The Brain as a Final Frontier

Dr. Vetter’s laboratory is focused on understand-ing the molecular pathways controlling neural development and neurodegeneration. Her focus is on the retina, which is of critical importance since disorders of eye development can lead to congen-ital blindness, while degeneration of retinal neu-rons causes progressive loss of vision at later ages.

Dr. Baccei received a B.S. in Psychology from Duke University and a Ph.D. in Neuroscience from Yale University. He completed a postdoctoral fel-lowship in the Department of Anatomy and Devel-opmental Biology at University College London studying the maturation of nociceptive pathways in the CNS under normal and pathological condi-tions. He is currently an Associate Professor in the Department of Anesthesiology at the University of Cincinnati and serves as the Associate Director of the Neuroscience Graduate Program. Dr. Baccei’s lab is currently investigating the short- and long-

term consequences of neonatal tissue injury for the function of synaptic circuits in the developing spinal dorsal horn. This work is expected to yield new insight into the neurobiological basis for hyperalgesia in infants and children, and could also help explain why early tissue dam-age appears capable of altering nociceptive processing throughout life.

Dr. Bruchas received both his Bachelor of Science degree in biology and his Ph.D. in pharmacology from Creighton University in 2004. He complet-ed a postdoctoral fellowship in neuroscience at the University of Washington – Seattle, where he spent his post-doctoral research efforts examining how the brain encodes emotional behaviors, and how stress impacts anxiety, depression, and addiction. He was then recruited as an assistant professor to Washington University School of Medicine in late 2010 and was rapidly promoted to associate pro-fessor with tenure in July 2015. Over the course

of his relatively young academic career, Dr. Bruchas’ work has been continually funded by the NIH and has led to more than 50 peer-re-viewed publications, book chapters, and a plethora of invited lectures worldwide. He has served as a member of several National Institutes of Health (NIH) review panels, international science review boards, and serves as a reviewer for multiple high impact research journals. In 2012, he received the very prestigious NIH Director’s Transformative Research Award, as well as an NIH EUREKA (Exceptional Uncon-ventional Research Enabling Knowledge Acceleration) Award in 2013.

Dr. Mashour is an anesthesiologist and NIH-funded neuroscientist at the University of Michigan Med-ical School. He is internationally recognized for his work on consciousness, mechanisms of anes-thetic-induced unconsciousness, and intraoperative awareness. Dr. Mashour has authored >125 articles and commentaries, with key publications appearing in the New England Journal of Medicine and the Proceedings of the National Academy of Scienc-es. He has also edited four textbooks, published by Cambridge University Press and Oxford University Press. Dr. Mashour plays a number of leadership

roles at the University of Michigan. At the departmental level, he is the Bert N. La Du Professor and Associate Chair for Anesthesiology Re-search. At the medical school level, he serves as the Associate Dean for Clinical & Translational Research and is the founding director of the Center for Consciousness Science. At the institutional level, he serves as the Director of the Michigan Institute for Clinical & Health Research, an NIH-funded institute dedicated to advancing translational research. More recently, he has been appointed Director of Translational Re-search in the central Office of Research, with responsibilities across all schools and campuses at the University of Michigan. Additionally, Dr. Mashour serves on the board of the Foundation for Anesthesia Educa-tion and Research and will serve as President of the Society for Neuro-science in Anesthesiology & Critical Care (SNACC) from 2016-2017. Dr. Mashour trained at Georgetown University and Harvard Medical School, and was a two-time Fulbright Scholar in the neurosciences. He has been the recipient of numerous honors, including the Presiden-tial Scholar Award from the American Society of Anesthesiologists.

Monica Vetter, PhDUniversity of Utah

Mark Baccei, PhDUniversity of Cincinnati

Michael Bruchas, PhDWashington University

George Mashour, MD, PhDUniversity of Michigan

Scott Junkins, MD University of Utah

Dr. Junkins completed an anesthesiology residen-cy and a pain medicine fellowship at the Univer-sity of Utah. With additional board certification in Hospice and Palliative Medicine, Dr. Junkins is an Associate Professor in the Department of Anes-thesiology, practicing general anesthesiology and chronic pain medicine. He is Vice Chair for Pain Medicine in the Dept of Anesthesiology and Medi-cal Director of the Pain Management Center atthe University of Utah. Other interests include telemedicine, international medicine, and anesthe-sia education.

Chair: Talmage Egan, MD

Co-Chair: Ken Johnson, MD

Moderators: Alan Light, PhDNathan Pace, MD, MStat

Session Host: Harriet Hopf, MD

Program Manager: Ami Stuart, PhDami.stuart@hsc.utah.edu

Event Coordinator: Annalyse Erickson, MBAannalyse.erickson@hsc.utah.edu

Please address questions to the Program Manager and Event Coordinator

Symposium Organizing Committee

University of Utah Department of Anesthesiology • 30 N 1900 E, RM 3C444 SOM SLC, UT 84132 • 801-581-6393

University of Utah Department of Anesthesiology • 30 N 1900 E, RM 3C444 SOM SLC, UT 84132 • 801-581-6393

stanleysymposium.uofumedicine.org

Theodore H. Stanley Research Symposium 2017Data Mining for Anesthesia GoldSATURDAY MORNING/April 29, 2017

7:30 am Registration, Continental Breakfast, and Poster Viewing8:00 am Welcome and Introductions – Talmage Egan, MD8:10 am “The Promise of Big Data – What Does It Mean for Us?” – Kai Kuck, PhD 8:30 am “What Do Clinicians Want from Big Data?” - Amber Bledsoe, MD8:50 am “Fulfilling the Promise of Big Data Analytics: How Do We Get There from Here?” – Sachin Kheterpal, MD9:40 am Coffee Break and Poster Viewing10:10 am “What Color Should I Paint My Barn? Hubris and Humility in Perioperative Machine Learning” – Patrick Tighe, MD, MS10:50 am “A Brief Primer on Using Medicare Claims for Anesthesia-Related Research” – Catherine Chen, MD11:30 am Moderated Discussion/Questions – Nathan Pace, MD, MStat12:00 Lunch

The Brain as a Final FrontierSATURDAY AFTERNOON/April 29, 2017

1:00 pm Reconvene and Introductions – Harriet Hopf, MD1:10 pm “What’s Hot in Neuroscience?” – Monica Vetter, PhD1:30 pm “What Anesthesiologists and Pain Docs Want from Neuroscience” – Scott Junkins, MD1:50 pm “Communication Breakdown: Cortical Mechanisms of Anesthetic-Induced Unconsciousness” – George Mashour, MD, PhD2:40 pm Poster Presentations3:25 pm “Rewiring of Spinal Nociceptive Circuits by Neonatal Injury” – Mark Baccei, PhD4:05 pm “Dissecting Neuromodulatory Circuits in Affective Behavioral States” – Michael Bruchas, PhD4:45 pm Moderated Discussion/Questions – Alan Light, PhD5:15 pm Adjourn

SATURDAY EVENING/April 29, 2017Log Haven Restaurant - 6451 E. Millcreek Canyon Road, Salt Lake City, Utah 6:30 pm Dinner

Scientific posters will be featured as part of the meeting. Abstracts of studies relating to anesthesiology big data and neuroscience investigations are welcome. The top abstract will be awarded a $500 prize, with two runners up prizes of $250 each.

Instructions for abstract submission and content guide-lines are provided at http://stanleysymposium.uofumed-icine.org.

Accreditation: The University Of Utah School Of Medicine is accredited by the Accreditation Council for Continuing Med-ical Education (ACCME) to provide con-tinuing medical education for physicians.

AMA Credit: The University of Utah School of Medicine designates this live activity for a maximum of 7 AMA PRA Category 1 Credit(s)™. Physicians should claim only the cred-it commensurate with the extent of their participation in the activity.

Disclosure: None of the faculty or planners or anyone in control of content for this continuing medical education activity have any rel-evant financial relationships since the content does not cover any products/services of a commercial interest; therefore, there are no relevant financial relationships to disclose. Requests for reason-able accommodations for disabilities should be made in advance.

Call for Abstracts

Data Mining for Anesthesia Gold

Throughout his work, Dr. Kuck has been involved in the research and development of innovative medical technologies with a focus on anesthesia and critical care. His areas of focus include car-diorespiratory monitoring, intelligent decision support, and ventilation. His experience covers the whole range from hands-on engineering for hardware, software, algorithm, and graphical user interface development all the way to man-aging projects, programs, and large teams of re-searchers. In his last position he oversaw the research of Dräger, the global market leader in

anesthesia equipment and critical care ventilation. Since 2014, in his role as Director of Bioengineering at the University of Utah’s Depart-ment of Anesthesiology, he has worked closely with clinicians and learned about real-world needs and opportunities for technologies. Because transforming healthcare increasingly involves innovations at the system and workflow level, this collaborative approach is es-sential to creating technologies that address real needs in the clinic.

Dr. Tighe serves in the Division of Acute Pain Med-icine and provides care in the blockroom, acute pain service, and operating room. Additionally, he is the director of the Perioperative Analytic Group. This team applies advanced analytical techniques in an operational clinical environment to improve perioperative data utilization. Dr. Tighe’s research examines how machine learning algorithms, sto-chastic process modeling, social network analyses and computer vision can improve processes relat-ed to acute postoperative pain and perioperative patient safety. Following completion of a K23

from the National Institute of General Medical Sciences at the Na-tional Institutes of Health, he was awarded an R01 in July of 2015 to examine the temporal dynamics of postoperative pain. He collab-orates with a diverse array of researchers from the Colleges of Engi-neering, Business, Dentistry, and Liberal Arts and Sciences. Dr. Tighe serves as section co-editor for the Acute and Perioperative Section of the journal Pain Medicine, and is active in the American Acade-my of Pain Medicine’s Acute Pain Medicine Special Interest Group.

Dr. Catherine Chen is an Assistant Professor in the Department of Anesthesia and Perioperative Care at the University of California, San Francis-co (UCSF). She is also affiliated with the Philip R. Lee Institute for Health Policy Studies and the UCSF Center for Healthcare Value. Dr. Chen re-ceived a BA in English from Rice University in 2001. After a brief stint in investment banking, Dr. Chen obtained her MD from the Johns Hopkins University School of Medicine in 2010, while si-multaneously earning an MPH at the Johns Hop-kins Bloomberg School of Public Health in 2009.

Dr. Chen completed her internship and residency in the Department of Anesthesia and Perioperative Care at UCSF. Dr. Chen’s research interests include identifying and reducing healthcare over-utiliza-tion as well as streamlining healthcare delivery during the periop-erative period. She received a Research Fellowship Grant from the Foundation for Anesthesia Education and Research (FAER) in 2013, and a Mentored Research Training Grant from FAER in 2016. In her spare time, Dr. Chen enjoys playing Scrabble, reading the New York Times, and relaxing at home with her husband and two children.

Kai Kuck, PhDUniversity of Utah

Patrick Tighe, MD, MSUniversity of Florida

Catherine Chen, MDUniversity of California, San Francisco

Sachin Kheterpal is an Associate Professor of An-esthesiology at the University of Michigan Medical School. Prior to a clinical anesthesiology career, he was the lead architect of a leading commercial-ly available clinical information system—General Electric Centricity. He led the global clinical infor-mation system product development team at GE Healthcare IT. He brings nearly two decades of in-formatics, software development and business ad-ministration experience to perioperative outcomes research. He is the principal investigator of the Mul-ticenter Perioperative Outcomes Group (MPOG), a

research and quality improvement consortium of more than 40 anesthe-siology and surgical departments. He is recognized as a national leader in perioperative large dataset clinical research and has published numer-ous articles, editorials and book chapters regarding intraoperative man-agement and long-term postoperative outcomes. Dr. Kheterpal’s current research focus is evaluating the comparative effectiveness of intraop-erative anesthesiology interventions on long-term patient outcomes.

Sachin Kheterpal, MDUniversity of Michigan

Amber Bledsoe, MD University of Utah

Dr. Bledsoe is an Associate Professor in the De-partment of Anesthesiology at the University of Utah, specializing in perioperative medicine, perioperative echocardiography, and quality im-provement. She completed her residency in Anes-thesiology at the University of Utah and then com-pleted a one-year Perioperative Echocardiography Fellowship. She is board certified by the American Board of Anesthesiology and the National Board of Echocardiography in Perioperative Transesoph-ageal Echocardiography and Adult Echocardiog-raphy. She is the Director of Quality Assurance

for the Department of Anesthesiology, and is the local champion for Anesthesiology Performance Improvement and Reporting Exchange (ASPIRE), a national quality improvement initiative. Her role as the Director of Quality Assurance has lead to several process improvement projects designed to reduce waste and improve the quality of patient care. She is also an Associate Medical Director of the Preoperative Clinic whose mission is to practice evidence-based care to reduce ad-verse perioperative events. Outside of the hospital, she enjoys reading, skiing, hiking, and spending time with family at their Wyoming cabin.

Celebrating the legacy of Dr. Stanley