• Tobethecentreofexcellenceinadvancingevidence-informedhealthcareinAfricaandglobally

Mission

• Excellence

• Integrity

• Credibility

• Relevance

• Collaboration

Vision

• Toconductandsupportrelevantsystematicreviewsandprimaryresearchrelatedtoevidence-informedhealthcare

• Toenhanceevidence-informedhealthcareknowledge,skillsandpracticesthroughtrainingofhealthcareprofessionalsandotherstakeholders

• Topromotetheuptakeofcurrentbestevidenceinhealthcarepolicyandpractice

• TopromotetheoptimalfunctioningandsustainablegrowthoftheCentreforEvidence-basedHealthCare

Values and guiding principles

TheCentreforEvidence-basedHealthCare(CEBHC)isacoordinatinganddirectiveinstitutionforresearchandtrainingoftheFacultyofMedicineandHealthSciences,StellenboschUniversity,inthefieldofevidence-basedhealthcare.

Research Training Knowledge Translation

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Messages

ForewordbythechairpersonoftheCEBHCGoverningBoard:ProfUsufChikte 02MessagefromtheDirectorandDeputy-DirectoroftheCEBHC:ProfsTarynYoungandCharlesWiysonge 03

2015 - CEBHC impacting health care on various fronts

Research 04

Knowledgetranslation 06

Trainingandsupport 09

Management 11

ANNEX 1: Research outputs 2015

Publicationsinpeer-reviewedjournals 12

Publishedprotocols 14

Scientificletters,Editorials,Columns 14

Internationalpresentations 15

Nationalpresentations 16

Postgraduatestudentsupervision 17

Supportinggraduatestopublishtheirresearchprojects 18

ANNEX 2: Intellectual input 19

ANNEX 3: Teaching sessions/lectures/workshops

Undergraduate 21

Postgraduate 22

Continuingprofessionaldevelopment:Presentations,seminarsandworkshops 25

ANNEX 4: Governance 26

ANNEX 5: Staff 27

Contents

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Foreword by the Chairperson of the CEBHC Governing Board: Prof Usuf Chikte

ItisagreatpleasuretoprovidetheforewordtotheCentreforEvidencebasedHealth

Care(CEBHC)AnnualReport.Thisyear,theCEBHCexceededexpectationsintermsofits

outputsasmeasuredagainstthestrategicplan.Undertheableandinspiringleadership

ofTarynYoung,teamCEBHCiscloserintheprocessofbecomingadistinguishedcentre

forevidence-informedhealthcareinAfricaandtheworld.TheWorldHealthOrganisation

recentlyconferredthestatusofaRegionalTrainingCentreinImplementationResearch.

TheachievementsoftheCEBHCinresearch,translationofresearchevidencetopolicyand

practice,andteachingarethefruitsofdiligentworkbyanextraordinaryteam.Theimpact

ofthisisacknowledgedintheprovinceandreverberatesnationallyandcontinentally.

Oneofthehighlightsforthisyearhasbeentheprestigioustrainingfellowshipawardedby

WellcomeTrusttoDrEleanorOchodo.Iwouldliketotaketheopportunitytoapplaudthe

effortsofadynamicteamattheCEBHC.Thisannualreportshowcasestherichacademic

harvesttheCEBHChasyieldedthroughitsdedicationandcommitment.Thepublications

soaredyetagain.

WearegratefulforthesupportoftheFacultyofMedicineandHealthSciences,funders,

localandinternationalcollaboratorsandpartners,amongothers,intheexecutionofour

tasks.ThesoundjudgementthroughinvestmentintheCEBHChasyieldeddividendsfar

beyondourexpectations.

Professor Usuf ChikteChairGoverningBoardCentreforEvidence-basedHealthCare

'ThisannualreportshowcasestherichacademicharvesttheCEBHChasyieldedthroughitsdedicationandcommitment.'

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'Ourconfidenceliesinourteamwork,inthesupportfromourinstitution,ourpartnershipsandinourvalues–excellence,integrity,credibility,relevanceandcollaboration.'

Message from the Director and Deputy-Director of the CEBHC: Profs Taryn Young and Charles Wiysonge

ThroughtheCEBHC’sresearch,knowledgetranslation,andtrainingactivitiesourteam

sharestheidealsofexcellence,integrity,credibility,relevanceandcollaboration.These

valuesdetermineourprioritiesandgovernthewaywework.WiththeworkoftheCEBHC

increasinglyrecognizednationally,regionallyandinternationally,theCentrehasincreased

itsscopeofactivities,implementedandlednewprojectsandfosterednewcollaborative

engagements.Theteam,wholivesoutthevaluesoftheCEBHCineverythingtheydo,has

workedhardatincreasing,andpromotingtheuseof,researchoutputsandhasmadegreat

progresswiththeimplementationofintegratedteachingandlearningofevidence-informed

decisionmaking.

ThetaskofmaintainingtheCEBHCasaglobalcentreofexcellenceinevidence-informed

healthcareishuge.However,weareconfidentthattheCEBHCwillconsolidatecurrent

achievementsandmakefurtherprogress.Ourconfidenceliesinourteamwork,inthe

supportfromourinstitution,ourpartnershipsandinourvalues–excellence,integrity,

credibility,relevanceandcollaboration.TheCEBHChasagoodstorytotell,butabetter

storyisyettocome.

WewishtoexpressourgratitudeforthesupportfromtheheadofDepartmentof

InterdisciplinaryHealthSciences,theFacultyofMedicineandHealthSciences,theCEBHC

GoverningBoard,andourfundersandcollaborators.Ourspecialthanksgotoourteam

whoworktirelesslytowardstherealisationoftheCEBHCgoals.

Profs Taryn Young and Charles WiysongeDirectorandDeputy-DirectorCentreforEvidence-basedHealthCare

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2015 - CEBHC impacting health care on various fronts

Strategic goal:

To conduct and support relevant systematic reviews and primary

research related to evidence-informed health care

CEBHC Research outputs 2011 - 2015

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2011

Book chaptersPoster presentations

Oral presentations

Systematic review protocols

Peer reviewed papers

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602015

2014

2013

2012

2011

Book chaptersPoster presentations

Oral presentations

Systematic review protocols

Peer reviewed papers

Research

TheCEBHCconductshigh-quality,up-to-datesystematicreviewsaimedatimprovinghealthoutcomesinvulnerablegroups;conductsrelevantandrigorousprimaryresearchandevaluationonknowledgetranslationstrategies,teachingevidence-basedhealthcare(EBHC),methodologicalissuesandhealthcarestrategies;andcollaborateswithandsupportsresearchconductedbypostgraduatestudents,healthcareprofessionalsandresearchers.Researchoutputshavegrownoverthepastfiveyears(Figure)withvarioushighprofilepublicationsinhighimpactjournals.Centrestaffsuperviseandprovidemethodologicalmentorshipandsupportto33postgraduatestudents.TheCEBHChoststhreepost-doctoralstudentsandhassecuredfundingforafourthpost-doctoralfellowship.Annex1providesdetailsofallresearchoutputs.

Incollaborationwithnationalandinternationalpartners,theCEBHC,fundedbytheUKDepartmentofInternationalDevelopment(DFID),aimstoincreaseevidence-informeddecisionmakingtoimprovehealthandhealthcareforthepoorinlow-andmiddle-incomecountries(LMICs)viatheEffective Health Care Research Consortium (EHCRC)(www.evidence4health.org).ThefoundationoftheConsortiumisacollaborativeeffortbetweenfiveinternationalpartnersbasedinAfrica,East-Asia,China,NorwayandtheUK.TogetherpartnersworktowardspreparingandupdatingCochraneReviewsontheeffectsofhealthcareinterventionsrelevanttolow-andmiddle-incomecountries;andidentifyingapproachestoensuredisseminationanduseoftheresultsofsystematicreviewsindecisionmaking.ThisConsortiumhasperformedwellingeneratingproductsthathaverelevancetothehealthsectorinLMICs.Since2011,30oftheConsortium’sCochraneReviewshavebeenusedtoinformthedevelopmentofglobalguidelines.TheCEBHCleadsthisworkintheAfricanregionandprovidesprojectmanagementtocollaborationpartnersinCameroon,Nigeria,andSouthAfrica.WithinSouthAfrica,theCEBHCworkscloselywithCochraneSouthAfricaattheSouthAfricanMedicalResearchCouncil.

TheStellenbosch University (SU) BEME International Collaboration Centre (BICC)wasestablishedinMarch2014andisjointlycoordinatedbytheCEBHCandtheCentreforHealthProfessionsEducation(CHPE).ThelessonslearntandexperienceoftheCEBHCinconductingresearchsynthesisinhealthcarearenowbeingtransferredtoinformmedicaleducationsystematicreviews.TheBestEvidenceMedicalEducation(BEME)collaborationisaninternationalgroupofindividuals,universitiesandprofessionalorganisationscommittedtothedevelopmentofevidenceinformededucationinthemedicalandhealthprofessions.TheSUBICC’sinvolvementwithBEMErelatestocontributingtotheidentificationandconceptualisationofrelevanttopicsfornewsystematicreviews;promotingtheuseof

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systematicreviewstoinformmedicalandhealthprofessionseducation;contributingtotheeditorialroleandfunctionofBEMEreviewgroups;providingmentorshipandsupportforconductingnewBEMEreviews;andseekingfundstosupportthefunctionsoftheBICCandforconductingnewsystematicreviews.In2015weembarkedonaprojecttoidentify,anddescribe,existingBEMEsystematicreviewsandtoassesstheirrelevancetotheAfricanregion.Itisenvisagedthatthisworkwillinformquestionsfornewsystematicreviews,aswellasfutureinitiativestopromotetheuseofBEMEreviews.Wealsohostedalocalandinternationalworkshoponaccessing,assessingandinterpretingBEMEreviews.BICCmembersactivelyparticipatedinthe2015BEMEmeetingsatAMEE2015.

Cochranewww.cochrane.orgisaglobalindependentnetworkofresearchers,professionals,patients,carers,andpeopleinterestedinhealth.Thefocusisonconductingsystematicreviewstoinformhealthcaredecisionmaking.TheCEBHCconductsvariousCochrane ReviewsandindoingsoworkswithmanyCochranereviewgroups.TheprocessstartswithdefiningclearquestionsandthendevelopingandpublishingtheprotocolfortheCochraneReview.ThereviewteamthenconductsthereviewandpublishesthefinalpeerreviewedproductintheCochraneDatabaseforSystematicReviewsintheCochraneLibrary(impactfactor6).In2015theCEBHCpublished12reviewsintheCochraneLibrary.InadditiontoconductingCochraneReviews,CEBHCstaffalsoserveaspeerreviewers,andareappointedasCochraneeditorsorassociateeditors(Annex2).

Overthepast3yearsweembarkedonresearchonhowtheteaching and learning of EBHCcanbestbedoneintrainingofmedicalstudentstoenhancestudentEBHCknowledge,attitudeandskills.Tostartwith,wetookstockofexistingsystematicreviewsassessingtheeffectsofteachingEBHC.Thisoverviewidentified16reviewscovering

undergraduate,postgraduateandcontinuingprofessionaldevelopment.Itshowedthatclinicallyintegratedmultifacetedstrategieswithassessmentweremoreeffectivethansingleinterventionsornointerventionsforenhancingknowledge,attitudeandskills.TolearnmoreabouttheimplementationofclinicallyintegratedEBHCteachingandlearningwethenconductedinterviewswithprogrammecoordinatorsfromaroundtheworld.Asanoverarchingapproach,therewasconsensusthatlearningofEBHCshouldstartinthepre-clinicalyearsthroughtheuseofrealclinicalscenariosandbeconsolidatedwithapplicationtorealpatientsettingsandassessmentwithintheclinicalyears.TheEBHCcurriculumcontentshouldcoverthefullspectrumofEBHCandnotfocusonjustspecificaspectssuchascriticalappraisalor

CEBHC conducts Cochrane reviews with the following Cochrane review groups

• Developmental,PsychosocialandLearningProblemsGroup• EffectivePracticeandOrganizationofCare• Hypertension• InfectiousDiseases• Injuries• Neonatal• Neuromuscular• PregnancyandChildbirth• SexuallyTransmittedInfectious

RESEARCH ARTICLE

Patience, Persistence and Pragmatism:Experiences and Lessons Learnt from theImplementation of Clinically IntegratedTeaching and Learning of Evidence-BasedHealth Care – A Qualitative StudyTaryn Young1,2,3*, Anke Rohwer1, Susan van Schalkwyk4, Jimmy Volmink1,2, Mike Clarke5

1 Centre for Evidence-based Health Care, Faculty of Medicine and Health Sciences, StellenboschUniversity, Cape Town, South Africa, 2 South African Cochrane Centre, South African Medical ResearchCouncil, Cape Town, South Africa, 3 Division of Community Health, Faculty of Medicine and HealthSciences, Stellenbosch University, Cape Town, South Africa, 4 Centre for Health Professions Education,Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, 5 All IrelandHub for Trials Methodology Research, Queen’s University Belfast, Belfast, Northern Ireland

* tyoung@sun.ac.za

Abstract

Background

Clinically integrated teaching and learning are regarded as the best options for improving

evidence-based healthcare (EBHC) knowledge, skills and attitudes. To inform implementa-

tion of such strategies, we assessed experiences and opinions on lessons learnt of those

involved in such programmes.

Methods and Findings

We conducted semi-structured interviews with 24 EBHC programme coordinators from

around the world, selected through purposive sampling. Following data transcription, a mul-

tidisciplinary group of investigators carried out analysis and data interpretation, using the-

matic content analysis. Successful implementation of clinically integrated teaching and

learning of EBHC takes much time. Student learning needs to start in pre-clinical years with

consolidation, application and assessment following in clinical years. Learning is supported

through partnerships between various types of staff including the core EBHC team, clinical

lecturers and clinicians working in the clinical setting. While full integration of EBHC learning

into all clinical rotations is considered necessary, this was not always achieved. Critical suc-

cess factors were pragmatism and readiness to use opportunities for engagement and

including EBHC learning in the curriculum; patience; and a critical mass of the right teachers

who have EBHC knowledge and skills and are confident in facilitating learning. Role model-

ling of EBHC within the clinical setting emerged as an important facilitator. The institutional

context exerts an important influence; with faculty buy-in, endorsement by institutional

PLOS ONE | DOI:10.1371/journal.pone.0131121 June 25, 2015 1 / 19

OPEN ACCESS

Citation: Young T, Rohwer A, van Schalkwyk S,Volmink J, Clarke M (2015) Patience, Persistenceand Pragmatism: Experiences and Lessons Learntfrom the Implementation of Clinically IntegratedTeaching and Learning of Evidence-Based HealthCare – A Qualitative Study. PLoS ONE 10(6):e0131121. doi:10.1371/journal.pone.0131121

Editor: Kenneth Bond, Canadian Agency for Drugsand Technologies in Health, CANADA

Received: December 3, 2014

Accepted: May 28, 2015

Published: June 25, 2015

Copyright: © 2015 Young et al. This is an openaccess article distributed under the terms of theCreative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited.

Data Availability Statement: All relevant data arecontained in the paper as anonymised quotes whichsupport the results. This is in line with our informedconsent process.

Funding: This research is supported in part by theNational Research Foundation of South Africa(UNIQUE GRANT NO 86420). TY and AR aresupported in part by the Effective Health CareResearch Consortium, which is funded by UKaid fromthe UK Government Department for InternationalDevelopment, www.evidence4health.org. SvS is

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searching.Byfarthemostcommonchallengeswerelackofspaceintheclinicalsetting,EBHCmisconceptions,resistanceofstaffandlackofconfidenceoftutors,time,andnegativerolemodelling.CriticalsuccessfactorsforprogrammeimplementationwerepragmatismandnimblenessinrespondingtoopportunitiesforengagementandincludingEBHClearningintothecurriculum,patience,andacriticalmassoftherightteacherswhohaveEBHCknowledge,attitudesandskillsandareconfidentinfacilitatinglearning.Inaddition,rolemodellingwithintheclinicalsettingandtheoverallinstitutionalcontextwerefoundtobeimportantforsuccess.

TheCEBHChostedadedicatedresearch dayin2015toshowcaseandshareresearchfindings.Thefocuswasonsharingmethodsforconductingrigorousresearchandeffectiveknowledgetranslation.

Topic Presenter

Keynotetalk:Researchevidencetoprovideanswerstocliniciansandpolicymakerquestions ProfKarenGrimmer

Methodsforguidelinedevelopment,implementationandevaluation JanineDizon

SA-Argentinaproject:usertestinganevidence-to-decisionframework NyanyiweMbeye

Lessonslearntfromaplanned,targeteddisseminationofasystematicreviewonacontroversialtopicinthefieldofnutrition

CelesteNaude

SettingprioritiesandmonitoringhealthresearchinAfrica CharlesWiysonge

Developinglogicmodelsforacomplexsystematicreviewone-learningtoincreaseevidence-basedhealthcarecompetencies

AnkeRohwer

Analyticalframeworkforoverdiagnosis:thecaseofMalaria EleanorOchodo

Meta-analysis:limitationsandpotentialsolutions TonyaEsterhuizen

Strategic goal: To promote the use of best

evidence in health care decision making and the uptake of current

best evidence in health care policy and practice

Knowledge Translation

CoretotheworkoftheCEBHCisthepromotionoftheuptakeofbestevidenceindecisionmaking.Akeystrategyisengagementwithrelevantstakeholders.TheCentreworksincollaborationwithanumberoflocalandinternationalinstitutions,andstaffserveonvariouscommittees(Annex2).Thekeyprinciplesaretoencouragedialogue,enhanceEBHCactivitiesandavoidduplication.

TheCentreworkswithdifferentdivisionswithintheDepartmentofInterdisciplinaryHealthSciences(DIHS)andotherdepartmentswithintheFMHSatStellenboschUniversity.WithintheWesternCapeProvincewepartnerwithvariouspolicymakers.TheCentrelinkswiththeHeartandStrokeFoundation(HSF),ChronicDiseaseInitiativeinAfrica(CDIA)andkeystakeholdersfromtheUniversitiesoftheWesternCape(UWC),CapeTown(UCT),Witwatersrand(WITS)andKwaZulu-Natal(UKZN).AtthenationalleveltheCentrecollaborateswiththeMedicalResearchCouncil(MRC)specificallyCochraneSouthAfricatosupporttheconductofCochraneReviewsandpromoteEBHCintheAfricanregion,andalsolinkstotheCollaborationforEvidence-basedHealthinAfrica(CEBHA).Internationally,theCentrecollaborateswiththeEHCRC(fundedbyDFID)aswellastheChristianMedicalCollegeVellore(India),ChongqingMedicalUniversity(China),LiverpoolSchoolofTropicalMedicine(UK),theGREATNetwork,theAgencedeMédecinePréventive(AMP),iCAHEinAustraliaandtheNorwegianKnowledgeCentrefortheHealthServices(Norway)toincreaseevidence-informeddecisionsinordertoimprovehealthandhealthcareforthepoorinlow-andmiddle-incomecountries.TheCEBHCalsoworkswiththeGlobalAllianceforVaccinesandImmunisation(GAVI),variousCochraneReviewgroupsandlinksactivelywiththeWorldHealthOrganisation(WHO)atnational,regionalandinternationallevels.

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DIHS and FMHS

Intern

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al Regional National

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Local and international stakeholders

Inaspecifictailoredstrategy,thePolicy BUDDIESprojecthttp://www.cebhc.co.za/policy-buddies/,fundedbytheAllianceforHealthPolicyandSystemsResearch,WHO,drawsonpartners’experienceinworkinginknowledgetranslation.Theproject,conductedinSouthAfricaandCameroon,commencedwithasituationalanalysisinterviewstoidentifysub-nationalpolicy-makers’capacityandenablersandbarrierstodemandingevidenceduringpolicy-making.Theprojectthenfocusedonstrengtheningrelationships,engagementandnetworks,bylinkingsub-nationalpolicymakersandresearchersinordertoenhancetheirinteractionanddialogue,createopportunitiestolearnmoreabouteachother’sworldsandidentifyareasofworkrelatedtoevidence-informeddecisionmaking.Anexternalevaluation,conductedin2015,highlightedkeylessonslearnt(box).

Key lessons learned from Policy BUDDIES implementation

• Relationshipsopenthedoortomutualrespectandlearning.Researcherbuddiesbenefitedinlearningaboutthepolicy-makingworld

• Individualchampionsmustbelocatedinanetwork

• Evidence-informedhealthpolicy(EIHP)facesopportunities–andbarriers–insub-nationalcontexts

• Evidenceplaysanobjectiveandneutralizingrolebesidepowerfulexperts

• Organizational-levelsystemsandprocessescouldbeimprovedtosupportEIHP

• Progresscannotbesustainedwithoutdedicatedtimeandresources

• PolicyBUDDIESisdiffusingwithinSouthAfrica,butitstransfertoothercountrieswillrequireconsideration

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TheCEBHCisacollaboratingpartnerofProject SAGE (South African Guidelines Excellence)http://www.mrc.ac.za/cochrane/sage.htm,thataimstoenhancethequalityofprimaryhealthcarebyengaginginastakeholder-drivenprocesstoimprovethestandardsoflocalclinicalguidelinedevelopment,adaptation,contextualisationand,ultimately,implementation.In2015keyactivitiesincludedconductingresearchtounderstandguidelinedevelopmentprocessesinSouthAfrica,andtakingstockofexistingclinicalpracticeguidelinecapacitydevelopmentinitiatives.Thelatterinformedthedevelopmentofdedicatedcapacitydevelopmentpackageswhichwasimplementedinworkshops.AseriesofeditorialsintheSouthAfricanMedicalJournalonclinicalguidelinemattersareco-authoredbySAGEcollaborators.ProjectSAGEisfundedbyathree-year(2014-2016)FlagshipGrantfromtheSouthAfricanMedicalResearchCouncil(SAMRC).

InAugust2015CEBHCstaffparticipatedinaninternationalexploratorymeetinginCapeTowntoestablishaCochrane Nutrition Field (CNF).ThemeetingexploredthelevelofsupportforestablishingaCNF,discussedandfurtherdevelopedadraftproposal,andexploredpotentialcontributors,partnersandfundingsources.ACNFwillsupporttheproductionofhigh-qualityreviews;implementknowledgetranslationactivitiestopromotetheuseofevidencefromCochraneandotherhigh-qualitynutritionreviewsamongrelevantstakeholders,aswellastrainingstakeholdersintheuseofsystematicreviews,andretrieval,summaryandassessmentofevidence;andcontributetostrengtheningthemethodologyforconductingsystematicreviewsinthefieldofnutritionaddressingallformsofmalnutrition.

TheCEBHCispartoftheGREAT Network,http://greatnetworkglobal.org/,aWorldHealthOrganization(WHO)-affiliatedcollaborationfundedbytheCanadianInstitutesofHealthResearch,whichhasdesignatedcollaboratingcentresinSouthAfrica(theCEBHC),Kosovo,ThailandandArgentina.ThenetworkprovidesaninfrastructuretosupportLMICstoadapt,implement,evaluate,andsustaintheuseofevidence-basedWHOguidelinesonmaternalhealth.Thenetwork’sactivitiesareguidedbytheKnowledge-to-Actionprocessmodelandincludeprovisionofcoaching,technicalassistance,resourceallocation(fundingopportunities),andcapacity-buildingworkshopsandtrainings.WhiletheGREATNetworkcurrentlyfocusesonmaternalhealth,theunique,integratedknowledgetranslation(KT)processusedisreplicableinothersettingsandwithotherpriorityareasandguidelinetopics.Developingmulti-stakeholder,cross-countrycollaborationsisanopportunitytoleverageexistingtoolsandimplementationexpertisetoprovidelowandmiddle-incomecountrypartnerswithin-kind(e.g.,capacity-building,coaching)andfinancialresources(e.g.,seedgrantfunding)tooperationalizeimplementationinitiativestoimprovetheuseofevidenceproductssuchasguidelines.TheGREATNetworkhassupportedguidelineimplementationforoverthreeyears,fundedfiveKTprojectsthroughseedgrants(China,Ethiopia,Italy,SriLanka,andUganda),completedplanningworkshopsinfivecountries(Ethiopia,KosovoMyanmar,SriLanka,andUganda),andconductedatwoyearcountry-specificfollow-upevaluationinonecountry(Kosovo).WebelievetheuniqueKTapproach,globalstructure,successstories,andlessonslearnedaretransferrabletootherhealthsystemsresearchandimplementationwork.

TheCEBHChasalongwithSU'sDepartmentofSportsScience,partneredwiththeprovincialgovernment,inahealthpromotioninitiativecalledWestern Cape on Wellness (WoW!),whichisaimedataddressingtherisingproblemofobesity.ThepilotoftheinitiativewaslaunchedinCapeTownon31March2015andCEBHCisinvolvedbothtechnicallyandwiththeimplementationandtheresearchcomponentofWoW!.Theinitiativeconsistsofarangeofinterventionsdirectedatpromotingandenablingphysicalactivityandhealthyeatingchampionedbyteamsfrom13WesternCapeprovincialgovernmentdepartments,10communitiesand10schools.BesidesCEBHC,otherpartnersinthisinitiativeincludetheuniversitiesofCapeTownandtheWesternCape,aswellastheBiokineticsAssociationSouthAfrica,theHeartandStrokeFoundationandanumberofotherprivateandparastatalcompanies.

CEBHCregularlyengageswiththemedia,whichisakeystakeholderinknowledgetranslationactivities.Thisengagementin2015hasincludedvarioustopicspredominantlyrelatedtochildhoodimmunisation,childhoodnutritionandobesity.Mediaengagementisaimedatcommunicatingbestevidenceandpromotingitsuptakeindecisionmaking,andin2015includedprintanddigitalmedia,aswellasradioandtelevisioninterviews.

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Strategic goal:

To enhance EBHC knowledge, skills and practices through

teaching health care professionals and other

stakeholders

Training and Support

PromotingandenhancingtheteachingandlearningofEBHCiscoretotheworkoftheCEBHC.During2015,varioussessions/workshopswereofferedatundergraduate,postgraduateandcontinuingprofessionaldevelopmentlevel(Annex3).

WithintheStellenbosch University Rural Medical Education Partnership InitiativetheCEBHCprovidesleadershipfortheEBHCsubprojectwhichaimstoenhanceteachingofEBHCatunder-andpostgraduatelevels,aswellastohealthcareprofessionalsworkinginthefield.ToinformundergraduatelevelinitiativesweconductedacomprehensivesituationalanalysistotakestockofwhatwascoveredintheundergraduatecurriculaofferedbytheFMHS.Thesefindingsinformedenhancedoffering,whichwasapprovedbytheundergraduatemedicalprogrammecommitteein2013andimplementedfrom2014.Whatworkedwellweretheuseofthesituationalanalysisandfurtherresearchtoinformenhancementsinthecurriculum,jointplanningwithmoduleconvenorsandclinicians,ensuringrelevance,clearlydefininglearningoutcomes,interactivesmallgroupsessions,usingonlinetoolsandresources,practicalapplication,usingsimplelanguagetoexplaintheconceptsandavoidingjargon,providingfeedback,integratingEBHCconceptsinassessmentsandtasks,facultydevelopmentandhavingadedicatedteamdrivingtheimplementation.

EnhancingandexpandingtheprogrammaticofferingoftheMSc in Clinical Epidemiology:TheMScinClinicalEpidemiology(www.sun.ac.za/clinepi),registeredwithintheDivisionofCommunityHealth,offersrigorousmethodologicaltrainingforhealthprofessionalswhowishtopursuecareersinclinicalresearchand/orevidence-basedhealthcarepractice.TheacademicleadershipforthisprogrammeisprovidedbytheDirectoroftheCEBHC.Programmeintakehasgrownexponentiallyoverthepastfewyearsandweareattractingstudentsfromawidegeographicarea.From2008-2015,163studentshaveenrolledintheprogramme.StudentscomefromvarioushealthcaredisciplinesandvariouscountriesintheAfricanregion.Eighty(80)studentsgraduatedand32studentspublishedtheirresearch

Geographical information for MSc Clinical Epidemiology Students at Stellenbosch University Cape Town, South Africa

SouthAfrica–80students

Swaziland–2students

Botswana–4students

Zimbabwe–34students

Zambia–3students

Malawi–1student

Tanzania–2students

DRC–24students

Burundi–1student

Rwanda–2students

Kenya–3students

Uganda–1student

Cameroon–8students

Nigeria–23students

Ghana–1student

Gambia–1student80

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inpeerreviewedjournalsincludinghighimpactfactorjournalssuchastheInternationalJournalofEpidemiology,theCochraneDatabaseofSystematicReviewsandPLOSOne.TheMScinClinicalEpidemiologyprogrammeisinseparablefromtheworkoftheCEBHCasstaffplaykeyrolesinenhancingandexpandingtheprogrammaticoffering-staffconvenevariousmodules,facilitatesessions,provideteachingassistanceandsupport,andareinvolvedinthedevelopmentandimplementationofnewstructuredmodules.

TheCEBHClinkswithCochrane South AfricatopromotetheuseofCochranereviewsandtosupporttrainingandmentorshipofCochranereviewauthors.CochraneSouthAfrica,partoftheinternationalCochranecollaboration,isoneof14CochraneCentresworldwide.CEBHCstaffserveasmentorsfornoviceCochraneauthors.InNovember2015weparticipatedinaleadershipdevelopmenteventinCapeTownwhichbroughttogetherseniorCochraneauthorsintheregionandprovidedanopportunitytoplantogethertoadvanceCochraneintheregion,andforparticipantstoacquireorupdatetheirskillsinfacilitation,knowledgetransfer,leadershipandcoaching,communicationsandfundraising.

In2015,acoursebasedonthesuccessfulECRU Research Methods CoursewasofferedatStellenboschUniversity.ThirtyparticipantsfromvariousAfricancountriesparticipated.Participantswereequippedwithknowledge,skillsandmentorshipto:Plan,conduct,analyzeandpublisharandomisedclinicaltrial,follow‘GoodClinicalPractice’guidelines;conductasystematicreviewofrandomisedtrialsforpublicationintheCochraneLibrary;anduseReviewManager,Epi-info,ExcelandWHOReproductiveHealthLibrarysoftware.WeacknowledgefundingreceivedfromtheRegionalResearchCommitteefortheAfricanandEasternMediterraneanRegions,WorldHealthOrganisation.

CEBHCstaffataleadershipdevelopmentevent,CapeTown

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Strategic goal:

Promote the optimal functioning and sustainable

growth of the CEBHC

Management

TheworkoftheCEBHCisguidedbytheConstitutionoftheCentre.TheCentreismanagedbyaDirector,herdeputyandManagementCommittee,whileoversightisprovidedbyaGoverningBoard(Annex4).TheCEBHCplaysakeyroleinprovidingprojectleadershipnationally,regionally,andinternationally.

Effective Health Care Research Consortium:Incollaborationwithnationalandinternationalpartners,theCEBHC,fundedbytheUKDFID,aimstoincreaseevidence-informeddecision-makingtoimprovethehealthandhealthcareforthepoorinlow-andmiddle-incomecountriesviatheEffectiveHealthCareResearchConsortium(EHCRC)(www.evidence4health.org).TheCEBHCleadsthisworkintheAfricanregionandprovideprojectmanagementtopartnersinCameroon(CentrefortheDevelopmentofBestPracticesinHealth),Nigeria(CalabarInstituteofTropicalDiseasesandPrevention),andSouthAfrica(CochraneSouthAfrica).

Policy BUDDIES – Building demand for evidence in decision making through interaction and enhancing skills:TheCEBHCprovidesleadershipandprojectmanagementforthePolicyBUDDIEScollaborativeproject.TheCEBHCworkswiththeCochraneSouthAfrica,theHealthSystemsandServicesResearchUnitatStellenboschUniversity,theCentrefortheDevelopmentofBestPracticesinHealth(Cameroon)andtheLiverpoolSchoolofTropicalMedicine(UK).TheprojectisfundedbytheWorldHealthOrganisation.

R3 for CDIA - Relevant and robust systematic reviews to support the chronic diseases initiatives in Africa:CochraneSouthAfrica,SouthAfricanMedicalResearchCouncilandtheCEBHCwereawardedjointfundingfromtheCochraneCollaboration’sGlobalEvidenceSynthesisInitiative(GESI)forthisprojectthroughwhichtheseinstitutionswillsupportCDIAbydeliveringsystematicreviewsoftheeffectsofinterventionsthatwillhelpinformpoliciesandstrategiesaimedataddressingthehighburdenofnon-communicablediseasesinAfrica.

SURMEPI:WithintheSURMEPIprojecttheCEBHCleadstheEBHCactivitiesatunder-,postgraduateandcontinuingprofessionaldevelopmentlevels.

SUCCEED: WithinanewFMHSprojecttheCEBHCcontributestothemanagementcommitteeandcoordinatestheimplementationofcapacitydevelopmentandtechnicalsupportforimplementationresearch.

TheworkoftheCEBHCissupportedbyanexcellentteamoffull-timeandpart-timestaffaswellasexternalstaffappointedasextra-ordinarystaff(Annex5).Staffserveinvariouscapacitiesoncommittees(Annex2).Allstaffhaveperformanceagreementsandpersonaldevelopmentplansinplace.Staffcontinuetobeactiveinleadingandcontributingtofundingproposals(Annex6).

ParticipantsattheECRUResearchMethodsCourse,StellenboschUniversity

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ANNEX 1: Research Outputs 2015

Publications in peer-reviewed journals

1. TurawaEB,Musekiwa A, Rohwer AC.Interventionsforpreventingpostpartumconstipation.CochraneDatabaseofSystematicReviews2015,Issue9.Art.No.:CD011625.DOI:10.1002/14651858.CD011625.pub2.

2. Naude CE,ZaniB,Ongolo-ZogoP,Wiysonge CS,DudleyL,KredoT,GarnerP,Young T.Researchevidenceandpolicy:qualitativestudyinselectedprovincesinSouthAfricaandCameroon.ImplementationScience2015;10:126.http://www.implementationscience.com/content/10/1/126

3. LutgeEE,Wiysonge CS,KnightSE,SinclairD,Volmink J.Incentivesandenablerstoimproveadherenceintuberculosis.CochraneDatabaseofSystematicReviews.2015Sep3;9:CD007952.http://onlinelibrary.wiley.com/enhanced/doi/10.1002/14651858.CD007952.pub3

4. PuleGD,MowlaS,NovitzkyN,Wiysonge CS,WonkamA.Asystematicreviewofknownmechanismsofhydroxyurea-inducedfetalhemoglobinfortreatmentofsicklecelldisease.ExpertRevHematol.2015Sep1:1-11.[Epubaheadofprint].http://www.tandfonline.com/doi/abs/10.1586/17474086.2015.1078235?journalCode=ierr20#.VewN3k3ovVI

5. FarebrotherJ,Naude CE, Nicol L,AnderssonM,ZimmermannMB.Iodisedsaltandiodinesupplementsforprenatalandpostnatalgrowth:arapidscopingofexistingsystematicreviews.NutritionJournal(2015)14:89DOI10.1186/s12937-015-0079-z

6. IrusenH,Rohwer AC,SteynDW,Young T.Treatmentsforbreastabscessesinbreastfeedingwomen.CochraneDatabaseofSystematicReviews2015,Issue8.Art.No.:CD010490.DOI:10.1002/14651858.CD010490.pub2

7. GonzálezU,PinartM,SinclairD,FiroozA,EnkC,VélezID,Esterhuizen TM,TristanM,AlvarJ.Vectorandreservoircontrolforpreventingleishmaniasis.CochraneDatabaseofSystematicReviews2015,Issue8.Art.No.:CD008736.DOI:10.1002/14651858.CD008736.pub2.

8. UsenboA,KramerV,Young T, Musekiwa A(2015)PrevalenceofArthritisinAfrica:ASystematicReviewandMeta-Analysis.PLoSONE10(8):e0133858.doi:10.1371/journal.pone.0133858

9. DomingoAK,AsmalL,SeedatS,Esterhuizen TM,LaurenceC,Volmink J..Investigatingtheassociationbetweendiabetesmellitus,depressionandpsychologicaldistressinacohortofSouthAfricanteachers.SAfrMedJ2015;105(12):1057-1060.DOI:10.7196/SAMJ.2015.v105i12.9843

10. Machekano R, Young T,ConradieW,RusakanikoS,ThabaneL.Workshopreport:buildingbiostatisticscapacityinSub-saharanAfrica-takingaction.ThePanAfricanMedicalJournal.2015;21:167

11. Machekano R, Young T,RusakanikoS,MusondaP,SartoriusB,ToddJ,etal.onbehalfoftheparticipantsattheworkshoponBuildingBiostatisticsCapacityinSub-SaharanAfrica..TheAfricaCenterforBiostatisticalExcellence:aproposalforenhancingbiostatisticscapacityforsub-SaharanAfrica.Statist.Med.2015(wileyonlinelibrary.com)DOI:10.1002/sim.6572

12. Uthman OA, Okwundu C,GbengaK,Volmink J,DowdyD,ZumlaA,etal.OptimalTimingofAntiretroviralTherapyInitiationforHIV-InfectedAdultswithNewlyDiagnosedPulmonaryTuberculosis.ASystematicReviewandMeta-analysis.AnnInternMed.2015;163:32-39.doi:10.7326/M14-2979

13. DurãoS,AjumobiO,KredoT,Naude CE,LevittN,SteynKS,BradshawD,Young T.Evidenceinsufficienttoconfirmthevalueofpopulationscreeningfordiabetesandhypertensioninlow-andmiddle-incomesettings.SAfrMedJ2015;105(2):98-102.DOI:10.7196/SAMJ.8819

14. AthumanM,KabanywanyiAM,Rohwer AC.Intermittentpreventiveantimalarialtreatmentforchildrenwithanaemia.CochraneDatabaseofSystematicReviews2015,Issue1.Art.No.:CD010767.DOI:10.1002/14651858.CD010767.pub2http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010767.pub2/abstract

15. Rohwer AC,WillemsB,Young T.Takingstockofevidence-basedhealthcareintheundergraduatemedicalcurriculumatStellenboschUniversity:Combiningareviewofcurriculumdocumentsandinputfromrecentgraduates.AfricanJournalofHealthProfessionsEducation,[S.l.],v.7,n.1,p.98-104,jun.2015.ISSN2078-5127.Availableat:http://hmpg.co.za/index.php/ajhpe/article/view/7977

16. DudleyLD,Young TN, Rohwer AC,WillemsB,DramowskiA,GoliathC,etal.Fitforpurpose?AreviewofamedicalcurriculumanditscontributiontostrengtheninghealthsystemsinSouthAfrica.AfricanJournalofHealthProfessionsEducation,[S.l.],v.7,n.1,p.81-85,jun.2015.ISSN2078-5127.Availableat:http://hmpg.co.za/index.php/ajhpe/article/view/7987

17. vanEnstWA,NaaktgeborenCA,Ochodo EAdeGrootJAH,LeeflangMM,ReitsmaJB,ScholtenRJPM,MoonsKGM,ZwindermanAH,BossuytPMMandHooftL.Small-studyeffectsandtimetrendsindiagnostictestaccuracymeta-analyses:ameta-epidemiologicalstudy.SystematicReviews(2015)4:66.DOI10.1186/s13643-015-0049-8

18. Ochodo EA,GopalakrishnaG,SpekB,ReitsmaJB,vanLieshoutL,PolmanK,LambertonP,BossuytPM,LeeflangMM.Circulatingantigentestsandurinereagentstripsfordiagnosisofactiveschistosomiasisinendemicareas.CochraneDatabaseSystematicReviews.2015Issue3,Art.No.:CD009579.DOI:10.1002/14651858.CD009579.pub2.

19. AwotiwonAA,OduwoleO,SinhaA,Okwundu CI.Zincsupplementationforthetreatmentofmeaslesinchildren.CochraneDatabaseofSystematicReviews2015,Issue3.Art.No.:CD011177.DOI:10.1002/14651858.CD011177.pub2.

20.AnderssonMI,RajbhandariR,KewMC,VentoS,PreiserW,HoepelmanAIM,TheronG,CottonM,CohnJ,GlebeD,LesiO,

13

ThurszM,PetersM,ChungR,Wiysonge CS.Mother-to-childtransmissionofhepatitisBvirusinsub-SaharanAfrica:timetoact.LancetGlobHealth2015;3(7):e358–e359.DOI:http://dx.doi.org/10.1016/S2214-109X(15)00056-X

21. DraperCE,Grobler L,MicklesfieldLK,NorrisSA.Impactofsocialnormsandsocialsupportondiet,physicalactivityandsedentarybehaviourofadolescents:ascopingreview.ChildCareHealthDev.2015Mar25.doi:10.1111/cch.12241.[Epubaheadofprint]PMID:25809525

22.CoussensAK,Naude CE,GoliathR,ChaplinG,WilkinsonRJ,JablonskiNG.High-dosevitaminD3reducesdeficiencycausedbylowUVBexposureandlimitsHIV-1replicationinurbanSouthernAfricans.PNAS,June15,2015.doi:10.1073/pnas.1500909112.www.pnas.org/cgi/doi/10.1073/pnas.1500909112

23.Young T, Rohwer AC,vanSchalkwykS,Volmink J,ClarkeM(2015)Patience,PersistenceandPragmatism:ExperiencesandLessonsLearntfromtheImplementationofClinicallyIntegratedTeachingandLearningofEvidence-BasedHealthCare–AQualitativeStudy.PLoSONE10(6):e0131121.doi:10.1371/journal.pone.0131121

24.Grobler L,MaraisBJ,MabundaS.Interventionsforincreasingtheproportionofhealthprofessionalspractisinginruralandotherunderservedareas.CochraneDatabaseofSystematicReviews2015,Issue6.Art.No.:CD005314.DOI:10.1002/14651858.CD005314.pub3.

25.NkhataLA.Esterhuizen TM,SiziyaS,PhiriPDC,Munalula-NkanduE,ShulaH.ThePrevalenceandPerceivedContributingFactorsforWork-RelatedMusculoskeletalDisordersamongNursesattheUniversityTeachingHospitalinLusaka,Zambia.ScienceJournalofPublicHealth.Vol.3,No.4,2015,pp.508-513.doi:10.11648/j.sjph.20150304.18

26.KarinjaMN,Esterhuizen TM,FriedrichSO,DiaconAH.2015.Sputumvolumepredictssputummycobacterialloadduringthefirst2weeksofantituberculosistreatment.JClinMicrobiol53:1087–1091.doi:10.1128/JCM.02379-14

27. BMBiccard,TEMadiba,(Machekano R)onbehalfoftheSouthAfricanSurgicalOutcomesStudyinvestigators.TheSouthAfricanSurgicalOutcomesStudy:A7-dayprospectiveobservationalcohortstudy.SAfrMedJ2015;105(6):465-475.DOI:10.7196/SAMJ.9435

28.ChiveseT,Esterhuizen TM,BassonAR(2015)TheInfluenceofSecond-HandCigaretteSmokeExposureduringChildhoodandActiveCigaretteSmokingonCrohn’sDiseasePhenotypeDefinedbytheMontrealClassificationSchemeinaWesternCapePopulation,SouthAfrica.PLoSONE10(9):e0139597.doi:10.1371/journal.pone.0139597

29. KashanguraR,SenaES,Young T,GarnerP.EffectsofMVA85Avaccineontuberculosischallengeinanimals:systematicreview.Int.J.Epidemiol.firstpublishedonlineSeptember8,2015doi:10.1093/ije/dyv142

30. DalalS,HolmesMD,LaurenceC,BajunirweF,GuwatuddeD,NjelekelaM,AdebamowoC,Nankya-MutyobaJ,ChiwangaFS,Volmink J,AjayiI,KalyesubulaR,ReidTG,DockeryD,HemenwayDandAdamiHO.Feasibilityofalargecohortstudyinsub-SaharanAfricaassessedthroughafour-countrystudy.GlobalHealthAction,[S.l.],v.8,may.2015.ISSN1654-9880.Availableat:<http://www.globalhealthaction.net/index.php/gha/article/view/27422>.Datedoi:http://dx.doi.org/10.3402/gha.v8.27422

31. Young T, Rohwer A, Volmink J,ClarkeM.PerspectivesofundergraduatemoduleconvenorsataSouthAfricanacademicinstitutiononmedicalstudenttraininginevidence-basedhealthcare:aqualitativestudy.SouthAfricanFamilyPractice2015,DOI:10.1080/20786190.2015.1090689.

32. AdetokunbohOO,Schoonees A,BalogunTA,Wiysonge CS.Efficacyandsafetyofabacavir-containingcombinationantiretroviraltherapyasfirst-linetreatmentofHIVinfectedchildrenandadolescents:asystematicreviewandmeta-analysis.BMCInfectDis.2015Oct26;15(1):469.http://www.biomedcentral.com/1471-2334/15/469

33. NaidooI,CharltonKE,Esterhuizen TMandCassimB.HighriskofmalnutritionassociatedwithdepressivesymptomsinolderSouthAfricanslivinginKwaZulu-Natal,SouthAfrica:across-sectionalsurvey.JournalofHealth,PopulationandNutrition(2015)33:19.DOI10.1186/s41043-015-0030-0.

34. LewisJM,MacphersonP,AdamsER,Ochodo E,SandsA,Taegtmeyer,M.Fieldaccuracyoffourth-generationrapiddiagnostictestsforacuteHIV-1:asystematicreview.AIDS.Volume29(18),28November2015,p2465–2471

35.WerfalliM,EngelME,Musekiwa A,KengneAP,LevittNS.Theprevalenceoftype2diabetesamongolderpeopleinAfrica:asystematicreviewLancetDiabetes-Endocrinol2015.http://dx.doi.org/10.1016/S2213-8587(15)00363-0

36.MangesiL,Hofmeyr GJ,SmithV,SmythRMD.Fetalmovementcountingforassessmentoffetalwellbeing.CochraneDatabaseofSystematicReviews2015,Issue10.Art.No.:CD004909.DOI:10.1002/14651858.CD004909.pub3.

37. Young T, Esterhuizen TM, Volmink J,ClarkeM.Attitudeandconfidenceofundergraduatemedicalprogrammeeducatorstopracticeandteachevidence-basedhealthcare.InternationalJournalofEvidence-BasedHealthcare11/2015;DOI:10.1097/XEB.0000000000000068

38. MelangaAnyaBP,MihigoR,Wiysonge CS,DochezC,AkanmoriBD.EnhancingcapacityofprofessionalsandacademicsforvaccinesandimmunizationinAfrica:The3rdRegionalVaccinologyCourseforFrancophoneCountries,Mbour,Senegal,12th-19thSeptember2015.AnnVaccinesImmunization2015;2(1):1011.http://www.jscimedcentral.com/Vaccines/vaccines-2-1011.pdf

39. AdebayoEF,UthmanOA,Wiysonge CS,SternEA,LamontKT,AtagubaJE.Asystematicreviewoffactorsthataffectuptakeofcommunity-basedhealthinsuranceinlow-incomeandmiddle-incomecountries.BMCHealthServicesResearch

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2015(acceptedforpublication).BMCHealthServicesResearch2015;15:543doi:10.1186/s12913-015-1179-3.http://www.biomedcentral.com/content/pdf/s12913-015-1179-3.pdf

40.WerfalliM,EngelME,Musekiwa A,KengneAP,LevittNS.Theprevalenceoftype2diabetesamongolderpeopleinAfrica:asystematicreview.www.thelancet.com/diabetes-endocrinology.PublishedonlineNovember5,2015.http://dx.doi.org/10.1016/S2213-8587(15)00363-0

41. LamontK,SliwaK,StewartS,CarringtonM,PretoriusS,LibhaberE,Wiysonge CS,AdebayoEF,Klipstein-GrobuschK.Shortmessageservice(SMS)asaneducationaltoolduringpregnancy:Aliteraturereview.HealthEducationJournal2015(PublishedonlinebeforeprintOctober29,2015)doi:10.1177/0017896915607910http://hej.sagepub.com/content/early/2015/10/28/0017896915607910.full.pdf+html

42. GuwatuddeD,Nankya-MutyobaJ,KalyesubulaR,LaurenceC,AdebamowoC,AjayiIO,BajunirweF,NjelekelaM,ChiwangaFS,ReidT,Volmink J,AdamiHO,HolmesMDandDalalS.Theburdenofhypertensioninsub-SaharanAfrica:afour-countrycrosssectionalstudy.BMCPublicHealth(2015)15:1211.DOI10.1186/s12889-015-2546-z

43. ZeierMD,BothaMHH,EngelbrechtS,Machekano R,JacobsGB.CombinationantiretroviraltherapyreducesthedetectionriskofcervicalhumanpapillomavirusinfectioninwomenlivingwithHIV.AIDS.Volume29.

44. Hofmyer GJ,SeucAH,BetranAP,PurnatTD,CigandaA,MunjanjaSP,ManyameS,SingataM,FawcusS,FrankK,HallDR.Theeffectofcalciumsupplementationonbloodpressureinnon-pregnantwomenwithpreviouspre-eclampsia:Anexploratory,randomizedplacebocontrolledstudy.PregnancyHypertension:AnInternationalJournalofWomen'sCardiovascularHealth.2015

45. NaidooI,CharltonKE,Esterhuizen TM,CassimB.HighriskofmalnutritionassociatedwithdepressivesymptomsinolderSouthAfricanslivinginKwaZulu-Natal,SouthAfrica:across-sectionalsurvey.JHealthPopulNutr.2015Oct19;33(1):19.doi:10.1186/s41043-015-0030-0.PubMedPMID:26825267.

46. ChimaSC,NkwanyanaNM,Esterhuizen TM.Impactofashortbiostatisticscourseonknowledgeandperformanceofpostgraduatescholars:ImplicationsfortrainingofAfricandoctorsandbiomedicalresearchers.NigerJClinPract.2015Dec;18Suppl:S62-70.doi:10.4103/1119-3077.170818.PubMedPMID:26620624.

Published Protocols

1. DuraoS,Schoonees A,RamokoloV,OliveiraJMD,KristjanssonE.Community-levelinterventionsforimprovingaccesstofoodinlow-andmiddle-incomecountries.CochraneDatabaseofSystematicReviews2015,Issue2.Art.No.:CD011504.DOI:10.1002/14651858.CD011504.

2. FarebrotherJ,Naude CE, Nicol L,SangZ,YangZ,AnderssonM,JoostePL,ZimmermannMB.Systematicreviewoftheeffectsofiodisedsaltandiodinesupplementsonprenatal

andpostnatalgrowth:studyprotocol.BMJOpen.2015Apr23;5(4):e007238.doi:10.1136/bmjopen-2014-007238.PMID:25908676

3. Motaze NV,ChiCP,Ongolo-ZogoP,NdongoJS,Wiysonge CS.Governmentregulationofprivatehealthinsurance(Protocol).CochraneDatabaseofSystematicReviews2015,Issue4.Art.No.:CD011512.DOI:10.1002/14651858.CD011512.http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011512/abstract

4. LukusaLA,Mbeye NN, Adeniyi FB, Wiysonge CS.Protocolforasystematicreviewoftheeffectsofinterventionstoinformoreducatecaregiversaboutchildhoodvaccinationinlowandmiddle-incomecountries.BMJOpen2015;5:e008113.doi:10.1136/bmjopen-2015-008113

5. TurawaEB,Musekiwa A, Rohwer AC.Interventionsforpreventingpostpartumconstipation(Protocol).CochraneDatabaseofSystematicReviews2015,Issue3.Art.No.:CD011625.DOI:10.1002/14651858.CD011625.

6. ChachouMJ,MukindaFK,Motaze V, Wiysonge CS.Electronicandpostalremindersforimprovingimmunisationcoverageinchildren:protocolforasystematicreviewandmeta-analysis.BMJOpen.2015Oct15;5(10):e008310.http://bmjopen.bmj.com/content/5/10/e008310.long

7. AbdullahiLH,KaginaBMN,Wiysonge CS,HusseyGD.Improvingvaccinationuptakeamongadolescents.CochraneDatabaseofSystematicReviews2015,Issue9.Art.No.:CD011895.http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011895/full

8. AWOTIDEBEAW,INGLIS-JASSIEMG,YOUNGTN.Low-levellasertherapyandexerciseforpatientswithshoulderdisordersinphysiotherapypractice(asystematicreviewprotocol).Systematicreviews.D0110.1186/s13643-015-0050-2

Scientific letters, editorials, columns

1. Wiysonge CS,ZaniB,MbachamW,HodelEM,TerlouwDJ.CochraneColumn:Dihydroartemisinin-piperaquinefortreatinguncomplicatedfalciparummalaria.IntJEpidemiol.2015;44(5):1502–1505.doi:10.1093/ije/dyv163.

2. Wiysonge CS,KredoK,OsiemoD,BoulleA,FordN.CochraneColumn:Improvingpeople’saccesstoHIVtreatment.InternationalJournalofEpidemiology2015;44(3):750-755.doi:10.1093/ije/dyv111.http://ije.oxfordjournals.org/content/early/2015/06/25/ije.dyv111.full

3. KredoT,Young T, Wiysonge CS, McCaul M, Volmink J.TheCochraneCornerintheSAMJ:SummariesofCochranesystematicreviewsforevidence-informedpractice.S.Afr.Med.J.2015:105;7http://dx.doi.org/10.7196/SAMJNEW.8035

4. MachingaidzeS,KredoT,LouwQ,Young T,GrimmerK.SouthAfricanGuidelinesExcellence(SAGE):Clinicalpracticeguidelines–qualityandcredibility.S.Afr.Med.J.2015;105(9):743-745.DOI:10.7196/SAMJnew.7697

5. KredoT,McCaul M,&Volmink J.(2015).Task-shiftingfrom

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doctorstonon-doctorsforinitiationandmaintenanceofantiretroviraltherapy.SouthAfricanMedicalJournal,105(8),626.doi:10.7196/SAMJnew.8271(editorial)

6. McCaul M,LourensA,&KredoT.(2015).Cochranecorner:prehospitalversusin-hospitalthrombolysisforST-elevationmyocardialinfarction.Heart,heartjnl–2015–307779.doi:10.1136/heartjnl-2015-307779(Editorial/Columns)

7. Wiysonge CS, Young T,KredoT,McCaul M, Volmink J.Interventionsforimprovingchildhoodvaccinationcoverageinlow-andmiddle-incomecountries.SouthAfricanMedicalJournal2015;105(11):892-893.DOI:10.7196/SAMJ.2015.v105i11.10177

International Presentations

1. Wiysonge CS, Mbeye NM,AdetokunbohO,NegussieE,KredoT.TheEffectsofShiftingResponsibilityfromPharmacytoNon-pharmacyPersonnelforDispensingAntiretroviralMedicationstoPatientsInfectedwithHIV:ASystematicReviewandMeta-analysis.18thInternationalConferenceonHIV/AIDSandSTIsinAfrica.Harare,Zimbabwe;29November-04December2015(oralpresentation).

2. Wiysonge CS,AnyeIB,EPOCOverviewWritingGroup.Interventionsforfinancingresource-constrainedhealthsystems.18thInternationalConferenceonHIV/AIDSandSTIsinAfrica.Harare,Zimbabwe;29November-04December2015(posterpresentation).

3. Wiysonge CS.ChildhoodvaccinationprogrammesinAfrica;wheretopost-2015?9thConferenceonGlobalHealthandVaccinationResearch.Oslo,Norway.17-18March2015(posterpresentation).

4. AdebayoEF,UthmanOA,AtagubaJE,SternEA,LamontKT,Wiysonge CS.Asystematicreviewofdeterminantsofcommunity-basedhealthinsurancecoverageinlow-incomeandmiddle-incomecountries.9thConferenceonGlobalHealthandVaccinationResearch.Oslo,Norway.17-18March2015(posterpresentation).

5. PantojaT,OpiyoN,CiapponiA,DudleyL,GagnonMP,HerreraCA,LewinS,GarciaMartiS,OxmanAD,PaulsenE,PeñalozaB,RadaG,Volmink J, Wiysonge CS.Implementationstrategiesforhealthsystemsinlow-incomecountries:anoverviewofsystematicreviews.9thConferenceonGlobalHealthandVaccinationResearch.Oslo,Norway.17-18March2015(posterpresentation).

6. Rohwer A, Motaze NV,RehfuessE,Young T.E-learningofevidence-basedhealthcare(EBHC):Whiche-learningcomponentsarenecessaryforsuccessfulEBHCe-learning?7thInternationalConferenceforEBHCTeachersandDevelopers,Taormina,Italy,28-31October2015(oralpresentation)

7. AbramsA,KredoT,Young T,LouwQ,GrimmerK,DanielsK.ReporteduseandperceptionsofvalueofCochraneevidencebySouthAfricanguidelinedevelopers.CochraneColloquium,Vienna,Austria,2-6October2015(oralpresentation)

8. KredoT,DuraoSandYoung T.CochraneTraining-facilitationskills:Creatingapositivelearningclimateforeffectivelearning.CochraneColloquium,Vienna,Austria,2-6October2015(workshop)

9. Young T, Naude CE, Wiysonge CS,KredoT,DudleyL,GarnerP.PolicyBUDDIES:lessonslearntbyresearchersengagingin“buddying”withprovincialpolicymakersinSouthAfricatoadvanceevidence-informeddecision-making.CochraneColloquium,Vienna,Austria,2-6October2015(oralpresentation)

10. Naude CE, Schoonees A, Young T,SenekalM,GarnerP,Volmink J.Lessonslearntfromaplanned,targeteddisseminationofasystematicreviewonacontroversialtopicinthefieldofnutrition.CochraneColloquium,Vienna,Austria,2-6October2015(oralpresentation)

11. OdendaalW,DanielsK,LewinS,KredoT,Young T.Usingprioritysettingtoenhancethepolicyrelevanceofsystematicreviews:acasestudyfromtheSouthAfricanInitiativeforSystematicReviewsonHealthPoliciesandSystems.CochraneColloquium,Vienna,Austria,2-6October2015(oralpresentation)

12. Rohwer AC,MotazeV,RehfuessE,Young T.InformingCochranelearningstrategies:effectivenessofe-learningstrategiestoincreaseevidence-basedhealthcare(EBHC)competencies.CochraneColloquium,Vienna,Austria,2-6October2015(posterpresentation)

13. Durao S, Oliver J, Young T, Kredo T.Providingtimeoutthroughdedicatedfellowships:strategytoimproveCochraneauthorsupporttowardsreviewcompletion.CochraneColloquium,Vienna,Austria,2-6October2015(posterpresentation)

14. HarperA,Naude CE,DuraoS,Volmink J.ScopeandqualityofCochraneReviewsofnutrition-relatedinterventions.23rdCochraneColloquium.Vienna,Austria.3-7October2015(rapidoralpresentation)

15. Young T, Rohwer A,vSchalkwykS,Volmink J,ClarkeM.Experiencesandlessonslearntfromtheimplementationofclinicallyintegratedteachingandlearningofevidence-basedhealthcare.AMEE,Glasgow,Scotland,5-9September2015(oralpresentation)

16. Ochodo E, Rohwer A,NortjieG,Young T.TeamteachingofevidencebasedhealthcaretoundergraduatemedicalstudentsinSouthAfrica.7thInternationalSharedDecisionMaking(ISDM)Conferenceandthe4thInternationalSocietyforEvidence-BasedHealthCare(ISEHC)Conference2015,Sydney,Australia,19-22July2015(oralpresentation)

17. PantojaT,OpiyoN,CiapponiA,HerreraCA,LewinS,OxmanAD,PaulsenE,RadaG,Wiysonge CS.Strategiesforimprovinghealthsystemsinlow-incomecountries:lessonslearntfromfouroverviewsofsystematicreviewsofhealthsystemsinterventions.23rdCochraneColloquium.Vienna,Austria.3-7October2015(rapidoralpresentation)

16

18. Wiysonge CS.Researchagendasettingandimplementationresearch.MeetingonstrengtheningcollaborationbetweenNationalMalariaControlProgrammesandResearchInstitutionsintheAfricanRegion.Ouagadougou,BurkinaFaso.10-12June2015(oralpresentation).

19. Wiysonge CS.AcceptabilityofmultipleinjectionsduringasinglevaccinationvisitinSouthAfricaandTanzania.MeetingoftheStrategicAdvisorygroupofExperts(SAGE)onImmunisation.Geneva,Switzerland.14-16April2015(oralpresentation).

20.Esterhuizen TM.Meta-analysis:usefulornot?Apro/condebate.WorldCongressofNephrology2015.March13-172015.CapeTown(oralpresentation).

21. Naude CE,DuraoS,HarperA,Volmink J.ScopeandQualityofCochraneReviewsofNutrition-RelatedInterventions.CochraneColloquium,Vienna,Austria,2-6October2015(oralpresentation).

22.Dizon J.ImplementingthePARMguidelines:amultidisciplinaryapproach.InternationalSocietyofPhysicalandRehabilitationMedicine,MaritimeHotel,Berlin,Germany,June19-23,2015(oralpresentation).

23.Schoonees A,vanSchalkwykS,Young T.Layofthelandofhealthprofessionseducationsystematicreviews:scopeandmethodologicalqualityofBEMEsystematicreviews.7thInternationalConferenceforEBHCTeachersandDevelopers.Taormina,Italy,30October2015(oralpresentation).

24. OrtonK,Rohwer AC.Perceptionsandself-perceivedknowledgeofevidence-basedhealthcareamongstregisterednursesandmidwivesinruralareasoftheWesternCape.7thInternationalConferenceforEBHCTeachersandDevelopers,Taormina,Italy,28-31October2015(posterpresentation).

25.OrtonK,Rohwer AC.Perceptionsandself-perceivedknowledgeofevidence-basedhealthcareamongstregisterednursesandmidwivesinruralareasoftheWesternCape.7thInternationalSharedDecisionMaking(ISDM)Conferenceandthe4thInternationalSocietyforEvidence-BasedHealthCare(ISEHC)Conference2015,Sydney,Australia,19-22July2015(oralpresentation).

26.Grobler L,MehtarS,DhedaK,AdamsS,BabatundeS,vanderWaltM,OsmanM.SystematicreviewoftheepidemiologyofandprogrammaticresponsetoTBinSouthAfricanhealthcareworkers.46thUnionWorldConferenceonLungHealth.CapeTownSouthAfrica.2-6December2015(posterpresentation).

27. AbramsA,MachingaidzeS,DanielsK,GrimmerK,Young T,LouwQ,KredoT.SouthAfricanGuidelineExcellence(SAGE)project:anannovativepartnershipforclinicalguidelineexcellence.G-I-NConference.Amsterdam,TheNetherlands.7-10October2015(posterpresentation).

28.MachingaidzeS,GrimmerK,LouwQ,KredoT,Young T.ClinicalguidanceterminologyinSouthAfrica:producingbelievable,appropriateandimplementableevidencestatements.G-I-N

Conference.Amsterdam,TheNetherlands.7-10October2015(posterpresentation).

29.MachingaidzeS,LouwQ,KredoT,Young T,GrimmerK.Clinicalpracticeguidelinequality:aneffectiveappraisalinstrumentforbusypeople.G-I-NConference.Amsterdam,theNetherlands.7-10October2015(posterpresentation).

30. LazarusE,NicolS,PenazzatoM,CottonM,TablanteeE,OliverJ,ViolariA,Nicol L.Systematicreviewon2ndand3rdlineARTinchildren.7thInternationalWorkshoponHIVPediatrics.Vancouver.July2015(posterpresentation).

National Presentations

1. Wiysonge CS.Systematicreviewsandmeta-analysis:lookingatthetotalityofevidence.Evidence-BasedPolicy-Making&Implementation(hostedbythePresidencyandUCT).Johannesburg.27-29May2015(TED-like:oralpresentation).

2. Wiysonge CS.Newvaccines:medicalneedsandcurrentdevelopments.3rdAnnualRegulatoryWorkshop-NewDevelopmentsinDrugRegulations.Pretoria.8-9Sep2015(oralpresentation).

3. Wiysonge CS.Evidence-basedmedicine.HarambeeNationalConference–ConnectingScience,HealthandCommunity.CapeTown,SouthAfrica.13-15March2015(oralpresentation).

4. Wiysonge CS.CochraneSouthAfrica.SAMRCIntra-andExtramuralUnitDirectors’Meeting,CapeTown,SouthAfrica.,8-9October2015(oralpresentation).

5. Naude CE, Schoonees A, Young T,SenekalM,GarnerP,Volmink J.Lessonslearntfromaplanned,targeteddisseminationofasystematicreviewonacontroversialtopicinthefieldofnutrition.CEBHCResearchDay,FacultyofMedicineandHealthSciences,StellenboschUniversity,29July2015(oralpresentation)

6. Naude CE.ProfitsversusHealth:theroleof‘bigfood’inshapingtheenvironmentsthatinfluenceourdiets.ContinuingNutritionEducationUpdate,StellenboschUniversity,24June2015(oralpresentation)

7. Zunza M,CottonM,EsserM.InfantfeedingchoicesandeffectsoninfantsgrowthandmorbidityinPMTCTprogramstransitioningto"OptionB+"inWesternCape,SouthAfrica.6thFISSACongress,Drakensberg,SouthAfrica,6-8November2015(oralpresentation).

8. Dizon J, McCaul MandLouwQ.IntroductiontoClinicalPracticeGuidelines.RuralHealthConference,Mpumalanga,SouthAfrica,September23-25September2015(oralpresentation).

9. Dizon J, McCaul MandLouwQ.IntroductiontoClinicalPracticeGuidelines.DepartmentofHealthworkshop,Mpumalanga,SouthAfrica,24–25September2015(oralpresentation).

17

10. Dizon J.Methodsforguidelinedevelopment,implementationandevaluation-SAGEapproach.CEBHCResearchDay,StellenboschUniversity,SouthAfrica,29July2015(oralpresentation).

11. Dizon J.IntroductiontoContextualisationworkshop.MedicalResearchCouncil,CapeTown,SouthAfrica,25July2015(oralpresentation).

12. Dizon J,MachingaidzeS,GrimmerK.Adopt,AdaptorContextualise?RuralHealthConference,Mpumalanga,SouthAfrica,23–25September2015(posterpresentation).

Postgraduate student supervision

1. JeremyStockhall,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:SouthAfricanPhysiotherapists’ConfidenceinEvidence-BasedPractice:aCrossSectionalStudy.(Supervisor:Taryn Young)

2. NicholasMangeya,MScClinicalEpidemiology,StellenboschUniversity-ongoing.Topic:Detectionofhumanimmunodeficiencyvirus(HIV)type-1antibodiesinsaliva,asanalternativemethodofHIVdiagnosis:adiagnosticaccuracystudyandapreliminaryassessmentforhome-basedHIVtestinginSouthAfrica.(Supervisor:Tonya Esterhuizen)

3. OgunjaleAdeniyi,MScClinicalEpidemiology,StellenboschUniversity-ongoing.Topic:RilpivirineversusEfavirenzasinitialtherapyintreatment-naïve,HIV-1-infectedpatients.Asystematicreview.(Supervisor:Charles Okwundu)

4. CasperTarumbuwa,MScClinicalEpidemiology,StellenboschUniversity-ongoing.Topic:MorbidityandmortalityfrommalnutritioninHIV-exposedinfantsenrolledinthepreventionofmother-to-childtransmissionofHIVprogramme(PMTCT)atadistricthospitalinNamibia:theroleofinfantfeedingpractices(Supervisor:Celeste Naude)

5. BenjaminKagina,Postdoc,UniversityofCapeTown-ongoing.Topic:StrengtheningimmunisationprogrammesinAfricathroughevidence-basedmedicine.(Supervisor:CharlesWiysonge)

6. CharlesOkwundu,PhD,StellenboschUniversity-ongoing.Topic:ScreeningforriskofseverehyperbilirubinemiainSouthAfricannewborns.(Supervisor:Charles Wiysonge).

7. OlatunbosunOlawale,MSc,StellenboschUniversity-ongoing.Topic:Knowledge,attitudesandpracticesofdiabeticsinPretoria,SouthAfricaregardingseasonalinfluenzaandinfluenzavaccination.(Supervisor:CharlesWiysonge)

8. ShingaiMachingaidze,PhD,UniversityofMunich-ongoing.Topic:Reachingtheunvaccinatedandunder-vaccinatedchildrenofAfrica.(Supervisor:Charles Wiysonge)

9. LeilaAbdullahi,PhD,StellenboschUniversity-ongoing.Topic:AdolescentimmunisationinAfricainthedecadeofvaccines.(Supervisor:Charles Wiysonge)

10. ArthemonNguweneza,MScClinicalEpidemiology,StellenboschUniversity-ongoing.Topic:Theimpactofmassmediainterventionsonimmunisationcoverage:asystematicreview(Supervisor:Charles Wiysonge)

11. OlatunjiAdetokunboh,MScClinicalEpidemiology,StellenboschUniversity–graduated2015.Topic:AsystematicreviewoftheeffectivenessandsafetyofabacavirbackbonetherapiesfortreatmentofHIV-infectedchildren.(Supervisors:Charles WiysongeandAnel Schoonees)

12. JudyGatei,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:BarriersandfacilitatorstoexclusivebreastfeedingpracticesamongHIVinfectedwomenandtheiruninfectedinfantsinSouthAfricaandNigeria.(Co-supervisor:Moleen Zunza)

13. VictoriaNdarukwa,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:Riskfactorsformother-to-childtransmissionofHIVat6weekspostpartuminPMTCTprogramsinHarare,Zimbabwe.(Co-supervisor:Moleen Zunza)

14. KuhlulaMaluleke,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:DeterminantsofadherencetoARTamongHIV-infectedyoungadultsattendingtheLetabaHospitalHIVclinic,LimpopoProvince,SouthAfrica.(Co-supervisor:Moleen Zunza)

15. AdedapoAwotidebe,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:Low-LevelLaserTherapyandExerciseforPatientswithShoulderDisordersinPhysiotherapyPractice(Supervisor:Taryn Young)

16. LeyMuyaya,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:PredictorsofMortalityduringTuberculosisTreatmentinTB-HIVco-infectedPatientsinBotswana:DifferencesbetweenSubjectsNaïvetoandpreviouslystartedonHAART(Supervisor:Taryn Young)

17. EsperanceManwana,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:EpidemiologyoforthopedicinjuriesinBotswana:AnalysisofinpatientdataatPrincessMarinaHospital(Supervisor:Taryn Young)

18. AnkeRohwer,PhD,StellenboschUniversity–ongoing.Topic:Researchintegrityinreportingresearch:Perceptionsandexperiencesaroundplagiarism,conflictofinterestandauthorshipcriteriainlow-andmiddleincomecountries(Supervisor:Taryn Young)

19. PierreSmit,MPhilEmergencyMedicine,UniversityofCapeTown–ongoing.Topic:Rapidreviewofketamineaspre-hospitalinductionagentforheadinjurypatients(Supervisor:Michael McCaul).

20. ItaiMagodoro,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:Across-sectional,facilitybasedstudyofcomorbidnon-communicablediseasesamongadultslivingwithHIVinfectioninZimbabwe.(Supervisor:Tonya Esterhuizen)

18

21. BrianMoyo,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:PrevalenceofunsuppressedviraemiainHIVpositivefemalesexworkersonthedailysingledoseTDF/3TC/EFVtabletfor6months:PSI-Zimbabwesexworkercohort(Supervisor:Tonya Esterhuizen)

22.TaiwoSogunle,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:CHRONICDISEASEANDCOMPLEMENTARYANDALTERNATIVEMEDICINEINADULTSATTENDINGAPRIMARYCARECLINICINWESTERNNIGERIA.(Supervisor:Tonya Esterhuizen)

23. DumisaniMajombozi,MBChB-5,StellenboschUniversity:StudentelectiveinEBHC(Supervisor:Charles Wiysonge).

24. LungeniA.Lukusa,MScClinicalEpidemiology,StellenboschUniversity–ongoing.Topic:Systematicreviewoftheeffectsofinterventionstoinformoreducatecaregiversaboutchildhoodvaccinationinlowandmiddle-incomecountries(Supervisor:Charles Wiysonge).

25.MartelChachou,MScClinicalEpidemiology,StellenboschUniversity-ongoing.Topic:EffectivenessofElectronicandpostalremindersforimprovingimmunisationcoverageinchildren-systematicreview(Supervisor:Charles Wiysonge).

26.OlatunbosunOlawale,MScClinicalEpidemiology,StellenboschUniversity-ongoing.Topic:Knowledge,attitudesandpracticesofdiabeticsinPretoria,SouthAfricaregardingseasonalinfluenzaandinfluenzavaccination(Supervisor:Charles Wiysonge).

27. ArletteMouakoLeufak,MScClinicalEpidemiology,StellenboschUniversity-ongoing.Topic:PeerreviewedresearchpublicationsinSouthAfricaforthelast30years(Supervisor:Charles Wiysonge)

28.CynthiaTchuem,PhD,StellenboschUniversity-ongoing.Topic:HepatitisBvirusmother-to-Child-transmissioninNamibia:transmissiondynamicsandpossibilitiesforelimination.(Supervisor:Charles Wiysonge).

29. VillyenMotaze,PhD,StellenboschUniversity-ongoing.Topic:DiseaseburdenandcostofcongenitalrubellasyndromeinSouthAfrica.(Supervisor:Charles Wiysonge)

30. ChinweIwu,PhD,StellenboschUniversity-ongoing.(Opentochange):ImmunisationsupplychaininSouthAfrica.(Supervisor:Charles Wiysonge).

31. ElvisKiyang,PhD,StellenboschUniversity-ongoing.Topic(opentochange):EvaluationoftheroutinechildhoodimmunisationscheduleinAfrica(Supervisor:Charles Wiysonge).

32. AbduAdamu,PhD,StellenboschUniversity-ongoing.Topic(opentochange):Bacterialinfectionsandvaccinationinsicklecelldisease(Supervisor:Charles Wiysonge).

33. ValantineNdze,Postdoc,StellenboschUniversity-ongoing.Topic:Overviewofsystematicreviewsoninterventionsforimprovingvaccinationcoverage(Supervisor:Charles Wiysonge).

Supporting graduates to publish their research projects

1. AnthonyUsenbo,MScClinicalEpidemiology,StellenboschUniversity–graduatedApril2014.Topic:PrevalenceandriskfactorsofArthritisinAfrica.(Supervisors:Alfred MusekiwaandTaryn Young).

2. HayleyIrusen,MScClinicalEpidemiology,StellenboschUniversity–Graduated2014.Topic:Managementofbreastabscessesinbreastfeedingwomenforimprovingoutcomes.(Supervisors:Anke RohwerandTaryn Young)

3. EuniceTurawa,MScClinicalEpidemiology,StellenboschUniversity–Graduated2014.Interventionsforpreventingandtreatingpostpartumconstipation.(Supervisors:Alfred MusekiwaandAnke Rohwer)

19

ANNEX 2: Intellectual Input

Taryn Young1. Member,Cochraneauthorforum,2013–ongoing

2. Member,Curriculumcommittee,InternationalSocietyonEvidence-basedHealthCare,2013–ongoing

3. Member,Scientificcommittee,7thInternationalConferenceforEBHCTeachersandDevelopers(2015)

4. Member,InternationalAdvisoryBoard,23rdCochraneColloquium(2015)

5. AssociateEditorSystematicreviews

6. Editor,CochraneSexuallyTransmittedDiseasesReviewGroup.July2008–ongoing

7. ChairoftheMastersinClinicalEpidemiologyprogramme,selectionandbursarycommittees2008–ongoing

8. MemberofEHCRCExecutiveCommittee,2011–ongoing

9. SouthAfricanEpidemiologyAssociation(SACEA)executivecommitteemember,2013–ongoing

10. InvitedmemberoftheChronicDiseaseInitiativeforAfrica,April2014–ongoing

Charles Wiysonge1. AssociateEditor:BMCHealthServicesResearch;

2014–ongoing.

2. Editor,CochraneColumn,InternationalJournalofEpidemiology:2014–ongoing.

3. Peerreviewer,BMJOpen,July2015

4. Peerreviewer,HealthResearchPolicyandSystems.September2015.

5. Peerreviewer,Vaccine.April2015.

6. Peerreviewer,Vaccine.August2015.

7. Peerreviewer,GlobalHealthAction.April2015.

8. Peerreviewer,Trials.May2015.

9. Peerreviewer,Vaccine.December2015.

10. Peerreviewer,PharmacoepidemiologyandDrugSafety.June2015.

11. Peerreviewer,SocialScience&Medicine,June2015.

12. Peerreviewer,JournalofClinicalEpidemiology.July2015.

13. Member,PhDEvaluationCommittee,StellenboschUniversity;July–August2015

14. Member,WHOAfricanAdvisoryCommitteeonHealthResearchandDevelopment;2014–ongoing.

15. Member,WHOAfricanTaskForceonImmunisation;2014–ongoing.

16. StrategicAdvisoryGroupofExpertsonImmunisation(SAGE).

WHOGlobal;2015–ongoing.

17. SAGEWorkingGrouponEbolaVaccinesandVaccination,WHO,Global;2014–ongoing.

18. SAGEWorkingGrouponMaternalandNeonatalTetanusElimination,WHO,Global;2015-ongoing

19. Member,IndependentReviewCommittee,GlobalAllianceforVaccinesandImmunisation,Geneva,Switzerland;2014–ongoing.

20.Member,ExecutiveCommittee,GREAT(Guideline-driven,Researchpriorities,Evidencesynthesis,Applicationofevidence,andTransferofknowledge)Network;2014–ongoing.

21. Member,ScientificandOrganisingCommittee,9thInternationalConferenceonTyphoidFeverandOtherInvasiveSalmonelloses;April2014toMay2015.

22.Peerreviewer,Draftreportingguidelinesforimplementationresearch,WHO,September2015.

23. Peerreviewer,Implementationresearchtoaddresspriorityimmunisationissues(multipleproposals).WHO,April–May2015.

24. Peerreviewer,Introductionofnewandunder-utilisedvaccinesinnationalimmunisationprogrammes(multiplecountryapplications).GlobalAllianceforVaccinesandImmunisation(Gavi),March2015.

25.Peerreviewer,Healthsystemstrengthening(multiplecountryapplications).GlobalAllianceforVaccinesandImmunisation(Gavi).March2015.

Celeste Naude1. SouthAfricanEpidemiologyAssociation(SACEA)executive

committeemember,2013–ongoing

2. TechnicalReferenceGrouponHealthyEating.WesternCapeGovernmentHealth.July2014–ongoing

3. TaskteamforNationalObesitystrategy:2015–2020.NationalDepartmentofHealth,2014–2015

4. InvitedmemberoftheChronicDiseaseInitiativeforAfrica,April2014–ongoing

5. MemberoftheCochraneFieldsExecutiveCommittee,2015–ongoing

6. AssociateEditor,CochraneEffectivePracticeandOrganisationofCareGroup,2015–ongoing

7. MemberoftheMinisterialCommitteeonMortalityandMorbidityinChildren(CoMMiC),NationalDepartmentofHealth;Directorate:Child&YouthHealth;2015–ongoing

8. PRICELESSSA(PriorityCostEffectiveLessonsforSystemStrengtheningSouthAfrica)initiative,WitsUniversitySchoolofPublicHealth:Sugar-sweetenedbeveragesinSouthAfrica,March2015

9. NutritionDirectorate,NationalDepartmentofHealth:Evidenceonoptionsforpoliciesandactionstoaddressobesity,February2015;Implementationframeworkfornationalobesitystrategy,July2015;Evidenceondietforpreventingobesityanddietfortreatingobesity,August2015

20

10. AssociationforDieteticsinSouthAfrica:Evidenceonlowcarbohydratediets,March2015;Definitionofevidence-baseddietaryguidelines,May2015

11. Peerreviewer.SouthAfricanJournalofClinicalNutrition,19February2015

12. Peerreviewer.AmericanJournalofClinicalNutrition,15April2015

13. Peerreviewer.BritishJournalofSportsMedicine,13September2015

14. MemberofScientificCommitteefortheNationalNutritionCongress,CapeTownin2016;2015–2016

15. MemberofProgrammeCommitteefortheWorldPublicHealthNutritionAssociationConference,CapeTownin2016,2015–2016

16. MemberoflocalorganisingcommitteefortheInternationalSocietyofBehaviouralNutritionandPhysicalActivityCongress,CapeTownin2016;2014–2016

17. MemberoftheWorkgroupfortheRevisedFood-BasedDietaryGuidelines(FBDG)forSouthAfrica,NationalDepartmentofHealth;Directorate:Nutrition;2011–2014

Anke Rohwer1. Peerreviewer,SystematicReviews(August2015)

2. EditorialAssistant(MethodsAdvisor)CochranePublicHealthGroup,October2014–ongoing

Eleanor Ochodo1. ExtendedmemberofSTARDgroup(Standardsforthe

reportingofDiagnosticAccuracy)

Moleen Zunza1. Executivemember;SouthAfricanEpidemiologyAssociation

(SACEA)2013–ongoing

2. Member;InternationalEpidemiologyAssociation(IEA)2014–ongoing

3. InternalexaminerofMaster’sthesis;MasterofNursingScience,StellenboschUniversity;03February2015

Anel Schoonees1. Peerreviewer.EffectofCoenzymeQ10(Co-Q10)

supplementationondiabetes'biomarkers:asystematicreviewandmeta-analysisofrandomizedcontrolledclinicaltrials;Nutrition,25March2015.

Tonya Esterhuizen1. Executivemember;SouthAfricanEpidemiologyAssociation

(SACEA)2013–ongoing

2. PeerReviewer:CochraneInfectiousDiseasesGroup2012–ongoing

3. PeerReviewer:CochraneDiagnosticTestAccuracyGroup2013–ongoing

4. MemberoftheMastersinClinicalEpidemiologyprogramme,selectionandbursarycommittees2012–ongoing

Michael McCaul1. Vice-president,EmergencyCareSocietyofSouthAfrica

(ECSSA)2014–ongoing

2. Editor,Sanguine,ProfessionalSocietymagazineofECSSA2014–ongoing

3. ExecutiveCommitteeMemberoftheECSSA2014–ongoing

4. ECSSA2016ConferenceAdvisoryBoardmember2016

5. CapePeninsulaUniversityofTechnology(CPUT)DepartmentofEmergencyMedicalSciencesAdvisoryCommitteemember2015–ongoing

6. EmergencyMedicineDepartmentalResearchCommitteemember(UCTandStellenbosch),2015–ongoing

7. JoannaBriggsInstitute(JBI)EmergencyandTraumaCorrespondingReferenceGroupReviewmember2014–ongoing

21

ANNEX 3: Teaching Sessions/Lectures/Workshops

Undergraduate

MB,ChB (SU)

Year Sessions

1 •Principlesofclinicalepidemiologyandvalueofresearchinhealthcare•PrinciplesofEBHCandPhrasingresearchquestions•Approachtosearchingtheliterature•Overviewofdifferenttypesofstudies•Bias,errorandconfounding•Studiesaboutriskfactors:Case-controlstudies•Studiesaboutdiagnosticaccuracy•Studiesabouteffectsofinterventions:RCT•Evidence-informeddecisionmakingandroleofsystematicreviewsforchoiceofdrugtreatments•Descriptivestatistics•Measuresofoccurrence•Diagnosticaccuracy•Measuresofassociation•Measuresofeffect•Confidenceintervals

2 •Diagnostictestaccuracy

Middle phase •Readingapaperonriskfactor

5 •PrinciplesandapplicationofEBM•FindingtheEvidence•Criticalappraisalofsystematicreviews

Late phase •Readingasystematicreviewontreatment

6 Lectureto:StudentinternsatRCS•Formulatingclearquestions•Findingtheevidence:Howtosearchelectronicdatabases•Howtoreadapaperaboutdiagnostictests•Howtoreadapaperontherapy(RCT)•Howtoreadasystematicreviewofariskfactorquestion•EBHCprojectpresentations

Dietetics (SU) NaudeCE.Nutrigenomicsmodule(partofTherapeuticNutrition378).Lectureto:3rdyearundergraduate;BScDieteticsstudents.Date:23-24October2014

22

Postgraduate

MSc in Clinical Epidemiology (SU)

MSc in Clinical Epidemiology: Co-conveners of modules

• FundamentalsofEpidemiology(TarynYoung,MarkEngel)• SystematicReviewsandMeta-Analysis(TarynYoung,AnelSchoonees)• WritingandReviewingScientificpapers(TarynYoung,CharlesWiysonge,AnelSchoonees)• DiagnosisandScreening(CharlesOkwundu,MeganRensburg)• BiostatisticsI(TonyaEsterhuizen)• BiostatisticsII(TonyaEsterhuizen)• ResearchProposalWritingandGrantmanship(TonyaEsterhuizen)• TeachingEBHC(TarynYoung,SusanvanSchalkwyk)

MSc in Clinical Epidemiology: Teaching assistants of modules

• BiostatsI&II–MoleenZunza• SystematicReviews–MichaelMcCaul• Randomisedcontrolledtrials–MichaelMcCaul• Clinicalpracticeguidelines–MichaelMcCaul

MSc in Clinical Epidemiology: Teaching sessions offered

Module Session

Biostatistics • EsterhuizenT.Lecture:Introductionanddescribingdata.Date:3February2015• EsterhuizenT.Exercise:Describingdata.Date:3February2015• EsterhuizenTandZunzaM.Practical:IntroductiontoStatsanddescribingdata.Date:3February2015• EsterhuizenT.Lecture:EstimationI.Date:4February2015• EsterhuizenT.Exercise:EstimationI.Date:4February2015• EsterhuizenTandZunzaM.Practical:EstimationI.Date:4February2015• EsterhuizenT.Lecture:EstimationII.Date:5February2015• EsterhuizenT.Exercise:EstimationII.Date:5February2015• EsterhuizenTandZunzaM.Practical:EstimationII.Date:5February2015• EsterhuizenT.Lecture:T-tests.Date:15April2015• EsterhuizenT.Exercise:T-tests.Date:15April2015• EsterhuizenTandZunzaM.Practical:T-tests.Date:15April2015• EsterhuizenT.Lecture:Nonparametrictests.Date:16April2015• EsterhuizenT.Exercise:Nonparametrictests.Date:16April2015• EsterhuizenTandZunzaM.Practical:Nonparametrictests.Date:16April2015• EsterhuizenT.Lecture:Categoricaldata.Date:17April2015• EsterhuizenT.Exercise:Categoricaldata.Date:17April2015• EsterhuizenTandZunzaM.Practical:Categoricaldata.Date:17April2015

Fundamentals of Epidemiology

• EngelM.IntroductiontoFundamentalsofepidemiology.Date:3February2015• EngelM.Studydesigns:Experimentalstudies.Date:3February2015• EngelM.Studydesigns:Observationalstudies.Date:3February2015• EngelM.Linkingexposureanddisease-measuresofeffect/association.Date:13April2015• EngelM.Theproblemofrandomandsystematicerror.Date:13April2015• EngelMandBalogunT.Thechallengeofconfoundingandeffectmodification.Date:14April2015• EngelM.Earlydetection:screening.Date:14April2015• EngelM.Associationandcausation.Date:14April2015• EngelMandBalogunT.IntroductiontoFundamentalsofepidemiology.Date:20July2015• EngelM.Studydesigns:Observationalstudies.Date:20July2015• EngelM.Linkingexposureanddisease-measuresofeffect/association.Date:7September2015• EngelM.Theproblemofrandomandsystematicerror.Date:7September2015• EngelM.Thechallengeofconfoundingandeffectmodification.Date:8September2015• EngelM.Earlydetection:screening.Date:8September2015• EngelM.Associationandcausation.Date:8September2015

23

Research proposal writing and grantmanship

• YoungT.Studydesignreviewandpracticalexercises.Date:21July2015• EsterhuizenT.Overview:Moduleinperspective.Date:22July2015• EsterhuizenT.Biostatisticalapplications:Samplesizeandpowercalculations–Theory&Practice.

Date:20August2015• EsterhuizenT.Samplingtechniques.Date:20August2015• EsterhuizenT.Questionnairedesign.Date:21August2015• EsterhuizenT.DataAnalysisPlan.Date:21August2015• EsterhuizenT.Datamanagement.Date:09September2015• EsterhuizenT.DataAnalysis(I)and(II).Date:10September2015

Writing and reviewing scientific papers

• YoungT.Howtocriticallyappraiseaclinicaltrial.Date:02March2015• YoungT.Howtocriticallyappraiseacase-controlstudy.Date:02March2015• YoungTandWiysongeC.Howtocriticallyappraiseasystematicreviewandmeta-analysis.Date:02

March2015• YoungT.Howtocriticallyappraiseapaperaboutdiagnostictests.Date:03March2015• YoungT.Howtocriticallyappraiseacross-sectionalstudy.Date:03March2015• YoungT.Howtocriticallyappraiseacohortstudy.Date:03March2015

Systematic reviews • YoungT.Introductiontoresearchsynthesis.Date:20July2015• YoungT.Zoominginonsystematicreviews:whataretheyandwherecanwefindthem?Date:20July

2015• KredoT.Planning&preparingforasystematicreview.Definingthesystematicreviewquestion&

developingcriteriaforselectingstudies.Date:20July2015• SchooneesAandMcCaulM.RevisionofBlock1’scontentandQuiz.Date17August2015• SchooneesAandDuraoS.AssessingriskofbiasinincludedstudiesDate17August2015• SchooneesAandDuraoS.AssessingriskofbiasinincludedstudiesExercisesonRevMan.Date17

August2015• McCaulM.Review:datatypes,measuresofdiseaseoccurrenceandassociation.Date:17August2015• McCaulMandMusekiwaA.Analysingdataandundertakingmeta-analysis.Date18August2015• McCaulMandMusekiwaA.Analysingdataandundertakingmeta-analysisExercisesonRevMan.

Date18August2015• McCaulM.GRADEingtheevidence-theory.Date18August2015• McCaulM.GRADEinpractice:posterexercise.Date18August2015• McCaulM.UsingGRADEProSoftwareforGRADEingevidence.Date:19August2015• VolminkJ.PresentingresultsandSummaryofFindingstable.Date19August2015• MusekiwaA.Interpretingresultsanddrawingconclusions.Date19August2015• WiysongeC.Evidenceintopolicyandpractice:incorporatingsystematicreviewsintodecision-making.

Date:19August2015

Biostatistics II • EsterhuizenT.Analysisofvariance(ANOVA).Date:05August2015• EsterhuizenT.Correlationandsimpleregression.Date:06August2015• EsterhuizenT.Multiplelinearregression.Date:07August2015• EsterhuizenTandZunzaM.Logisticregression.Date:3September2015• EsterhuizenTandZunzaM.Survivalanalysis.Date:4September2015• EsterhuizenTandZunzaM.Revision.Date:9October2015

Randomised control trials • McCaulM.MinimizationinRCTs.Date:31August2015• MahomedH.Samplesizecalculationsappliedtostudentsplannedprotocols.Date:31August2015• EsterhuizenT.Data/statisticalanalysis.Date:01September2015• GeldenhuysM.GoodClinicalPractice.Date:02September2015

Diagnosis and Screening • SmiejaM.TheBasics.Date:04March2015• SmiejaM.AdvancedConcepts.Date:04March2015• ErasmusR.CriticalAppraisal.Date:05March2015• ErasmusR.BiasinDiagnosticStudies.Date:05March2015• OkwunduC.StudyDesign.Date:06March2015• OkwunduC.Designofdiagnosticstudies.Date:06March2015• RensburgM.PrinciplesofScreening.Date:24April2015• OchodoE.Introductiontodiagnostictestaccuracyreviews.Date:24April2015

24

Nursing (Honours programme)

• SchooneesA.Evidence-basedhealthcare&researchsynthesisthewhat,whyandhow?LecturetoNursingstudents(honoursprogramme).FacultyofMedicineandHealthSciences,StellenboschUniversity.22May2015

• DizonJ.Phrasingtherightquestionandsettingtheeligibilitycriteria.LecturetoNursingstudents(honoursprogramme).22May2015

• RohwerA.Findingsystematicreviewstoincludeinascopingreview.LecturetoNursingstudents(honoursprogramme).FacultyofMedicineandHealthSciences,StellenboschUniversity.22May2015

• RohwerA,SchooneesA,DizonJ.Phrasingaquestionforthescopingreview.PracticalsessionwithNursingstudents(honoursprogramme).FacultyofMedicineandHealthSciences,StellenboschUniversity.22May2015

• SchooneesA.Howtostartafterthesearch?Selectingstudiesanddataextraction.LecturetoNursingstudents(honoursprogramme).FacultyofMedicineandHealthSciences,StellenboschUniversity.28May2015

• DizonJ.Stepsofascopingreview:Mappingtheresultsofstudiesintableformat.LecturetoNursingstudents(honoursprogramme).FacultyofMedicineandHealthSciences,StellenboschUniversity.28May2015

• RohwerA,SchooneesA,DizonJ.Findingsystematicreviewstoincludeinthescopingreview.PracticalsessionwithNursingstudents(honoursprogramme).FacultyofMedicineandHealthSciences,StellenboschUniversity.28May2015

• SchooneesA.CriticalappraisalofincludedsystematicreviewsusingAMSTAR.LecturetoNursingstudents(honoursprogramme).FacultyofMedicineandHealthSciences,StellenboschUniversity.28May2015

• SchooneesA.Finalisingtheprotocol.PracticalsessionwithNursingstudents(honoursprogramme).FacultyofMedicineandHealthSciences,StellenboschUniversity.June2015

Postgraduate diploma in Healthcare Management

• RohwerA,SchooneesA.Phrasingquestions.LectureandpracticalsessionwithstudentsdoingthepostgraduatediplomainHealthcareManagement.FacultyofMedicineandHealthSciences,StellenboschUniversity.16November2015

• RohwerA,SchooneesA.Findingsystematicreviews.LectureandpracticalsessionwithstudentsdoingthepostgraduatediplomainHealthcareManagement.FacultyofMedicineandHealthSciences,StellenboschUniversity.16November2015

• RohwerA.Interpretingfindingsandassessingapplicability.LectureandpracticalsessionwithstudentsdoingthepostgraduatediplomainHealthcareManagement.FacultyofMedicineandHealthSciences,StellenboschUniversity.17November2015

Postgraduate certificate in Health Technology Assessment (Online course)

• SchooneesA,RohwerA.Session1:Introductiontoevidence-basedhealthcare(EBHC).Onlinepresentationforstudentsdoingthepostgraduatecertificateinhealthtechnologyassessment.August2015

• SchooneesA,RohwerA.Session2:Questionsandstudydesigns.Onlinepresentationforstudentsdoingthepostgraduatecertificateinhealthtechnologyassessment.August2015

• SchooneesA,RohwerA.Session3:OverviewofthestepsofEBHC.Onlinepresentationforstudentsdoingthepostgraduatecertificateinhealthtechnologyassessment.August2015

Pre-doctoral Short Course Programme

• EsterhuizenT.Statisticaldesignofquantitativeresearch.18thFebruary2015

• YoungT.EvidenceBasedHealthCare.19thFebruary2015

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Biostats Seminars

Date Topic Facilitator

25Feb2015 IntroductoryDataManagement TonyaEsterhuizen

25March2015 Samplesizecalculation RhoderickMachekano

29April2015 Exploratorydataanalysis MichaelMcCaul

27May2015 Presentingresults MoleenZunza

Biostats: Data Management Workshop

Date Topic Facilitator

13July2015 DataManagement TonyaEsterhuizen

13July2015 IntroductiontoSTATA AlfredMusikewa

14July2015 ExploratoryDataAnalysis(EDA)UsingSTATA MoleenZunza

14July2015 Statisticaltests MaxwellChirewa

14July2015 Epitab:TableforEpidemiologists MichaelMcCaul

14July2015 Simplelinearregressionandcorrelation AlfredMusikewa

Lectures and presentations

• McCaulM.Fundamentalsofdescriptiveresearch.WebinarEvent,ECSSA.25thFebruary2015

• McCaulM.Bias,errorandconfounding.WebinarEvent,ECSSA.25thMarch2015

• RohwerA.Compilingadataextractionform.LecturetoparticipantsoftheSystematicReviewsProgramme,UCT.Date:5February2015

• RohwerA.Biasandcriticalappraisal.LecturetoparticipantsoftheSystematicReviewsProgramme,UCT.Date:12February2015

• RohwerA.Case-controlstudies:Designandcriticalappraisal.Lectureto:Post-graduatestudentsandcliniciansdoingtheshortcourseinclinicalresearchskills.FacultyofMedicineandHealthSciences,StellenboschUniversity.Date:22June2014

Workshops

• McCaulM.FundamentalsofBiostatistics.MastersRehabilitationsstudents.Date:23&24February2015

• DizonJ.LouwQ.McCaulM.WhatmakesagoodCPG?RUDASAConferenceworkshop,DullstroomMpumalanga.Date:24thSeptember2015

• DizonJ.LouwQ.McCaulM.CPGsforAlliedHealth.DepartmentofHealth,Mpumalanga,Witbank.Date:22ndSeptember2015

• ProfHofmyer,SchooneesA.McCaulM.ResearchMethodsCourse.Postgraduateclinicians.StellenboschFMHS.Date:26&27November2015

• RohwerA.StellenboschUniversityBEMEInternationalCollaboratingCentre(SUBICC)Workshop:Accessing,assessingandinterpretingfindingsofBEMEsystematicreviews.20May2015

• VanSchalkwykS,YoungTandSchoonneesA.StellenboschUniversityBEMEInternationalCollaboratingCentre(SUBICC)Workshop:Readingasystematicreview.20May2015

Seminar Series

• McCaulM.CohortstudiesandRCTs.Shortcourseinclinicalresearch,FMHS.Date:22ndJune2015

TheBiostatisticsUnitalsofacilitatedmonthly1.5-hourbiostatisticsseminarseriescoveringcurrenttopicalissues.Themainobjectiveoftheseminarserieswastocreateawarenessandliteracyofbiostatisticalmethodsthatarecommonlyfoundinresearcharticles.Suchknowledgeassistsstudentsandresearchersininterpretingandevaluatingevidencefromstudiesthatapplytheseadvancedmethods.Participantsweregivenanarticlerelevanttothetopicunderdiscussiontoreadpriortotheseminar.

Continuing Professional Development: Presentations, seminars and workshops

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ANNEX 4: Governance

TheworkoftheCEBHCisguidedbytheConstitutionoftheCentre.TheCentreismanagedbyaDirectorandherManagementCommittee,whileoversightisprovidedbyaGoverningBoard.

Governing Board:ThegoverningbodyconsistsofthedirectoroftheCentreandfivetosixindividualsincludingforinstancetheDean,deputy-DeanforResearch/Teaching/CommunityServiceand-interactionLiaison,HeadoftheDIHS,arepresentativeofoneoftheotherdepartmentswithintheFaculty,anexternalexpertinthefieldofEBHCandarepresentativeoftheNationalorProvincialDepartmentofHealth.ThegoverningbodymeetsannuallyandprovidesstrategicoversightanddirectiontotheCentre.

Board members

• DrTaniaBrodovcky

• ProfUsufChikte(Chairperson)

• DrThereseFish

• ProfPaulGarner(DeputyChairperson)

• ProfWilhelmSteyn

• DrKrishVallabhjee

• ProfJimmyVolmink

• DrTarynYoung(Director)

Management committee: ThemanagementcommitteeconsistingoftheDirector,headofDIHSandtwotothreestaffmembersmeetsregularlytodiscussmanagementissues.Specificindividualsareco-optedwhennecessary,basedontheagendaofthespecificmanagementcommitteemeeting.

GoverningBoard

ManagementCommitee

CEBHC

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1. Dr Gillian Balbir Singh Gillianholdsamedicaldegree(MbChB)fromtheUniversity

ofAuckland,NewZealandandisatrainednephrologistandFellowoftheRoyalAustralasianCollegeofPhysicians(FRACP).ShehasaMastersinPublicHealthfromtheUniversityofAuckland.ShehasrecentlybeenonaresearchfellowshipatUlsanUniversityHospital,SouthKoreafocusingondataanalysisandinterpretationinthefieldofinterventionalcardiology.ShecurrentlyworksfortheSouthAfricanRenalRegistryandisanephrologistatTygerbergHospital.Sheworkspart-timeattheCEBHCandiscurrentlyworkingonascopingreviewontheprevalenceofchronickidneydiseaseinAfrica.Sheisalsoinvolvedinundergraduateclinicalmedicineandevidencebasedmedicineteaching.

2. Mr Maxwell Chirehwa Maxwellhasanhonoursdegreeinappliedmathematicsand

anMScinstatistics(specialisinginbiostatistics)fromHasseltUniversity,Belgium.HeisregisteredwiththeRoyalStatisticalSociety(RSS),UKasagraduatestatistician.Hecurrentlyprovidesstatisticalconsultingservicestostudentsandstaffinthefacultyofmedicineandhealthsciences.Hismaininterestisontheapplicationofnonlinear-mixedeffectsmodelstooptimizetreatmentsuccessanddescribevariabilityindrugexposure.

3. Mr Tawanda Chivese TawandaisaresearcherwhograduatedwithaMastersin

ClinicalEpidemiologyDegreefromtheStellenboschUniversityin2014.HealsoholdsanhonoursBachelorofScienceDegreefromtheUniversityofZimbabwe.HejoinedtheCentreforEvidenceBasedHealthCareinNovember2015andhelpswithbiostatisticalconsulting,research,andteaching.HeiscurrentlystudyingtowardshisPhDinMedicine(focussingonthepreventionoftype2diabetesaftergestationaldiabetes)withtheUniversityOfCapeTown.Heisinterestedinhealthsystemsstrengthening,non-communicablediseaseepidemiologyandprevention.HerecentlypublishedhispaperonCrohn’sDiseasephenotypeandcigarettesmoking.Hehasalsoco-authoredanumberofpapersinpeerreviewedinternationaljournalsandpresentedresearchfindingatInternationalconferences.

4. Dr Janine Margarita R. Dizon Janine,PhD,MSPT,PTRP,isfromthePhilippinesandisa

researchfellowatCEBHCworkingontheSouthAfricanGuidelinesEvaluation(SAGE)projectandisinvolvedinteachingEBHCtomedical,nursingandalliedhealthstudentsatStellenboschUniversity.SheisaphysiotherapistbytrainingandholdsadoctoraldegreeinHealthSciencesfromtheUniversityofSouthAustralia(President’sScholar).Janine’sworkisfocusedondevelopingandevaluatingtailoredEBHCteachingprogramsforhealthprofessionalsindifferentcountries(Philippines,HongKong,AustraliaandSouthAfrica).HerworkonEBHChasevolvedintoqualityimprovementinhealthcaresuchasclinicalguidelinedevelopment,implementation,monitoringandevaluationinpractice.

5. Ms Tonya Esterhuizen TonyaEsterhuizenhasanhonoursdegreeinbiochemistryand

immunologyandanMScinEpidemiologyfromtheLondonSchoolofHygieneandTropicalMedicine.Sheprovidesbiostatisticalconsulting,participatesincollaborativeresearch,andteachesonbothunder-andpostgraduatelevel.SheworkswithlocalandinternationalCochraneReviewauthorsandgroups,assistinginthepreparationofstatisticalmethodsinreviewprotocolsandmeta-analysisofdata.SheisastatisticalreviewerfortheCochraneInfectiousDiseasesgroup.Tonyahasmanycollaborativepublicationsinappliedbiostatisticsandepidemiology,invarioushealthdisciplines.

6. Ms Liesel Esterhuizen LieselEsterhuizenistheAdministrativeAssistantforthe

BiostatisticsUnit.Sheisresponsiblefortheday-to-dayrunningoftheBiostatisticsUnitandalsoforallthelogisticsregardingtheBiostatisticsUnitandtheiractivities.

ANNEX 5: Staff

The work of the CEBHC is supported by an excellent team of full-time and part-time staff. Each staff member has a detailed job description, key performance areas and development plans. 1. 2. 3.

4. 5. 6.

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9. Dr Nyanyiwe Mbeye NyanyiweholdsaPhDinTropicalMedicinefromtheUniversity

ofLiverpoolandUniversityofMalawi,CollegeofMedicine,aMastersofSciencedegreeinEpidemiologyfromErasmusUniversityRotterdamintheNetherlands,aMastersdegreeinPublicHealthfromtheCollegeofMedicine,UniversityofMalawi.ShehasaBachelorofSciencedegreeinNursingandalsoholdsaUniversityCertificateinMidwifery.CurrentlysheisaPost-doctoralresearchfellowattheCentreforEvidenceBasedHealthCareatStellenboschUniversity,CapeTown.Hermainfocusissystematicreviewsandknowledgetranslation.Overtime,Nyanyiwehasgainedalotofexperienceinresearchandprogrammemanagement.ShehasrannationalprogrammesonreproductivehealthandmalariainMalawi.Shehasanumberofpublicationsinpeerreviewedjournals.

10. Mr Michael McCaul Michaelisaregisteredemergencycarepractitionerandis

passionateaboutpre-hospitalemergencycareandresearch,havingworkedasanoperationalparamediclocally(CapeTownandDurban)andinternationally.Heiscurrentlythevice-presidentoftheEmergencyCareSocietyofSouthAfrica(ECSSA)andisactivelyinvolvedindevelopingemergencycareresearchinSouthAfrica.MichaelholdsaBHScinEmergencyMedicalCare(DUT)andanMScinClinicalEpidemiologyatStellenboschUniversity.HeiscurrentlyundertakinghisPhDinepidemiologyfocusingonguidelinedevelopmentmethodsinemergencycare.HeiscurrentlyworkingasaresearcherattheBiostatisticsunit,muchofhisworkinvolvesundergraduateandpostgraduateteaching,biostatisticsconsultation,knowledgetranslationincludingguidelinedevelopmentandresearch.

11. Mrs Traci Naidoo TraciNaidooistheprojectmanagerattheCentreforEvidence-

basedHealthCare.Sheisresponsiblefortheday-to-dayrunningoftheCentreaswellasorganisingvariousworkshopsandseminars.ShealsodoesthemarketingoftheCentre,includingupdatingtheFacebookpage,Twitterfeedandwebsite.

7. 8. 9.

10. 11.

7. Ms Lynn Hendricks LynnisaregisteredResearchPsychologistwhoholdsaBSc

fromFreed-HardemanUniversity,UnitedStatesandadualMAResearchPsychologydegreefromtheUniversityoftheWesternCapeandOsloUniversity.Shehasexperienceinundergraduateandpostgraduateresearchlecturingandsupervision,policywriting,monitoringandevaluation,mixedmethodsprimaryresearchanddataanalysis.Shehasauthoredandco-authoredpapersinpeer-reviewedjournals,disseminatedresearchfindingsatinternationalandnationalcongressesaswellassymposiums,andworkshops.OtheractivitiesincludeexecutivecommitteemembershipfortheDivisionofResearchandMethodology,PsychologicalSocietyofSouthAfrica.HerresponsibilitiesattheCentreforEvidence-basedHealthCareincludeprojectmanagementandtrainingfacilitationtobuildoperationalresearchcapacity.

8. Prof Rhoderick N Machekano RhoderickNMachekanoholdsaPhDinBiostatisticsanda

MPHinEpidemiologyandBiostatistics.HeiscurrentlytheHeadoftheBiostatisticsUnitwhereheleadsthedevelopmentofbiostatisticscapacitybuildingatStellenboschFMHS.HisdutiesincludemanagingtheUnit,teaching,biostatisticalconsulting,researchcollaboration,andmentoringofpostgraduatestudents.Hehasworkedinpublichealthforover20years,focusingondesigningandevaluatingHIV/AIDS/STIsinterventionsinbothdevelopedanddevelopingcountries.Overthecourseofhisprofessionalcareer,hehasacquiredvaluableskillsintranslatingresearchintopolicy,exercisinghisabilitytotransformdataintoknowledge.Hehaspublishedmodestlyinreputablescientificjournals.

29

12. Dr Celeste Naude CelesteNaudeisaregistereddieticianandseniorresearcher.

Sheholdsamaster’sdegreeinNutrition(2007)andaPhD(NutritionalSciences)(2012)fromStellenboschUniversity.Herrolesincluderesearch,knowledgetranslation,projectmanagementandteachingandherprimaryinterestsarepublichealthnutritionandevidence-informeddecision-making.Celesteisamemberofthetechnicalauthorteamforsystematicreviewsandevidencesummaries,aninvestigatorforprimaryresearchprojectsandisinvolvedinAfricanandinternationalresearchnetworksviatheECHRCandCochrane.Sheiscurrentlyinvolvedinanumberofactivitiespromotingevidence-informeddecision-makingwithprovincialandnationalstakeholders.Sheservesonanumberofinternationalandnationalscientificandtechnicalcommittees,isapeer-reviewerfornationalandinternationaljournals,andasupervisorandexaminerforpostgraduatestudents.

13. Dr Valantine Ndze ValantineisapostdocresearchfellowattheCEBHC.Hehasa

backgroundinclinicallaboratorysciencesandholdsaPhDinInfectiousdiseasesfromtheUniversityofYaoundéI,Cameroon.Hispreviousresearchhasbeenontheepidemiology,diagnosis,andgenomicsofviruses(rotavirus,bocavirus,measles,rubella,hepatitisB&C)andbacteriainhumansandanimals.Hehasaspecialinterestinpediatricvaccinepreventableinfectiousdiseases,evidencebasehealthcareandvaccinology.Heispresentlyinvolveinvariousactivitiesincluding,conductingandsupportingmethodologicallysoundsystematicreviewsonprioritytopicsrelevanttotheSustainableDevelopmentGoals.

14. Dr Liesl Anne Nicol LieslNicoliscurrentlyapart-timeseniorresearcher.Her

responsibilitiesattheCentreforEvidence-basedHealthCareincludeprojectmanagement,researchandknowledgetranslation.SheobtainedherPhDinExercisePhysiologyattheUniversityofCapeTownin2003.ShehasexperienceinconductingandsupportofCochraneReviews,andfacilitatingthelearningofevidence-basedhealthcare.Recentprojectinclude:EVidencetoInformSouthAfricanTBpolicies:EVISATProject(projectmanager);informingWHOguidelinesaroundprovidingsupplementaryfoodtoundernourishedchildren;evidencefortheeffectivenessofnutritionalsupplementationtoTBpatientsonactiveTBtreatment;effectivenessofprovidingparenteralglutaminesupplementationtocriticallyillpatients.

15. Dr Eleanor Ochodo EleanorOchodoisaseniorresearcherandWellcomeTrust

researchfellowattheCEBHC.ShequalifiedasamedicaldoctorfromtheUniversityofNairobi,Kenya(MBChB).ShealsoholdsapostgraduatecertificateinInfectiousDiseasesfromtheUniversityofEdinburgh(UK),anMScinInternationalHealthfromtheFreeUniversityofAmsterdam(VrijeUniversiteit)andaPhDinClinicalEpidemiologyfromtheUniversityofAmsterdam,TheNetherlands.Herresearchrevolvesaroundevidence-basedmedicinewithafocusondiagnostictestsandmarkers,specificallytheiraccuracy,impactandhowtheirresultscanbetranslatedtopolicyandpractice.

16. Dr Charles Okwundu CharlesOkwunduwastrainedamedicaldoctoratthe

UniversityofLagos,Nigeria,andcompletedamaster’sinPublicHealthattheUniversityofCapeTown.Heiscurrentlyworkingasaresearcher.CharleshasbeeninvolvedwiththeCochraneCollaborationsince2006asareviewauthorandhasbeeninvolvedinanumberofCochranesystematicreviews.Hisparticularinterestsareinevidence-basedhealthcareandpaediatrics.HeiscurrentlyinvolvedinanumberofactivitiesaimedatpromotingthepracticeofEBHCwithintheAfricanregionandalsoincreasingtheinvolvementofCochraneauthorsfromtheAfricanregion.

12. 13. 14.

15. 16.

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17. Ms Anke Rohwer AnkeRohwerisaresearcherattheCentreforEvidence-based

HealthCare.Shehasabackgroundinmidwifery(BCur),hascompletedherMastersinClinicalEpidemiologyin2010andisaregisteredPhDstudentatStellenboschUniversity.AspartofherPhDstudies,sheisleadingaprojectonresearchintegrityinlow-andmiddle-incomecountries.Herotherresearchactivitiesincludesystematicreviewsandresearchrelatedtoteachingevidence-basedhealthcare(EBHC).Inadditiontodoingresearch,AnkeisinvolvedwithteachingactivitiesthatincludeteachingEBHCprinciplestohealthcareprofessionalsatundergraduate,postgraduateandcontinuingmedicaleducationlevel,supervisingMaster’sstudentsandmentoringnoviceauthorsofsystematicreviews.ShecurrentlyactsasamethodsadvisorfortheCochranePublicHealthGroup,peer-reviewsarticlesforinternationaljournalsandhaspresentedherworkatnationalandinternationalconferences.

18. Ms Anel Schoonees AnelSchooneesisaresearcherwithundergraduatetraining

inFoodScience(2006).Shealsoholdsamaster’sdegreeinNutrition(2011)andamaster’sdegreeinClinicalEpidemiology(2012)fromSU.Anel’srolesattheCEBHCincluderesearch,teachingandknowledgetranslation.Sheistheauthorandco-authorofanumberofsystematicreviewsandotherresearch(e.g.evaluationofalliedhealthcurriculaforEBHCcompetencies),andhasdisseminatedresearchfindingsatinternationalandnationalconferences.Sheisalsoinvolvedinpeer-reviewingsystematicreviewsandexaminingpostgraduatestudents.SheteachessystematicreviewsandEBHCtohealthcareprofessionals,undergraduateandpostgraduatestudents,andprovidesguidancetonewsystematicreviewauthors.Ontheknowledgetranslationfrontshewritessummariesofsystematicreviews,editsWikipediatorefertosystematicreviewsandinteractswithstakeholderssuchasthemediaandaNGO.

19. Prof Charles Shey Wiysonge CharlesistheDeputyDirectoroftheCEBHC.HeobtainedaPhD

fromtheUniversityofCapeTown,anMPhilfromtheUniversityofCambridge(UK)andanMDfromtheUniversityofYaoundéI(Cameroon),undertookaresearchfellowshipinevidence-basedhealthcareattheUKCochraneCentre,andisaMemberoftheAcademyofScienceofSouthAfrica.Recently,hisresearchworkhasfocusedonevidencesynthesisforchildhoodimmunisationandhealthsystemstrengthening.HehasanH-indexof28andaResearchGateindexof42.57.CharlesisamemberoftheStrategicAdvisoryGroupofExpertsonImmunisation;theAfricanAdvisoryCommitteeonHealthResearchandDevelopment;theIndependentReviewCommitteeofTheGlobalAllianceforVaccinesandImmunisation;theGradingofRecommendationsAssessmentDevelopmentandEvaluation(GRADE)WorkingGroup,andotherinternationalscientificadvisorycommittees.

20. Prof Taryn Young Taryn,MBChB,FCPHM,MMED,PHD.DirectoroftheCentrefor

Evidence-basedHealthCareandconsultanttotheSouthAfricanCochraneCentre,isanepidemiologistwithaspecialistdegreeinpublichealthandconsiderableexpertiseinthefieldofevidence-basedhealthcare.Shecoordinatesinternationalcollaborativeprojectswhichfacilitatetheuseofbestevidenceinhealthcarepolicyandpractice,andhasconductedmanysystematicreviewsandprovidedintensivetraining,mentorshipandeditorialsupporttoauthorsofCochraneandothersystematicreviews.Integraltoherworkistheco-ordinationandevaluationoftrainingprogrammesforunder-andpostgraduatestudentsinpublichealthandepidemiology,evidence-basedhealthcareandresearchsynthesisnationallyandintheAfricanregion.

21. Dr Moleen Zunza Moleenqualifiedasanursein2004attheUniversityof

Zimbabweandreceivedamaster’sdegreeinClinicalEpidemiology(2011),honoursinAppliedStatistics(2016)andPhD(2016),atStellenboschUniversity.HermaininterestsareinMaternalandChildHealthandHIV/AIDSresearchandBiostatistics.SheiscurrentlyworkingfortheCentreforEvidenced-basedHealthCare,StellenboschUniversity.Herworkinvolvesconductingprimaryandsecondaryresearch,teaching,statisticalconsultationsandsupervisionofpostgraduatestudents.

17. 18.

19. 20. 21.

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Extraordinary staff appointments

The work of the CEBHC is also supported by the following extraordinary staff:

• ProfMikeClarke,NorthernIrelandNetworkforTrialsMethodologyResearch,Queen’sUniversityBelfast,Belfast,NorthernIreland

• ProfPaulGarner,LiverpoolSchoolofTropicalMedicine,UnitedKingdom

• MrAlfredMusekiwa,SouthAfrica

• ProfMarekSmieja,McMasterUniversity,Canada

• ProfLehanaThabane,McMasterUniversity,Canada

• DrOlalekanUthman,WarwickUniversity,UnitedKingdom

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The achievements of the CEBHC are made possible by the excellent team who supports the work of the Centre.

This annual report is a reflection of the teams’ dedication and accomplishments.

Prepared by:TYoung,TNaidoo,CWiysonge,CNaude

Contact details:CentreforEvidence-basedHealthCare(CEBHC)DepartmentofInterdisciplinaryHealthSciencesFacultyofMedicineandHealthSciencesStellenboschUniversityPOBox241CapeTown,8000SouthAfrica

Website: www.sun.ac.za/cebhcEmail: tyoung@sun.ac.zaortracin@sun.ac.zaTel: +2721938-9886Fax: +2721938-9734Facebook:www.facebook.com/cebhcTwitter: @cebhcwww.twitter.com/cebhc