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The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M. van Gisbergen, Paul L. Klarenbeek, Natasja A.M. Kragten, Peter-Paul A. Unger, Marieke B.B. Nieuwenhuis, Felix M. Wensveen, Anja ten Brinke, Paul P. Tak, Eric Eldering, Martijn A. Nolte, Rene A.W. van Lier Immunity Volume 35, Issue 1, Pages 97-108 (July 2011) DOI: 10.1016/j.immuni.2011.04.020 Copyright © 2011 Elsevier Inc. Terms and Conditions

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Page 1: The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M

The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants 

Klaas P.J.M. van Gisbergen, Paul L. Klarenbeek, Natasja A.M. Kragten, Peter-Paul A. Unger, Marieke B.B. Nieuwenhuis, Felix M. Wensveen, Anja ten Brinke, Paul P. Tak, Eric Eldering, Martijn A. Nolte, Rene A.W. van Lier 

Immunity Volume 35, Issue 1, Pages 97-108 (July 2011)

DOI: 10.1016/j.immuni.2011.04.020

Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M

Figure 1

Immunity 2011 35, 97-108DOI: (10.1016/j.immuni.2011.04.020) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M

Figure 2

Immunity 2011 35, 97-108DOI: (10.1016/j.immuni.2011.04.020) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M

Figure 3

Immunity 2011 35, 97-108DOI: (10.1016/j.immuni.2011.04.020) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M

Figure 4

Immunity 2011 35, 97-108DOI: (10.1016/j.immuni.2011.04.020) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M

Figure 5

Immunity 2011 35, 97-108DOI: (10.1016/j.immuni.2011.04.020) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M

Figure 6

Immunity 2011 35, 97-108DOI: (10.1016/j.immuni.2011.04.020) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 8: The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M

Figure 7

Immunity 2011 35, 97-108DOI: (10.1016/j.immuni.2011.04.020) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 9: The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants Klaas P.J.M

Immunity 2011 35, 97-108DOI: (10.1016/j.immuni.2011.04.020) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

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