RTG kick-off dayThe Center for Inflammation and

Regenerative Modeling

Gilles Clermont, Medical DirectorAssociate Professor of Critical Care Medicine,

Industrial Engineering and Mathematics, University of Pittsburgh)

www.mirm.pitt.edu/cirm

Mathematical biology of acute inflammation

Hot! This will change the worldMultidisciplinarity

Mathematics, Medicine, Engineering, Computational Biology, CS, BioinformaticsUndergrads, Grad students, post-docsPitt, CMU

Close mentorshipScientific guidancePapers, grant writing (post-docs)Exposure (conference)

Employment

Mathematical disciplines involved

DynamicsModel design and simulation

OptimizationLinear algebra, applied analysis, statistical mathematics, control, differential geometry, numerics

Machine-learning algorithms

Computation

Numerical algorithmsDistributed and parallel computing

Specific projects

Biological models of influenza A virusMultiscale (lung function/cells/pathways)Ermentrout/Swigon

Model-based therapy of uncontrolled inflammationSEPsIS project (Rubin)Vocal cord injury and healing (Swigon)Multiorgan failure (Ermentrout/Rubin)

Renal failureEpidemiology and models of acute pancreatitis

Medical decision supportModel-based bayesian inference (Rubin)Machine-learning inference

The SEPsIS project

Animal (LPS, CLP model of sepsisAdjust hemoadsorption intervention to optimize outcome

Mathematical model of diseaseComputational tools

The SEPsIS project