopkins Community Physicians, Johns Hopkins Bayview and Johns Hopkins Home Care Group. Other restrictions may apply. To find out more, contact the Office of Work, Life and Engagement at 443-997-7000 or go to web.jhu.edu/lnyw/index.html.

’04 Lexus RX 330, gray w/beige leather seats, one owner, no accidents, runs well, cosmetic dents/scratches, passed MD state inspection, 95K mi. uni1condo@hotmail .com.

’03 Cadillac Deville, V-8, black exterior and interior, gold emblems, 130K mi. $5,700/best offer. 443-942-0857.

’03 Honda Civic Ex, gold, automatic, in very good cond, 119K mi. $6,200. 410-688-6547.

ITeMS For SaLe

Fisher-Price Smart Cycle Racer, physical learning system, like new, used twice, 2 game cartridges incl’d. $65. 443-803-7401.

Lyric Opera, La Traviata, Nov 4, 7:30pm, 2 premium orchestra seats (H122, 123). $100/both. Barbara, 410-661-4376.

Samick 6 ft 1 inch grand piano, profession-ally maintained. 410-444-1273 or http://baltimore.craigslist.org/msg/2544736267.html (for photos and complete appraisal).

Inversion therapy table by Teeter Hang Up. $200. Marie, 410-825-8349.

Baby crib, mattress w/pad cover, in excel cond. $75. 410-633-2064.

Kawai upright piano, in very good cond. $2,000. [email protected]

Towson spa eyebrow waxing certificate. Best offer. 410-337-9877 (after 8pm) or [email protected].

Sand beach chairs (2), inkjet printer, oil-filled heaters (3) and baseboard heaters (2), portable canvas chair, keyboard case, 100W amplifier. 410-455-5858 or iricse [email protected].

Music cassette tapes, fitness chair, 21" TV, 35mm cameras, silk flowers and vase, Asian decor pillows, office file units (lot of 10), men’s travel bag, dining rm set, full-length silver fox coat, new exterior French doors, Blackberry Bold accessories, more. 443-824-2198 or [email protected].

Woman’s leather motorcycle jacket w/insu-lated lining, brown, size XS, $125; woman’s Milwaukee motorcycle boots, black, size 7, $95; both nearly new, photos avail. [email protected].

Double bed, boxspring/mattress/frame, like new. $10/best offer. Al, 443-804-1927 or [email protected].

Conn alto saxophone, in excel cond. 410-488-1886.

Rare Mathushek spinet, 1930s model, not only a superb piano, a beautiful piece of furniture. $500. 410-206-6450.

Women’s vintage leather coats, tweed suit, wool blazers, all like new and cheap; can send photos. [email protected].

SerVICeS/ITeMS oFFereD or WaNTeD

Graduate student looking for a rm next to Columbia campus for spring semester. 904-410-1949 or [email protected].

12 THE GAZETTE • September 26, 2011

Calendar B L o o D D r I V e S

Sat., oct. 1, 8 a.m. to 2 p.m. JHU/American Red Cross Blood Drive. For more information, email johnshopkinsblooddrive@ jhmi.edu or call 410-614-0913. Mount Washington Campus.

C o L L o Q u I a

Tues., Sept. 27, 4:15 p.m. “Metal- and Ligand-Centered Redox Chemistry, and Dioxygen Activation With Iridium and Nickel,” a Chemistry colloquium with Jan-Uwe Rohde, University of Iowa. 233 Remsen. HW

Wed., Sept. 28, 5 to 7 p.m. “Be Careful What You Say and Be Careful How You Say It,” a Pea-body DMA Musicology colloqui-um with Ray Sprenkle, Peabody. Cohen-Davison Family Theatre. Peabody

Thurs., Sept. 29, 3 p.m. “Turn-ing the Page on Atlases: Pictur-ing Anatomy Through Systems of Display in Enlightenment Brit-ain,” a History of Science, Medi-cine and Technology colloquium with Carin Berkowitz, Chemical Heritage Foundation. 330 Gilman. HW

Thurs., Sept. 29, 3:45 p.m. “Toward a Computational Neu-roanatomy of Speech Production and Its Relation to Speech Per-ception,” a Cognitive Science colloquium with Greg Hickok, University of California, Irvine. 111 Krieger. HW

Fri., Sept. 30, 2 p.m. “A Digi-tal Wonderland: Virtual Reality Applications for Everybody,” an Applied Physics Laboratory collo-quium with Carolina Cruz-Neira, University of Louisiana, Lafay-ette. Co-sponsored by the Hispan-ic Heritage Committee. Parsons Auditorium. aPL

C o N F e r e N C e S

Fri., Sept. 30, 10 a.m. to 7 p.m. Jean Starobinski: Le Regard Critique, a German and Romance Languages and Literatures confer-ence, with various speakers. 388 Gilman. HW

D I S C u S S I o N S /T a L K S

Tues., Sept. 27, 4:30 p.m. “Rule of Law for 2011 Fair Election in the Democratic Republic of the Congo (DRC),” a SAIS African Studies Program discussion with Kengo Wa Dondo, president of the Senate in the DRC and 2011 DRC candidate. For informa-tion, call 202-663-5676 or email [email protected]. 500 Bernstein-Offit Bldg. SaIS

Wed., Sept. 28, 9 a.m. “Strategic Asia 2011–2012: Asia Responds to Its Rising Powers—China and India,” a SAIS China Studies Pro-gram panel discussion with Ashley Tellis, National Bureau of Asian

r e a D I N G S / B o o K T a L K S

Tues., Sept. 27, 5 p.m. Michael Mandelbaum of SAIS and Thomas Friedman, New York Times, will discuss their new book, That Used to Be Us: How America Fell Behind in the World It Invented and How We Can Come Back. (See In Brief, p. 2.) Sponsored by the SAIS Ameri-can Foreign Policy Program. A live webcast will be accessible at www .sais-jhu.edu. To RSVP, go to bit.ly/ mandelbaumfriedman. Kenney Auditorium, Nitze Bldg. SaIS

Tues., Sept. 27, 7 p.m. JHU Writing Program alumna Rae Bry-ant will read from and sign copies of her latest book, The Indefinite State of Imaginary Morals. Barnes & Noble Johns Hopkins. HW

Wed., Sept. 28, 7 p.m. Reading by author Amitav Ghosh from his latest novel, River of Smoke. (See photo, this page.) A reception and author signing will be held at 6 p.m. Sponsored by the Friends of the Libraries. Reservations requested: 410-516-7943 or [email protected]. 132 Gilman. HW

Thurs., Sept. 29, 7 p.m. Charles Village poet Michael Fallon will read from and sign copies of his new poetry collection, The Great Before and After. Barnes & Noble Johns Hopkins. HW

r e L I G I o N

Wed. to Fri., Sept. 28 to 30. Rosh Hashana services. For more information, call 410-516-0333 (Conservative and Reform) or 410-243-3700 (Orthodox). HW

• Conservative. Led by JHU stu-dent Oren Pollak and Jewish Theological Seminary stu-dent Alex Salzberg, sponsored by Hopkins Hillel.

Wed., 6 p.m., Glass Pavil-ion; 7 p.m. dinner for stu-dents in the Smokler Center ($12, reservations required: www.hopkinshillel.org).

Thurs., 9:15 a.m., Glass Pavilion; 6 p.m., Smokler Center followed by dinner (see above for details).

• Reform. Led by Rabbi Debbie Pine, sponsored by Hopkins Hillel.

Wed., 6 p.m., Bunting-Mey-erhoff Interfaith Center.

• Orthodox. Led by Rabbi Zev Gopin, sponsored by Chabad of Central Baltimore and JHU; Inn at the Colonnade, 4 W. University Parkway.

Wed., 7 p.m., followed by dinner ($10 for students, $25 for community members, reservations required: www .chabadhopkins.org).

Thurs. and Fri., 9:30 a.m.

S e M I N a r S

Mon., Sept. 26, noon. “EM, SAXS, Molecular Modeling and Traditional Biochemistry Reveal the Topology of Cleavage Factor I, an Essential Heteroheptameric Complex in mRNA Processing,” a Biophysics seminar with Andrew Bohm, Tufts University. 111 Mer-genthaler. HW

Mon., Sept. 26, noon. “Posttran-scriptional Regulation of Cancer

S E P T . 2 6 – O C T . 3

(Events are free and open to the public except where indicated.)

aPL Applied Physics LaboratoryBrB Broadway Research BuildingCrB Cancer Research BuildingCSeB Computational Science and Engineering BuildingeB East BaltimoreHW HomewoodKSaS Krieger School of Arts and SciencesNeB New Engineering BuildingPCTB Preclinical Teaching BuildingSaIS School of Advanced International StudiesSoM School of MedicineSoN School of NursingSPH School of Public HealthWBSB Wood Basic Science BuildingWSe Whiting School of Engineering

CalendarKey

Research; Michael Green, Cen-ter for Strategic and International Studies; Teresita Schaffer, Brook-ings Institution; and Rory Med-calf, Lowy Institute. Co-sponsored by the National Bureau of Asian Research. To RSVP, call 202-663-5816 or email [email protected]. Kenney Auditorium, Nitze Bldg. SaIS

Wed., Sept. 28, 12:45 p.m. “Citizen Security in Latin Ameri-ca: Comparing the Cases of Ven-ezuela, Colombia and Brazil,” a SAIS Latin American Studies Program discussion with Roberto Briceno Leon, Research School of Social Sciences, Venezuela. To RSVP, call 202-663-5734 or email [email protected]. 517 Nitze Bldg. SaIS

Thurs., Sept. 29, noon. “The United States’ ‘New Silk Road’ Strategy: What Is It? Where Is It Headed?” a Central Asia–Cau-casus Institute at SAIS panel discussion with Robert Hormats, U.S. undersecretary of state for economic, energy and agricultur-al affairs; Sham Bathija, senior economic adviser to Afghanistan President Hamid Karzai; and Juan Miranda, Asia Development Bank. To RSVP, call 202-663-7721 or email [email protected]. Kenney Auditorium, Nitze Bldg. SaIS

Thurs., Sept. 29, 4:30 p.m. “The Persistence of Partisan Politics: Evidence From 9/11,” a SAIS International Econom-ics Program discussion with Ethan Kaplan, University of Maryland, College Park. For information, call 202-663-7787 or email [email protected]. 714 Bernstein-Offit Bldg. SaIS

Mon., oct. 3, 12:30 p.m. “China’s Regulatory State: A New Strategy for Globalization,” a SAIS China Studies Program discussion with Roselyn Hsueh, Temple University. To RSVP, call 202-663-5816 or email zji@jhu .edu. 806 Rome Bldg. SaIS

F L u V a C C I N e S

Tues., Sept. 27, 12:30 to 3:30 p.m. Free flu vaccines available for JHU students, faculty and staff. Participants must bring their J-cards. Clothing should allow access to upper arm. Herter Room, Nitze Bldg. SaIS

I N F o r M a T I o N S e S S I o N S

Tues., Sept. 27, 12:15 p.m. Information session with repre-sentatives from IQ Solutions, who will talk about the structure of their organization, types of positions being recruited for and more. Sponsored by SPH Career Services. W2008 SPH. eB

L e C T u r e S

Tues., Sept. 27, noon. The 11th Dodge Lecture—“Food Systems, Famines and Human Rights” by Olivier De Schut-ter, UN special rapporteur on the right to food. Sponsored by the Center for a Livable Future. W1214 SPH. eB

Wed., Sept. 28, 2:30 p.m. “The NIH Undiagnosed Dis-eases Program: Rare and Ultra-rare,” an Institute of Genetic Medicine lecture by William Gahl, National Human Genome Research Institute. G-007 Ross (Darner Conference Room). eB

Thurs . , Sept . 29 , 5 p .m. “On Ruling Over the Dead and Other Impossibilities (on Od. 11.482-87 and Petelia 10-11),” a Classics lecture by Mata Dova, Hellenic College. 108 Gilman. HW

Mon., oct. 3, 4:30 p.m. Kempf Lecture Series—“Multiview Geometry” by Bernd Sturmfels, University of California, Berkeley. The second in the series takes place Oct. 4. Sponsored by Math-ematics. 304 Krieger. HW

Mon., oct. 3, 5 p.m. “Indigenas, Indigenistas e Indigeneidad en el Cine Latinoamericano Reci-ente,” a German and Romance Languages and Literatures lecture with Claudia Ferman, Richmond College. 479 Gilman. HW

M u S I C

Tues., Sept. 27, 8 p.m. The Peabody Symphony Orchestra performs music by Torke, Liszt and Mussorsgsky, with guest pianist Alexander Shtarkman. $15 general admission, $10 for senior citizens and $5 for stu-dents with ID. Friedberg Hall. Peabody

Traits by HuR,” a Biochemistry and Molecular Biology seminar with Myriam Gorospe, NIA/NIH. W1020 SPH. eB

Mon., Sept. 26, 12:15 p.m. “Histone Variants, Nucleosome Dynamics and Epigenetics,” a Carnegie Institution Embryology seminar with Steve Henikoff, Fred Hutchinson Cancer Research Center. Rose Auditorium, 3520 San Martin Drive. HW

Mon., Sept. 26, 4 p.m. “Spe-cialties: The Ottoman Empire and Early Modern World His-tory,” a History seminar with Giancarlo Casale, University of Minnesota. 308 Gilman. HW

Mon., Sept. 26, 4 p.m. The David Bodian Seminar—“Basal Ganglia Dynamics During Action Selection and Suppres-sion” with Joshua Berke, Univer-sity of Michigan. Sponsored by the Krieger Mind/Brain Institute. 338 Krieger. HW

Mon., Sept. 26, 4:30 p.m. “Symplectic Topology and Rigid Analytic Geometry,” a Topology seminar with Mohammed Abou-zaid, MIT. Sponsored by Math-ematics. 304 Shaffer. HW

Tues., Sept. 27, noon. “Keratin Intermediate Filaments: Struc-tural Insight, At Long Last,” a Biological Chemistry seminar with Pierre Coulombe, SPH. 612 Physiology. eB

Tues., Sept. 27, noon. “GABA Signaling Elements, Brain Devel-opment and Schizophrenia,” a Psychiatry seminar with Tom Hyde, Lieber Institute for Brain Development. 1-191 Meyer. eB

Tues., Sept. 27, 12:10 p.m. “The Role of Aeromedical Transports in Emergency Care Systems,” a Graduate Seminar in Injury Research and Policy with Doug Floccare, Maryland Institute for Emergency Medical Services Sys-tems. Co-sponsored by Health Policy and Management and the Center for Injury Research and Policy. 250 Hampton House. eB

Tues., Sept. 27, 3 p.m. “Reg-ulation of Protein Kinase CK2 Through Posttranslational Modi-fications,” a Pharmacology and Molecular Sciences thesis defense seminar with Mary Katherine Tarrant. 303 WBSB. eB

Tues., Sept. 27, 3 p.m. M. Gordon Wolman Seminar—“Learning From Large Systems Risk Assessment After Katrina” with Gregory Baecher, University

Best-selling author amitav Ghosh reads this week from his new book, ‘river of Smoke.’ The book is the second of a proposed trilo-gy, the first of which, ‘Sea of Poppies,’ was short-listed for the Man Booker Prize in 2008. Ghosh’s work has been translated into 20 languages, and his essays have appeared in ‘The New york Times,’ ‘The New yorker’ and ‘The New republic.’ a reception and author signing precede the reading. See readings.

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